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1. 发明授权

US4731493A Process for producing condensed bromoacenaphthylene 失效
标题翻译：缩合溴代苊烯的制备方法
公开(公告)号：US4731493A
公开(公告)日：1988-03-15
申请号：US819269
申请日：1986-01-16
申请人： Masashige Kubo , Mitsuaki Yoshimitsu , Yukihiro Tsutsumi
发明人： Masashige Kubo , Mitsuaki Yoshimitsu , Yukihiro Tsutsumi
IPC分类号： C07C17/12 , C07C17/38 , C07C25/22 , C07C17/26 , C07C17/02 , C07C17/34
CPC分类号： C07C17/38 , C07C17/12
摘要： Process for producing condensed bromoacenaphthylene comprising:(A) a step of brominating and condensating acenaphthene with bromine in a halogenated hydrocarbon solvent in the presence of a Lewis acid catalyst;(B) a step of removing the Lewis acid catalyst and then continuing the bromination with bromine with an added radical initiator; and(C) a step of carrying out dehydrobromination reaction.In a modified process, the bromination is effected in a halogenated hydrocarbon solvent at a temperature not lower than 60.degree. C. using bromine at least 3 times as much in moles as acenaphthene in the presence of an iron catalyst.Further, the condensed bromoacenaphthylene is purified by bringing it into contact with an adsorbent in an organic solvent.
摘要翻译：制备浓缩溴苊烯的方法，包括：（A）在路易斯酸催化剂存在下，在卤代烃溶剂中溴与溴反应缩合和缩合步骤; （B）除去路易斯酸催化剂，然后用加入的自由基引发剂用溴继续溴化的步骤; 和（C）进行脱氢溴化反应的步骤。在改性方法中，溴化在卤代烃溶剂中在不低于60℃的温度下进行，使用在铁催化剂存在下至少为苊烯摩尔数的3倍。此外，通过使其与有机溶剂中的吸附剂接触来纯化缩合的溴苊烯。

2. 发明授权

US4393246A Process for brominating side chain of m-phenoxytoluene 失效
标题翻译：溴化苯氧基甲苯侧链的方法
公开(公告)号：US4393246A
公开(公告)日：1983-07-12
申请号：US316448
申请日：1981-10-29
申请人： Masashige Kubo , Mitsuaki Yoshimitsu , Kanzi Katsuragawa
发明人： Masashige Kubo , Mitsuaki Yoshimitsu , Kanzi Katsuragawa
IPC分类号： C07C43/29 , B01J27/00 , C07C41/00 , C07C41/22 , C07C67/00
CPC分类号： C07C41/22
摘要： A side chain of m-phenoxytoluene is brominated with a polyhalogenated ethane having the formula ##STR1## wherein W and Z respectively represent Cl or Br and X and Y respectively represent Cl, Br or H, as a brominating agent in a liquid phase in the presence of an amorphous carbon.
摘要翻译：间苯氧基甲苯的侧链用具有式“IMAGE”的多卤代乙烷溴化，其中W和Z分别表示Cl或Br，X和Y分别表示Cl，Br或H，作为溴化剂在液相中存在无定形碳。

3. 发明授权

US4898998A Process for producing brominated acenaphthylene condensates 失效
标题翻译：生产溴化苊缩合物的方法
公开(公告)号：US4898998A
公开(公告)日：1990-02-06
申请号：US615541
申请日：1984-05-31
申请人： Masashige Kubo , Hideo Sakka , Yukihiro Tsutsumi
发明人： Masashige Kubo , Hideo Sakka , Yukihiro Tsutsumi
IPC分类号： C07C17/25 , C07C25/22
CPC分类号： C07C17/269 , C07C17/10 , C07C17/14 , C07C17/25 , C07C17/392 , C07C25/22 , C07C2103/20
摘要： A process for producing brominated acenaphthylene condensates of the formula: ##STR1## wherein x is 1 or 2, y is an integer from 1 to 6 and n is 1 or more, from elementary units of the following formulas: ##STR2## wherein y is as defined above, comprising, (A) brominating the side chain of the acenaphthene with 0.2 to 2.0 times as many moles of bromine as acenaphthene, said bromination initiated by ultraviolet radiation or by a radical initiator in a halogenated hydrocarbon solvent, (B) adding a Lewis acid catalyst to the reaction solution of step (A) to promote the condensation of the brominated acenaphthene product of step (A), (C) adding to the reaction solution of step (B) an equimolar or more amount of bromine relative to the amount of acenaphthene starting material, to further brominate and condense the brominated acenaphthene and/or brominated acenaphthene condensates; and (D) dehydrobrominating the brominated acenaphthene condensates.
摘要翻译：其中x为1或2，y为1至6的整数，n为1或更大的下式的基本单元：＆lt; IMAGE＆gt;和/或其中y如上所定义，包括：（A）用苊的0.2至2.0倍的溴的量使溴化苊的侧链，所述紫外线辐射引发的溴化或卤代烃中的自由基引发剂溶剂，（B）向步骤（A）的反应溶液中加入路易斯酸催化剂以促进步骤（A）的溴化苊产物的缩合，（C）向步骤（B）的反应溶液中加入等摩尔或更多量的溴相对于苊原料，进一步溴化和缩合溴化苊和/或溴化苊缩合物; 和（D）溴化苊缩合物脱氢溴化。

4. 发明授权

US5015526A Radiation-resistant high molecular composition 失效
标题翻译：耐辐射高分子组成
公开(公告)号：US5015526A
公开(公告)日：1991-05-14
申请号：US412087
申请日：1989-09-25
申请人： Masashige Kubo , Yukihiro Tsutsumi , Fumio Okisaki , Shunichi Fujimura , Teruo Fukuda
发明人： Masashige Kubo , Yukihiro Tsutsumi , Fumio Okisaki , Shunichi Fujimura , Teruo Fukuda
IPC分类号： C08K3/00 , C08K5/03 , C08K5/06 , H01B3/30
CPC分类号： C08K5/06 , C08K3/0091 , C08K5/03 , H01B3/30 , Y10T428/2938 , Y10T428/294 , Y10T428/2958 , Y10T428/296 , Y10T428/3154 , Y10T428/31544 , Y10T428/31699
摘要： A radiation-resistant high molecular composition is disclosed, charqacterized in that, to the high molecular polymer, a halogenated acenaphtylene and/or condensates thereof represented by a following general formula [I] ##STR1## (wherein, X indicates a chlorine or bromine atom, a indicates 0 to 2, b indicates 1 to 6 and n indicates an integer not less than 1) and a diphenyl ether derivative represented by a following general formula [II] ##STR2## (wherein, R.sub.1 and R.sub.2 indicate any ones of hydrogen atom, alkyl, alkoxy, phenyl phenoxy, diphenyloxy and terphenyloxy group) and/or basic lead compound are formulated.

5. 发明授权

US4900766A Radiation-resistant high molecular composition 失效
标题翻译：耐辐射高分子组成
公开(公告)号：US4900766A
公开(公告)日：1990-02-13
申请号：US98883
申请日：1987-09-21
申请人： Masashige Kubo , Yukihiro Tsutsumi , Fumio Okisaki , Shunichi Fujimura , Teruo Fukuka
发明人： Masashige Kubo , Yukihiro Tsutsumi , Fumio Okisaki , Shunichi Fujimura , Teruo Fukuka
IPC分类号： C08K3/00 , C08K5/03 , C08K5/06 , H01B3/30
CPC分类号： C08K5/06 , C08K3/0091 , C08K5/03 , H01B3/30 , Y10T428/2938 , Y10T428/294 , Y10T428/2958 , Y10T428/296 , Y10T428/3154 , Y10T428/31544 , Y10T428/31699
摘要： A radiation-resistant high molecular composition is disclosed, characterized in that, to the high molecular polymer, a halogenated acenaphtylene and/or condensates thereof represented by a following general formula [I] ##STR1## (wherein, X indicates a chlorine or bromine atom, a indicates 0 to 2, b indicates 1 to 6 and n indicates an integer not less than 1) and a diphenyl ether derivative represented by a following general formula [II] ##STR2## (wherein, R.sub.1 and R.sub.2 indicate any ones of hydrogen atom, alkyl, alkoxy, phenyl phenoxy, diphenyloxy and terphenyloxy group) and/or basic lead compound are formulated.
摘要翻译：公开了耐辐射高分子组合物，其特征在于，对于高分子聚合物，由以下通式[I]表示的卤化亚萘基和/或缩合物：其中X表示氯或溴原子，a表示0〜2，b表示1〜6，n表示1以上的整数）和由以下通式[II]表示的二苯醚衍生物[II]（其中，R1和 R2表示任何氢原子，烷基，烷氧基，苯氧基，二苯氧基和三苯氧基）和/或碱性铅化合物。

6. 发明授权

US4822931A Method for preparation of polybromoacenaphthene and/or its condensate 失效
标题翻译：聚溴苊和/或其缩合物的制备方法
公开(公告)号：US4822931A
公开(公告)日：1989-04-18
申请号：US123533
申请日：1987-11-18
申请人： Fumio Okisaki , Masashige Kubo , Hideo Sakka
发明人： Fumio Okisaki , Masashige Kubo , Hideo Sakka
IPC分类号： C07C17/00 , C07C17/12 , C07C25/22 , C07C67/00 , C08K5/02 , C07C25/18
CPC分类号： C07C17/12
摘要： A method for preparing Con-BAN, in which Con-AN is reacted with bromine in the presence of an iron Lewis acid catalyst and in which the solution of Con-AN and bromine are supplied simultaneously at a given rate into a reactor already containing a halogenated hydrocarbon and an iron catalyst.
摘要翻译：一种制备Con-BAN的方法，其中Con-AN在铁路易斯酸催化剂存在下与溴反应，其中Con-AN和溴的溶液以给定的速率同时供给到已经含有卤代烃和铁催化剂。

7. 发明授权

US4309341A Method for purifying .alpha.- L-aspartyl-L-phenylalanine lower alkyl ester 失效
标题翻译： α-L-天冬氨酰-L-苯丙氨酸低级烷基酯的纯化方法
公开(公告)号：US4309341A
公开(公告)日：1982-01-05
申请号：US138728
申请日：1980-04-09
申请人： Masashige Kubo , Yuji Nonaka , Keiichi Kihara
发明人： Masashige Kubo , Yuji Nonaka , Keiichi Kihara
IPC分类号： B01D15/00 , C07C67/00 , C07C231/00 , C07K5/072 , C07K5/075 , C07C103/52
CPC分类号： C07K5/0613 , Y10S530/801
摘要： A method for purifying an .alpha.-L-aspartyl-L- phenylalanine lower alkyl ester containing impurities. The .alpha.-L-aspartyl-L-phenylalanine lower alkyl ester is brought into contact with a Cl-type anion exchange resin in an aqueous medium to have the impurities adsorbed by the anion exchange resin. The impurities contained in the .alpha.-L-aspartyl-L-phenylalanine lower ester, particularly diketopiperazine and .alpha.-L-aspartyl-L-phenylalanine are selectively and easily removed. The desired matter thus can be easily recovered and disposal of waste liquid, etc. can also be carried out without difficulty.
摘要翻译：一种纯化含有杂质的α-L-天冬氨酰-L-苯丙氨酸低级烷基酯的方法。使α-L-天冬氨酰基-L-苯丙氨酸低级烷基酯与水性介质中的Cl型阴离子交换树脂接触，使杂质被阴离子交换树脂吸附。包含在α-L-天冬氨酰基-L-苯丙氨酸低级酯，特别是二酮哌嗪和α-L-天冬氨酰基-L-苯丙氨酸中的杂质是有选择且易于除去的。因此可以容易地回收所需的物质，也可以毫无困难地进行废液等的处理。

8. 发明授权

US5138103A Process for producing tetrabromobisphenol A 失效
标题翻译：生产四溴异苯酚A的方法
公开(公告)号：US5138103A
公开(公告)日：1992-08-11
申请号：US745888
申请日：1991-08-16
申请人： Hisao Eguchi , Masashige Kubo , Noritaka Nagasaki , Koji Kunimoto
发明人： Hisao Eguchi , Masashige Kubo , Noritaka Nagasaki , Koji Kunimoto
IPC分类号： C07C37/62
CPC分类号： C07C37/62
摘要： A process for producing tetrabromobisphenol A of high quality, which comprises brominating bisphenol A with bromine, wherein a solvent mixture comprising a hydrohalogenic acid and an alcohol, is used as the solvent for reaction. Also disclosed is a process for producing tetrabromobisphenol A of high quality, which comprises brominating bisphenol A with bromine in an alcohol, wherein the reaction temperature is set at a level of from -10.degree. to +20.degree. C., and water is added in an aging step.

9. 发明授权

US5059726A Process for producing tetrabromobisphenol A 失效
标题翻译：生产四溴双酚A的方法
公开(公告)号：US5059726A
公开(公告)日：1991-10-22
申请号：US600817
申请日：1990-10-22
申请人： Hisao Eguchi , Masashige Kubo , Koji Kunimoto , Sadami Shimizu , Masakatsu Sato , Hanzo Tamabayashi
发明人： Hisao Eguchi , Masashige Kubo , Koji Kunimoto , Sadami Shimizu , Masakatsu Sato , Hanzo Tamabayashi
IPC分类号： C07C37/62
CPC分类号： C07C37/62
摘要： A process for producing tetrabromobisphenol A, which comprises brominating bisphenol A in methanol, wherein the substrate concentration of bisphenol A to methanol is at most 20 wt/vol %.
摘要翻译：一种生产四溴双酚A的方法，其包括在甲醇中溴化双酚A，其中双酚A至甲醇的底物浓度为至多20重量/体积％。

10. 发明授权

US4564471A Method for reductive elimination of protecting groups 失效
标题翻译：还原消除保护基团的方法
公开(公告)号：US4564471A
公开(公告)日：1986-01-14
申请号：US188107
申请日：1980-09-17
申请人： Katsumi Sugiyama , Hideo Takeda , Hiroko Sato , Yuji Nonaka , Kiyotaka Oyama , Masashige Kubo
发明人： Katsumi Sugiyama , Hideo Takeda , Hiroko Sato , Yuji Nonaka , Kiyotaka Oyama , Masashige Kubo
IPC分类号： C07B31/00 , C07B51/00 , C07C67/00 , C07C227/00 , C07C227/16 , C07C227/18 , C07C227/20 , C07C231/00 , C07K1/06 , C07K1/12 , C07K5/075 , C07C101/02
CPC分类号： C07K1/12 , C07K5/0613 , Y02P20/55
摘要： The invention provides a novel and efficient method for the elimination of protecting groups, e.g. benzyloxycarbonyl group, from a protected amino acid, peptide or derivative thereof having at least one functional group protected by a protecting group, e.g. a lower alkyl ester of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine by catalytic hydrogen reduction to produce free amino acid, peptide or derivative thereof. In contrast to the conventional procedures in which the reaction is carried out in a solvent dissolving both the starting compound and the product compound or a solvent dissolving the starting compound but not dissolving the product compound, the inventive method utilizes a binary two-phase reaction medium composed of water and an organic solvent not freely miscible with water such as toluene. The reaction takes place in the organic phase containing the starting compound dissolved and the catalyst dispersed therein whereas the reaction product which is water-soluble is smoothly and successively transferred into the aqueous phase so that advantages are obtained in the unexpectedly high yield of the product as well as in the easiness of handling the reaction mixture after completion of the reaction.
摘要翻译：本发明提供了一种用于消除保护基团的新型和有效的方法，例如，苄氧羰基，被保护的氨基酸，具有至少一个被保护基保护的官能团的肽或衍生物。 N-苄氧羰基-α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯通过催化氢还原反应产生游离氨基酸，肽或其衍生物。与在溶解起始化合物和产物化合物的溶剂或溶解起始化合物但不溶解产物化合物的溶剂中进行反应的常规方法相反，本发明的方法利用二元二相反应介质由水和不能与水如甲苯自由混溶的有机溶剂组成。反应发生在含有溶解的起始化合物和分散在其中的催化剂的有机相中，而水溶性的反应产物顺利地依次转移到水相中，从而获得了产品出乎意料的高产率的优点，以及在反应完成后容易处理反应混合物。

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