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    • 3. 发明授权
    • Manufacture and use of novel glycosides of catechol estrogens
    • 儿茶酚雌激素新型糖苷的生产和使用
    • US5739302A
    • 1998-04-14
    • US322711
    • 1994-10-05
    • Takehiko SuzukiSadaaki KomuraNaoko IshidaNobuko OhishiKunio Yagi
    • Takehiko SuzukiSadaaki KomuraNaoko IshidaNobuko OhishiKunio Yagi
    • A61F2/00C07J1/00C07J17/00C07J51/00C07H1/00
    • C07J51/00C07J1/007C07J1/0074C07J17/005A61F2210/0019Y02P20/55
    • There are described novel glycosides of catechol estrogen, a method of preparing the same, and a medicament comprising one of the glycosides as an active ingredient. The glycosides are shown by the formula of ##STR1## wherein X is carbonyl group or ##STR2## R.sub.10 is hydroxyl group or glycosyloxy group, and R.sub.2 is a hydrogen atom or ethynyl group; R.sub.11 is a hydrogen atom, hydroxyl group, or glycosyloxy group; R.sub.12 is hydroxyl group or glycosyloxy group; and R.sub.13 is hydroxyl group or glycosyloxy group, in which glycosyloxy group is selected from the group consisting of glycosyloxy, galactosyloxy, mannosyloxy, arabinosyloxy, ribosyloxy, xylosyloxy, fructosyloxy, rhamnosyloxy, fucosyloxy, maltosyloxy, cellobiosyloxy, lactosyloxy, sucrosyloxy, maltotriosyloxy, maltotetraosyloxy, maltopentaosyloxy, maltohexaosyloxy, maltoheptaosyloxy, and sialosyloxy, and in this case, at least one of R.sub.10, R.sub.11, R.sub.12, and R.sub.13 is glycosyloxy group as defined above.
    • 描述了儿茶酚雌激素的新型糖苷,其制备方法,以及包含其中一种糖苷作为活性成分的药物。 糖苷由下式表示:其中X是羰基,或者R10是羟基或糖氧基,R2是氢原子或乙炔基; R11为氢原子,羟基或糖氧基; R12是羟基或糖氧基; 并且R 13是羟基或糖氧基,其中糖氧基选自糖氧基,半乳糖氧基,甘露糖氧基,阿拉伯糖氧基,核糖氧基,木糖氧基,果糖氧基,鼠李糖氧基,岩藻糖氧基,麦芽糖氧基,纤维二糖氧基,乳糖氧基,蔗糖氧基,麦芽三糖基氧基,麦芽四糖基氧基, 麦芽六糖氧基,麦芽庚糖基氧基和唾液酸氧基,在这种情况下,R 10,R 11,R 12和R 13中的至少一个为如上定义的糖氧基。
    • 4. 发明授权
    • Glycosides of catechol estrogens
    • 儿茶酚雌激素的糖苷
    • US5405944A
    • 1995-04-11
    • US950512
    • 1992-09-25
    • Takehiko SuzukiSadaaki KomuraNaoko IshidaNobuko OhishiKunio Yagi
    • Takehiko SuzukiSadaaki KomuraNaoko IshidaNobuko OhishiKunio Yagi
    • A61F2/00C07J1/00C07J17/00C07J51/00A61K37/14A61K31/58A61K31/595
    • C07J51/00C07J1/007C07J1/0074C07J17/005A61F2210/0019Y02P20/55
    • There are described novel glycosides of catechol estrogen, a method of preparing the same, and a medicament comprising one of the glycosides as an active ingredient. The glycosides are shown by the formula of ##STR1## wherein X is carbonyl group or ##STR2## R.sub.10 is hydroxyl group or glycosyloxy group, and R.sub.2 is a hydrogen atom or ethynyl group; R.sub.11 is a hydrogen atom, hydroxyl group, or glycosyloxy group; R.sub.12 is hydroxyl group or glycosyloxy group; and R.sub.13 is hydroxyl group or glycosyloxy group,in which glycosyloxy group is selected from the group consisting of glucosyloxy, galactosyloxy, mannosyloxy, arabinosyloxy, ribosyloxy, xylosyloxy, fructosyloxy, rhamnosyloxy, fucosyloxy, maltosyloxy, cellobiosyloxy, lactosyloxy, sucrosyloxy, maltotriosyloxy, maltotetraosyloxy, maltopentaosyloxy, maltohexaosyloxy, maltoheptaosyloxy, and sialosyloxy, and in this case, at least one of R.sub.10, R.sub.11, R.sub.12, and R.sub.13 is glycosyloxy group as defined above.
    • 描述了儿茶酚雌激素的新型糖苷,其制备方法,以及包含其中一种糖苷作为活性成分的药物。 糖苷由下式表示:其中X是羰基,或者R10是羟基或糖氧基,R2是氢原子或乙炔基; R11为氢原子,羟基或糖氧基; R12是羟基或糖氧基; 并且R 13是羟基或糖氧基,其中糖氧基选自葡糖基氧基,半乳糖氧基,甘露糖氧基,阿拉伯糖基氧基,核糖氧基,木糖氧基,果糖氧基,鼠李糖氧基,岩藻糖氧基,麦芽糖氧基,纤维二糖氧基,乳糖氧基,蔗糖氧基,麦芽三糖基氧基,麦芽四糖基氧基, 麦芽六糖氧基,麦芽庚糖基氧基和唾液酸氧基,在这种情况下,R 10,R 11,R 12和R 13中的至少一个为如上定义的糖氧基。
    • 5. 发明授权
    • Method of obtaining a composition containing 9-cis .beta.-carotene in
high-purity
    • 获得含有高纯度的9-顺式β-胡萝卜素的组合物的方法
    • US6057484A
    • 2000-05-02
    • US47346
    • 1998-03-25
    • Takehiko SuzukiNobuko OhishiKunio Yagi
    • Takehiko SuzukiNobuko OhishiKunio Yagi
    • C12P23/00C07C20060101C07C29/74C07C403/00C07C403/24C12N1/00C12N1/12C12R1/89C12S99/00
    • C07C403/24
    • There are disclosed a composition containing 9-cis .beta.-carotene in high-purity and an industrially applicable method of obtaining the same from an alga. The composition can be obtained through steps of washing with ethanol dry powder of the alga belonging to Dunaliella, adding hexane to the washed algal powder, stirring the same, subjecting the same to filtration to obtain a filtrate, concentrating the filtrate to obtain a semi-solidic concentrate, adding hexane to the semi-solidic concentrate in an amount of 10-18 ml of hexane to 1 g of the semi-solidic concentrate, stirring the same, subjecting the same to filtration to obtain a filtrate, concentrating the filtrate to obtain an oily concentrate, adding hexane to the oily concentrate in an amount of 2-4.5 ml of hexane to 1 g of the oily concentrate to dissolve the same, and leaving the solution, as it is, under lower temperature condition to cause a separation of the composition. The composition is a rubiginous powder or crystals and contains 9-cis .beta.-carotene in an amount of 75% or more to total amount of the composition.
    • 公开了一种含有高纯度的9-顺式β-胡萝卜素的组合物,以及从藻类获得相同的工业上适用的方法。 该组合物可以通过以下方法获得:通过用属于杜氏盐藻的藻类的乙醇干燥粉末洗涤,向洗涤的藻粉中加入己烷,搅拌,同时过滤得到滤液,浓缩滤液, 固体浓缩物,向半固体浓缩物中加入己烷至10-18ml己烷至1g半固体浓缩物,搅拌该混合物,过滤得到滤液,浓缩滤液,得到 油状浓缩物,将含有2-4.5ml己烷的己烷至己烷至1g油状浓缩物溶解,并将其溶解在较低温度条件下,使其分离 组成。 该组合物是一种红宝石粉末或晶体,并含有相对于组合物总量的75%或更多量的9-顺式β-胡萝卜素。