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1. 发明授权

US4392916A Paper-making process with regenerated chitin fibers 失效
标题翻译：造纸过程与再生几丁质纤维
公开(公告)号：US4392916A
公开(公告)日：1983-07-12
申请号：US351636
申请日：1982-02-23
申请人： Masashi Nishiyama , Yoshinari Kobayashi , Seiichi Tokura , Norio Nishi
发明人： Masashi Nishiyama , Yoshinari Kobayashi , Seiichi Tokura , Norio Nishi
IPC分类号： D01F9/00 , A61L15/28 , D21H13/10 , D21H5/12
CPC分类号： D21H5/1227 , A61L15/28 , D21H13/30
摘要： The invention provides a novel method for making paper of regenerated chious fibers without the use of any binder materials. By virtue of the inherent physiological inertness of the chitinous fibers and the absence of any binder materials, the paper obtained by the inventive method is advantageously used in medical treatment in contact with living body tissues. The principle of the method is that the chitinous fibers prepared by a wet spinning process are never brought into a dry condition or always kept wet with water down to the step of sheet making so that the self-bonding power of the fibers by the hydrogen bonding is never decreased and a chitinous paper with sufficient strengths can be prepared without a binder material. Alternatively, once dried chitinous fibers can be treated with a hydrogen-bond forming agent, e.g. urea, so that the sheet making is equally successful without the use of a binder material.
摘要翻译：本发明提供了不使用任何粘合剂材料制造再生几丁质纤维纸的新方法。由于几丁质纤维的固有生理惰性和不存在任何粘合剂材料，通过本发明方法获得的纸有利地用于与生物体组织接触的医疗中。该方法的原理是通过湿纺丝方法制备的壳多糖纤维不会进入干燥状态，或者始终保持用水润湿直至制片步骤，使得通过氢键的纤维的自粘合力不会减少，并且可以在没有粘合剂材料的情况下制备具有足够强度的几丁质纸。或者，一旦干燥的几丁质纤维可以用氢键形成剂，例如，尿素，使得片材制造同样成功，而不使用粘合剂材料。

2. 发明授权

US5236903A Polypeptide comprising repeated cell-adhesive core sequences 失效
标题翻译：多肽包含重复的细胞粘附核心序列
公开(公告)号：US5236903A
公开(公告)日：1993-08-17
申请号：US912323
申请日：1992-07-13
申请人： Ikuo Saiki , Norio Nishi , Ichiro Azuma , Seiichi Tokura
发明人： Ikuo Saiki , Norio Nishi , Ichiro Azuma , Seiichi Tokura
IPC分类号： A61K38/00 , C07K14/47 , C07K14/78
CPC分类号： C07K14/78 , C07K14/47 , A61K38/00
摘要： A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula:(Arg-Gly-Asp)n or (Tyr-Ile-Gly-Ser-Arg)nwherein n is a number ranging from 2 to 20; or a pharmaceutical acceptable salt thereof, which is valuable as an antimetastatic agent for cancer.
摘要翻译：一种多肽，其包含由式（Arg-Gly-Asp）n或（Tyr-Ile-Gly-Ser-Arg）n表示的细胞粘附蛋白的重复氨基酸序列，其中n为2至20的数; 或其药学上可接受的盐，其作为癌症的抗转移剂是有价值的。

3. 发明授权

US5183804A Polypeptide comprising repeated cell-adhesive core sequences 失效
标题翻译：包含重复的细胞粘附核酸序列的多肽
公开(公告)号：US5183804A
公开(公告)日：1993-02-02
申请号：US370182
申请日：1989-06-23
申请人： Ikuo Saiki , Norio Nishi , Ichiro Azuma , Seiichi Tokura
发明人： Ikuo Saiki , Norio Nishi , Ichiro Azuma , Seiichi Tokura
IPC分类号： A61K38/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/78 , C08G69/00
CPC分类号： C07K14/78 , C07K14/47 , A61K38/00 , Y02P20/55
摘要： A polypeptide comprising repeated amino acid sequences of a cell-adhesive protein represented by the formula:(Arg--Gly--Asp)nor(Tyr--Ile--Gly--Ser--Arg)nwherein n is a number ranging from 2 to 20; or a pharmaceutical acceptable salt thereof, which is valuable as an antimetastatic agent for cancer.

4. 发明申请

US20060134158A1 Chitosan/acidic biopolymer hybrid fiber and culture base for animal cells 审中-公开
标题翻译：壳聚糖/酸性生物聚合物混合纤维和动物细胞培养基
公开(公告)号：US20060134158A1
公开(公告)日：2006-06-22
申请号：US10519541
申请日：2003-06-26
申请人： Tokifumi Majima , Norimasa Iwasaki , Tadanao Funakoshi , Akio Minami , Shin-ichiro Nishimura , Seiichi Tokura , Kazuo Harada , Sachiko Nonaka , Nobuhiki Maekawa
发明人： Tokifumi Majima , Norimasa Iwasaki , Tadanao Funakoshi , Akio Minami , Shin-ichiro Nishimura , Seiichi Tokura , Kazuo Harada , Sachiko Nonaka , Nobuhiki Maekawa
IPC分类号： C12N5/08 , B32B27/04 , A61F13/00
CPC分类号： A61L27/3817 , A61K35/12 , A61L27/20 , A61L27/3804 , A61L27/3843 , A61L27/3895 , A61L27/48 , A61L27/58 , C12N5/0068 , C12N5/0655 , C12N2533/72 , C12N2533/74 , D01F8/16 , Y10T442/2566 , C08L5/08
摘要： It is intended to provide a three-dimensional scaffolds appropriate for culturing animal cells such as chondrocytes and fibroblasts. These three-dimensional scaffolds which comprise a chitosan/acidic biopolymers hybrid fibers composed of chitosan or its salts in the inside of the fiber and complexes of chitosan with biodegradable acidic biopolymers coating the fiber surface, are made of fibers capable of retaining their shapes after allowing to stand Dulbecco's modified Eagle's medium (DMEM) containing 10% of FBS (fetal bovine serum) at room temperature for 2 weeks.
摘要翻译：旨在提供适合于培养动物细胞如软骨细胞和成纤维细胞的三维支架。这些三维支架由纤维内部由壳聚糖或其盐形成的壳聚糖/酸性生物聚合物混合纤维和壳聚糖与可生物降解的酸性生物聚合物复合物包覆纤维表面组成，由能够在允许后保留其形状的纤维制成在室温下放置含有10％FBS（胎牛血清）的Dulbecco改良的Eagle培养基（DMEM）2周。

5. 发明授权

US4958012A Squid chitin formed material 失效
标题翻译：鱿鱼甲壳素形成材料
公开(公告)号：US4958012A
公开(公告)日：1990-09-18
申请号：US319724
申请日：1989-03-07
申请人： Seiichi Tokura , Tsuyoshi Koriyama , Yoshiyuki Chiba , Mikio Satake
发明人： Seiichi Tokura , Tsuyoshi Koriyama , Yoshiyuki Chiba , Mikio Satake
IPC分类号： A61L15/16 , A61L17/00 , A61M1/22 , C08B37/08 , C08J5/00 , C08L5/00 , C08L5/08 , D01F9/00
CPC分类号： C08L5/08 , C08B37/003 , D01F9/00
摘要： A novel squid chitin formed material is disclosed. Squid chitin is prepared by pulverizing squid crust and treating the pulverized chitin with caustic soda and then with hydrochloric acid to remove proteins and ashes. Squid chitin formed material such as sheet or fiber is then prepared by a freeze-defrost treatment. The squid chitin sheet and fiber have better physical properties than conventional crab chitin formed materials in terms of strength and folding endurance.
摘要翻译：公开了一种新型的鱿鱼壳多糖形成的材料。鱿鱼甲壳素通过粉碎鱿鱼皮并用苛性钠处理粉碎的甲壳素，然后用盐酸去除蛋白质和灰分来制备。然后通过冷冻除霜处理制备鱿鱼甲壳素形成的材料如片或纤维。鱿鱼壳甲壳素和纤维在强度和耐折性方面具有比常规螃蟹甲壳质成形材料更好的物理性能。

6. 发明授权

US4873092A Slow-releasing preparation 失效
标题翻译：缓释制剂
公开(公告)号：US4873092A
公开(公告)日：1989-10-10
申请号：US53072
申请日：1987-05-21
申请人： Ichiro Azuma , Seiichi Tokura , Shinichiro Nishimura , Hiroshi Seo
发明人： Ichiro Azuma , Seiichi Tokura , Shinichiro Nishimura , Hiroshi Seo
IPC分类号： A61K9/20
CPC分类号： A61K9/205
摘要： A slow-releasing preparation comprises porous granules of deacetylated chitin as a carrier and a physiologically active substance contained in the granules. The slow-releasing prepartion can be embedded in a body for curing diseases.
摘要翻译：缓释制剂包括脱乙酰壳多糖作为载体的多孔颗粒和颗粒中所含的生理活性物质。缓释制剂可以嵌入身体治疗疾病。

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