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    • 5. 发明授权
    • Method for synthesis of ciguatoxin CTX1B and compounds useful for the synthesis of ciguatoxin CTX1B
    • 雪卡毒素CTX1B的合成方法和雪卡毒素CTX1B的合成
    • US07939679B2
    • 2011-05-10
    • US12161047
    • 2007-01-10
    • Masahiro HiramaMasayuki Inoue
    • Masahiro HiramaMasayuki Inoue
    • C07D313/00
    • C07D519/00C07D493/22C07F7/1804
    • Disclosed is a method for total synthesis of CTX1B, which is developed for the synthesis of a ciguatoxin analogue such as CTX3C and enables the more efficient application of an established reaction to the total synthesis of CTC1B. More specifically, disclosed is a method for total synthesis of CTX1B comprising; an O.S-acetal formation for synthesizing a novel compound (3); a radical cyclization reaction for constructing a 9-membered ring formation reaction including a novel compound (6) through a novel compound (8) and yielding a compound (D); and a deprotection for yielding CTX1B. Also disclosed are novel compounds (1) to (8) which are particularly useful for synthesis of CTX1B and can be used for the synthesis of a ciguatoxin analogue.
    • 公开了一种全合成CTX1B的方法,该方法被开发用于合成诸如CTX3C之类的雪卡毒素类似物,并且使得能够更有效地将已建立的反应应用于CTC1B的总合成。 更具体地,公开了CTX1B的全合成方法,其包括: 用于合成新化合物(3)的O-缩醛形式; 通过新化合物(8)构成包含新化合物(6)的9-元环形成反应并产生化合物(D)的自由基环化反应; 以及产生CTX1B的去保护。 还公开了对CTX1B的合成特别有用的新化合物(1)至(8),可用于合成雪卡毒素类似物。
    • 6. 发明申请
    • METHOD FOR SYNTHESIS OF CIGUATOXIN CTX1B AND COMPOUNDS USEFUL FOR THE SYNTHESIS OF CIGUATOXIN CTX1B
    • 合成CIGUATOXIN CTX1B及合成CIGUATOXIN CTX1B的化合物的方法
    • US20100160651A1
    • 2010-06-24
    • US12161047
    • 2007-01-10
    • Masahiro HiramaMasayuki Inoue
    • Masahiro HiramaMasayuki Inoue
    • C07D313/00
    • C07D519/00C07D493/22C07F7/1804
    • Disclosed is a method for total synthesis of CTX1B, which is developed for the synthesis of a ciguatoxin analogue such as CTX3C and enables the more efficient application of an established reaction to the total synthesis of CTC1B. More specifically, disclosed is a method for total synthesis of CTX1B comprising; an 0.5-acetal formation for synthesizing a novel compound (3); a radical cyclization reaction for constructing a 9-membered ring formation reaction including a novel compound (6) through a novel compound (8) and yielding a compound (D); and a deprotection for yielding CTX1B. Also disclosed are novel compounds (1) to (8) which are particularly useful for synthesis of CTX1B and can be used for the synthesis of a ciguatoxin analogue.
    • 公开了一种全合成CTX1B的方法,该方法被开发用于合成诸如CTX3C之类的雪卡毒素类似物,并且使得能够更有效地将已建立的反应应用于CTC1B的总合成。 更具体地,公开了CTX1B的全合成方法,其包括: 用于合成新化合物(3)的0.5缩醛形成物; 通过新化合物(8)构成包含新化合物(6)的9-元环形成反应并产生化合物(D)的自由基环化反应; 以及产生CTX1B的去保护。 还公开了对CTX1B的合成特别有用的新化合物(1)至(8),可用于合成雪卡毒素类似物。