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1. 发明申请

US20060016699A1 Apparatus and method for measuring biological material 失效
公开(公告)号：US20060016699A1
公开(公告)日：2006-01-26
申请号：US11072507
申请日：2005-03-07
申请人： Masao Kamahori , Yoshiaki Yazawa , Maki Shimoda
发明人： Masao Kamahori , Yoshiaki Yazawa , Maki Shimoda
IPC分类号： G01N27/26 , G01N33/487
CPC分类号： G01N33/5438 , G01N27/4145
摘要： Disclosed is a biomolecular detection device that can be used easily, at a low operating cost, and with a detection probe that can be immobilized easily. Using an insulated gate field effect transistor having a conductive electrode on the gate insulator between a source and a drain, a probe for detecting biomolecules is immobilized on the surface of the conductive electrode. For analysis, a conductive electrode on which a probe for detecting biomolecules is immobilized on the surface, and a reference electrode are placed in the sample solution in the analytical cell, an alternating current voltage is applied from a power source to the reference electrode and the electrical characteristics of the insulated gate field effect transistor that changes before and after binding of the measurement target substance such as DNA and proteins included in the sample solution with a probe for detecting biomolecules, namely the changes in the current values running between the source and the drain, are detected.

2. 发明授权

US08383396B2 Apparatus and method for measuring biological material 失效
标题翻译：用于测量生物材料的装置和方法
公开(公告)号：US08383396B2
公开(公告)日：2013-02-26
申请号：US11072507
申请日：2005-03-07
申请人： Masao Kamahori , Yoshiaki Yazawa , Maki Shimoda
发明人： Masao Kamahori , Yoshiaki Yazawa , Maki Shimoda
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/5438 , G01N27/4145
摘要： Disclosed is a biomolecular detection device that can be used easily, at a low operating cost, and with a detection probe that can be immobilized easily. Using an insulated gate field effect transistor having a conductive electrode on the gate insulator between a source and a drain, a probe for detecting biomolecules is immobilized on the surface of the conductive electrode. For analysis, a conductive electrode on which a probe for detecting biomolecules is immobilized on the surface, and a reference electrode are placed in the sample solution in the analytical cell, an alternating current voltage is applied from a power source to the reference electrode and the electrical characteristics of the insulated gate field effect transistor that changes before and after binding of the measurement target substance such as DNA and proteins included in the sample solution with a probe for detecting biomolecules, namely the changes in the current values running between the source and the drain, are detected.
摘要翻译：公开了一种生物分子检测装置，可以以低的操作成本容易地使用，并且可以容易地固定检测探针。使用在源极和漏极之间的栅绝缘体上具有导电电极的绝缘栅场效应晶体管，用于检测生物分子的探针固定在导电电极的表面上。为了分析，将用于检测生物分子的探针固定在表面上的导电电极，将参考电极置于分析单元中的样品溶液中，从电源向参考电极施加交流电压，绝缘栅场效应晶体管的电气特性在样品溶液中包含的测量目标物质如DNA和蛋白质与用于检测生物分子的探针结合之前和之后发生变化，即在源和漏水，被检测到。

3. 发明申请

US20060223170A1 Biomolecule detecting apparatus and biomolecule detecting method employing the same 审中-公开
标题翻译：生物分子检测装置及采用该方法的生物分子检测方法
公开(公告)号：US20060223170A1
公开(公告)日：2006-10-05
申请号：US11329086
申请日：2006-01-11
申请人： Masao Kamahori , Yu Ishige , Maki Shimoda
发明人： Masao Kamahori , Yu Ishige , Maki Shimoda
IPC分类号： C12M1/34
CPC分类号： G01N27/4145
摘要： A biomolecule detecting element capable of easily immobilizing a detecting probe and being used in a simple manner without requiring a dark box and the like. A biomolecule detecting probe is immobilized on the surface of a conductive electrode of an insulated gate field effect transistor, the conductive electrode being formed on the surface of a gate insulating material between a source and a drain. Portions other than the conductive electrode are covered with a light-shielding member so as to eliminate the influence of light. During measurement, the conductive electrode having a biomolecule detecting probe immobilized on the surface thereof and a reference electrode are disposed in a buffer solution in a measurement cell. A rectangular wave is applied to the reference electrode from a power supply, and a response waveform that changes before and after the binding of a measurement target, such as DNA or protein contained in the buffer solution, to the biomolecule detecting probe, namely, a change in the value of current that flows between the source and the drain, is detected.
摘要翻译：一种生物分子检测元件，其能够容易地固定检测探针，并且以简单的方式使用而不需要暗盒等。生物分子检测探针被固定在绝缘栅场效应晶体管的导电电极的表面上，导电电极形成在源极和漏极之间的栅极绝缘材料的表面上。除了导电电极以外的部分被遮光部件覆盖，以消除光的影响。在测量期间，将具有固定在其表面上的生物分子检测探针和参考电极的导电电极设置在测量单元中的缓冲溶液中。从电源向参考电极施加矩形波，并且将测量对象（例如缓冲溶液中包含的DNA或蛋白质）结合到生物分子检测探针之前和之后变化的响应波形，即，检测到在源极和漏极之间流动的电流值的变化。

4. 发明授权

US07888708B2 Examination apparatus for biological sample and chemical sample 有权
标题翻译：生物样品和化学样品检测仪器
公开(公告)号：US07888708B2
公开(公告)日：2011-02-15
申请号：US11976831
申请日：2007-10-29
申请人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
发明人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
IPC分类号： H01L29/66
CPC分类号： G01N27/414 , G01N27/4148 , H01L27/1203 , H01L51/0098
摘要： A wireless sensor chip suitable for the compact, high-sensitive, and low-cost examination apparatus for easily examining a biological material such as gene at low cost is provided. A sensor chip is formed on an SOI substrate, and an n type semiconductor layer on which a pMOS transistor is formed and a p type semiconductor layer on which an nMOS transistor is formed are isolated by a pn junction. Therefore, the p type semiconductor layer at the outermost portion (chip edge portion to be in contact with solution) is set to floating, and the maximum potential and the minimum potential of the chip are supplied to an n type semiconductor layer and a p type semiconductor layer inside the outermost portion, respectively. Also, the chip is covered with an ion impermeable insulating film for reducing the penetration of positive ions through the oxide layer.
摘要翻译：提供了适用于以低成本容易地检测诸如基因等生物材料的紧凑，高灵敏度，低成本的检查装置的无线传感器芯片。传感器芯片形成在SOI衬底上，并且其上形成有pMOS晶体管的n型半导体层和其上形成nMOS晶体管的p型半导体层被pn结隔离。因此，最外侧部分（与溶液接触的芯片边缘部分）的p型半导体层被设置为浮置，并且芯片的最大电位和最小电位被提供给n型半导体层和p型半导体分别在最外部分内。此外，芯片被不透水的绝缘膜覆盖，用于减少正离子穿过氧化物层的穿透。

5. 发明授权

US07163822B2 Apparatus and method for luminometric assay 有权
标题翻译：用于光度测定的装置和方法
公开(公告)号：US07163822B2
公开(公告)日：2007-01-16
申请号：US10338899
申请日：2003-01-09
申请人： Yoshiaki Yazawa , Hideki Kambara , Masao Kamahori , Kunio Harada , Kazunori Okano
发明人： Yoshiaki Yazawa , Hideki Kambara , Masao Kamahori , Kunio Harada , Kazunori Okano
IPC分类号： C12M1/34
CPC分类号： C12Q1/6825 , C12Q1/6827 , Y10S435/808 , C12Q2565/607 , C12Q2565/501 , C12Q2565/301
摘要： A small sized, cost-effective genetic testing apparatus that provides high sensitivity testing, for performing genetic testing simply and at low cost. An optical sensor array for the apparatus and method for luminometric assay comprises a means that simultaneously selects 2 pixels and detects minute amounts of chemiluminescence by obtaining the differential output of the respective signals.
摘要翻译：一种小尺寸，具有成本效益的遗传检测仪器，提供高灵敏度测试，简单且低成本地进行遗传测试。用于发光测定的装置和方法的光学传感器阵列包括同时选择2个像素并通过获得各个信号的差分输出来检测微量化学发光的装置。

6. 发明申请

US20060141474A1 Biomolecule detecting element and method for analyzing nucleic acid using the same 审中-公开
标题翻译：生物分子检测元件及使用其分析核酸的方法
公开(公告)号：US20060141474A1
公开(公告)日：2006-06-29
申请号：US10563475
申请日：2004-08-27
申请人： Yuji Miyahara , Toshiya Sakata , Masao Kamahori , Yoshiaki Yazawa
发明人： Yuji Miyahara , Toshiya Sakata , Masao Kamahori , Yoshiaki Yazawa
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6837 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , G01N27/4145 , C12Q2565/607 , C12Q2563/173
摘要： An inexpensive DNA chip/DNA microarray system capable of highly accurate measurement with low running cost. A DNA probe 8 is immobilized on a floating electrode 7 connected to a gate electrode 5 of a field effect transistor. Hybridization with a target gene is carried out on the surface of the floating electrode, when a change in surface charge density is detected using a field effect.
摘要翻译：一种廉价的DNA芯片/ DNA微阵列系统，能够以低运行成本进行高精度测量。 DNA探针8被固定在连接到场效应晶体管的栅电极5的浮置电极7上。当使用场效应检测表面电荷密度的变化时，在浮动电极的表面上进行与靶基因的杂交。

7. 发明申请

US20080061323A1 Examination apparatus for biological sample and chemical sample 有权
标题翻译：生物样品和化学样品检测仪器
公开(公告)号：US20080061323A1
公开(公告)日：2008-03-13
申请号：US11976831
申请日：2007-10-29
申请人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
发明人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
IPC分类号： H01L23/58
CPC分类号： G01N27/414 , G01N27/4148 , H01L27/1203 , H01L51/0098
摘要： A wireless sensor chip suitable for the compact, high-sensitive, and low-cost examination apparatus for easily examining a biological material such as gene at low cost is provided. A sensor chip is formed on an SOI substrate, and an n type semiconductor layer on which a PMOS transistor is formed and a p type semiconductor layer on which an nMOS transistor is formed are isolated by a pn junction. Therefore, the p type semiconductor layer at the outermost portion (chip edge portion to be in contact with solution) is set to floating, and the maximum potential and the minimum potential of the chip are supplied to an n type semiconductor layer and a p type semiconductor layer inside the outermost portion, respectively. Also, the chip is covered with an ion impermeable insulating film for reducing the penetration of positive ions through the oxide layer.
摘要翻译：提供了适用于以低成本容易地检测诸如基因等生物材料的紧凑，高灵敏度，低成本的检查装置的无线传感器芯片。传感器芯片形成在SOI衬底上，并且其上形成PMOS晶体管的n型半导体层和其上形成nMOS晶体管的p型半导体层被pn结隔离。因此，最外侧部分（与溶液接触的芯片边缘部分）的p型半导体层被设置为浮置，并且芯片的最大电位和最小电位被提供给n型半导体层和p型半导体分别在最外部分内。此外，芯片被不透水的绝缘膜覆盖，用于减少正离子穿过氧化物层的穿透。

8. 发明授权

US07157050B2 System and method for detecting biological and chemical material 有权
标题翻译：检测生物和化学物质的系统和方法
公开(公告)号：US07157050B2
公开(公告)日：2007-01-02
申请号：US10445038
申请日：2003-05-27
申请人： Yoshiaki Yazawa , Masao Kamahori , Hideki Kambara , Mitsuo Usami , Ken Takei
发明人： Yoshiaki Yazawa , Masao Kamahori , Hideki Kambara , Mitsuo Usami , Ken Takei
IPC分类号： G01N15/06
CPC分类号： G01N33/54386 , G01N27/4145
摘要： A system and method are provided for detecting biological and chemical material. To measure biological materials such as genes easily at low costs, the device for implementing a small-sized, high sensitive, economical measurement apparatus is provided. Probes appropriate for target biological materials are fixed on a chip, on which a sensor, identification number, and radio communication function are implemented, the captured targets are detected by the sensors, and the result of sensing are transferred to an external control unit by the radio communication function. The small-sized, high sensitivity measurement apparatus for detecting biological and chemical materials such as genes and measuring physical and chemical amounts such as temperature, pressure, pH, and the like can be implemented.
摘要翻译：提供了用于检测生物和化学材料的系统和方法。为了容易地以低成本测量基因等生物体材料，提供了实现小型，高灵敏度，经济的测量装置的装置。适用于目标生物材料的探针固定在其上实现传感器，识别号和无线电通信功能的芯片上，由传感器检测捕获的目标，并且通过传感器将感测结果传送到外部控制单元无线电通信功能。可以实现用于检测诸如基因的生物和化学材料以及测量物理和化学量如温度，压力，pH等的小尺寸，高灵敏度的测量装置。

9. 发明申请

US20050156207A1 Examination apparatus for biological sample and chemical sample 审中-公开
标题翻译：生物样品和化学样品检测仪器
公开(公告)号：US20050156207A1
公开(公告)日：2005-07-21
申请号：US10933339
申请日：2004-09-03
申请人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
发明人： Yoshiaki Yazawa , Kazuki Watanabe , Masao Kamahori , Yukinori Kunimoto
IPC分类号： G01N27/414 , H01L21/768 , H01L21/822 , H01L21/8238 , H01L23/522 , H01L27/04 , H01L27/08 , H01L27/092 , H01L27/12 , H01L29/786 , H01L29/76
CPC分类号： G01N27/414 , G01N27/4148 , H01L27/1203 , H01L51/0098
摘要： A wireless sensor chip suitable for the compact, high-sensitive, and low-cost examination apparatus for easily examining a biological material such as gene at low cost is provided. A sensor chip is formed on an SOI substrate, and an n type semiconductor layer on which a pMOS transistor is formed and a p type semiconductor layer on which an nMOS transistor is formed are isolated by a pn junction. Therefore, the p type semiconductor layer at the outermost portion (chip edge portion to be in contact with solution) is set to floating, and the maximum potential and the minimum potential of the chip are supplied to an n type semiconductor layer and a p type semiconductor layer inside the outermost portion, respectively. Also, the chip is covered with an ion impermeable insulating film for reducing the penetration of positive ions through the oxide layer.
摘要翻译：提供了适用于以低成本容易地检测诸如基因等生物材料的紧凑，高灵敏度，低成本的检查装置的无线传感器芯片。传感器芯片形成在SOI衬底上，并且其上形成有pMOS晶体管的n型半导体层和其上形成nMOS晶体管的p型半导体层被pn结隔离。因此，最外侧部分（与溶液接触的芯片边缘部分）的p型半导体层被设置为浮置，并且芯片的最大电位和最小电位被提供给n型半导体层和p型半导体分别在最外部分内。此外，芯片被不透水的绝缘膜覆盖，用于减少正离子穿过氧化物层的穿透。

10. 发明申请

US20130029872A1 ARRAY FOR DETECTING BIOLOGICAL SUBSTANCE, ASSAY SYSTEM AND ASSAY METHOD 审中-公开
标题翻译：用于检测生物物质，测定系统和测定方法的阵列
公开(公告)号：US20130029872A1
公开(公告)日：2013-01-31
申请号：US13639350
申请日：2011-04-04
申请人： Yu Ishige , Masao Kamahori , Yusuke Goto
发明人： Yu Ishige , Masao Kamahori , Yusuke Goto
IPC分类号： C40B40/10 , C40B30/04
CPC分类号： G01N33/569 , G01N27/3275 , G01N33/5438
摘要： Provided are a device, whereby cells, a bacterium or a virus can be quantified in a single unit, an assay system and an assay method. A subject to be assayed such as cells, a bacterium or a virus, which are present on a sensor, can be quantified by using a sensor equipped with multiple electrodes, said electrodes being similar in size to the subject to be assayed, detecting, concerning each electrode, the presence or absence of the subject in the vicinity of the electrode, and adding up the electrodes in which the subject is detected.
摘要翻译：提供了一种装置，其中细胞，细菌或病毒可以在单个单位中量化，测定系统和测定方法。可以通过使用配备有多个电极的传感器来量化存在于传感器上的诸如细胞，细菌或病毒的受试者，所述电极的尺寸与要测定的受试者相似，检测有关每个电极，在电极附近存在或不存在受试者，并且将检测到被检体的电极相加。

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