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1. 发明授权

US06726926B2 Gene-entrapped liposomes preparation and process for the preparation thereof 失效
标题翻译：基因截留的脂质体制备及其制备方法
公开(公告)号：US06726926B2
公开(公告)日：2004-04-27
申请号：US09790727
申请日：2001-02-23
申请人： Haruyoshi Yajima , Keizo Sakuda , Hideshi Ideno , Kunio Yagi , Nobuko Ohishi , Jun Yoshida
发明人： Haruyoshi Yajima , Keizo Sakuda , Hideshi Ideno , Kunio Yagi , Nobuko Ohishi , Jun Yoshida
IPC分类号： A61K9127
CPC分类号： A61K31/711 , A61K9/1271 , A61K9/1272 , C12N15/88
摘要： It provides a gene-entrapping liposome preparation which can be preserved over a long period of time, and a process for the preparation of the same. The preparation can be prepared by adding an aqueous solution of disaccharide to gene-entrapping liposomes. The frozen preparation can be preserved for 6 months or more at preservation temperature of −20° C., and the preparation shows excellent restoration ability in water and does not show reduction in biological activity. In the case of the lyophilized preparation, it can be preserved for longer time of about 1 year, shows excellent restoration ability in water, and does not show reduction in biological activity.
摘要翻译：它提供了可以长期保存的基因捕获脂质体制剂及其制备方法。该制剂可以通过将二糖水溶液加入到基因捕获的脂质体中来制备。冷冻制剂可在-20℃的保存温度下保存6个月以上，该制剂在水中显示出优异的恢复能力，并且不显示出生物活性的降低。在冻干制剂的情况下，其可以保存较长时间约1年，在水中显示出优异的恢复能力，并且不显示生物活性的降低。

2. 发明授权

US5969798A Image inspection apparatus in plate making process and image inspection method in plate making process 失效
标题翻译：制版过程中的图像检查装置和制版过程中的图像检查方法
公开(公告)号：US5969798A
公开(公告)日：1999-10-19
申请号：US895910
申请日：1997-07-17
申请人： Seiji Nakagawa , Kunio Yagi , Makoto Shimooka , Shinji Kawashima , Tomokazu Taniguchi
发明人： Seiji Nakagawa , Kunio Yagi , Makoto Shimooka , Shinji Kawashima , Tomokazu Taniguchi
IPC分类号： G03F1/00 , G03F3/08 , G06T7/00 , G03B27/60 , G03B27/32
CPC分类号： G06T7/001 , G06T2207/30108
摘要： Provided are an image inspection apparatus and an image inspection method in a plate making process which can perform inspection over a wide range including not only correction errors in the plate making process but errors caused in formation of an original plate film and a stage between the formation of the original plate film and completion of printing. A first revise recording a color image is regarded as a reference, for reading the image on this first revise. A second revise is regarded as an object, for reading an image on this second revise. The color images on the first revise (reference) and the second revise (object) are compared with each other for detecting mismatching portions of these images. Finally, the mismatching portions are displayed in a specified format.
摘要翻译：本发明提供一种能够进行宽范围检查的图像检查装置和图像检查方法，该范围不仅包括制版处理中的校正误差，而且在原版印版的形成和形成之间产生错误的原版薄膜和完成印刷。记录彩色图像的第一次修改被视为参考，用于在该第一次修订时读取图像。第二次修改被视为一个对象，用于在第二次修订中阅读图像。将第一修正（参考）和第二修正（对象）上的彩色图像彼此进行比较，以检测这些图像的不匹配部分。最后，不匹配部分以指定的格式显示。

3. 发明授权

US5037981A Intermediates for synthesizing BH.sub.4 and its derivatives 失效
标题翻译：用于合成BH4及其衍生物的中间体
公开(公告)号：US5037981A
公开(公告)日：1991-08-06
申请号：US515962
申请日：1990-04-27
申请人： Masayasu Kurono , Takehiko Suzuki , Tomio Ogasawara , Nobuko Ohishi , Kunio Yagi
发明人： Masayasu Kurono , Takehiko Suzuki , Tomio Ogasawara , Nobuko Ohishi , Kunio Yagi
IPC分类号： C07D405/12 , C07D475/04 , C12P25/00
CPC分类号： C07D405/12 , C07D475/04 , C12P25/00
摘要： The present invention relates to intermediates for synthesizing BH.sub.4 and derivatives thereof. The intermediates are shown as follows; ##STR1## wherein R.sub.1 is a hydrogen atom, alkyl, aralkyl, or aryl group; R.sub.2 is an alkyl, hydroxyalkyl, or polyhydroxyalkyl group; R.sub.3 and R.sub.4 are the same or different and represent alkyl, aralkyl, or aryl group; R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are the same or different and represent a hydrogen atom or acyl group; R.sub.9 is an alkyl, aralkyl, or aryl group; R.sub.10 and R.sub.11 are the same or different and represent a hydrogen atom or acyl group; n is an integer of 5 or less; and HX is an acid. The invention also relates to a process for the preparation of L-biopterin.

4. 发明授权

US4656303A Novel resolution method of racemic mixture 失效
标题翻译：外消旋混合物的新型拆分方法
公开(公告)号：US4656303A
公开(公告)日：1987-04-07
申请号：US663923
申请日：1984-10-23
申请人： Masayasu Kurono , Takafumi Iida , Katsuhiro Hayashi , Kunio Yagi
发明人： Masayasu Kurono , Takafumi Iida , Katsuhiro Hayashi , Kunio Yagi
IPC分类号： C07B31/00 , C07B57/00 , C07C67/00 , C07C301/00 , C07C303/32 , C07C309/25 , C07C121/43
CPC分类号： C07B57/00
摘要： A novel resolution method of a racemic mixture, wherein four kinds of salts are dissolved in a resolving solvent to fractionally crystallize a desired optically active isomer through an exchange reaction between counter ions.
摘要翻译：一种外消旋混合物的新型拆分方法，其中四种盐溶解在拆分溶剂中以通过抗衡离子之间的交换反应分级结晶所需的光学活性异构体。

5. 发明申请

US20080264597A1 Die Casting Mold and Improved Vent Structure Used Therein 审中-公开
标题翻译：压铸模具和改进的排气结构
公开(公告)号：US20080264597A1
公开(公告)日：2008-10-30
申请号：US11569141
申请日：2006-01-31
申请人： Hiroki Harada , Yukio Nishigata , Kunio Yagi
发明人： Hiroki Harada , Yukio Nishigata , Kunio Yagi
IPC分类号： B22D45/00
CPC分类号： B22D17/145
摘要： A die casting mold includes a resistance member (17) disposed in a vent passage (16) to reduce a flow velocity of molten metal as the molten metal advances along the vent passage. The resistant member comprises a plurality of discrete protrusions (24) arranged in staggered relation to one another in both a longitudinal direction and a transverse direction of the vent passage so as to define therebetween a labyrinthine part (34) extending between an inlet side and an outlet side of the vent passage.
摘要翻译：压铸模具包括设置在排气通道（16）中的阻力构件（17），以当熔融金属沿排气通道前进时降低熔融金属的流速。阻力构件包括在排气通道的纵向方向和横向两个方向上彼此交错设置的多个离散突起（24），以便在其间限定一个迷宫部件（34），其在入口侧和排气通道出口侧。

6. 发明授权

US4937342A Intermediates for synthesizing BH.sub.4 and its derivatives 失效
标题翻译：用于合成BH4及其衍生物的中间体
公开(公告)号：US4937342A
公开(公告)日：1990-06-26
申请号：US277109
申请日：1988-11-29
申请人： Masayasu Kurono , Takehiko Susuki , Tomio Ogasawara , Nobuko Ohishi , Kunio Yagi
发明人： Masayasu Kurono , Takehiko Susuki , Tomio Ogasawara , Nobuko Ohishi , Kunio Yagi
IPC分类号： C07D405/12 , C07D475/04 , C12P25/00
CPC分类号： C07D405/12 , C07D475/04 , C12P25/00
摘要： The present invention relates to intermediates for synthesizing BH.sub.4 and derivatives thereof. The intermediates are shown as follows: ##STR1## wherein R.sub.1 is a hydrogen atom, alkyl, aralkyl, or aryl group; R.sub.2 is an alkyl, hydroxyalkyl, or polyhydroxyalkyl group; R.sub.3 and R.sub.4 are the same or different and represent alkyl, aralkyl, or aryl group; R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are the same or different and represent a hydrogen atom or acyl group; R.sub.9 is an alkyl, aralkyl, or aryl group; R.sub.10 and R.sub.11 are the same or different and represent a hydrogen atom or acyl group; n is an integer of 5 or less; and HX is an acid. The invention also relates to a process for the preparation of L-biopterin.

7. 发明授权

US4906477A Antineoplastic agent-entrapping liposomes 失效
标题翻译：抗肿瘤药物包埋脂质体
公开(公告)号：US4906477A
公开(公告)日：1990-03-06
申请号：US153302
申请日：1988-02-08
申请人： Masayasu Kurono , Hitoshi Noda , Tomio Ogasawara , Hidefumi Yamakawa , Takafumi Iida , Kunio Yagi
发明人： Masayasu Kurono , Hitoshi Noda , Tomio Ogasawara , Hidefumi Yamakawa , Takafumi Iida , Kunio Yagi
IPC分类号： A61K9/10 , A61K9/127 , A61K31/70 , A61P35/00
CPC分类号： A61K9/1272 , Y10T428/2984
摘要： Some of antineoplastic agents, for instance, adriamycin and daunorubicin, have a positive charge at physiological pH. Such drugs possess high affinity for binding to steroidal sulfate by means of electrostatic force. The invention utilizes this property to prepare steroidal sulfate liposomes having a net negative charge and encapsulating the antineoplastic agent.

8. 发明授权

US5744159A Plasmid entrapping multilamellar liposomes 失效
标题翻译：质粒夹带多层脂质体
公开(公告)号：US5744159A
公开(公告)日：1998-04-28
申请号：US818716
申请日：1997-03-14
申请人： Kunio Yagi , Mariko Kitoh , Nobuko Ohishi
发明人： Kunio Yagi , Mariko Kitoh , Nobuko Ohishi
IPC分类号： C12N15/09 , A61K9/127 , A61K48/00 , A61P35/00 , B01J13/02 , C07H21/04 , C12N15/88 , C12N15/63
CPC分类号： C12N15/88 , A61K9/1272 , Y10T428/2984
摘要： A plasmid entrapping multilamellar liposome for introducing a gene into cells, which liposome has constitutive lipids of N-(.alpha.-trimethylammonioacetyl)-didodecyl-D-glutamate chloride (TMAG); dioctanoylphosphatidyl choline (DOPC) or didecanoylphosphatidyl choline (DDPC); and dioleoylphosphatidyl ethanolamine (DOPE) or dilauroylphosphatidyl ethanolamine (DLPE) and in a molar ratio of 1:2-3:2-1 in case of lipid combination of TMAG, DOPC and DOPE, or 1:2:2 in case of lipid combination of TMAG, DDPC or DOPC and DLPE.
摘要翻译：用于将基因导入细胞的多层脂质体的质粒，该脂质体具有N-（α-三甲基铵乙酰基） - 十二烷基-D-谷氨酸盐（TMAG）的组成型脂质; 二辛酰磷脂酰胆碱（DOPC）或二癸酰磷脂酰胆碱（DDPC）; 和二油酰磷脂酰乙醇胺（DOPE）或二月桂酰磷脂酰乙醇胺（DLPE），在脂质组合TMAG，DOPC和DOPE的情况下，摩尔比为1：2-3：2-1，或在脂质组合的情况下为1:2:2 的TMAG，DDPC或DOPC和DLPE。

9. 发明授权

US5552157A Liposome for entrapping gene, liposomal preparation and process for the manufacture of the preparation 失效
标题翻译：用于捕获基因的脂质体，脂质体制备和制备方法
公开(公告)号：US5552157A
公开(公告)日：1996-09-03
申请号：US412107
申请日：1995-03-28
申请人： Kunio Yagi , Hitoshi Noda , Nobuko Ohishi , Masayasu Kurono
发明人： Kunio Yagi , Hitoshi Noda , Nobuko Ohishi , Masayasu Kurono
IPC分类号： C12N15/09 , A61K9/127 , A61K31/00 , A61K48/00 , A61P43/00 , B01J13/02 , C12N15/64 , A61K9/27 , C12N11/00 , C12N11/02
CPC分类号： A61K9/1272 , C12N15/64
摘要： For increasing gene entrapping efficiency, it is preferable that liposome membrane to be formed is positively charged. For this purpose, a lipid with quaternary amine has been employed as one of constitutional lipids, but the such lipid may show toxicity to cells to be transformed with the gene for expression. The invention selects, as constitutional lipids for liposomes, N-(.alpha.-trimethylammonioacetyl)-didodecyl-D-glutamate chloride (TMAG), dilauroylphosphatidylcholine (DLPC), and dioleoylphosphatidylethanolamine (DOPE) with molar ratio of 1:2:2, and vortex treatment for preparing the liposomes with multi-layers to entrap the gene therein.
摘要翻译：为了增加基因捕获效率，优选形成的脂质体膜带正电。为此，已经使用具有季胺的脂质作为构成脂质之一，但是这样的脂质可能对用于表达的基因转化的细胞显示毒性。作为脂质体的构成脂质，选择摩尔比为1:2:2的N-（α-三甲基铵乙酰基） - 十二烷基-D-谷氨酸氯化物（TMAG），二月桂酰磷脂酰胆碱（DLPC）和二油酰磷脂酰乙醇胺（DOPE）用于制备多层脂质体以捕获其中的基因的处理。

10. 发明授权

US6057484A Method of obtaining a composition containing 9-cis .beta.-carotene in high-purity 失效
标题翻译：获得含有高纯度的9-顺式β-胡萝卜素的组合物的方法
公开(公告)号：US6057484A
公开(公告)日：2000-05-02
申请号：US47346
申请日：1998-03-25
申请人： Takehiko Suzuki , Nobuko Ohishi , Kunio Yagi
发明人： Takehiko Suzuki , Nobuko Ohishi , Kunio Yagi
IPC分类号： C12P23/00 , C07C20060101 , C07C29/74 , C07C403/00 , C07C403/24 , C12N1/00 , C12N1/12 , C12R1/89 , C12S99/00
CPC分类号： C07C403/24
摘要： There are disclosed a composition containing 9-cis .beta.-carotene in high-purity and an industrially applicable method of obtaining the same from an alga. The composition can be obtained through steps of washing with ethanol dry powder of the alga belonging to Dunaliella, adding hexane to the washed algal powder, stirring the same, subjecting the same to filtration to obtain a filtrate, concentrating the filtrate to obtain a semi-solidic concentrate, adding hexane to the semi-solidic concentrate in an amount of 10-18 ml of hexane to 1 g of the semi-solidic concentrate, stirring the same, subjecting the same to filtration to obtain a filtrate, concentrating the filtrate to obtain an oily concentrate, adding hexane to the oily concentrate in an amount of 2-4.5 ml of hexane to 1 g of the oily concentrate to dissolve the same, and leaving the solution, as it is, under lower temperature condition to cause a separation of the composition. The composition is a rubiginous powder or crystals and contains 9-cis .beta.-carotene in an amount of 75% or more to total amount of the composition.
摘要翻译：公开了一种含有高纯度的9-顺式β-胡萝卜素的组合物，以及从藻类获得相同的工业上适用的方法。该组合物可以通过以下方法获得：通过用属于杜氏盐藻的藻类的乙醇干燥粉末洗涤，向洗涤的藻粉中加入己烷，搅拌，同时过滤得到滤液，浓缩滤液，固体浓缩物，向半固体浓缩物中加入己烷至10-18ml己烷至1g半固体浓缩物，搅拌该混合物，过滤得到滤液，浓缩滤液，得到油状浓缩物，将含有2-4.5ml己烷的己烷至己烷至1g油状浓缩物溶解，并将其溶解在较低温度条件下，使其分离组成。该组合物是一种红宝石粉末或晶体，并含有相对于组合物总量的75％或更多量的9-顺式β-胡萝卜素。

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