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1. 发明授权

US09277924B2 Systems and methods for enclosing an anatomical opening 有权
标题翻译：用于封闭解剖开口的系统和方法
公开(公告)号：US09277924B2
公开(公告)日：2016-03-08
申请号：US13695184
申请日：2010-09-03
申请人： Gilbert Clarke , Brent Gerberding , Robert M. Abrams , Masoud Molaei
发明人： Gilbert Clarke , Brent Gerberding , Robert M. Abrams , Masoud Molaei
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B17/12145 , A61B17/12172 , A61B17/1219 , A61B2017/00632 , A61B2017/00867 , A61B2017/12054
摘要： Implantable therapeutic devices and methods for endovascular placement of devices at a target site, such an opening at a neck of an aneurysm, are disclosed. Selected embodiments of the present technology have closures (102) that at least partially occlude the neck of an aneurysm to stabilize embolic or coagulative treatment of the aneurysm. In one embodiment, for example, an aneurysm closure device comprises a closure structure (102) and a supplemental stabilizer (103). The closure structure can have a curved portion configured to extend along a first vessel, such as a side branch of a bifurcated vessel that extends along a lateral axis (T). The supplemental stabilizer extends from the closure structure along a longitudinal axis (L) transverse to the lateral axis of the first vessel. The supplemental stabilizer is configured to exert an outward force against a second vessel, such as a parent vessel, that extends transversely to the first vessel.
摘要翻译：公开了用于在靶位置处的装置的血管内放置的可植入治疗装置和方法，例如在动脉瘤颈部的开口。本技术的选择的实施例具有闭合件（102），其至少部分地封闭动脉瘤的颈部以稳定动脉瘤的栓塞或凝固治疗。在一个实施例中，例如，动脉瘤闭合装置包括封闭结构（102）和补充稳定器（103）。闭合结构可以具有弯曲部分，其被构造成沿着第一容器延伸，例如沿着横向轴线（T）延伸的分叉容器的侧分支。补充稳定器沿着横向于第一容器的横向轴线的纵向轴线（L）从封闭结构延伸。辅助稳定器被配置成向横向于第一容器延伸的第二容器（例如母体容器）施加向外的力。

2. 发明授权

US09089332B2 Vascular remodeling device 有权
标题翻译：血管重建装置
公开(公告)号：US09089332B2
公开(公告)日：2015-07-28
申请号：US13428237
申请日：2012-03-23
申请人： Masoud Molaei , Evan David Epstein , Gabriel Francis Wilgus Newell , Quang Tran
发明人： Masoud Molaei , Evan David Epstein , Gabriel Francis Wilgus Newell , Quang Tran
IPC分类号： A61M29/00 , A61B17/12 , A61B17/00
CPC分类号： A61B17/12118 , A61B17/12172 , A61B2017/00526 , A61F2/07
摘要： A vascular remodeling device is provided. The device has an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. The device also includes a distal portion sized for deployment in a blood vessel. The distal portion is radially expandable from a collapsed state to an expanded state and has a distal face that is sufficiently occlusive in the distal-to-proximal direction to perform a therapeutic blocking function in an aneurysm neck. The device also has an intermediate portion that interconnects a distal end of the anchor portion and a proximal end of the distal portion. In some embodiments, the anchor portion and/or distal portion has a plurality of interconnected struts.
摘要翻译：提供血管重塑装置。该装置具有锚定部分，其尺寸适于部署在血管中，其可从折叠状态径向伸展至膨胀状态。该装置还包括尺寸适于部署在血管中的远端部分。远端部分可从收缩状态径向伸展至扩张状态，并且具有在远端至近端方向上足够闭塞的远端面，以在动脉瘤颈部中执行治疗阻塞功能。该装置还具有将锚固部分的远端和远侧部分的近端互连的中间部分。在一些实施例中，锚定部分和/或远侧部分具有多个互连的支柱。

3. 发明申请

US20070299498A1 METHODS AND DEVICES FOR AIDING IN SITU ASSEMBLY OF REPAIR DEVICES 审中-公开
标题翻译：用于在维修设备的现场装置中进行辅助的方法和装置
公开(公告)号：US20070299498A1
公开(公告)日：2007-12-27
申请号：US11767785
申请日：2007-06-25
申请人： Juan Perez , Masoud Molaei , Shahrokh Farahani , Michael Wei , Shuji Uemura , Natalie Fawzi
发明人： Juan Perez , Masoud Molaei , Shahrokh Farahani , Michael Wei , Shuji Uemura , Natalie Fawzi
IPC分类号： A61F2/06
CPC分类号： A61F2/954 , A61F2/07 , A61F2002/067 , A61F2002/9511 , A61F2250/0039
摘要： Methods and devices for facilitating the repair of vasculature. The methods and devices described accomplish engagement of components employed during in situ assembly of repair devices.
摘要翻译：促进脉管系统修复的方法和装置。所描述的方法和装置实现了在修理装置的原位组装期间采用的部件的接合。

4. 发明申请

US20060142851A1 Medical devices including metallic films and methods for making same 有权
标题翻译：医疗器械包括金属膜及其制造方法
公开(公告)号：US20060142851A1
公开(公告)日：2006-06-29
申请号：US11025464
申请日：2004-12-29
申请人： Masoud Molaei , John Peckham
发明人： Masoud Molaei , John Peckham
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/075 , A61F2002/30329 , A61F2002/823 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/0025 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054
摘要： An endoprosthesis for deployment within a body passage includes an external tubular framework disposed about a tubular member, e.g., a metallic film having a thickness of about 50 μm or less. The tubular member may be sandwiched between the external tubular framework and an internal tubular framework located internally of the external tubular framework and the tubular member. Whether or not the internal tubular framework is included, the endoprosthesis can be self-expanding. During deployment of the endoprosthesis using a deployment device, the external tubular framework prevents substantial frictional contact between the deployment device and the tubular member.
摘要翻译：用于在身体通道内部署的内用假体包括围绕管状构件设置的外部管状框架，例如厚度为约50μm或更小的金属膜。管状构件可以夹在外部管状框架和位于外部管状框架和管状构件内部的内部管状框架之间。是否包括内部管状框架，内部假体可以自我扩张。在使用展开装置部署内置假体期间，外部管状框架防止了展开装置和管状构件之间的实质摩擦接触。

5. 发明申请

US20050197689A1 Medical devices including metallic films and methods for making same 有权
标题翻译：医疗器械包括金属膜及其制造方法
公开(公告)号：US20050197689A1
公开(公告)日：2005-09-08
申请号：US11025860
申请日：2004-12-29
申请人： Masoud Molaei
发明人： Masoud Molaei
IPC分类号： A61F2/82 , A61F2/86 , A61F2/90 , A61L31/02 , A61F2/06
CPC分类号： A61F2/01 , A61F2/07 , A61F2/86 , A61F2/90 , A61F2002/823 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61L31/022 , C23C16/06
摘要： Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a metallic film comprising nickel, titanium, and chromium, wherein a ratio of a weight of chromium of the metallic film to a combined weight of nickel, titanium, and chromium of the metallic film is at least 0.001. The metallic film can include a shape memory alloy.
摘要翻译：公开了医疗装置，例如内用假体，以及制造装置的方法。医疗装置可以包括镍，钛和铬的金属膜，其中金属膜的铬的重量与金属膜的镍，钛和铬的组合重量的比率至少为0.001。金属膜可以包括形状记忆合金。

6. 发明授权

US08632580B2 Flexible medical devices including metallic films 有权
标题翻译：柔性医疗器械包括金属膜
公开(公告)号：US08632580B2
公开(公告)日：2014-01-21
申请号：US11025158
申请日：2004-12-29
申请人： Masoud Molaei , Alexander Leynov , Robert Z. Obara
发明人： Masoud Molaei , Alexander Leynov , Robert Z. Obara
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/88 , A61F2002/075 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/0013
摘要： Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a stent body and a cover including a deposited metallic film. The medical device can be delivered using a delivery device along a tortuous body passage to a treatment site without damaging the medical device, delivery device, or the body passage. In some cases, the stent body is a flexible helical stent body, which may be threaded through one or more fenestrations of the cover. The cover may include longitudinally extending slits or seams, which help the cover to pass through small radii passages without buckling.
摘要翻译：公开了医疗装置，例如内用假体，以及制造装置的方法。医疗装置可以包括支架主体和包括沉积的金属膜的盖。可以使用输送装置将医疗装置沿曲折的身体通道输送到治疗部位，而不会损坏医疗装置，输送装置或身体通道。在一些情况下，支架主体是柔性螺旋支架体，其可以穿过盖的一个或多个开窗。盖可以包括纵向延伸的狭缝或接缝，这有助于盖通过小的半径而没有弯曲。

7. 发明申请

US20130204290A1 SYSTEMS AND METHODS FOR ENCLOSING AN ANATOMICAL OPENING 有权
标题翻译：用于封闭解剖学开放的系统和方法
公开(公告)号：US20130204290A1
公开(公告)日：2013-08-08
申请号：US13695184
申请日：2010-09-03
申请人： Gilbert Clarke , Brent Gerberding , Robert M. Abrams , Masoud Molaei
发明人： Gilbert Clarke , Brent Gerberding , Robert M. Abrams , Masoud Molaei
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B17/12145 , A61B17/12172 , A61B17/1219 , A61B2017/00632 , A61B2017/00867 , A61B2017/12054
摘要： Implantable therapeutic devices and methods for endovascular placement of devices at a target site, such an opening at a neck of an aneurysm, are disclosed. Selected embodiments of the present technology have closures (102) that at least partially occlude the neck of an aneurysm to stabilize embolic or coagulative treatment of the aneurysm. In one embodiment, for example, an aneurysm closure device comprises a closure structure (102) and a supplemental stabilizer (103). The closure structure can have a curved portion configured to extend along a first vessel, such as a side branch of a bifurcated vessel that extends along a lateral axis (T). The supplemental stabilizer extends from the closure structure along a longitudinal axis (L) transverse to the lateral axis of the first vessel. The supplemental stabilizer is configured to exert an outward force against a second vessel, such as a parent vessel, that extends transversely to the first vessel.
摘要翻译：公开了用于在靶位置处的装置的血管内放置的可植入治疗装置和方法，例如在动脉瘤颈部的开口。本技术的选择的实施例具有闭合件（102），其至少部分地封闭动脉瘤的颈部以稳定动脉瘤的栓塞或凝固治疗。在一个实施例中，例如，动脉瘤闭合装置包括封闭结构（102）和补充稳定器（103）。闭合结构可以具有弯曲部分，其被构造成沿着第一容器延伸，例如沿着横向轴线（T）延伸的分叉容器的侧分支。补充稳定器沿着横向于第一容器的横向轴线的纵向轴线（L）从封闭结构延伸。辅助稳定器被配置成向横向于第一容器延伸的第二容器（例如母体容器）施加向外的力。

8. 发明申请

US20120245675A1 VASCULAR REMODELING DEVICE 有权
标题翻译：血管再造装置
公开(公告)号：US20120245675A1
公开(公告)日：2012-09-27
申请号：US13428237
申请日：2012-03-23
申请人： Masoud Molaei , Evan David Epstein , Gabriel Francis Wilgus Newell , Quang Tran
发明人： Masoud Molaei , Evan David Epstein , Gabriel Francis Wilgus Newell , Quang Tran
IPC分类号： A61F2/06
CPC分类号： A61B17/12118 , A61B17/12172 , A61B2017/00526 , A61F2/07
摘要： A vascular remodeling device is provided. The device has an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. The device also includes a distal portion sized for deployment in a blood vessel. The distal portion is radially expandable from a collapsed state to an expanded state and has a distal face that is sufficiently occlusive in the distal-to-proximal direction to perform a therapeutic blocking function in an aneurysm neck. The device also has an intermediate portion that interconnects a distal end of the anchor portion and a proximal end of the distal portion. In some embodiments, the anchor portion and/or distal portion has a plurality of interconnected struts.
摘要翻译：提供血管重塑装置。该装置具有锚定部分，其尺寸适于部署在血管中，其可从折叠状态径向伸展至膨胀状态。该装置还包括尺寸适于部署在血管中的远端部分。远端部分可从收缩状态径向伸展至扩张状态，并且具有在远端至近端方向上足够闭塞的远端面，以在动脉瘤颈部中执行治疗阻塞功能。该装置还具有将锚固部分的远端和远侧部分的近端互连的中间部分。在一些实施例中，锚定部分和/或远侧部分具有多个互连的支柱。

9. 发明申请

US20120245674A1 VASCULAR REMODELING DEVICE 审中-公开
标题翻译：血管再造装置
公开(公告)号：US20120245674A1
公开(公告)日：2012-09-27
申请号：US13428199
申请日：2012-03-23
申请人： Masoud Molaei , Evan David Epstein , Gabriel Francis Wilgus Newell , Quang Tran
发明人： Masoud Molaei , Evan David Epstein , Gabriel Francis Wilgus Newell , Quang Tran
IPC分类号： A61F2/94
CPC分类号： A61B17/12118 , A61B17/12172 , A61B2017/00526 , A61F2/07
摘要： A vascular remodeling device is provided. The device includes an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. The device also includes a distal portion that is sized for deployment in a blood vessel. The distal portion is radially expandable from a collapsed state to an expanded state and, in some embodiments, has a distal face that is sufficiently occlusive in the distal-to-proximal direction to perform a therapeutic blocking function at an aneurysm. Some embodiments have an intermediate portion that connects a distal end of the anchor portion and a proximal end of the distal portion, and in some embodiments, the anchor portion and distal portion are able to pivot relative to each other at or near the intermediate portion.
摘要翻译：提供血管重塑装置。该装置包括尺寸适于部署在血管中的锚定部分，其可以从折叠状态径向伸展至膨胀状态。该装置还包括远端部分，其尺寸适于部署在血管中。远端部分可从收缩状态径向伸展至扩张状态，并且在一些实施例中具有在远端至近端方向上足够闭塞的远侧面以在动脉瘤处执行治疗性阻塞功能。一些实施例具有连接锚定部分的远端和远端部分的近端的中间部分，并且在一些实施例中，锚定部分和远侧部分能够相对于彼此在中间部分处或附近枢转。

10. 发明申请

US20100280587A1 VARIABLE DENSITY BRAID STENT 有权
标题翻译：可变密度BRAID STENT
公开(公告)号：US20100280587A1
公开(公告)日：2010-11-04
申请号：US12836357
申请日：2010-07-14
申请人： John Ortiz , Masoud Molaei , Frank Musbach , Brent C. Gerberding
发明人： John Ortiz , Masoud Molaei , Frank Musbach , Brent C. Gerberding
IPC分类号： A61F2/82
CPC分类号： A61F2/90 , A61F2002/823 , A61F2250/0015 , A61F2250/0023 , A61F2250/0048 , D04C1/06
摘要： A stent comprises at least one stent member woven to form a substantially tubular body that defines a flow path. The tubular body comprises a first region and a second region. In the first region the at least one stent member defines a plurality of first region openings and in the second region at least one first portion of the at least one member and at least one second portion of the at least one member are engaged together to form at least one primary strand. The at least one primary strand defines a plurality of second region openings. The at least one of the plurality of second region openings is in fluid communication with the flow path. The plurality of second region openings provide the second region with a greater porosity than the first region.
摘要翻译：支架包括至少一个编织的支架构件，以形成限定流路的基本上管状的主体。管状体包括第一区域和第二区域。在第一区域中，至少一个支架构件限定多个第一区域开口，并且在第二区域中，至少一个构件的至少一个第一部分和至少一个构件的至少一个第二部分接合在一起形成至少一个主链。至少一个主股限定了多个第二区域开口。多个第二区域开口中的至少一个与流动路径流体连通。多个第二区域开口为第二区域提供比第一区域更大的孔隙率。

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