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1. 发明授权

US5739302A Manufacture and use of novel glycosides of catechol estrogens 失效
标题翻译：儿茶酚雌激素新型糖苷的生产和使用
公开(公告)号：US5739302A
公开(公告)日：1998-04-14
申请号：US322711
申请日：1994-10-05
申请人： Takehiko Suzuki , Sadaaki Komura , Naoko Ishida , Nobuko Ohishi , Kunio Yagi
发明人： Takehiko Suzuki , Sadaaki Komura , Naoko Ishida , Nobuko Ohishi , Kunio Yagi
IPC分类号： A61F2/00 , C07J1/00 , C07J17/00 , C07J51/00 , C07H1/00
CPC分类号： C07J51/00 , C07J1/007 , C07J1/0074 , C07J17/005 , A61F2210/0019 , Y02P20/55
摘要： There are described novel glycosides of catechol estrogen, a method of preparing the same, and a medicament comprising one of the glycosides as an active ingredient. The glycosides are shown by the formula of ##STR1## wherein X is carbonyl group or ##STR2## R.sub.10 is hydroxyl group or glycosyloxy group, and R.sub.2 is a hydrogen atom or ethynyl group; R.sub.11 is a hydrogen atom, hydroxyl group, or glycosyloxy group; R.sub.12 is hydroxyl group or glycosyloxy group; and R.sub.13 is hydroxyl group or glycosyloxy group, in which glycosyloxy group is selected from the group consisting of glycosyloxy, galactosyloxy, mannosyloxy, arabinosyloxy, ribosyloxy, xylosyloxy, fructosyloxy, rhamnosyloxy, fucosyloxy, maltosyloxy, cellobiosyloxy, lactosyloxy, sucrosyloxy, maltotriosyloxy, maltotetraosyloxy, maltopentaosyloxy, maltohexaosyloxy, maltoheptaosyloxy, and sialosyloxy, and in this case, at least one of R.sub.10, R.sub.11, R.sub.12, and R.sub.13 is glycosyloxy group as defined above.
摘要翻译：描述了儿茶酚雌激素的新型糖苷，其制备方法，以及包含其中一种糖苷作为活性成分的药物。糖苷由下式表示：其中X是羰基，或者R10是羟基或糖氧基，R2是氢原子或乙炔基; R11为氢原子，羟基或糖氧基; R12是羟基或糖氧基; 并且R 13是羟基或糖氧基，其中糖氧基选自糖氧基，半乳糖氧基，甘露糖氧基，阿拉伯糖氧基，核糖氧基，木糖氧基，果糖氧基，鼠李糖氧基，岩藻糖氧基，麦芽糖氧基，纤维二糖氧基，乳糖氧基，蔗糖氧基，麦芽三糖基氧基，麦芽四糖基氧基，麦芽六糖氧基，麦芽庚糖基氧基和唾液酸氧基，在这种情况下，R 10，R 11，R 12和R 13中的至少一个为如上定义的糖氧基。

2. 发明授权

US5405944A Glycosides of catechol estrogens 失效
标题翻译：儿茶酚雌激素的糖苷
公开(公告)号：US5405944A
公开(公告)日：1995-04-11
申请号：US950512
申请日：1992-09-25
申请人： Takehiko Suzuki , Sadaaki Komura , Naoko Ishida , Nobuko Ohishi , Kunio Yagi
发明人： Takehiko Suzuki , Sadaaki Komura , Naoko Ishida , Nobuko Ohishi , Kunio Yagi
IPC分类号： A61F2/00 , C07J1/00 , C07J17/00 , C07J51/00 , A61K37/14 , A61K31/58 , A61K31/595
CPC分类号： C07J51/00 , C07J1/007 , C07J1/0074 , C07J17/005 , A61F2210/0019 , Y02P20/55
摘要： There are described novel glycosides of catechol estrogen, a method of preparing the same, and a medicament comprising one of the glycosides as an active ingredient. The glycosides are shown by the formula of ##STR1## wherein X is carbonyl group or ##STR2## R.sub.10 is hydroxyl group or glycosyloxy group, and R.sub.2 is a hydrogen atom or ethynyl group; R.sub.11 is a hydrogen atom, hydroxyl group, or glycosyloxy group; R.sub.12 is hydroxyl group or glycosyloxy group; and R.sub.13 is hydroxyl group or glycosyloxy group,in which glycosyloxy group is selected from the group consisting of glucosyloxy, galactosyloxy, mannosyloxy, arabinosyloxy, ribosyloxy, xylosyloxy, fructosyloxy, rhamnosyloxy, fucosyloxy, maltosyloxy, cellobiosyloxy, lactosyloxy, sucrosyloxy, maltotriosyloxy, maltotetraosyloxy, maltopentaosyloxy, maltohexaosyloxy, maltoheptaosyloxy, and sialosyloxy, and in this case, at least one of R.sub.10, R.sub.11, R.sub.12, and R.sub.13 is glycosyloxy group as defined above.
摘要翻译：描述了儿茶酚雌激素的新型糖苷，其制备方法，以及包含其中一种糖苷作为活性成分的药物。糖苷由下式表示：其中X是羰基，或者R10是羟基或糖氧基，R2是氢原子或乙炔基; R11为氢原子，羟基或糖氧基; R12是羟基或糖氧基; 并且R 13是羟基或糖氧基，其中糖氧基选自葡糖基氧基，半乳糖氧基，甘露糖氧基，阿拉伯糖基氧基，核糖氧基，木糖氧基，果糖氧基，鼠李糖氧基，岩藻糖氧基，麦芽糖氧基，纤维二糖氧基，乳糖氧基，蔗糖氧基，麦芽三糖基氧基，麦芽四糖基氧基，麦芽六糖氧基，麦芽庚糖基氧基和唾液酸氧基，在这种情况下，R 10，R 11，R 12和R 13中的至少一个为如上定义的糖氧基。

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