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1. 发明授权

US11591351B2 Benzyl compound 有权
公开(公告)号：US11591351B2
公开(公告)日：2023-02-28
申请号：US17032357
申请日：2020-09-25
申请人： SEKISUI MEDICAL CO., LTD.
发明人： Shinya Yano , Yuki Wakasugi , Yosuke Iwanaga
IPC分类号： C07F7/18 , C07B51/00 , C07K1/06
摘要： The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization. Provided is a benzyl compound represented by Formula (1) where X1 represents —CH2OR14 (where R14 represents a hydrogen atom, a halogenocarbonyl group, or an active ester-type protecting group), —CH2NHR5 (where R15 represents a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group), a halogenomethyl group, a methyl azide group, a formyl group, or an oxime; and at least one of R1, R2, R3, R4, and R5 is a group represented by Formula (2), and the remainders each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, where R6 represents a linear or branched alkylene group having 1 to 16 carbon atoms; X2 represents O or CONR16 (where R16 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); and A represents a group represented by Formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), or (13).

2. 发明授权

US11505551B2 Methods for preparing substituted pyridinone-containing tricyclic compounds 有权
公开(公告)号：US11505551B2
公开(公告)日：2022-11-22
申请号：US17046139
申请日：2019-04-11
申请人： Arbutus Biopharma Corporation
发明人： Shuai Chen , Bruce D. Dorsey , Dimitar B. Gotchev , Duyan Nguyen , Mahesh Kumar Pallerla , Ganapati Reddy Pamulapati
IPC分类号： C07D471/14 , C07B49/00 , C07B51/00
摘要： The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.

3. 发明授权

US11091504B2 Process for the preparation of tavaborole, its novel polymorphic forms and the polymorphs thereof 有权
公开(公告)号：US11091504B2
公开(公告)日：2021-08-17
申请号：US16579879
申请日：2019-09-24
申请人： Biophore India Pharmaceuticals PVT. Ltd.
发明人： Manik Reddy Pullagurla , Mecheril Valsan Nanda Kumar , Bhaskar Reddy Pitta , Jagadeesh Babu Rangisetty
IPC分类号： C07F5/02 , B01D9/00 , C07B51/00
摘要： The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for preparation of those polymorphic forms. The invention also relates to process for purification of Tavaborole to obtain the Tavaborole in significantly high yield and substantially pure form.

4. 发明授权

US10851120B2 Diphenylmethane protective agent 有权
公开(公告)号：US10851120B2
公开(公告)日：2020-12-01
申请号：US16307105
申请日：2017-06-19
申请人： SEKISUI MEDICAL CO., LTD.
发明人： Shinya Yano , Hideki Kubota
IPC分类号： C07F7/18 , C07B51/00
摘要： An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction.A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—O—R11—X-A (2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).

5. 发明授权

US10800737B2 Method for preparing treprostinil and intermediate therefor 有权
公开(公告)号：US10800737B2
公开(公告)日：2020-10-13
申请号：US16096766
申请日：2017-04-18
申请人： YONSUNG FINE CHEMICAL CO., LTD.
发明人： Hyun Ik Shin , Hyoseon Lee , Kyung Jin Lee , Kee Young Lee , Changyoung Oh
IPC分类号： C07C35/37 , C07C405/00 , C07D317/44 , C07C59/72 , C07B51/00
摘要： The present invention relates to a cost-effective and efficient method for preparing treprostinil with high purity, and an intermediate therefor.

6. 发明申请

US20180141883A1 METHODS FOR PREPARING BRIDGED BI-AROMATIC LIGANDS 审中-公开
公开(公告)号：US20180141883A1
公开(公告)日：2018-05-24
申请号：US15568017
申请日：2016-04-18
申请人： UNIVATION TECHNOLOGIES, LLC
发明人： Catherine Anne FALER , Kevin P. RAMIREZ
IPC分类号： C07C15/14 , C07C15/20 , C07C41/30 , C07C43/23 , C07F5/02 , C07B39/00 , C07B51/00
摘要： New methods for preparing bridged bi-aromatic ligands are disclosed. The methods employ aryl coupling of unprotected phenols. The ligands may be used to prepare transition metal compounds useful as catalysts in olefin polymerization.

7. 发明授权

US09278905B2 Production method for compound comprising amino group and/or hydroxyl group 有权
标题翻译：包含氨基和/或羟基的化合物的制备方法
公开(公告)号：US09278905B2
公开(公告)日：2016-03-08
申请号：US14382455
申请日：2013-03-04
申请人： Takashi Ohshima , Hiroyuki Morimoto , Yuhei Shimizu
发明人： Takashi Ohshima , Hiroyuki Morimoto , Yuhei Shimizu
IPC分类号： C07C211/00 , C07C209/62 , C07D217/02 , C07B41/02 , C07B43/04 , C07B51/00 , C07C213/02 , C07C227/06 , C07D209/16 , C07F7/18 , C07C41/26 , C07C29/00 , C07C41/18 , C07C227/04 , C07D209/08 , C07D309/12 , C07D317/28
CPC分类号： C07C209/62 , C07B41/02 , C07B43/04 , C07B51/00 , C07C29/00 , C07C41/18 , C07C41/26 , C07C213/02 , C07C227/04 , C07C227/06 , C07D209/08 , C07D209/16 , C07D217/02 , C07D309/12 , C07D317/28 , C07F7/1804 , C07F7/1892 , C07C31/205 , C07C33/22 , C07C43/23 , C07C211/27 , C07C211/46 , C07C215/76 , C07C215/30 , C07C215/44 , C07C229/60 , C07C217/84 , C07C217/02 , C07C211/38
摘要： Disclosed is a method for producing a compound having an amino group and/or a hydroxyl group from a substrate compound having an atomic group containing CO or CS by eliminating such atomic group. The substrate compound, having an atomic group containing CO or CS (for example, an amide, a carbamate, or the like), is allowed to react with a compound expressed by formula (I) below, at a temperature of 120° C. or lower, preferably in the presence of an ammonium salt, to eliminate such atomic group containing CO or CS. In formula (I) A may not be present, and in a case where A is present, A represents an alkyl group having 1 to 6 carbon atoms. H2N-A-NH2 (I).
摘要翻译：公开了通过除去这种原子团，从具有含有CO或CS的原子团的底物化合物制备具有氨基和/或羟基的化合物的方法。使具有含有CO或CS的原子团（例如酰胺，氨基甲酸酯等）的底物化合物与下述式（I）表示的化合物在120℃的温度下反应。或更低，优选在铵盐存在下，以消除含有CO或CS的原子团。在式（I）中，A可以不存在，并且在存在A的情况下，A表示具有1至6个碳原子的烷基。 H2N-A-NH2（I）。

8. 发明申请

US20050222241A1 Pyrrole derivative and process for producing the same 审中-公开
标题翻译：吡咯衍生物及其制备方法
公开(公告)号：US20050222241A1
公开(公告)日：2005-10-06
申请号：US10520050
申请日：2003-06-30
申请人： Masahiko Kato , Akira Kaneko
发明人： Masahiko Kato , Akira Kaneko
IPC分类号： C07B51/00 , C07D495/04 , A61K31/407 , C07D498/02
CPC分类号： C07D495/04
摘要： An object of the present invention is to provide novel pyrrole derivatives and processes for producing the derivatives, and to provide novel pyrrole derivatives (intermediates) which may be used as a starting material for the pyrrole derivatives and processes for producing the derivatives (intermediates). The pyrrole derivatives may be characterized by being represented by the formulae [1] and [2] wherein R1 and R2 each independently represents a hydrogen atom or a substituted or unsubstituted C1-10 hydrocarbon group and Z represents an organic group; and the process for producing the compound represented by the formula [1] may be characterized by separating Z from the compound represented by the formula [2].
摘要翻译：本发明的目的是提供新颖的吡咯衍生物和衍生物的制备方法，并提供可用作吡咯衍生物的起始原料的新颖的吡咯衍生物（中间体）及其制备方法（中间体）。吡咯衍生物的特征可以由式[1]和[2]表示，其中R 1和R 2各自独立地表示氢原子或取代或未取代的 C 1-10烃基，Z表示有机基团; 并且由式[1]表示的化合物的制备方法的特征在于将Z与式[2]表示的化合物分离。

9. 发明申请

US20050214828A1 Very large scale immobilized polymer synthesis 审中-公开
标题翻译：非常大规模的固定化聚合物合成
公开(公告)号：US20050214828A1
公开(公告)日：2005-09-29
申请号：US11040520
申请日：2005-01-21
申请人： Michael Pirrung , J. Read , Stephen Fodor , Lubert Stryer
发明人： Michael Pirrung , J. Read , Stephen Fodor , Lubert Stryer
IPC分类号： G01N33/48 , B01J19/00 , B01J19/08 , B01L7/00 , B05D3/00 , C07B51/00 , C07B61/00 , C07C229/14 , C07C229/16 , C07C231/02 , C07C237/22 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K14/00 , C07K16/00 , C07K17/02 , C07K17/06 , C07K17/08 , C07K17/14 , C08F2/46 , C12M1/34 , C12Q1/68 , C40B30/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N1/30 , G01N15/14 , G01N21/25 , G01N21/64 , G01N33/53 , G01N33/533 , G01N33/536 , G01N33/541 , G01N33/543 , G01N33/566 , G01N33/58 , G01N37/00 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , H01L21/98
CPC分类号： C08G69/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K7/06 , C07K17/06 , C07K17/14 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , C40B80/00 , G01N15/1475 , G01N21/253 , G01N21/6428 , G01N21/6452 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , H01L25/50 , H01L2924/0002 , Y02P20/55 , Y10S435/961 , Y10S435/968 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809 , Y10T428/31971 , Y10T436/2575 , H01L2924/00
摘要： A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
摘要翻译：一种用于制备含有多个序列的底物的方法和装置。可除光组附着在基片的表面上。将基板的选定区域暴露于光以便激活所选择的区域。还提供了一种还含有可光除去基团的单体，以在所选择的区域上结合基材。使用各种单体如氨基酸重复该过程，直到获得所需长度的序列。还公开了检测方法和装置。

10. 发明授权

US06930200B2 Multicomponent synthesis of amino acids and derivatives thereof 有权
标题翻译：氨基酸及其衍生物的多组分合成
公开(公告)号：US06930200B2
公开(公告)日：2005-08-16
申请号：US10607234
申请日：2003-06-26
申请人： Adnan M. M. Mjalli
发明人： Adnan M. M. Mjalli
IPC分类号： C07B43/00 , C07B51/00 , C07B61/00 , C07C227/18 , C07C229/08 , C07C229/34 , C07C229/36 , C07C229/48 , C07C231/12 , C07C237/04 , C07C237/14 , C07C237/20 , C07C237/24 , C07C271/22 , C07D207/16 , C07D211/60 , C07D211/62 , C07D211/66 , C07D213/56 , C07D303/48 , C07D309/14 , C07D317/72 , C07D333/38 , C07D335/02 , C07F7/18 , C07C229/02 , C07D211/40 , C07D407/08 , C07D409/08
CPC分类号： C07D317/72 , C07C229/08 , C07C229/36 , C07C229/48 , C07C271/22 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D207/16 , C07D211/60 , C07D211/66 , C07D213/56 , C07D309/14 , C07D333/38 , C07D335/02
摘要： Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha positon with one (mono-) or two (di-) substituents (R2 and/or R3) as shown in Formula 1: N(R4R5)C(R2R3)CO(OR1).
摘要翻译：在α位置上用一个（单）或两（二）取代基取代的单取代和二取代的α-氨基酸及其衍生物（R 2 O 2和/或R 2） 3）如式1所示：N（R 4，R 5）C（R 2 R 3） CO（OR 1））。

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