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1. 发明授权

US08314085B2 Agent for overcoming resistance to anti-cancer agent 有权
标题翻译：克服抗癌药物抗药性的药剂
公开(公告)号：US08314085B2
公开(公告)日：2012-11-20
申请号：US13169670
申请日：2011-06-27
申请人： Masuharu Hirano , Tomio Yamakawa , Toshihisa Ishikawa , Hikaru Saito
发明人： Masuharu Hirano , Tomio Yamakawa , Toshihisa Ishikawa , Hikaru Saito
IPC分类号： A61K31/33
CPC分类号： C07D513/04 , A61K31/426 , A61K31/444 , A61K31/4745 , A61K31/519 , A61K45/06 , C07D277/20 , C07D277/56 , C07D401/14 , C07D487/04
摘要： An agent comprising, as an active ingredient, a xanthine oxidase inhibitor such as 2-[3-cyano-4-(4-fluorophenoxy)phenyl]-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-[3-cyano-4-(4-fluorophenoxy)phenyl]thiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-(3-cyano-4-phenoxyphenyl)thiazolo[5,4-d]pyrimidine, TMX-67, and FYX-051, which can be used as an agent for overcoming anti-cancer agent resistance.
摘要翻译：作为活性成分包含黄嘌呤氧化酶抑制剂如2- [3-氰基-4-（4-氟苯氧基）苯基] -4-羟基噻唑并[5,4-d]嘧啶钾盐，2- [3 （4-氟苯氧基）苯基]噻唑并[5,4-d]嘧啶，2-（3-氰基-4-苯氧基苯基）-4-羟基噻唑并[5,4-d]嘧啶，2-（3 2-氰基-4-苯氧基苯基）-4-羟基噻唑并[5,4-d]嘧啶钾盐，2-（3-氰基-4-苯氧基苯基）噻唑并[5,4-d]嘧啶，TMX-67和FYX- 051，可用作克服抗癌剂抵抗力的药剂。

2. 发明申请

US20100234399A1 AGENT FOR OVERCOMING RESISTANCE TO ANTI-CANCER AGENT 审中-公开
标题翻译：抗癌药物耐药性的药剂
公开(公告)号：US20100234399A1
公开(公告)日：2010-09-16
申请号：US12305809
申请日：2007-06-22
申请人： Masuharu Hirano , Tomio Yamakawa , Toshihisa Ishikawa , Hikaru Saito
发明人： Masuharu Hirano , Tomio Yamakawa , Toshihisa Ishikawa , Hikaru Saito
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00
CPC分类号： C07D513/04 , A61K31/426 , A61K31/444 , A61K31/4745 , A61K31/519 , A61K45/06 , C07D277/20 , C07D277/56 , C07D401/14 , C07D487/04
摘要： An agent comprising, as an active ingredient, a xanthine oxidase inhibitor such as 2-[3-cyano-4-(4-fluorophenoxy)phenyl]-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-[3-cyano-4-(4-fluorophenoxy)phenyl]thiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine, 2-(3-cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-(3-cyano-4-phenoxyphenyl)thiazolo[5,4-d]pyrimidine, TMX-67, and FYX-051, which can be used as an agent for overcoming anti-cancer agent resistance.
摘要翻译：作为活性成分包含黄嘌呤氧化酶抑制剂如2- [3-氰基-4-（4-氟苯氧基）苯基] -4-羟基噻唑并[5,4-d]嘧啶钾盐，2- [3 （4-氟苯氧基）苯基]噻唑并[5,4-d]嘧啶，2-（3-氰基-4-苯氧基苯基）-4-羟基噻唑并[5,4-d]嘧啶，2-（3 - 氰基-4-苯氧基苯基）-4-羟基噻唑并[5,4-d]嘧啶钾盐，2-（3-氰基-4-苯氧基苯基）噻唑并[5,4-d]嘧啶，TMX-67和FYX- 051，可用作克服抗癌剂抵抗力的药剂。

3. 发明申请

US20070275754A1 Portable Personal Server Device With Biometric User Authentication 有权
标题翻译：便携式个人服务器设备，具有生物特征用户认证
公开(公告)号：US20070275754A1
公开(公告)日：2007-11-29
申请号：US10584118
申请日：2003-12-25
申请人： Shunichi Oshima , Hikaru Saito , Shogo Nakazato , Tomoaki Narahara , Haruhiro Kikkawa , Yukimasa Katsuhara , Takeshi Ogi
发明人： Shunichi Oshima , Hikaru Saito , Shogo Nakazato , Tomoaki Narahara , Haruhiro Kikkawa , Yukimasa Katsuhara , Takeshi Ogi
IPC分类号： G06F15/00
CPC分类号： G06F21/32 , G06F3/002 , G06F21/78 , H04L63/0428 , H04L63/0861
摘要： A portable personal server connectable through a network with a PC connected with an external network that permits communication with the PC only when user's fingerprint information read out by means of a fingerprint authentication unit matches registered information. In order to communicate through the network, the portable personal server and the PC acquires an address, preferably using APIPA, so that the collision of address does not take place in the external network. Consequently, the portable personal server also functions as a network server on the external network. A portable personal server exhibiting high confidentiality of data and suitable for central management of data can thereby be realized.
摘要翻译：一种便携式个人服务器，可通过网络与PC连接，PC与外部网络连接，只有当用指纹认证单元读取的用户指纹信息与注册信息相匹配时才允许与PC通信。为了通过网络进行通信，便携式个人服务器和PC获取优选地使用APIPA的地址，使得地址的冲突不会发生在外部网络中。因此，便携式个人服务器还用作外部网络上的网络服务器。因此可以实现具有高数据保密性并且适合数据中央管理的便携式个人服务器。

4. 发明申请

US20060294249A1 Communication system, communication terminal comprising virtual network switch, and portable electronic device comprising organism recognition unit 审中-公开
标题翻译：通信系统，包括虚拟网络交换机的通信终端和包括生物识别单元的便携式电子设备
公开(公告)号：US20060294249A1
公开(公告)日：2006-12-28
申请号：US10538527
申请日：2002-12-11
申请人： Shunichi Oshima , Hikaru Saito , Tomoaki Narahara , Shogo Nakazato , Haruhiro Kikkawa , Takeshi Ogi
发明人： Shunichi Oshima , Hikaru Saito , Tomoaki Narahara , Shogo Nakazato , Haruhiro Kikkawa , Takeshi Ogi
IPC分类号： G06F15/16
CPC分类号： H04L63/02 , H04L63/0272 , H04L63/0428 , H04L63/0861 , H04L63/145
摘要： The communication terminal of a communication system comprises a virtual network switch which can forcibly alter the destination of data being transmitted/received between the communication terminal and a network. Data is transmitted/received between the network and the communication terminal through a portable electronic device. Various functions, including a security function, can be supplemented by providing the function in software mounted on the portable electronic device. Even if a communication terminal connected directly with the network is not provided with such functions as a VPN, firewall or virus check, high-safety communication is ensured utilizing these security ensuring means mounted on the portable electronic device.
摘要翻译：通信系统的通信终端包括虚拟网络交换机，该虚拟网络交换机可以强制地改变在通信终端和网络之间正在发送/接收的数据的目的地。通过便携式电子设备在网络和通信终端之间发送/接收数据。可以通过在安装在便携式电子设备上的软件中提供功能来补充包括安全功能在内的各种功能。即使直接与网络连接的通信终端没有提供诸如VPN，防火墙或病毒检查的功能，也可以利用安装在便携式电子设备上的安全保证装置来确保高安全性的通信。

5. 发明授权

US5615830A Apparatus and method for supply and transport of powder particles 失效
标题翻译：用于供应和运输粉末颗粒的装置和方法
公开(公告)号：US5615830A
公开(公告)日：1997-04-01
申请号：US351702
申请日：1994-12-08
申请人： Masafumi Matsunaga , Wataru Kakuta , Hikaru Saito
发明人： Masafumi Matsunaga , Wataru Kakuta , Hikaru Saito
IPC分类号： B65G53/40 , B05B5/16 , B05B7/14 , B41F23/06 , B65G47/84 , B65G53/44 , B65G53/46 , B65G65/48 , A62C5/02
CPC分类号： B05B7/144 , B05B5/1683 , B41F23/06 , B65G53/4641
摘要： An improved powder particle supply and transport apparatus and method include a hopper filled with powder particles, an ejection chamber spaced from the hopper and a movable conveying member with a plurality of cavities formed therein. During operation, the conveying member moves the cavities between the hopper and the chamber, and the cavities are filled with powder particles at the hopper and emptied of powder particles at the chamber. An ejector nozzle sprays pressurized air into the chamber toward an aligned outlet, thereby to: 1) create negative pressure in the chamber to draw powder particles from the cavities as the cavities are moved therethrough; and 2) transport powder particles through the outlet to a spray gun. Additional structure may be used to assure complete powder filling of the cavities at the hopper and/or complete powder emptying of the cavities in the chamber. The invention achieves supply and transport of uniform and stable quantities of powder particles to a spray gun, even over very small units of time, regardless of powder particle size and/or cohesive properties.
摘要翻译：改进的粉末颗粒供应和输送装置和方法包括填充有粉末颗粒的料斗，与料斗间隔开的喷射室和在其中形成有多个空腔的可移动输送构件。在操作期间，输送构件使料斗和腔室之间的空腔移动，并且空腔在料斗处填充有粉末颗粒，并在室处排出粉末颗粒。喷射器喷嘴将加压空气喷射到朝向对准的出口的腔室中，从而：1）当腔体通过其移动时，在腔室中产生负压以从空腔抽吸粉末颗粒; 和2）通过出口将粉末颗粒输送到喷枪。可以使用附加结构来确保在料斗处的空腔的完全粉末填充和/或完全粉末排空腔室中的空腔。本发明即使在非常小的单位时间内也能够均匀稳定地将粉末颗粒供给和输送到喷枪，而与粉末粒度和/或内聚性无关。

6. 发明申请

US20120122126A1 ANTI-PSK ANTIBODY 审中-公开
标题翻译：抗PSK抗体
公开(公告)号：US20120122126A1
公开(公告)日：2012-05-17
申请号：US13386653
申请日：2010-07-23
申请人： Hirotaka Hoshi , Hikaru Saito , Motoyuki Uchida
发明人： Hirotaka Hoshi , Hikaru Saito , Motoyuki Uchida
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： C07K16/14 , C07K2317/76 , G01N2400/10
摘要： An antibody which recognizes PSK is provided.The object of the present invention is solved by an antibody characterized by recognizing PSK and inhibiting anti-tumor activity of PSK. In particular, the inhibition of anti-tumor activity of PSK is an inhibition of cytotoxic activity or an inhibition of anti-TGF-β1 activity of PSK. A physiologically active PSK can, using the present invention, be detected high-accurately and quantitatively. For example, the present invention is useful for detecting and measuring the physiologically active PSK contained in a medicine or a food and drink, and for analyzing pharmacokinetics after administrating the physiologically active PSK.
摘要翻译：提供了识别PSK的抗体。本发明的目的是通过识别PSK并抑制PSK的抗肿瘤活性的抗体来解决。特别地，PSK的抗肿瘤活性的抑制是对PSK的细胞毒性活性或抗TGF-β1活性的抑制的抑制。可以高精度和定量地检测使用本发明的生理活性PSK。例如，本发明可用于检测和测量药物或食物和饮料中所含的生理活性PSK，并且用于分析给药生理活性PSK后的药代动力学。

7. 发明申请

US20110245325A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER AND ASTHMA 失效
标题翻译：用于治疗癌症和哮喘的药物组合物
公开(公告)号：US20110245325A1
公开(公告)日：2011-10-06
申请号：US13139280
申请日：2009-12-14
申请人： Hirotaka Hoshi , Motoyuki Uchida , Hikaru Saito
发明人： Hirotaka Hoshi , Motoyuki Uchida , Hikaru Saito
IPC分类号： A61K31/7105 , C07H21/02 , C07H21/04 , C12N15/74 , A61K31/7088 , C12N5/10 , C12Q1/02 , A61P35/00 , A61P11/06
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14
摘要： Provided is a pharmaceutical composition for treating cancer and asthma.The object can be solved by a pharmaceutical composition comprising a siRNA molecule that directs cleavage of mRNA of mucin subtype 5 AC via RNA interference, or an antibody against mucin subtype 5AC as an active ingredient. According to the pharmaceutical composition of the present invention, diseases involving an overexpression of mucin subtype 5 AC can be treated efficiently. In particular, the pharmaceutical composition comprising a siRNA molecule of the present invention is effectively used in the treatment of a cancer, particularly pancreatic cancer. In addition, the siRNA or the antibody of the present invention can inhibit the expression or function of MUC5AC, thereby preventing or treating the symptoms of asthma effectively.
摘要翻译：提供了用于治疗癌症和哮喘的药物组合物。该目的可以通过药物组合物来解决，所述药物组合物包含通过RNA干扰引导粘蛋白亚型5AC的mRNA的切割的siRNA分子，或抗5mM的粘蛋白抗体作为活性成分。根据本发明的药物组合物，可以有效地治疗涉及5型AC粘蛋白过表达的疾病。特别地，包含本发明的siRNA分子的药物组合物有效地用于治疗癌症，特别是胰腺癌。此外，本发明的siRNA或抗体可以抑制MUC5AC的表达或功能，从而有效地预防或治疗哮喘的症状。

8. 发明申请

US20060229988A1 Card settlement method using portable electronic device having fingerprint sensor 审中-公开
标题翻译：使用具有指纹传感器的便携式电子设备的卡结算方法
公开(公告)号：US20060229988A1
公开(公告)日：2006-10-12
申请号：US10542888
申请日：2003-01-21
申请人： Shunichi Oshima , Hikaru Saito , Tomoaki Narahara , Shogo Nakazato , Haruhiro Kikkawa , Takeshi Ogi
发明人： Shunichi Oshima , Hikaru Saito , Tomoaki Narahara , Shogo Nakazato , Haruhiro Kikkawa , Takeshi Ogi
IPC分类号： G06Q99/00
CPC分类号： G07F7/1008 , G06Q20/341 , G06Q20/40145 , G07C9/00087
摘要： In a card settlement system using a portable electronic device having a fingerprint sensor, a credit card and a portable electronic device (5) having a fingerprint sensor are issued to a person who has made application. To this electronic device (5), card information (12), a storage public key Kp1, and
摘要翻译：在使用具有指纹传感器的便携式电子设备的卡结算系统中，向已经申请的人发行具有指纹传感器的信用卡和便携式电子设备（5）。对于该电子装置（5），卡信息（12），存储公钥Kp 1，

9. 发明授权

US08389711B2 Pharmaceutical composition for treatment of cancer and asthma 失效
标题翻译：用于治疗癌症和哮喘的药物组合物
公开(公告)号：US08389711B2
公开(公告)日：2013-03-05
申请号：US13139280
申请日：2009-12-14
申请人： Hirotaka Hoshi , Motoyuki Uchida , Hikaru Saito
发明人： Hirotaka Hoshi , Motoyuki Uchida , Hikaru Saito
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/14
摘要： Provided is a pharmaceutical composition for treating cancer and asthma.The object can be solved by a pharmaceutical composition comprising a siRNA molecule that directs cleavage of mRNA of mucin subtype 5 AC via RNA interference, or an antibody against mucin subtype 5AC as an active ingredient. According to the pharmaceutical composition of the present invention, diseases involving an overexpression of mucin subtype 5 AC can be treated efficiently. In particular, the pharmaceutical composition comprising a siRNA molecule of the present invention is effectively used in the treatment of a cancer, particularly pancreatic cancer. In addition, the siRNA or the antibody of the present invention can inhibit the expression or function of MUC5AC, thereby preventing or treating the symptoms of asthma effectively.
摘要翻译：提供了用于治疗癌症和哮喘的药物组合物。该目的可以通过药物组合物来解决，所述药物组合物包含通过RNA干扰引导粘蛋白亚型5AC的mRNA的切割的siRNA分子，或抗5mM的粘蛋白抗体作为活性成分。根据本发明的药物组合物，可以有效地治疗涉及5型AC粘蛋白过表达的疾病。特别地，包含本发明的siRNA分子的药物组合物有效地用于治疗癌症，特别是胰腺癌。此外，本发明的siRNA或抗体可以抑制MUC5AC的表达或功能，从而有效地预防或治疗哮喘的症状。

10. 发明授权

US07962173B2 Portable personal server device with biometric user authentication 有权
标题翻译：便携式个人服务器设备，具有生物识别用户认证
公开(公告)号：US07962173B2
公开(公告)日：2011-06-14
申请号：US10584118
申请日：2003-12-25
申请人： Shunichi Oshima , Hikaru Saito , Shogo Nakazato , Tomoaki Narahara , Haruhiro Kikkawa , Yukimasa Katsuhara , Takeshi Ogi
发明人： Shunichi Oshima , Hikaru Saito , Shogo Nakazato , Tomoaki Narahara , Haruhiro Kikkawa , Yukimasa Katsuhara , Takeshi Ogi
IPC分类号： H04W4/00
CPC分类号： G06F21/32 , G06F3/002 , G06F21/78 , H04L63/0428 , H04L63/0861
摘要： A portable personal server connectable through a network with a PC connected with an external network that permits communication with the PC only when user's fingerprint information read out by means of a fingerprint authentication unit matches registered information. In order to communicate through the network, the portable personal server and the PC acquires an address, preferably using APIPA, so that the collision of address does not take place in the external network. Consequently, the portable personal server also functions as a network server on the external network. A portable personal server exhibiting high confidentiality of data and suitable for central management of data can thereby be realized.
摘要翻译：一种便携式个人服务器，可通过网络与PC连接，PC与外部网络连接，只有当用指纹认证单元读取的用户指纹信息与注册信息相匹配时才允许与PC通信。为了通过网络进行通信，便携式个人服务器和PC获取优选地使用APIPA的地址，使得地址的冲突不会发生在外部网络中。因此，便携式个人服务器还用作外部网络上的网络服务器。因此可以实现具有高数据保密性并且适合数据中央管理的便携式个人服务器。

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