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1. 发明申请

US20060016699A1 Apparatus and method for measuring biological material 失效
公开(公告)号：US20060016699A1
公开(公告)日：2006-01-26
申请号：US11072507
申请日：2005-03-07
申请人： Masao Kamahori , Yoshiaki Yazawa , Maki Shimoda
发明人： Masao Kamahori , Yoshiaki Yazawa , Maki Shimoda
IPC分类号： G01N27/26 , G01N33/487
CPC分类号： G01N33/5438 , G01N27/4145
摘要： Disclosed is a biomolecular detection device that can be used easily, at a low operating cost, and with a detection probe that can be immobilized easily. Using an insulated gate field effect transistor having a conductive electrode on the gate insulator between a source and a drain, a probe for detecting biomolecules is immobilized on the surface of the conductive electrode. For analysis, a conductive electrode on which a probe for detecting biomolecules is immobilized on the surface, and a reference electrode are placed in the sample solution in the analytical cell, an alternating current voltage is applied from a power source to the reference electrode and the electrical characteristics of the insulated gate field effect transistor that changes before and after binding of the measurement target substance such as DNA and proteins included in the sample solution with a probe for detecting biomolecules, namely the changes in the current values running between the source and the drain, are detected.

2. 发明授权

US08383396B2 Apparatus and method for measuring biological material 失效
标题翻译：用于测量生物材料的装置和方法
公开(公告)号：US08383396B2
公开(公告)日：2013-02-26
申请号：US11072507
申请日：2005-03-07
申请人： Masao Kamahori , Yoshiaki Yazawa , Maki Shimoda
发明人： Masao Kamahori , Yoshiaki Yazawa , Maki Shimoda
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/5438 , G01N27/4145
摘要： Disclosed is a biomolecular detection device that can be used easily, at a low operating cost, and with a detection probe that can be immobilized easily. Using an insulated gate field effect transistor having a conductive electrode on the gate insulator between a source and a drain, a probe for detecting biomolecules is immobilized on the surface of the conductive electrode. For analysis, a conductive electrode on which a probe for detecting biomolecules is immobilized on the surface, and a reference electrode are placed in the sample solution in the analytical cell, an alternating current voltage is applied from a power source to the reference electrode and the electrical characteristics of the insulated gate field effect transistor that changes before and after binding of the measurement target substance such as DNA and proteins included in the sample solution with a probe for detecting biomolecules, namely the changes in the current values running between the source and the drain, are detected.
摘要翻译：公开了一种生物分子检测装置，可以以低的操作成本容易地使用，并且可以容易地固定检测探针。使用在源极和漏极之间的栅绝缘体上具有导电电极的绝缘栅场效应晶体管，用于检测生物分子的探针固定在导电电极的表面上。为了分析，将用于检测生物分子的探针固定在表面上的导电电极，将参考电极置于分析单元中的样品溶液中，从电源向参考电极施加交流电压，绝缘栅场效应晶体管的电气特性在样品溶液中包含的测量目标物质如DNA和蛋白质与用于检测生物分子的探针结合之前和之后发生变化，即在源和漏水，被检测到。

3. 发明授权

US07888708B2 Examination apparatus for biological sample and chemical sample 有权
标题翻译：生物样品和化学样品检测仪器
公开(公告)号：US07888708B2
公开(公告)日：2011-02-15
申请号：US11976831
申请日：2007-10-29
申请人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
发明人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
IPC分类号： H01L29/66
CPC分类号： G01N27/414 , G01N27/4148 , H01L27/1203 , H01L51/0098
摘要： A wireless sensor chip suitable for the compact, high-sensitive, and low-cost examination apparatus for easily examining a biological material such as gene at low cost is provided. A sensor chip is formed on an SOI substrate, and an n type semiconductor layer on which a pMOS transistor is formed and a p type semiconductor layer on which an nMOS transistor is formed are isolated by a pn junction. Therefore, the p type semiconductor layer at the outermost portion (chip edge portion to be in contact with solution) is set to floating, and the maximum potential and the minimum potential of the chip are supplied to an n type semiconductor layer and a p type semiconductor layer inside the outermost portion, respectively. Also, the chip is covered with an ion impermeable insulating film for reducing the penetration of positive ions through the oxide layer.
摘要翻译：提供了适用于以低成本容易地检测诸如基因等生物材料的紧凑，高灵敏度，低成本的检查装置的无线传感器芯片。传感器芯片形成在SOI衬底上，并且其上形成有pMOS晶体管的n型半导体层和其上形成nMOS晶体管的p型半导体层被pn结隔离。因此，最外侧部分（与溶液接触的芯片边缘部分）的p型半导体层被设置为浮置，并且芯片的最大电位和最小电位被提供给n型半导体层和p型半导体分别在最外部分内。此外，芯片被不透水的绝缘膜覆盖，用于减少正离子穿过氧化物层的穿透。

4. 发明授权

US07163822B2 Apparatus and method for luminometric assay 有权
标题翻译：用于光度测定的装置和方法
公开(公告)号：US07163822B2
公开(公告)日：2007-01-16
申请号：US10338899
申请日：2003-01-09
申请人： Yoshiaki Yazawa , Hideki Kambara , Masao Kamahori , Kunio Harada , Kazunori Okano
发明人： Yoshiaki Yazawa , Hideki Kambara , Masao Kamahori , Kunio Harada , Kazunori Okano
IPC分类号： C12M1/34
CPC分类号： C12Q1/6825 , C12Q1/6827 , Y10S435/808 , C12Q2565/607 , C12Q2565/501 , C12Q2565/301
摘要： A small sized, cost-effective genetic testing apparatus that provides high sensitivity testing, for performing genetic testing simply and at low cost. An optical sensor array for the apparatus and method for luminometric assay comprises a means that simultaneously selects 2 pixels and detects minute amounts of chemiluminescence by obtaining the differential output of the respective signals.
摘要翻译：一种小尺寸，具有成本效益的遗传检测仪器，提供高灵敏度测试，简单且低成本地进行遗传测试。用于发光测定的装置和方法的光学传感器阵列包括同时选择2个像素并通过获得各个信号的差分输出来检测微量化学发光的装置。

5. 发明申请

US20060141474A1 Biomolecule detecting element and method for analyzing nucleic acid using the same 审中-公开
标题翻译：生物分子检测元件及使用其分析核酸的方法
公开(公告)号：US20060141474A1
公开(公告)日：2006-06-29
申请号：US10563475
申请日：2004-08-27
申请人： Yuji Miyahara , Toshiya Sakata , Masao Kamahori , Yoshiaki Yazawa
发明人： Yuji Miyahara , Toshiya Sakata , Masao Kamahori , Yoshiaki Yazawa
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6837 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , G01N27/4145 , C12Q2565/607 , C12Q2563/173
摘要： An inexpensive DNA chip/DNA microarray system capable of highly accurate measurement with low running cost. A DNA probe 8 is immobilized on a floating electrode 7 connected to a gate electrode 5 of a field effect transistor. Hybridization with a target gene is carried out on the surface of the floating electrode, when a change in surface charge density is detected using a field effect.
摘要翻译：一种廉价的DNA芯片/ DNA微阵列系统，能够以低运行成本进行高精度测量。 DNA探针8被固定在连接到场效应晶体管的栅电极5的浮置电极7上。当使用场效应检测表面电荷密度的变化时，在浮动电极的表面上进行与靶基因的杂交。

6. 发明申请

US20080061323A1 Examination apparatus for biological sample and chemical sample 有权
标题翻译：生物样品和化学样品检测仪器
公开(公告)号：US20080061323A1
公开(公告)日：2008-03-13
申请号：US11976831
申请日：2007-10-29
申请人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
发明人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
IPC分类号： H01L23/58
CPC分类号： G01N27/414 , G01N27/4148 , H01L27/1203 , H01L51/0098
摘要： A wireless sensor chip suitable for the compact, high-sensitive, and low-cost examination apparatus for easily examining a biological material such as gene at low cost is provided. A sensor chip is formed on an SOI substrate, and an n type semiconductor layer on which a PMOS transistor is formed and a p type semiconductor layer on which an nMOS transistor is formed are isolated by a pn junction. Therefore, the p type semiconductor layer at the outermost portion (chip edge portion to be in contact with solution) is set to floating, and the maximum potential and the minimum potential of the chip are supplied to an n type semiconductor layer and a p type semiconductor layer inside the outermost portion, respectively. Also, the chip is covered with an ion impermeable insulating film for reducing the penetration of positive ions through the oxide layer.
摘要翻译：提供了适用于以低成本容易地检测诸如基因等生物材料的紧凑，高灵敏度，低成本的检查装置的无线传感器芯片。传感器芯片形成在SOI衬底上，并且其上形成PMOS晶体管的n型半导体层和其上形成nMOS晶体管的p型半导体层被pn结隔离。因此，最外侧部分（与溶液接触的芯片边缘部分）的p型半导体层被设置为浮置，并且芯片的最大电位和最小电位被提供给n型半导体层和p型半导体分别在最外部分内。此外，芯片被不透水的绝缘膜覆盖，用于减少正离子穿过氧化物层的穿透。

7. 发明授权

US07157050B2 System and method for detecting biological and chemical material 有权
标题翻译：检测生物和化学物质的系统和方法
公开(公告)号：US07157050B2
公开(公告)日：2007-01-02
申请号：US10445038
申请日：2003-05-27
申请人： Yoshiaki Yazawa , Masao Kamahori , Hideki Kambara , Mitsuo Usami , Ken Takei
发明人： Yoshiaki Yazawa , Masao Kamahori , Hideki Kambara , Mitsuo Usami , Ken Takei
IPC分类号： G01N15/06
CPC分类号： G01N33/54386 , G01N27/4145
摘要： A system and method are provided for detecting biological and chemical material. To measure biological materials such as genes easily at low costs, the device for implementing a small-sized, high sensitive, economical measurement apparatus is provided. Probes appropriate for target biological materials are fixed on a chip, on which a sensor, identification number, and radio communication function are implemented, the captured targets are detected by the sensors, and the result of sensing are transferred to an external control unit by the radio communication function. The small-sized, high sensitivity measurement apparatus for detecting biological and chemical materials such as genes and measuring physical and chemical amounts such as temperature, pressure, pH, and the like can be implemented.
摘要翻译：提供了用于检测生物和化学材料的系统和方法。为了容易地以低成本测量基因等生物体材料，提供了实现小型，高灵敏度，经济的测量装置的装置。适用于目标生物材料的探针固定在其上实现传感器，识别号和无线电通信功能的芯片上，由传感器检测捕获的目标，并且通过传感器将感测结果传送到外部控制单元无线电通信功能。可以实现用于检测诸如基因的生物和化学材料以及测量物理和化学量如温度，压力，pH等的小尺寸，高灵敏度的测量装置。

8. 发明申请

US20050156207A1 Examination apparatus for biological sample and chemical sample 审中-公开
标题翻译：生物样品和化学样品检测仪器
公开(公告)号：US20050156207A1
公开(公告)日：2005-07-21
申请号：US10933339
申请日：2004-09-03
申请人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
发明人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
IPC分类号： G01N27/414 , H01L21/768 , H01L21/822 , H01L21/8238 , H01L23/522 , H01L27/04 , H01L27/08 , H01L27/092 , H01L27/12 , H01L29/786 , H01L29/76
CPC分类号： G01N27/414 , G01N27/4148 , H01L27/1203 , H01L51/0098
摘要： A wireless sensor chip suitable for the compact, high-sensitive, and low-cost examination apparatus for easily examining a biological material such as gene at low cost is provided. A sensor chip is formed on an SOI substrate, and an n type semiconductor layer on which a pMOS transistor is formed and a p type semiconductor layer on which an nMOS transistor is formed are isolated by a pn junction. Therefore, the p type semiconductor layer at the outermost portion (chip edge portion to be in contact with solution) is set to floating, and the maximum potential and the minimum potential of the chip are supplied to an n type semiconductor layer and a p type semiconductor layer inside the outermost portion, respectively. Also, the chip is covered with an ion impermeable insulating film for reducing the penetration of positive ions through the oxide layer.
摘要翻译：提供了适用于以低成本容易地检测诸如基因等生物材料的紧凑，高灵敏度，低成本的检查装置的无线传感器芯片。传感器芯片形成在SOI衬底上，并且其上形成有pMOS晶体管的n型半导体层和其上形成nMOS晶体管的p型半导体层被pn结隔离。因此，最外侧部分（与溶液接触的芯片边缘部分）的p型半导体层被设置为浮置，并且芯片的最大电位和最小电位被提供给n型半导体层和p型半导体分别在最外部分内。此外，芯片被不透水的绝缘膜覆盖，用于减少正离子穿过氧化物层的穿透。

9. 发明授权

US07355270B2 Semiconductor chip with coil antenna and communication system 有权
标题翻译：半导体芯片采用线圈天线和通讯系统
公开(公告)号：US07355270B2
公开(公告)日：2008-04-08
申请号：US11030058
申请日：2005-01-07
申请人： Takehiko Hasebe , Yasushi Goto , Kouichi Uesaka , Yoshiaki Yazawa , Makoto Torigoe
发明人： Takehiko Hasebe , Yasushi Goto , Kouichi Uesaka , Yoshiaki Yazawa , Makoto Torigoe
IPC分类号： H01L23/02
CPC分类号： H01Q1/2225 , G06K7/10178 , G06K19/07749 , G06K19/07756 , G06K19/07775 , G06K19/07779 , G06K19/07783 , G06K19/07784 , H01L23/48 , H01L23/5227 , H01L2223/6677 , H01L2224/04105 , H01L2924/0002 , H01L2924/3011 , H01Q1/22 , H01Q7/00 , H01L2924/00
摘要： The present invention intends to prevent the communication distance from becoming shorter with a reduction in size of a coil antenna to the chip size and with a consequent decrease of an induced voltage. According to the present invention there is provided a semiconductor chip having a coil antenna and a circuit surface and adapted to transmit and receive signals by radio to and from an external device. The semiconductor chip has a configuration for increasing an electromagnetic coupling coefficient between the coil antenna and the external device. According to a concrete example thereof, a magnetic material is disposed, the coil antenna is formed by a stacked structure comprising plural conductor layers and insulating layers superimposed one on another, or the coil antenna is disposed outside an external form of a circuit of the semiconductor chip.
摘要翻译：本发明旨在通过将线圈天线的尺寸减小到芯片尺寸以及由此导致的感应电压降低来防止通信距离变短。根据本发明，提供一种具有线圈天线和电路表面的半导体芯片，其适于通过无线电向外部设备发送和接收信号。半导体芯片具有用于增加线圈天线和外部设备之间的电磁耦合系数的配置。根据其具体实例，设置磁性材料，线圈天线由包括多个导体层和彼此重叠的绝缘层的堆叠结构形成，或者线圈天线设置在半导体的电路的外部形式的外部芯片。

10. 发明申请

US20070176772A1 RFID tag, RFID reader/writer, RFID system, and processing method of RFID system 有权
标题翻译： RFID标签，RFID读写器，RFID系统和RFID系统的处理方法
公开(公告)号：US20070176772A1
公开(公告)日：2007-08-02
申请号：US11491990
申请日：2006-07-25
申请人： Ryo Nemoto , Hiroshi Yoshigi , Yoshiaki Yazawa , Kazuki Watanabe
发明人： Ryo Nemoto , Hiroshi Yoshigi , Yoshiaki Yazawa , Kazuki Watanabe
IPC分类号： G08B1/08 , H04Q5/22 , G08B13/14
CPC分类号： G06K19/0717 , G06K7/0008 , G06K19/0701 , G06K19/0723
摘要： In an RFID system including RFID tags each incorporating a sensor, accuracy of measurement by the sensor can be improved. For example, when measurements are performed several times by using RFID tags each incorporating a sensor unit, generation of a carrier directed from an RFID reader/writer to the RFID tags is stopped for a predetermined period every time when a measurement ends. By this means, the chip temperature of the RFID tag increased due to power consumption in each measurement can be reduced to, for example, ambient temperature every time when a measurement ends. Therefore, an error in measurement by the sensor unit can be reduced, thereby achieving accurate measurement.
摘要翻译：在包括RFID传感器的RFID标签中，传感器的测量精度可以提高。例如，当通过使用包含传感器单元的RFID标签进行多次测量时，每当测量结束时，停止从RFID读取器/写入器引导到RFID标签的载体的预定时间的生成。通过这种方式，每次测量结束时，每个测量中的功率消耗增加的RFID标签的芯片温度可以降低到例如环境温度。因此，可以降低传感器单元的测量误差，从而实现精确的测量。

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