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1. 发明申请

US20120029187A1 HALOALKYLSULFONANILIDE DERIVATIVE 审中-公开
公开(公告)号：US20120029187A1
公开(公告)日：2012-02-02
申请号：US13258320
申请日：2010-04-14
申请人： Masanori Kai , Takamasa Furuhashi , Yoshihide Masuzawa , Tetsuhiko Yano , Fumiyo Saito , Yoshihiko Nakaya
发明人： Masanori Kai , Takamasa Furuhashi , Yoshihide Masuzawa , Tetsuhiko Yano , Fumiyo Saito , Yoshihiko Nakaya
IPC分类号： C07D267/04 , C07D273/01 , C07D273/04 , C07D265/22 , C07D265/10 , C07D265/30 , C07D267/10 , C07D279/12 , C07D265/12
CPC分类号： C07D265/08 , A01N43/72 , A01N43/84 , A01N43/86 , A01N43/88 , A01N47/04 , A01N47/24 , C07D265/10 , C07D265/32 , C07D267/04 , C07D267/10 , C07D273/01 , C07D273/04 , C07D279/06 , C07D279/12
摘要： Novel herbicides are provided.A haloalkylsulfonanilide derivative represented by the formula (1) or an agrochemically acceptable salt thereof: the formula (1): wherein Z is —C(R9)(R10)— or —N(R11)—, A is an oxygen atom, a sulfur atom or —N(R12)—, W is an oxygen atom or a sulfur atom, m is an integer of from 0 to 3, n is an integer of from 0 to 3, m+n is from 1 to 3, R1 is halo C1-C6 alkyl, R2 is a hydrogen atom, C1-C6 alkyl or the like, each of R3 and R4 is independently a hydrogen atom, C1-C6 alkyl or the like, each of R5, R6, R7, R8, R9 and R10 is independently a hydrogen atom, a halogen, C1-C6 alkyl or the like, each of R11 and R12 is a hydrogen atom, C1-C6 alkyl, halo C1-C6 alkyl or the like, and X is independently a hydrogen atom, a halogen, C1-C6 alkyl, or the like.
摘要翻译：提供了新型除草剂。式（1）表示的卤代烷基磺酰苯胺衍生物或其农业上可接受的盐：式（1）：其中Z为-C（R9）（R10） - 或-N（R11） - ，A为氧原子，硫原子或-N（R 12） - ，W为氧原子或硫原子，m为0〜3的整数，n为0〜3的整数，m + n为1〜3，R 1 是卤代C 1 -C 6烷基，R 2是氢原子，C 1 -C 6烷基等，R 3和R 4各自独立地是氢原子，C 1 -C 6烷基等，R 5，R 6，R 7，R 8， R 9和R 10独立地为氢原子，卤素，C 1 -C 6烷基等，R 11和R 12各自为氢原子，C 1 -C 6烷基，卤代C 1 -C 6烷基等，X独立地为氢原子，卤素，C 1 -C 6烷基等。

2. 发明申请

US20110039721A1 METHOD FOR PREDICTION ABOUT CARCINOGENICITY OF SUBSTANCE IN RODENT 审中-公开
标题翻译：关于物质致癌性的预测方法
公开(公告)号：US20110039721A1
公开(公告)日：2011-02-17
申请号：US12810100
申请日：2008-12-26
申请人： Yoshikuni Yakabe , Hiroshi Matsumoto , Fumiyo Saito , Koichi Saito , Kayo Sumida , Koji Nakayama , Masaru Sekijima
发明人： Yoshikuni Yakabe , Hiroshi Matsumoto , Fumiyo Saito , Koichi Saito , Kayo Sumida , Koji Nakayama , Masaru Sekijima
IPC分类号： C40B30/04
CPC分类号： C12Q1/6876 , C12Q2600/142 , C12Q2600/158
摘要： Disclosed is a method for predicting about the carcinogenicity of a substance of interest in a rodent, which comprises the steps of: administering a solution of the substance to a test group and administering a solvent used in the solution to a control group; extracting mRNA from each of the test group and the control group, and measuring the expression level of mRNA for each of genes obtained by selecting at least one gene from (A) genes each comprising a nucleotide sequence depicted in any one of SEQ ID NOs: 1 to 5, (B) genes each comprising a nucleotide sequence depicted in any one of SEQ ID NOs: 6 to 8 and (C) genes each comprising a nucleotide sequence depicted in any one of SEQ ID NOs: 9 to 32; determining whether or not a significant difference in the level of mRNA expressed from the gene is observed between the test group and the control group; and determining that the substance has carcinogenicity when a significant difference in the level of the expression of mRNA from any one of the genes is observed between the test group and the control group and the direction of increase or decrease in the level of the expression of mRNA from any one of the genes is the same as the tendency which is previously defined for each gene.
摘要翻译：公开了一种用于预测啮齿动物感兴趣的物质的致癌性的方法，其包括以下步骤：将所述物质的溶液施用于测试组并将所述溶液中使用的溶剂施用于对照组; 从每个测试组和对照组中提取mRNA，并通过选择至少一个来自（A）基因的基因测量每个基因的mRNA的表达水平，每个基因各自包含SEQ ID NO： 1〜5，（B）各自包含SEQ ID NO：6至8中任一项所示的核苷酸序列的基因和（C）各自包含SEQ ID NO：9至32中任一个所示的核苷酸序列的基因; 确定在测试组和对照组之间是否观察到从基因表达的mRNA水平的显着差异; 并且当在测试组和对照组之间观察到来自任何一个基因的mRNA的表达水平的显着差异以及mRNA表达水平的增加或降低的方向时，确定该物质具有致癌性来自任何一个基因与先前为每个基因定义的趋势相同。

3. 发明申请

US20130338367A1 PYRAZOLE DERIVATIVES AND PESTICIDES 审中-公开
标题翻译：吡唑衍生物和杀虫剂
公开(公告)号：US20130338367A1
公开(公告)日：2013-12-19
申请号：US13984796
申请日：2012-02-09
申请人： Akira Numata , Daisuke Tanima , Masanori Ando , Fumiyo Saito , Yuji Iwawaki
发明人： Akira Numata , Daisuke Tanima , Masanori Ando , Fumiyo Saito , Yuji Iwawaki
IPC分类号： C07D401/04 , A01N43/56 , C07D401/14
CPC分类号： C07D401/04 , A01N43/56 , A01N47/18 , A01N47/36 , A01N47/44 , C07D401/14 , C07F7/0812
摘要： Novel pesticide, especially insecticides or miticides are provided.Pyrazole derivative and pesticides represented by the formula (1): wherein A1 is —N(O)m2 or —CR1, each of R1, R3, R4 is a hydrogen atom, a halogen atom, C1-C6 alkyl or the like, Ra is a hydrogen atom, C1-C6 alkyl or the like, Rb is —C(O)R7, —C(O)N(R8a)R8 or the like, each of R7, R8, R8a is a hydrogen atom, C1-C6 alkyl or the like, and m1 is an integer of 0 or 1.
摘要翻译：提供了新型农药，特别是杀虫剂或杀螨剂。吡唑衍生物和由式（1）表示的农药：其中A1为-N（O）m2或-CR1，R1，R3，R4分别为氢原子，卤素原子，C1-C6烷基等，Ra 是氢原子，C1-C6烷基等，Rb是-C（O）R7，-C（O）N（R8a）R8等，R7，R8，R8a各自为氢原子，C1- C6烷基等，m1为0或1的整数。

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