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1. 发明授权

US5132402A Adsorbent, method for production thereof, and method for use thereof 失效
标题翻译：吸附剂，其制造方法及其使用方法
公开(公告)号：US5132402A
公开(公告)日：1992-07-21
申请号：US265540
申请日：1988-11-01
申请人： Masao Tanihara , Kiichiro Oka , Hideaki Yamada , Akira Kobayashi , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
发明人： Masao Tanihara , Kiichiro Oka , Hideaki Yamada , Akira Kobayashi , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
IPC分类号： A61M1/36 , C07K14/705
CPC分类号： C07K14/705 , A61M1/3679
摘要： There is disclosed an adsorbent, comprising a carrier on which is immobilized a peptide possessing an ability to bind to the human antibody to the nicotinic acetylcholine receptor and represented by the formula:H--X--A--Y--Zwherein A stands for a peptide residue, one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group. A method for the production of the adsorbent and a method for the use of the adsorbent are also disclosed.
摘要翻译：公开了一种吸附剂，其包含载体，其上固定有具有与烟碱乙酰胆碱受体的人抗体结合的能力并由下式表示的肽：HXAYZ其中A代表肽残基，X和Y之一对于单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基（其中n表示1至17的整数）或通过选自上述类别的至少一种的2至10个氨基酸残基和X和Y中的另一个的肽键形成的肽残基代表选自Asp，Glu，Lys和由下式表示的二价基团（其中n表示1〜17的整数），或由选自所述类别的至少一种的2〜10个氨基酸残基通过肽键形成的肽残基提到 Z代表羟基或氨基。还公开了制备吸附剂的方法和吸附剂的使用方法。

2. 发明授权

US4925787A Monoclonal anti-idiotypic antibody, method for production thereof, and hybridoma producing said antibody 失效
标题翻译：单克隆抗独特型抗体，其制备方法和产生所述抗体的杂交瘤
公开(公告)号：US4925787A
公开(公告)日：1990-05-15
申请号：US175303
申请日：1988-03-30
申请人： Masao Tanihara , Hideaki Yamada , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
发明人： Masao Tanihara , Hideaki Yamada , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
IPC分类号： C07K14/435 , A61K39/395 , A61P21/00 , A61P37/00 , C07K1/16 , C07K1/22 , C07K14/705 , C07K16/00 , C07K16/28 , C07K16/42 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/68 , G01N33/94
CPC分类号： C07K16/4258 , C07K16/286 , G01N33/686 , G01N33/9406 , Y10S530/808 , Y10S530/809 , Y10S530/813 , Y10S530/868
摘要： A monoclonal anti-idiotypic antibody specific to a human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor; a method for the production of the aforementioned monoclonal anti-idiotypic antibody by the steps of immunizing an animal with a human IgG.sub.1 type monoclonal antibody specific to nicotinic acetylcholine receptor, collecting antibody-producing cells from the animal, fusing the collected cells with neoplastic cells, selecting from the product of fusion a hybridoma capable of producing a monoclonal anti-idiotypic antibody specific to the human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor, propagating the selected hybridoma thereby giving rise to said monoclonal anti-idiotypic antibody, and collecting the produced monoclonal anti-idiotypic antibody; and use of the monoclonal anti-idiotypic antibody as a reagent and as an adsorbent.
摘要翻译：对具有烟碱型乙酰胆碱受体特异性的人IgG1型单克隆抗体特异性的单克隆抗独特型抗体; 通过以下步骤制备上述单克隆抗独特型抗体的方法：用对烟草乙酰胆碱受体特异性的人IgG1型单克隆抗体免疫动物，从动物收集抗体产生细胞，将收集的细胞与肿瘤细胞融合，从融合产物中选择能够产生对烟碱乙酰胆碱受体具有特异性的人IgG1型单克隆抗体特异性的单克隆抗独特型抗体的杂交瘤，繁殖所选择的杂交瘤，从而产生所述单克隆抗独特型抗体，并收集产生单克隆抗独特型抗体; 并使用单克隆抗独特型抗体作为试剂和吸附剂。

3. 发明授权

US4472303A Blood purification method 失效
标题翻译：血液净化方法
公开(公告)号：US4472303A
公开(公告)日：1984-09-18
申请号：US524931
申请日：1983-08-22
申请人： Masao Tanihara , Toshihide Nakashima , Koichi Takakura
发明人： Masao Tanihara , Toshihide Nakashima , Koichi Takakura
IPC分类号： A61K35/14 , A61M1/36 , B01D15/08 , B01J20/32 , B01D39/06 , C07G7/00
CPC分类号： A61M1/3679 , B01D15/08 , B01J20/28004 , B01J20/28019 , B01J20/28069 , B01J20/28078 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3204 , B01J20/327 , B01J2220/58 , Y10S530/829
摘要： Treatment of the blood by means of a blood purification device comprising packed, substantially spherical, smooth-surfaced, porous granules having at least 0.1 .mu.mole/m.sup.2 of the silanol group on the surface thereof, a blood inlet and a blood outlet scarcely causes decrease in leukocyte or platelet count or blood cell damage and can remove proteins from the blood by adsorption without high pressure loss.
摘要翻译：通过血液净化装置处理血液，该装置包括在其表面上具有至少0.1微摩尔/ m 2硅烷醇基团的填充的，基本上为球形的，光滑的多孔颗粒，血液入口和血液出口几乎不会减少在白细胞或血小板计数或血细胞损伤中，并且可以通过吸附而无需高压力损失从血液中去除蛋白质。

4. 发明授权

US4889917A Peptide 失效
标题翻译：肽
公开(公告)号：US4889917A
公开(公告)日：1989-12-26
申请号：US265550
申请日：1988-11-01
申请人： Masao Tanihara , Kiichiro Oka , Hideaki Yamada , Akira Kobayashi , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
发明人： Masao Tanihara , Kiichiro Oka , Hideaki Yamada , Akira Kobayashi , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
IPC分类号： A61K38/00 , A61M1/36 , A61P43/00 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/705 , G01N33/564 , G01N33/566
CPC分类号： C07K14/705 , A61M1/3679 , Y02P20/55
摘要： A peptide is disclosed which is represented by the formula:H-X-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Leu-Asp-Y -Zwherein one of X and Y stands for a single bond, an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR1## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above, the other of X and Y stands for an amino acid residue selected from the class consisting of Asp, Glu, Lys and a divalent group represented by the formula, ##STR2## (wherein n stands for an integer in the range of 1 to 17), or a peptide residue formed by peptide linkage of two to ten amino acid residues of at least one species selected from the class mentioned above and Z stands for a hydroxyl group or an amino group, and two cysteinyl mercapto groups in the Cys-Cys moiety may be interlinked to each other to form a disulfide bond.
摘要翻译：公开了由下式表示的肽：HX-Gly-Trp-Lys-His-Trp-Val-Tyr-Tyr-Thr-Cys-Cys-Pro-Asp-Thr-Pro-Tyr-Le-Asp- Y -Z其中X和Y中的一个代表单键，选自Asp，Glu，Lys和由下式表示的二价基团的氨基酸残基：其中n表示 1至17的范围）或通过选自上述类别的至少一种的2至10个氨基酸残基的肽键形成的肽残基，X和Y中的另一个表示选自以下的氨基酸残基：由Asp，Glu，Lys和由式表示的二价基团，其中n表示1〜17的整数，或由2〜10个氨基酸的肽键形成的肽残基选自上述类别中的至少一种的残基和Z表示羟基或氨基，并且Cys-Cys moie中的两个半胱氨酰巯基 ty可以彼此互连以形成二硫键。

5. 发明授权

US5192684A Human IgG.sub.1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody 失效
标题翻译：特异于烟碱乙酰胆碱受体的人IgG1单克隆抗体和产生抗体的杂交瘤
公开(公告)号：US5192684A
公开(公告)日：1993-03-09
申请号：US175304
申请日：1988-03-30
申请人： Masao Tanihara , Hideaki Yamada , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
发明人： Masao Tanihara , Hideaki Yamada , Toshihide Nakashima , Yoshiaki Omura , Koichi Takakura
IPC分类号： A61B10/00 , A61K39/395 , A61P21/00 , C07K16/28 , C12N5/10 , C12N5/24 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/566 , G01N33/577
CPC分类号： C07K16/286
摘要： A human IgG.sub.1 type monoclonal antibody which possesses a molecular weight in the range of 180,000.+-.20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of sodium dodecyl sulfate and is specific to nicotinic acetylcholine receptor. The human IgG.sub.1 type monoclonal antibody mentioned above is produced by a method which comprises fusing human cells capable of producing an antibody against nicotinic acetylcholine receptor with propagable human cells thereby giving rise to a hybridoma capable of producing the aforementioned human IgG.sub.1 type monoclonal antibody, selecting the hybridoma from the production of the fusion, culturing the hybridoma thereby giving rise to the aforementioned human IgG.sub.1 type monoclonal antibody, and selecting the antibody from the cultured medium. The hybridoma mentioned above is also identified.
摘要翻译：通过在十二烷基硫酸钠存在下进行的聚丙烯酰胺凝胶电泳测定，其具有180,000 +/- 20,000范围内的分子量的人IgG1型单克隆抗体，并且对烟碱乙酰胆碱受体是特异性的。上述人IgG1型单克隆抗体是通过将能够产生抗烟碱型乙酰胆碱受体抗体的人细胞与可扩增人细胞融合从而产生能产生上述人IgG1型单克隆抗体的杂交瘤的方法制备的，从产生融合物中获得杂交瘤，培养杂交瘤，从而产生上述人IgG1型单克隆抗体，并从培养基中选择抗体。也鉴定了上述杂交瘤。

6. 发明授权

US4352884A Carrier having acrylate copolymer coating for immobilization of bioactive materials 失效
标题翻译：具有用于固定生物活性材料的丙烯酸酯共聚物涂层的载体
公开(公告)号：US4352884A
公开(公告)日：1982-10-05
申请号：US232394
申请日：1981-02-09
申请人： Toshihide Nakashima , Masao Tanihara , Koichi Takakura
发明人： Toshihide Nakashima , Masao Tanihara , Koichi Takakura
IPC分类号： B01J20/26 , A61K9/18 , A61K39/385 , A61K39/44 , A61K47/32 , B01D15/08 , B01J20/32 , C07K14/76 , C07K16/00 , C07K17/08 , C07K19/00 , C12M1/40 , C12N11/00 , C12N11/02 , C12N11/08 , C12Q1/00 , G01N33/543 , G01N33/50 , G01N27/30 , G01N31/08 , G01N33/54
CPC分类号： B01J20/3276 , B01J20/286 , B01J20/3202 , B01J20/3274 , B01J20/328 , B01J20/3282 , C12N11/08 , C12Q1/002 , G01N33/543 , G01N33/5438 , B01D15/3804 , B01J2220/54 , Y10S435/962
摘要： Carriers coated with a copolymer of a hydrophilic acrylate or methacrylate monomer and a copolymerizable unsaturated carboxylic acid or unsaturated amine are provided which are substantially free from nonspecific adsorption of proteins and the like. Due to the side-chain carboxyl or amino groups of the copolymer, these coated carriers are able to immobilize bio-active materials such as antigens, antibodies, complements and enzymes. These carriers, on which bio-active materials can be immobilized, are useful as clinical selective adsorbents, affinity-chromatographic adsorbents, selective electrodes or columns for analysis.
摘要翻译：提供涂覆有亲水性丙烯酸酯或甲基丙烯酸酯单体和可共聚的不饱和羧酸或不饱和胺的共聚物的载体，其基本上不含蛋白质等的非特异性吸附。由于共聚物的侧链羧基或氨基，这些包被的载体能够固定生物活性物质如抗原，抗体，补体和酶。这些可以固定生物活性物质的载体可用作临床选择性吸附剂，亲和色谱吸附剂，选择性电极或用于分析的色谱柱。

7. 发明授权

US4420395A Blood purification device 失效
标题翻译：血液净化装置
公开(公告)号：US4420395A
公开(公告)日：1983-12-13
申请号：US395975
申请日：1982-07-07
申请人： Masao Tanihara , Toshihide Nakashima , Koichi Takakura
发明人： Masao Tanihara , Toshihide Nakashima , Koichi Takakura
IPC分类号： A61K35/14 , A61M1/36 , B01D15/08 , B01J20/32 , B01D39/06
CPC分类号： A61M1/3679 , B01D15/08 , B01J20/28004 , B01J20/28019 , B01J20/28069 , B01J20/28078 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3204 , B01J20/327 , B01J2220/58 , Y10S530/829
摘要： Treatment of the blood by means of a blood purification device comprising packed, substantially spherical, smooth-surfaced, porous granules having at least 0.1 .mu.mole/m.sup.2 of the silanol group on the surface thereof, a blood inlet and a blood outlet scarcely causes decrease in leukocyte or platelet count or blood cell damage and can remove proteins from the blood by adsorption without high pressure loss.
摘要翻译：通过血液净化装置处理血液，该装置包括在其表面上具有至少0.1微摩尔/ m 2硅烷醇基团的填充的，基本上为球形的，光滑的多孔颗粒，血液入口和血液出口几乎不会减少在白细胞或血小板计数或血细胞损伤中，并且可以通过吸附而无需高压力损失从血液中去除蛋白质。

8. 发明授权

US07132506B2 Peptide having osteogenetic activity and osteogenetic accelerator containing the same 有权
标题翻译：具有成骨活性的肽和含有其的成骨加速剂
公开(公告)号：US07132506B2
公开(公告)日：2006-11-07
申请号：US10233284
申请日：2002-08-30
申请人： Yoshihiko Nishimura , Yoshihisa Suzuki , Masao Tanihara
发明人： Yoshihiko Nishimura , Yoshihisa Suzuki , Masao Tanihara
IPC分类号： A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K7/04
CPC分类号： C07K14/51 , A61K38/00
摘要： A peptide has at least an amino acid sequence represented by SEQ ID NO:1 and it has an osteogenetic activity.
摘要翻译：肽至少具有SEQ ID NO：1所示的氨基酸序列，并具有成骨活性。

9. 发明授权

US5980883A Polymer gel for medical use 失效
标题翻译：用于医疗用途的聚合物凝胶
公开(公告)号：US5980883A
公开(公告)日：1999-11-09
申请号：US932096
申请日：1997-09-17
申请人： Masao Tanihara , Yoshimi Kakimaru
发明人： Masao Tanihara , Yoshimi Kakimaru
IPC分类号： A61K47/48 , A61K31/765 , A61K31/785
CPC分类号： A61K47/48784 , A61K47/48238
摘要： Provided is a medical material useful for wound dressings or a drug delivery system, which material is safe and has high healing effects, more specifically, which is free from cytotoxicity or other side effects caused by a drug and permits the selective healing of the diseased site in a small dosage without damaging the sites other than the diseased site.The medical material so provided is a polymer gel having a sequence represented by the formula: A-Sp1-E-Sp2-G wherein A represents a water-swelling polymer gel, Sp1 represents the first spacer, E represents a cleavable group with the main chain to be cleaved via an enzymatic reaction, Sp2 represents the second spacer and G represents a drug. When the polymer gel is used, the cleavable group (E) is cleaved according to an amount of an enzyme existing at the diseased site to release the drug in accordance with the amount of the enzyme.
摘要翻译：提供了一种用于伤口敷料或药物递送系统的医疗材料，该材料是安全的并且具有高愈合效果，更具体地说，其不受药物引起的细胞毒性或其它副作用，并允许病变部位的选择性愈合在不损害除病变部位之外的部位的小剂量。如此提供的医疗材料是具有由下式表示的序列的聚合物凝胶：A-Sp1-E-Sp2-G其中A表示水溶胀性聚合物凝胶，Sp1表示第一间隔物，E表示主要的可裂解基团链通过酶反应裂解，Sp2表示第二间隔物，G表示药物。当使用聚合物凝胶时，可切割基团（E）根据存在于患病部位的酶的量根据酶的量来释放药物而被切割。

10. 发明授权

US5770229A Medical polymer gel 失效
标题翻译：医用聚合物凝胶
公开(公告)号：US5770229A
公开(公告)日：1998-06-23
申请号：US826097
申请日：1997-03-24
申请人： Masao Tanihara , Hisao Kinoshita
发明人： Masao Tanihara , Hisao Kinoshita
IPC分类号： A61K47/48 , A61L15/44 , A61L15/60 , A61L26/00 , A61L27/54 , A61L31/14 , A61L31/16 , A61K9/10
CPC分类号： A61L31/145 , A61K47/48784 , A61L15/44 , A61L15/60 , A61L26/0066 , A61L26/008 , A61L27/54 , A61L31/16 , A61L2300/00 , A61L2300/602 , Y10S514/944
摘要： A medical polymer gel produced by immobilizing a drug onto a water swelling polymer gel through a cleavable group with the main chain to be cleaved via an enzymatic reaction and a spacer, and a water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a diaminoalkane derivative as the crosslinking reagent. Because the medical polymer gel exerts a drug releasing property depending on the level of an enzyme, the gel can release a therapeutically effective dose of a drug only at a focal lesion generating the enzyme. The medical polymer gel is useful as the structural component of wound dressings, adhesives for biological tissues, adhesion preventing agents, bone reinforcing agents, and drug releasing base materials. Wound dressings comprising the structural material of the water swelling polymer gel of the present invention, can be applied to a patient with wound, burn, and decubitus to promote the healing of the wounds of the patient.
摘要翻译：一种医用聚合物凝胶，其通过可裂解的基团将药物固定在水溶胀性聚合物凝胶上，通过酶反应和间隔物将待裂解的主链和通过共价交联具有羧基的多糖而产生的水溶性聚合物凝胶在分子内具有二氨基烷烃衍生物作为交联剂。由于医用聚合物凝胶根据酶的水平发挥药物释放性质，所以凝胶只能在产生酶的局灶性病变处释放治疗有效剂量的药物。医用聚合物凝胶可用作伤口敷料的结构组分，用于生物组织的粘合剂，防粘连剂，骨增强剂和药物释放基材。包含本发明的水溶性聚合物凝胶的结构材料的伤口敷料可以应用于患有伤口，烧伤和褥疮的患者，以促进患者的伤口的愈合。

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