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1. 发明授权

US07731990B2 Powdery composition for nasal administration 失效
标题翻译：用于鼻腔给药的粉状组合物
公开(公告)号：US07731990B2
公开(公告)日：2010-06-08
申请号：US10860058
申请日：2004-06-04
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
IPC分类号： A61K9/50 , A61K9/14
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水 - 不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量相对于吸水和凝胶形成的总量为约5-40重量％基材和吸水性和水不溶性基材，和（3）其中药物在吸水性和水不溶性基材中/吸水凝胶形成中的/不均匀分散基材。

2. 发明授权

US06881423B2 Powdery composition for nasal administration 失效
标题翻译：用于鼻腔给药的粉状组合物
公开(公告)号：US06881423B2
公开(公告)日：2005-04-19
申请号：US09125814
申请日：1997-02-26
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
IPC分类号： A61K9/00 , A61K9/50 , A61K9/14
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxyprophyl cellulose or hydroxpropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of water-absorbing and gel-forming base material is about 5-40 wt. % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量为约5-40wt。基于吸水和凝胶形成基材和吸水性和水不溶性基材的总量的％，和（3）其中药物不均匀地分散在吸水性和水不溶性的/ 基材比吸水和凝胶形成基材上/上。

3. 发明授权

US08206748B2 Powdery composition for nasal administration 失效
标题翻译：用于鼻腔给药的粉状组合物
公开(公告)号：US08206748B2
公开(公告)日：2012-06-26
申请号：US12610901
申请日：2009-11-02
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Takao Fujii
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Takao Fujii
IPC分类号： A61K9/14 , A61K9/50
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水 - 不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量相对于吸水和凝胶形成的总量为约5-40重量％基材和吸水性和水不溶性基材，和（3）其中药物在吸水性和水不溶性基材中/吸水凝胶形成中的/不均匀分散基材。

4. 发明授权

US5578324A Peptide proteinaceous drug nasal powder composition 失效
标题翻译：肽蛋白质药物鼻粉组合物
公开(公告)号：US5578324A
公开(公告)日：1996-11-26
申请号：US407000
申请日：1995-03-29
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Yoshiki Suzuki
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Yoshiki Suzuki
IPC分类号： A61K9/00 , A61K9/14 , A61K38/00 , A61K38/04 , A61K38/09 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/25 , A61K38/26 , A61K38/27 , A61K38/28 , A61K47/18 , A61K47/20 , A61K47/24 , B60H1/00 , B60H1/08 , F01P7/14 , G05D23/13 , A61K9/50
CPC分类号： B60H1/00485 , A61K38/09 , A61K38/23 , A61K38/25 , A61K47/183 , A61K9/0043
摘要： A peptide proteinaceous drug nasal powder composition containing (i) an absorption accelerant comprised of a compound, or its salt, having in its molecule a group expressed by the formula (I): ##STR1## wherein, ##STR2## indicates a cyclohexane ring or a benzene ring which may be substituted at least one of its 3-position, 4-position, and 5-position and n is an integer of 1 to 3 and (ii) a therapeutically effective amount of a peptide proteinaceous drug.
摘要翻译： PCT No.PCT / JP94 / 01257 Sec。 371日期1995年3月29日 102（e）1995年3月29日PCT PCT 1994年7月29日PCT公布。第WO95 / 03818号公报日期1995年2月9日一种肽蛋白质药物鼻粉组合物，其含有（i）由分子中具有式（I）表示的基团的化合物或其盐组成的吸收促进剂：环己烷环或苯环，取代其3-位，4-位和5-位中的至少一个，n为1〜3的整数，和（ii）治疗有效量的肽蛋白质药物。

5. 发明授权

US06824080B2 Powdered medicine multi-dose administering device 有权
标题翻译：粉药多剂量给药装置
公开(公告)号：US06824080B2
公开(公告)日：2004-11-30
申请号：US10049279
申请日：2002-02-11
申请人： Hideo Matsugi , Masahiko Dohi , Yasuhide Uejima , Yuji Makino
发明人： Hideo Matsugi , Masahiko Dohi , Yasuhide Uejima , Yuji Makino
IPC分类号： F23D1110
CPC分类号： A61M15/0065 , A61M11/003 , A61M15/0006 , A61M15/0048 , A61M15/005 , A61M15/0066 , A61M2202/062 , A61M2202/064 , A61M2205/075
摘要： A powdered medicine multi-dose administering device in which a hole (5c) is formed in the bottom surface of a medicine storage chamber (5a) capable of storing a powdered medicine of an amount of many times of administering operation, the hole (5c) being located at a position where a pump unit can be communicated with the exterior via a pipe (2g, 2d). At the administering position, the powdered medicine in a medicine container unit (5b) is injected out of the device together with the air through the pipe, while the hole is kept away from being brought into contact with opening means (2f).
摘要翻译：一种粉末药物多剂量给药装置，其中在能够储存多次给药操作的粉末药物的药物储存室（5a）的底表面中形成孔（5c），所述孔（5c）位于泵单元可经由管道（2g，2d）与外部连通的位置。在给药位置，药物容器单元（5b）中的粉末药物通过管子与空气一起从装置中注出，同时保持远离与开口装置（2f）接触的孔。

6. 外观设计

USD447230S1 Container with dispensing means 失效
标题翻译：集装箱配带装置
公开(公告)号：USD447230S1
公开(公告)日：2001-08-28
申请号：US29126490
申请日：2000-07-19
申请人： Hideo Matsugi , Yuji Makino , Masahiko Dohi , Yasuhide Uejima
设计人： Hideo Matsugi , Yuji Makino , Masahiko Dohi , Yasuhide Uejima

7. 发明授权

US06488648B1 Device for feeding a powder in a predetermined amount and method thereof 有权
标题翻译：用于以预定量供给粉末的装置及其方法
公开(公告)号：US06488648B1
公开(公告)日：2002-12-03
申请号：US09646159
申请日：2000-09-14
申请人： Hideo Matsugi , Yuji Makino , Masahiko Dohi , Yasuhide Uejima
发明人： Hideo Matsugi , Yuji Makino , Masahiko Dohi , Yasuhide Uejima
IPC分类号： A61M3100
CPC分类号： A61M15/0065 , A61M11/001 , A61M2202/064 , A61M2205/075
摘要： A powdered medicine multi-dose administering device has a medicine container unit (5b) for containing a unit-dose of medicine under the lower surface of the medicine storage chamber (5a) storing the medicine in a multi-dose amount. A medicine guiding unit (2) moves between a filling position and an administering position while maintaining a contact with the bottom surface. At the filling position, the medicine container unit is opened to the medicine storage chamber and is filled with the medicine. As the medicine container unit moves from the filling position to the administering position, the powdered medicine in the medicine container unit is swept and metered. At the administering position, the medicine in the medicine container unit is injected by the action of the pump unit (3) through a filter (6) and a pipe (2g, 2d, 2c).
摘要翻译：粉末药物多剂量给药装置具有药剂容纳单元（5b），用于在药物储存室（5a）的下表面容纳多剂量的药剂，以多剂量存储药物。药物引导单元（2）在保持与底面的接触的同时在填充位置和给药位置之间移动。在填充位置，药剂容器单元向药剂储存室开口并填充药剂。当药剂容器单元从填充位置移动到给药位置时，将药剂容器单元中的粉末药片扫过并计量。在给药位置，药剂容器单元中的药物通过泵单元（3）的作用通过过滤器（6）和管（2g，2d，2c）注入。

8. 发明授权

US6008206A Sodium alendronate preparation for local administration 失效
标题翻译：阿仑膦酸钠用于局部给药
公开(公告)号：US6008206A
公开(公告)日：1999-12-28
申请号：US86173
申请日：1998-05-28
申请人： Masahiko Dohi , Yuji Makino , Takao Hujii
发明人： Masahiko Dohi , Yuji Makino , Takao Hujii
IPC分类号： A61K31/66
CPC分类号： A61K31/663
摘要： The object of the present invention is to provide a preparation for local administration to permit selective delivery of an effective amount of sodium alendronate to the bone site where bone resorption is accentuated.
摘要翻译：本发明的目的是提供一种用于局部给药的制剂，以允许有选择地将有效量的阿仑膦酸钠递送到骨吸收增强的骨部位。

9. 发明授权

US5958908A Sodium alendronate preparation for local administration 失效
标题翻译：阿仑膦酸钠用于局部给药
公开(公告)号：US5958908A
公开(公告)日：1999-09-28
申请号：US59555
申请日：1998-04-13
申请人： Masahiko Dohi , Yuji Makino , Takao Hujii
发明人： Masahiko Dohi , Yuji Makino , Takao Hujii
IPC分类号： A61K31/66 , A61K9/00 , A61K31/663 , A61P3/00 , A61P19/08 , A61P43/00
CPC分类号： A61K31/663
摘要： The present invention provides a method local administration of an effective amount of sodium alendronate to permit selective delivery to the bone site where bone resorption is accentuated.
摘要翻译：本发明提供了局部施用有效量的阿仑膦酸钠的方法，以允许选择性递送到骨吸收增强的骨部位。

10. 发明授权

US07890830B1 Test signal generating apparatus 有权
标题翻译：测试信号发生装置
公开(公告)号：US07890830B1
公开(公告)日：2011-02-15
申请号：US12281751
申请日：2007-03-06
申请人： Takeshi Wada , Masahiko Dohi
发明人： Takeshi Wada , Masahiko Dohi
IPC分类号： G01R31/28
CPC分类号： G01R31/31813
摘要： The present invention is to provide a test signal generating apparatus which can generate a test signal for testing a device that dynamically change its operational state in response to a signal or the like. The test signal generating apparatus includes: a pattern storage unit 20 having patterns; a pattern selecting unit 23 for selecting a pattern from among the patterns; a test signal generating unit 25 for generating a test signal having a pattern selected by the pattern selecting unit 23, a trigger signal receiving unit 21 for receiving at least one trigger signal, and a pattern map storage unit 22 having a pattern map defining the number of repetitions for each pattern and a pattern corresponding to a test signal to be generated by the test signal generating unit after the test signal generating unit repeats the test signal on the basis of the number of repetitions.
摘要翻译：本发明是提供一种测试信号发生装置，其可以生成用于测试响应于信号等动态地改变其操作状态的装置的测试信号。测试信号产生装置包括：具有图案的图案存储单元20; 模式选择单元23，用于从模式中选择模式; 用于产生具有由模式选择单元23选择的模式的测试信号的测试信号产生单元25，用于接收至少一个触发信号的触发信号接收单元21以及具有定义数字的模式映射的模式图存储单元22 在测试信号生成单元根据重复次数重复测试信号之后，对于每个模式的重复以及与由测试信号生成单元生成的测试信号相对应的模式。

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