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1. 发明授权

US06881423B2 Powdery composition for nasal administration 失效
标题翻译：用于鼻腔给药的粉状组合物
公开(公告)号：US06881423B2
公开(公告)日：2005-04-19
申请号：US09125814
申请日：1997-02-26
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
IPC分类号： A61K9/00 , A61K9/50 , A61K9/14
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxyprophyl cellulose or hydroxpropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of water-absorbing and gel-forming base material is about 5-40 wt. % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量为约5-40wt。基于吸水和凝胶形成基材和吸水性和水不溶性基材的总量的％，和（3）其中药物不均匀地分散在吸水性和水不溶性的/ 基材比吸水和凝胶形成基材上/上。

2. 发明授权

US07731990B2 Powdery composition for nasal administration 失效
标题翻译：用于鼻腔给药的粉状组合物
公开(公告)号：US07731990B2
公开(公告)日：2010-06-08
申请号：US10860058
申请日：2004-06-04
申请人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
发明人： Masahiko Dohi , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
IPC分类号： A61K9/50 , A61K9/14
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水 - 不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量相对于吸水和凝胶形成的总量为约5-40重量％基材和吸水性和水不溶性基材，和（3）其中药物在吸水性和水不溶性基材中/吸水凝胶形成中的/不均匀分散基材。

3. 发明申请

US20100047206A1 POWDERY COMPOSITION FOR NASAL ADMINISTRATION 失效
标题翻译：粉末成分为NASAL管理
公开(公告)号：US20100047206A1
公开(公告)日：2010-02-25
申请号：US12610901
申请日：2009-11-02
申请人： Masahiko DOHI , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
发明人： Masahiko DOHI , Yoshihisa Nishibe , Yuji Makino , Tako Fujii
IPC分类号： A61P9/14 , A61K47/38 , A61K38/00 , A61K45/00 , A61K38/22 , A61K38/28 , A61K38/21
CPC分类号： A61K9/0043
摘要： A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or α-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.
摘要翻译：一种用于鼻腔给药的粉末组合物，其中（1）组合物包含（i）药物，（ii）吸水和凝胶形成基材如羟丙基纤维素或羟丙基甲基纤维素和（iii）吸水和水 - 不溶性基材如结晶纤维素或α-纤维素，（2）其中吸水和凝胶形成基材的量相对于吸水和凝胶形成的总量为约5-40重量％基材和吸水性和水不溶性基材，和（3）其中药物在吸水性和水不溶性基材中/吸水凝胶形成中的/不均匀分散基材。

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