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    • 9. 发明授权
    • Dispensing device, dispensing method and method of detecting defective discharge of solution containing biological sample
    • 分配装置,分配方法和检测含有生物样品的溶液的不良排放的方法
    • US07396511B2
    • 2008-07-08
    • US10626828
    • 2003-07-25
    • Masahiro FujiiHiroshi KoedaFumio Takagi
    • Masahiro FujiiHiroshi KoedaFumio Takagi
    • B41J29/38B41J2/045B01L3/00
    • G01N35/1074G01N2035/1018G01N2035/1041Y10T436/2575
    • Proposed is dispensing technology capable of reliably spotting a biological sample on a solid phase. A head chip applies a voltage pulse between a diaphragm and separate electrodes based on a drive control signal output from a head driver IC, and discharges a solution containing protein filled in a pressurized chamber as a result of the elastic deformation of the diaphragm. A drive pulse generation circuit generates a drive voltage pulse and supplies this to the head chip in order to discharge a solution containing protein from the head chip. The drive current detection circuit detects a drive current flowing between the diaphragm and separate electrodes. Since the waveform of the detected drive current and the peak current value and so on differ in the case where the discharge status is normal and in the case where it is abnormal, a defective discharge can be discriminated by detecting such change.
    • 提出了能够在固相上可靠地点样生物样品的分配技术。 头片基于从头驱动器IC输出的驱动控制信号在隔膜和分离的电极之间施加电压脉冲,并且由于隔膜的弹性变形而放出包含加压室中的蛋白质的溶液。 驱动脉冲产生电路产生驱动电压脉冲,并将其提供给头部芯片,以便从头部芯片排出含有蛋白质的溶液。 驱动电流检测电路检测在隔膜和分离电极之间流动的驱动电流。 由于在放电状态正常的情况下检测到的驱动电流和峰值电流值等的波形不同,并且在异常的情况下,可以通过检测这种变化来区分不良放电。