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1. 发明授权

US5979669A Blood filter unit 失效
标题翻译：血液过滤器单元
公开(公告)号：US5979669A
公开(公告)日：1999-11-09
申请号：US784481
申请日：1997-01-17
申请人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
发明人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
IPC分类号： G01N33/48 , B01D39/20 , B01D61/18 , B01D61/20 , B01D69/12 , G01N1/10 , G01N1/28 , G01N33/49 , B01D29/05 , B01D29/56 , B01D29/92
CPC分类号： B01D39/2017 , B01D61/18 , B01D61/20 , B01D69/12 , G01N33/491
摘要： A blood filter unit having a blood filter holder containing a blood filtering material of a glass fiber filter and a microporous membrane is described. The holder has a blood inlet and a filtrate outlet, and accommodates the blood filtering material so that the microporous membrane is located on the filtrate outlet side and has a space between the blood filtering material and the filtrate outlet. The holder provides means for preventing adhesion of the blood filtering material on the filtrate outlet side. The inventive blood filter unit allows separation of a desired volume of plasma or serum for analysis without interference by the hematocrit value of the blood.
摘要翻译：描述了具有含有玻璃纤维过滤器的血液过滤材料和微孔膜的血液过滤器保持器的血液过滤器单元。保持器具有血液入口和滤液出口，并且容纳血液过滤材料，使得微孔膜位于滤液出口侧，并且在血液过滤材料和滤液出口之间具有空间。保持器提供用于防止血液过滤材料在滤液出口侧粘附的装置。本发明的血液过滤器单元允许分离所需体积的血浆或血清用于分析，而不受血液的血细胞比容值的干扰。

2. 发明授权

US06225130B1 Method of separating serum from whole blood 失效
标题翻译：从全血中分离血清的方法
公开(公告)号：US06225130B1
公开(公告)日：2001-05-01
申请号：US09252310
申请日：1999-02-18
申请人： Masao Kitajima , Akemi Higo , Shigeru Tezuka
发明人： Masao Kitajima , Akemi Higo , Shigeru Tezuka
IPC分类号： G01N118
CPC分类号： G01N33/491 , B01L3/502 , Y10T436/106664 , Y10T436/119163 , Y10T436/25 , Y10T436/25375
摘要： A method for separating serum from whole blood in a vessel at an insertion speed of 30 cm/sec or less and maintaining the suction pressure of the suction nozzle at 400 mm Hg or less. Improved analytical results are obtained because the serum can be produced without hemolysis.
摘要翻译：以30cm /秒以下的插入速度将容器中的血液从血液中分离出来并将吸嘴的吸入压力维持在400mmHg以下的方法。获得改进的分析结果，因为血清可以在没有溶血的情况下产生。

3. 发明授权

US06170671B2 Blood filter unit 失效
标题翻译：血液过滤器单元
公开(公告)号：US06170671B2
公开(公告)日：2001-01-09
申请号：US09290650
申请日：1999-04-12
申请人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
发明人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
IPC分类号： B01D2900
CPC分类号： B01D39/2017 , B01D61/18 , B01D61/20 , B01D69/12 , G01N33/491
摘要： The blood filter unit of the invention is composed of a blood filtering material made of glass fiber filter and microporous membrane and a holder having a blood inlet and a filtrate outlet. The holder accommodates the blood filtering material so that the microporous membrane is located on the filtrate outlet side, provides a space between the blood filtering material and the filtrate outlet, and provides a means for preventing adhesion of the blood filtering material on the filtrate outlet side. By using the blood filter unit, a necessary volume of plasma or serum for analysis can be separated surely, irrespective of hematocrit value of the blood.
摘要翻译：本发明的血液过滤器单元由玻璃纤维过滤器和微孔膜制成的血液过滤材料和具有血液入口和滤液出口的保持器构成。保持器容纳血液过滤材料，使得微孔膜位于滤液出口侧，提供血液过滤材料和滤液出口之间的空间，并提供防止血液过滤材料在滤液出口侧粘附的手段。通过使用血液过滤器单元，可以确定地分离所需体积的血浆或血清，而不管血液的血细胞比容值如何。

4. 发明授权

US5996811A Plasma collecting device 失效
标题翻译：等离子体采集装置
公开(公告)号：US5996811A
公开(公告)日：1999-12-07
申请号：US994420
申请日：1997-12-19
申请人： Masao Kitajima , Akemi Higo
发明人： Masao Kitajima , Akemi Higo
IPC分类号： G01N33/48 , A61B5/15 , B01D61/18 , G01N1/28 , G01N33/49 , B01D24/26
CPC分类号： G01N1/4077 , B01D61/18 , G01N33/491
摘要： This invention relates to a plasma-collecting device which comprises a blood filtering material comprising glass fiber filter and microporous membrane, a holder having a blood inlet and a plasma outlet accommodating the blood filtering material, a blood-collecting needle being connected to the blood inlet, and a plasma receiver being provided on the plasma outlet side. The plasma-collecting device can collect a necessary amount of plasma for analysis from blood vessel directly, easily and surely.
摘要翻译：本发明涉及一种血浆收集装置，其包括由玻璃纤维过滤器和微孔膜构成的血液过滤材料，具有血液入口的保持器和容纳血液过滤材料的血浆出口，采血针连接到血液入口并且等离子体接收器设置在等离子体出口侧。等离子体收集装置可以直接，容易且可靠地从血管收集必要量的血浆用于分析。

5. 发明授权

US5569287A Means for collecting and spotting small amount of blood 失效
标题翻译：用于收集和发现少量血液的方法
公开(公告)号：US5569287A
公开(公告)日：1996-10-29
申请号：US353108
申请日：1994-12-09
申请人： Shigeru Tezuka , Hikaru Tsuruta , Teruaki Koizumi , Masao Kitajima
发明人： Shigeru Tezuka , Hikaru Tsuruta , Teruaki Koizumi , Masao Kitajima
IPC分类号： G01N33/48 , A61B5/15 , A61B5/151 , B01L3/02 , A61B17/14
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150099 , A61B5/150435 , A61B5/150664 , A61B5/15111 , A61B5/15117
摘要： A means for collecting and spotting a small amount of blood which comprises a cylinder, a piston, and a puncturing tip, wherein: the piston is inserted airtightly into one end of the cylinder; the puncturing tip is airtightly and exchangeably fitted onto another end of the cylinder; the puncturing tip comprises a blood conduit and a needle suspended by a spring within the blood conduit; the blood conduit has a volume which is equal to a volume of blood to be spotted to analytical means; and the needle is arranged to be pushed out from the puncturing tip by descent of the piston and then return back by ascent of the piston.
摘要翻译：一种用于收集和检测少量血液的装置，包括一个气缸，活塞和一个穿刺尖端，其中：活塞被气密地插入气缸的一端; 穿刺尖端气密地并且可交换地安装在气缸的另一端上; 穿刺尖端包括血液导管和由血液导管内的弹簧悬挂的针头; 血液导管的体积等于要分析的血液量; 并且针被布置成通过活塞下降从穿刺尖端推出，然后通过活塞的上升返回。

6. 发明授权

US06217540B1 Blood filter cartridge 失效
标题翻译：血液滤芯
公开(公告)号：US06217540B1
公开(公告)日：2001-04-17
申请号：US09349173
申请日：1999-07-09
申请人： Kenichiro Yazawa , Keiichi Ishizaki , Takeshi Igarashi , Masao Kitajima , Shigeru Tezuka , Takaki Arai , Toshihisa Ito , Osamu Seshimoto
发明人： Kenichiro Yazawa , Keiichi Ishizaki , Takeshi Igarashi , Masao Kitajima , Shigeru Tezuka , Takaki Arai , Toshihisa Ito , Osamu Seshimoto
IPC分类号： A61M3700
CPC分类号： G01N33/491
摘要： The invention provides a blood filter cartridge which is made so that the filtrate discharged from the filtrate outlet is not drawn back to the inside of the filtering chamber. The blood filter cartridge includes a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver which receives the filtrate discharged from the filtrate outlet. The blood filter catridge is provided with a means for preventing the filtrate in the filtrate receiver from returning to inside of the holder upon finishing filtration. Such means include the following: removing opposite faces around the filtrate outlet, making length of lower end of the filtrate outlet 0.8 mm or more, smoothing surface around the filtrate outlet, and forming surface around the filtrate outlet by a material having a small surface energy.
摘要翻译：本发明提供了一种血液过滤器滤芯，其被制成使得从滤液出口排出的滤液不会被抽回到过滤室的内部。血液过滤器滤芯包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器和接收从滤液出口排出的滤液的滤液接收器。血液过滤器夹具设置有用于防止滤液接收器中的滤液在完成过滤时返回到保持器内部的装置。这样的方法包括以下步骤：除去滤液出口周围的相对面，使滤液出口的下端长度为0.8mm以上，使滤液出口周围的表面光滑，并且通过具有小表面能的材料在滤液出口周围形成表面。

7. 发明授权

US5122969A Biochemical analysis apparatus, method for correcting the results of biochemical analyses, and correction value recording medium for the same 失效
标题翻译：生物化学分析装置，校正生物化学分析结果的方法和校正值记录介质
公开(公告)号：US5122969A
公开(公告)日：1992-06-16
申请号：US480466
申请日：1990-02-15
申请人： Osamu Seshimoto , Masao Kitajima
发明人： Osamu Seshimoto , Masao Kitajima
IPC分类号： G01N21/78 , G01N1/00 , G01N27/26 , G01N35/00 , G01N35/04
CPC分类号： G01N35/00029 , G01N35/00594 , G01N35/00693 , G01N35/00732 , G01N2035/00039 , G01N2035/00356 , G01N2035/00702 , G01N2035/00752
摘要： A biochemical analysis apparatus comprises a movement device which moves analysis media containing a reagent or an electrochemical sensor, which will interact with a specific biochemical substance contained in liquid samples and give rise to changes in the analysis media, along a movement path connecting an introducing section and an ejecting section. While the analysis media are present in the movement path, a measurement device measures changes which have occurred in analysis media. A reading device reads information about correction values, which are to be used in order to correct a calibration curve so that it becomes suitable for analysis media used in analyses, from a correction value recording medium. A correction device corrects the calibration curve on the basis of the correction values. An operation device uses the corrected calibration curve in order to determine the concentration or the activity of the specific biochemical substance in a liquid sample from the value measured by the measurement device.

8. 发明授权

US4981805A Method of using chemical analysis slide 失效
标题翻译：使用化学分析幻灯片的方法
公开(公告)号：US4981805A
公开(公告)日：1991-01-01
申请号：US682478
申请日：1984-12-17
申请人： Kenichiro Yazawa , Masao Kitajima , Asaji Kondo
发明人： Kenichiro Yazawa , Masao Kitajima , Asaji Kondo
IPC分类号： G01N1/28 , B01L3/00 , G01N21/78 , G01N21/86 , G01N33/48 , G01N33/52 , G02B21/34
CPC分类号： B01L3/508 , G01N21/8483 , G01N33/525 , G02B21/34 , B01L2200/142 , B01L2300/041 , B01L2300/048 , B01L2300/069 , B01L2300/0822 , B01L2400/0406
摘要： A method of using a chemical analysis slide comprising a slide frame and a sheet-like or film-like chemical analysis element for colorimetric determination of a specific component in an aqueous liquid sample, which comprisesapplying an aqueous liquid sample to the chemical analysis element, andcovering the upper face of the side of the slide frame to which the sample is applied with a sheet-like, plate-like or block or brick-like cover to thereby ensure a space between the chemical analysis element and the cover and to prevent evaporation of water or to control evaporation rate of water.
摘要翻译：一种使用包括滑动框架和片状或膜状化学分析元件的化学分析载玻片的方法，用于比色测定水性液体样品中的特定组分，其包括将水性液体样品施加到化学分析元件，并且将覆盖样品的滑动框架的侧面的上表面覆盖有片状，板状或块状或砖状的盖，从而确保化学分析元件与盖之间的空间，并防止蒸发水或控制水的蒸发速率。

9. 发明授权

US4870005A Multilayer analysis element 失效
标题翻译：多层分析单元
公开(公告)号：US4870005A
公开(公告)日：1989-09-26
申请号：US787713
申请日：1985-10-16
申请人： Yutaka Akiyoshi , Asaji Kondo , Masao Kitajima
发明人： Yutaka Akiyoshi , Asaji Kondo , Masao Kitajima
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , Y10S435/805 , Y10S435/97 , Y10S436/81
摘要： A dry type multilayer analysis element comprises at least one porous medium layer comprising a membrane filter, to which an antigen (or antibody) is immobilized, and at least one reagent layer through which a substance(s) which did not participate in an antigen-antibody reaction can permeate.The multilayer analysis element is effective for assaying components present in body fluids, blood, urine, etc., in a simple manner.
摘要翻译：干式多层分析元件包括至少一个多孔介质层，该多孔介质层包括固定有抗原（或抗体）的膜过滤器，以及至少一个试剂层，通过该试剂层不参与抗原 - 抗体反应可以渗透。该多层分析元件以简单的方式有效地测定体液，血液，尿液等中存在的成分。

10. 发明授权

US4437970A Device for determining ionic activity 失效
标题翻译：用于测定离子活性的装置
公开(公告)号：US4437970A
公开(公告)日：1984-03-20
申请号：US500600
申请日：1983-06-02
申请人： Masao Kitajima , Osamu Seshimoto , Kikuo Kubotera , Akira Yamaguchi
发明人： Masao Kitajima , Osamu Seshimoto , Kikuo Kubotera , Akira Yamaguchi
IPC分类号： G01N27/28 , G01N27/46 , G01N27/58
CPC分类号： G01N27/307 , G01N27/3335
摘要： A device for determining ionic activity composed of, as essential components, plural pairs of ion-selective solid electrodes each pair having two electrodes (one electrode on each of two sides) and each pair having a different ion-selective layer; two liquid distribution porous members, each member disposed over all the electrodes of each said side of the plural pairs; and a porous capillary bridge disposed on or between the liquid distribution porous members. The bridge can be in liquid contact with all the electrodes through the liquid distribution porous members and achieve electrical conduction between two electrodes in each pair after spotting a test solution and a reference solution. The device preferably further comprises a support frame and a cover having two apertures for liquid spotting. The device can simultaneously determine ionic activities of a plurality of different ions in a test solution, such as whole blood, plasma, serum, urine, etc., by spotting a test solution and a reference solution each in one operation and measuring an electrical potential difference of each pair.
摘要翻译：用于确定离子活性的装置，作为必要组分，每对具有两对电极（两侧各一个电极）和每对具有不同离子选择层的多对离子选择性固体电极，两个液体分配多孔构件，每个构件设置在多对的每个所述侧的所有电极上; 以及布置在液体分配多孔构件之间或之间的多孔毛细管桥。桥接器可以通过液体分配多孔构件与所有电极液体接触，并且在点样测试溶液和参考溶液之后实现每对中两个电极之间的导电。该装置优选地还包括支撑框架和具有用于液体点样的两个孔的盖。该装置可以通过在一个操作中分别检测测试溶液和参考溶液来测量测试溶液中的多种不同离子的离子活性，例如全血，血浆，血清，尿等，并测量电位每对差异。

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