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1. 发明授权

US4889917A Peptide 失效
标题翻译：肽
公开(公告)号：US4889917A
公开(公告)日：1989-12-26
申请号：US265550
申请日：1988-11-01
申请人： Masao Tanihara , Kiichiro Oka , Hideaki Yamada , Akira Kobayashi , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
发明人： Masao Tanihara , Kiichiro Oka , Hideaki Yamada , Akira Kobayashi , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
IPC分类号： A61K38/00 , A61M1/36 , A61P43/00 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/705 , G01N33/564 , G01N33/566
CPC分类号： C07K14/705 , A61M1/3679 , Y02P20/55
摘要： A peptide is disclosed which is represented by the formula:H-X-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Leu-Asp-Y -Zwherein one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above, the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group, and two cysteinyl mercapto groups in the Cys-Cys moiety may be interlinked to each other to form a disulfide bond.
摘要翻译：公开了由下式表示的肽：HX-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Le-Asp- Y -Z其中X和Y中的一个代表单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基：其中n表示 1至17的范围）或通过选自上述类别的至少一种的2至10个氨基酸残基的肽键形成的肽残基，X和Y中的另一个表示选自以下的氨基酸残基：由Asp，Glu，Lys和由式表示的二价基团，其中n表示1〜17的整数，或由2〜10个氨基酸的肽键形成的肽残基选自上述类别中的至少一种的残基和Z表示羟基或氨基，并且Cys-Cys moie中的两个半胱氨酰巯基 ty可以彼此互连以形成二硫键。

2. 发明授权

US5132402A Adsorbent, method for production thereof, and method for use thereof 失效
标题翻译：吸附剂，其制造方法及其使用方法
公开(公告)号：US5132402A
公开(公告)日：1992-07-21
申请号：US265540
申请日：1988-11-01
申请人： Masao Tanihara , Kiichiro Oka , Hideaki Yamada , Akira Kobayashi , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
发明人： Masao Tanihara , Kiichiro Oka , Hideaki Yamada , Akira Kobayashi , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
IPC分类号： A61M1/36 , C07K14/705
CPC分类号： C07K14/705 , A61M1/3679
摘要： There is disclosed an adsorbent, comprising a carrier on which is immobilized a peptide possessing an ability to bind to the human antibody to the nicotinic acetylcholine receptor and represented by the formula:H--X--A--Y--Zwherein A stands for a peptide residue, one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group. A method for the production of the adsorbent and a method for the use of the adsorbent are also disclosed.
摘要翻译：公开了一种吸附剂，其包含载体，其上固定有具有与烟碱乙酰胆碱受体的人抗体结合的能力并由下式表示的肽：HXAYZ其中A代表肽残基，X和Y之一对于单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基（其中n表示1至17的整数）或通过选自上述类别的至少一种的2至10个氨基酸残基和X和Y中的另一个的肽键形成的肽残基代表选自Asp，Glu，Lys和由下式表示的二价基团（其中n表示1〜17的整数），或由选自所述类别的至少一种的2〜10个氨基酸残基通过肽键形成的肽残基提到 Z代表羟基或氨基。还公开了制备吸附剂的方法和吸附剂的使用方法。

3. 发明授权

US4925787A Monoclonal anti-idiotypic antibody, method for production thereof, and hybridoma producing said antibody 失效
标题翻译：单克隆抗独特型抗体，其制备方法和产生所述抗体的杂交瘤
公开(公告)号：US4925787A
公开(公告)日：1990-05-15
申请号：US175303
申请日：1988-03-30
申请人： Masao Tanihara , Hideaki Yamada , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
发明人： Masao Tanihara , Hideaki Yamada , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
IPC分类号： C07K14/435 , A61K39/395 , A61P21/00 , A61P37/00 , C07K1/16 , C07K1/22 , C07K14/705 , C07K16/00 , C07K16/28 , C07K16/42 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/68 , G01N33/94
CPC分类号： C07K16/4258 , C07K16/286 , G01N33/686 , G01N33/9406 , Y10S530/808 , Y10S530/809 , Y10S530/813 , Y10S530/868
摘要： A monoclonal anti-idiotypic antibody specific to a human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor; a method for the production of the aforementioned monoclonal anti-idiotypic antibody by the steps of immunizing an animal with a human IgG.sub.1 type monoclonal antibody specific to nicotinic acetylcholine receptor, collecting antibody-producing cells from the animal, fusing the collected cells with neoplastic cells, selecting from the product of fusion a hybridoma capable of producing a monoclonal anti-idiotypic antibody specific to the human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor, propagating the selected hybridoma thereby giving rise to said monoclonal anti-idiotypic antibody, and collecting the produced monoclonal anti-idiotypic antibody; and use of the monoclonal anti-idiotypic antibody as a reagent and as an adsorbent.
摘要翻译：对具有烟碱型乙酰胆碱受体特异性的人IgG1型单克隆抗体特异性的单克隆抗独特型抗体; 通过以下步骤制备上述单克隆抗独特型抗体的方法：用对烟草乙酰胆碱受体特异性的人IgG1型单克隆抗体免疫动物，从动物收集抗体产生细胞，将收集的细胞与肿瘤细胞融合，从融合产物中选择能够产生对烟碱乙酰胆碱受体具有特异性的人IgG1型单克隆抗体特异性的单克隆抗独特型抗体的杂交瘤，繁殖所选择的杂交瘤，从而产生所述单克隆抗独特型抗体，并收集产生单克隆抗独特型抗体; 并使用单克隆抗独特型抗体作为试剂和吸附剂。

4. 发明授权

US5192684A Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody 失效
标题翻译：特异于烟碱乙酰胆碱受体的人IgG1单克隆抗体和产生抗体的杂交瘤
公开(公告)号：US5192684A
公开(公告)日：1993-03-09
申请号：US175304
申请日：1988-03-30
申请人： Masao Tanihara , Hideaki Yamada , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
发明人： Masao Tanihara , Hideaki Yamada , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
IPC分类号： A61B10/00 , A61K39/395 , A61P21/00 , C07K16/28 , C12N5/10 , C12N5/24 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/566 , G01N33/577
CPC分类号： C07K16/286
摘要： A human IgG.sub.1 type monoclonal antibody which possesses a molecular weight in the range of 180,000.+-.20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of sodium dodecyl sulfate and is specific to nicotinic acetylcholine receptor. The human IgG.sub.1 type monoclonal antibody mentioned above is produced by a method which comprises fusing human cells capable of producing an antibody against nicotinic acetylcholine receptor with propagable human cells thereby giving rise to a hybridoma capable of producing the aforementioned human IgG.sub.1 type monoclonal antibody, selecting the hybridoma from the production of the fusion, culturing the hybridoma thereby giving rise to the aforementioned human IgG.sub.1 type monoclonal antibody, and selecting the antibody from the cultured medium. The hybridoma mentioned above is also identified.
摘要翻译：通过在十二烷基硫酸钠存在下进行的聚丙烯酰胺凝胶电泳测定，其具有180,000 +/- 20,000范围内的分子量的人IgG1型单克隆抗体，并且对烟碱乙酰胆碱受体是特异性的。上述人IgG1型单克隆抗体是通过将能够产生抗烟碱型乙酰胆碱受体抗体的人细胞与可扩增人细胞融合从而产生能产生上述人IgG1型单克隆抗体的杂交瘤的方法制备的，从产生融合物中获得杂交瘤，培养杂交瘤，从而产生上述人IgG1型单克隆抗体，并从培养基中选择抗体。也鉴定了上述杂交瘤。

5. 发明授权

US4472303A Blood purification method 失效
标题翻译：血液净化方法
公开(公告)号：US4472303A
公开(公告)日：1984-09-18
申请号：US524931
申请日：1983-08-22
申请人： Masao Tanihara , Toshihide Nakashima , Koichi Takakura
发明人： Masao Tanihara , Toshihide Nakashima , Koichi Takakura
IPC分类号： A61K35/14 , A61M1/36 , B01D15/08 , B01J20/32 , B01D39/06 , C07G7/00
CPC分类号： A61M1/3679 , B01D15/08 , B01J20/28004 , B01J20/28019 , B01J20/28069 , B01J20/28078 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3204 , B01J20/327 , B01J2220/58 , Y10S530/829
摘要： Treatment of the blood by means of a blood purification device comprising packed, substantially spherical, smooth-surfaced, porous granules having at least 0.1 .mu.mole/m.sup.2 of the silanol group on the surface thereof, a blood inlet and a blood outlet scarcely causes decrease in leukocyte or platelet count or blood cell damage and can remove proteins from the blood by adsorption without high pressure loss.
摘要翻译：通过血液净化装置处理血液，该装置包括在其表面上具有至少0.1微摩尔/ m 2硅烷醇基团的填充的，基本上为球形的，光滑的多孔颗粒，血液入口和血液出口几乎不会减少在白细胞或血小板计数或血细胞损伤中，并且可以通过吸附而无需高压力损失从血液中去除蛋白质。

6. 发明授权

US4352884A Carrier having acrylate copolymer coating for immobilization of bioactive materials 失效
标题翻译：具有用于固定生物活性材料的丙烯酸酯共聚物涂层的载体
公开(公告)号：US4352884A
公开(公告)日：1982-10-05
申请号：US232394
申请日：1981-02-09
申请人： Toshihide Nakashima , Masao Tanihara , Koichi Takakura
发明人： Toshihide Nakashima , Masao Tanihara , Koichi Takakura
IPC分类号： B01J20/26 , A61K9/18 , A61K39/385 , A61K39/44 , A61K47/32 , B01D15/08 , B01J20/32 , C07K14/76 , C07K16/00 , C07K17/08 , C07K19/00 , C12M1/40 , C12N11/00 , C12N11/02 , C12N11/08 , C12Q1/00 , G01N33/543 , G01N33/50 , G01N27/30 , G01N31/08 , G01N33/54
CPC分类号： B01J20/3276 , B01J20/286 , B01J20/3202 , B01J20/3274 , B01J20/328 , B01J20/3282 , C12N11/08 , C12Q1/002 , G01N33/543 , G01N33/5438 , B01D15/3804 , B01J2220/54 , Y10S435/962
摘要： Carriers coated with a copolymer of a hydrophilic acrylate or methacrylate monomer and a copolymerizable unsaturated carboxylic acid or unsaturated amine are provided which are substantially free from nonspecific adsorption of proteins and the like. Due to the side-chain carboxyl or amino groups of the copolymer, these coated carriers are able to immobilize bio-active materials such as antigens, antibodies, complements and enzymes. These carriers, on which bio-active materials can be immobilized, are useful as clinical selective adsorbents, affinity-chromatographic adsorbents, selective electrodes or columns for analysis.
摘要翻译：提供涂覆有亲水性丙烯酸酯或甲基丙烯酸酯单体和可共聚的不饱和羧酸或不饱和胺的共聚物的载体，其基本上不含蛋白质等的非特异性吸附。由于共聚物的侧链羧基或氨基，这些包被的载体能够固定生物活性物质如抗原，抗体，补体和酶。这些可以固定生物活性物质的载体可用作临床选择性吸附剂，亲和色谱吸附剂，选择性电极或用于分析的色谱柱。

7. 发明授权

US4420395A Blood purification device 失效
标题翻译：血液净化装置
公开(公告)号：US4420395A
公开(公告)日：1983-12-13
申请号：US395975
申请日：1982-07-07
申请人： Masao Tanihara , Toshihide Nakashima , Koichi Takakura
发明人： Masao Tanihara , Toshihide Nakashima , Koichi Takakura
IPC分类号： A61K35/14 , A61M1/36 , B01D15/08 , B01J20/32 , B01D39/06
CPC分类号： A61M1/3679 , B01D15/08 , B01J20/28004 , B01J20/28019 , B01J20/28069 , B01J20/28078 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3204 , B01J20/327 , B01J2220/58 , Y10S530/829
摘要： Treatment of the blood by means of a blood purification device comprising packed, substantially spherical, smooth-surfaced, porous granules having at least 0.1 .mu.mole/m.sup.2 of the silanol group on the surface thereof, a blood inlet and a blood outlet scarcely causes decrease in leukocyte or platelet count or blood cell damage and can remove proteins from the blood by adsorption without high pressure loss.
摘要翻译：通过血液净化装置处理血液，该装置包括在其表面上具有至少0.1微摩尔/ m 2硅烷醇基团的填充的，基本上为球形的，光滑的多孔颗粒，血液入口和血液出口几乎不会减少在白细胞或血小板计数或血细胞损伤中，并且可以通过吸附而无需高压力损失从血液中去除蛋白质。

8. 发明授权

US4421684A Column for adsorption of blood proteins 失效
标题翻译：血液蛋白吸附柱
公开(公告)号：US4421684A
公开(公告)日：1983-12-20
申请号：US383137
申请日：1982-05-28
申请人： Toshihide Nakashima , Maso Tanihara , Koichi Takakura
发明人： Toshihide Nakashima , Maso Tanihara , Koichi Takakura
IPC分类号： A61K35/14 , A61M1/36 , B01D15/08 , B01J20/32 , A61K37/02 , C07G7/00
CPC分类号： A61M1/3679 , B01D15/08 , B01J20/261 , B01J20/264 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/3204 , B01J20/3219 , B01J20/3257 , B01J20/327 , B01J20/3276 , B01J2220/58 , Y10S530/83 , Y10S530/868
摘要： A column for adsorption of blood proteins is disclosed which comprises a blood inlet and a blood outlet each with a filter, and a porous material packed between both the filters, which material has a mean pore diameter (D) of 30-3,000 amgstroms with the volume occupied by pores with diameters of 0.8D-1.2D being at least 80% of the whole pore volume. The adsorption column can eliminate specific blood proteins by selective adsorption and is useful in the treatment of autoimmune diseases and cancer, for instance.
摘要翻译：公开了一种用于吸附血液蛋白的柱，其包括每个都具有过滤器的血液入口和血液出口，以及在两个过滤器之间填充的多孔材料，该材料的平均孔径（D）为30-3,000埃，与直径为0.8D-1.2D的孔所占的体积占整个孔体积的至少80％。吸附柱可以通过选择性吸附来消除特定的血液蛋白，例如可用于治疗自身免疫性疾病和癌症。

9. 发明授权

US4287177A Wound covering material 失效
标题翻译：伤口覆盖材料
公开(公告)号：US4287177A
公开(公告)日：1981-09-01
申请号：US66699
申请日：1979-08-15
申请人： Toshihide Nakashima , Osamu Nakaji , Koichi Takakura , Takayoshi Suzuki
发明人： Toshihide Nakashima , Osamu Nakaji , Koichi Takakura , Takayoshi Suzuki
IPC分类号： C08L33/00 , A61K9/06 , A61K9/70 , A61L26/00 , C08L33/02 , C08L33/04 , A61K31/78
CPC分类号： A61L26/008 , A61L26/0014 , A61L26/0071 , A61L26/0076 , Y10S424/13
摘要： The present invention provides a covering material consisting essentially of a hydrophilic, water insoluble polymer (component A), a high boiling plasticizer and/or organic solvent (component B) for said component A, and an aqueous liquid (component C). Said covering material is useful as a protective covering material for forming a film or coat on the skin and/or wound surface in the treatment of burn. The material is characterized in that film or coat formation on the skin and/or wound surface can be realized in a short time.
摘要翻译：本发明提供了一种基本上由用于所述组分A的亲水性，水不溶性聚合物（组分A），高沸点增塑剂和/或有机溶剂（组分B）和水性液体（组分C）组成的覆盖材料。所述覆盖材料可用作在烧伤治疗中在皮肤和/或伤口表面上形成膜或涂层的保护性覆盖材料。该材料的特征在于可以在短时间内实现皮肤和/或伤口表面上的膜或涂层形成。

10. 发明授权

US4171283A Hemoperfusion adsorbents 失效
标题翻译：血液灌注吸附剂
公开(公告)号：US4171283A
公开(公告)日：1979-10-16
申请号：US820380
申请日：1977-07-29
申请人： Toshihide Nakashima , Koichi Takakura
发明人： Toshihide Nakashima , Koichi Takakura
IPC分类号： A61K35/14 , A61M1/36 , B01J20/32 , C01B31/08 , C08F292/00 , D01F11/12 , B01D11/04
CPC分类号： A61K35/14 , A61M1/3679 , B01J20/20 , B01J20/261 , B01J20/264 , B01J20/267 , B01J20/28004 , B01J20/28019 , B01J20/3078 , B01J20/3092 , B01J20/3204 , B01J20/327 , B01J20/3276 , B01J20/3282 , C01B31/084 , C08F292/00 , D01F11/122 , B01J2220/4812 , B01J2220/58
摘要： A hemoperfusion adsorbent is provided comprising an adsorbent material containing at least one coating thereon of a hydrophilic polymer prepared by the polymerization of at least one monomeric acrylate or methacrylate with a copolymerizable monomer containing an epoxy moiety therein.In addition, a method is provided for removing air bubbles from such adsorbents comprising boiling said adsorbents in water or physiological saline, cooling said adsorbents, packing said adsorbents into a container and sterilizing the packed container by autoclaving.
摘要翻译：提供了一种血液灌注吸附剂，其包含吸收材料，其中至少含有一层亲水性聚合物，该亲水性聚合物是通过至少一种单体丙烯酸酯或甲基丙烯酸酯与其中含有环氧部分的可共聚单体的聚合而制备的。

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