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    • 1. 发明申请
    • METHOD FOR PREDICTION ABOUT CARCINOGENICITY OF SUBSTANCE IN RODENT
    • 关于物质致癌性的预测方法
    • US20110039721A1
    • 2011-02-17
    • US12810100
    • 2008-12-26
    • Yoshikuni YakabeHiroshi MatsumotoFumiyo SaitoKoichi SaitoKayo SumidaKoji NakayamaMasaru Sekijima
    • Yoshikuni YakabeHiroshi MatsumotoFumiyo SaitoKoichi SaitoKayo SumidaKoji NakayamaMasaru Sekijima
    • C40B30/04
    • C12Q1/6876C12Q2600/142C12Q2600/158
    • Disclosed is a method for predicting about the carcinogenicity of a substance of interest in a rodent, which comprises the steps of: administering a solution of the substance to a test group and administering a solvent used in the solution to a control group; extracting mRNA from each of the test group and the control group, and measuring the expression level of mRNA for each of genes obtained by selecting at least one gene from (A) genes each comprising a nucleotide sequence depicted in any one of SEQ ID NOs: 1 to 5, (B) genes each comprising a nucleotide sequence depicted in any one of SEQ ID NOs: 6 to 8 and (C) genes each comprising a nucleotide sequence depicted in any one of SEQ ID NOs: 9 to 32; determining whether or not a significant difference in the level of mRNA expressed from the gene is observed between the test group and the control group; and determining that the substance has carcinogenicity when a significant difference in the level of the expression of mRNA from any one of the genes is observed between the test group and the control group and the direction of increase or decrease in the level of the expression of mRNA from any one of the genes is the same as the tendency which is previously defined for each gene.
    • 公开了一种用于预测啮齿动物感兴趣的物质的致癌性的方法,其包括以下步骤:将所述物质的溶液施用于测试组并将所述溶液中使用的溶剂施用于对照组; 从每个测试组和对照组中提取mRNA,并通过选择至少一个来自(A)基因的基因测量每个基因的mRNA的表达水平,每个基因各自包含SEQ ID NO: 1〜5,(B)各自包含SEQ ID NO:6至8中任一项所示的核苷酸序列的基因和(C)各自包含SEQ ID NO:9至32中任一个所示的核苷酸序列的基因; 确定在测试组和对照组之间是否观察到从基因表达的mRNA水平的显着差异; 并且当在测试组和对照组之间观察到来自任何一个基因的mRNA的表达水平的显着差异以及mRNA表达水平的增加或降低的方向时,确定该物质具有致癌性 来自任何一个基因与先前为每个基因定义的趋势相同。
    • 10. 发明授权
    • Semiconductor device, light emitting apparatus and electronic device
    • 半导体装置,发光装置和电子装置
    • US08410482B2
    • 2013-04-02
    • US13075411
    • 2011-03-30
    • Kunihiro MatsudaHiroshi MatsumotoYukikazu Tanaka
    • Kunihiro MatsudaHiroshi MatsumotoYukikazu Tanaka
    • H01L29/04H01L29/76H01L21/02H01L31/062G11C21/00
    • H01L27/3262G09G3/3233G09G2300/0842H01L27/124
    • Disclosed in a semiconductor device including a substrate, a first transistor, a second transistor, and a first source electrode and a first drain electrode of the first transistor are arranged along a first direction and a second source electrode and a second drain electrode of the second transistor are arranged in a reverse order of the first source electrode and the first drain electrode along the first direction, the first source electrode and the second source electrode are connected by a source connecting wiring, the first drain electrode and the second drain electrode are connected by a drain connecting wiring, a first gate electrode and a second gate electrode are connected by a gate connecting wiring and the source connecting wiring and the drain connecting wiring are provided at positions except a region overlapped with the first gate electrode, the second gate electrode and the gate connecting wiring.
    • 公开在包括第一晶体管的衬底,第一晶体管,第二晶体管以及第一晶体管的第一源极和第一漏电极的半导体器件中,沿着第一方向布置第二源电极和第二漏电极, 晶体管沿着第一方向以与第一源电极和第一漏电极相反的顺序排列,第一源电极和第二源电极通过源极连接布线连接,第一漏电极和第二漏极连接 通过漏极连接布线,第一栅电极和第二栅极通过栅极连接布线连接,源极连接布线和漏极连接布线设置在除了与第一栅电极,第二栅电极 和门连接接线。