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1. 发明授权

US5690895A Flow cell apparatus 失效
标题翻译：流通池装置
公开(公告)号：US5690895A
公开(公告)日：1997-11-25
申请号：US761143
申请日：1996-12-06
申请人： Masaetsu Matsumoto , Isao Yamazaki , Ryo Miyake , Masaharu Ishii , Ryohei Yabe , Hiroshi Ohki , Hideyuki Horiuchi , Shinichi Sakuraba
发明人： Masaetsu Matsumoto , Isao Yamazaki , Ryo Miyake , Masaharu Ishii , Ryohei Yabe , Hiroshi Ohki , Hideyuki Horiuchi , Shinichi Sakuraba
IPC分类号： G01N15/00 , G01N15/02 , G01N15/06 , G01N15/14 , G01N21/05 , G01N33/49
CPC分类号： G01N21/05 , G01N15/1404 , G01N2021/0346
摘要： A flow cell apparatus, useful in an apparatus for measuring particles suspended in a liquid, comprises a sample liquid, supply device, a sheath liquid supply device, a flow cell which has a flow passage passing through a transparent measuring portion, and a nozzle for causing the sample liquid, from the supply device to flow in the flow passage of the flow cell. The nozzle has at least one discharge port which is disposed in the flow passage in a spaced relation from the inner wall of the flow cell flow passage. The sheath liquid supply device causes the sheath liquid to flow around the nozzle discharge port and surround the sample liquid flow to form a sheath flow. The flow passage of the flow cell and the nozzle are so formed as to ensure a sample liquid flow of a fixed width through the measuring portion. A stable sample flow having a fixed width can be formed in the measuring portion even when the flow is at a high velocity, and particles in the sample liquid can efficiently be photographed with high accuracy.
摘要翻译：一种用于测量悬浮在液体中的颗粒的装置中的流动池装置，包括样品液体，供给装置，皮肤液体供应装置，具有通过透明测量部分的流动通道的流动池，以及用于使来自供给装置的样品液体流入流动池的流路。喷嘴具有至少一个排出口，该排出口以与流动池流动通道的内壁隔开的关系设置在流动通道中。皮肤液体供给装置使皮肤液体在喷嘴排出口周围流动并且围绕样品液体流动形成鞘流。流动池和喷嘴的流动通道形成为确保通过测量部分具有固定宽度的样品液体流动。即使在流速高的情况下，也可以在测量部分形成具有固定宽度的稳定的样品流，并且可以高精度地有效地拍摄样品液体中的颗粒。

2. 发明授权

US5880835A Apparatus for investigating particles in a fluid, and a method of operation thereof 失效
标题翻译：用于调查流体中的颗粒的装置及其操作方法
公开(公告)号：US5880835A
公开(公告)日：1999-03-09
申请号：US703076
申请日：1996-08-26
申请人： Isao Yamazaki , Hiroshi Ohki , Masaetsu Matsumoto , Ryo Miyake , Ryohei Yabe , Hideyuki Horiuchi , Shinichi Sakuraba
发明人： Isao Yamazaki , Hiroshi Ohki , Masaetsu Matsumoto , Ryo Miyake , Ryohei Yabe , Hideyuki Horiuchi , Shinichi Sakuraba
IPC分类号： G01N15/14 , G01N15/02 , G01N15/06 , G01N33/48 , G01N33/49 , G01N33/493
CPC分类号： G01N15/147 , G01N2015/1409 , G01N33/49 , G01N33/493
摘要： In order to investigate particles in a fluid, a flow cell causes the fluid to flow past a sensor which receives light from a continuous light emission system. When the sensor detects a change in light, a particle detector is triggered, which in turn triggers a pulse generator and hence an intermittent light emission system. Light then illuminates the flow cell to allow a CCD camera to photograph the particle. The photographs taken by the CCD camera are analyzed by an image processor. In order to obtain an accurate particle concentration measurement, it is necessary to modify the initial concentration measurement derived from the analysis of particle images by the image processor by a compensation coefficient. This operation is carried out by a concentration compensator. The result may then be displayed. Additional analysis may be carried out by changing the magnification of the CCD camera, or by selecting for analysis only those particles of a selected size or type.
摘要翻译：为了研究流体中的颗粒，流动池使得流体流过从连续发光系统接收光的传感器。当传感器检测到光的变化时，触发粒子检测器，这又触发脉冲发生器，因此触发间歇发光系统。光然后照亮流动池，以允许CCD照相机拍摄颗粒。由CCD照相机拍摄的照片由图像处理器分析。为了获得准确的粒子浓度测量，需要通过图像处理器修正由粒子图像的分析得到的初始浓度测量值的补偿系数。该操作由浓度补偿器进行。然后可以显示结果。可以通过改变CCD照相机的放大倍率或通过选择仅分析选定尺寸或类型的那些颗粒来进行附加分析。

3. 发明授权

US5270212A Cell analysis apparatus 失效
标题翻译：细胞分析仪
公开(公告)号：US5270212A
公开(公告)日：1993-12-14
申请号：US841487
申请日：1992-02-26
申请人： Hideyuki Horiuchi , Shinichi Sakuraba , Toshio Kaneko , Nobuyuki Tatara , Ryohei Yabe , Hiroshi Ohki , Isao Yamazaki , Ryo Miyake
发明人： Hideyuki Horiuchi , Shinichi Sakuraba , Toshio Kaneko , Nobuyuki Tatara , Ryohei Yabe , Hiroshi Ohki , Isao Yamazaki , Ryo Miyake
IPC分类号： G01N1/00 , G01N1/28 , G01N15/00 , G01N15/14 , G01N33/48 , G01N35/00
CPC分类号： G01N35/1095 , G01N1/28 , G01N2015/0069 , G01N2015/0076 , G01N2015/1409 , G01N2021/6439 , Y10T436/111666
摘要： This invention relates to an apparatus for analyzing cells in a biological liquid sample, such as blood, in which apparatus a flow passage in a sample pretreatment system can be shortened with a simple construction. A sample metering chamber, a mixing chamber and a measurement liquid extracting chamber are formed in a rotary sliding member of a pretreatment portion. The rotary sliding member is intermittently rotated so as to shift a sample from one chamber to another to perform a necessary treatment. Fluorescence or scattering light with respect to the sample, mixed with a reagent in the pretreatment portion, is detected by a flow cell.
摘要翻译：本发明涉及用于分析生物液体样品如血液中的细胞的装置，其中可以用简单的结构缩短样品预处理系统中的流动通道。样品计量室，混合室和测量液体提取室形成在预处理部分的旋转滑动构件中。旋转滑动构件间歇地旋转，以将样品从一个室移动到另一个室进行必要的处理。通过流动池检测相对于样品的荧光或散射光与预处理部分中的试剂混合。

4. 发明授权

US5079959A Analyzing system using sheath flow of sample 失效
标题翻译：使用样品的流动分析系统
公开(公告)号：US5079959A
公开(公告)日：1992-01-14
申请号：US404559
申请日：1989-09-08
申请人： Ryo Miyake , Hiroshi Ohki , Isao Yamazaki , Toshio Kaneko , Hideyuki Horiuchi , Shinichi Sakuraba , Kaori Yasuda
发明人： Ryo Miyake , Hiroshi Ohki , Isao Yamazaki , Toshio Kaneko , Hideyuki Horiuchi , Shinichi Sakuraba , Kaori Yasuda
IPC分类号： G01N15/12 , G01N15/14 , G01N35/10
CPC分类号： G01N35/1083 , G01N15/1404 , G01N2035/1086 , G01N35/1004
摘要： Particles contained in a liquid sample are analyzed by moving the particles along a detection passage past a detector using a liquid flow in the detection passage. To reduce the time required for analysis of each sample, the sample is delivered at an input location at the upstream end of the detection passage by movement of a movable container carrying the sample to the input location. Immediately after the commencement of the delivery of the liquid sample, liquid flow is caused to occur in the detection passage. Washing liquid is supplied to the input location by a liquid supplier different from the movable container which carries the sample.

5. 发明授权

US5449622A Method and apparatus for analyzing stained particles 失效
标题翻译：用于分析染色颗粒的方法和装置
公开(公告)号：US5449622A
公开(公告)日：1995-09-12
申请号：US197515
申请日：1994-02-16
申请人： Ryohei Yabe , Shinichi Sakuraba , Masaaki Kurimura , Yasuaki Kojima
发明人： Ryohei Yabe , Shinichi Sakuraba , Masaaki Kurimura , Yasuaki Kojima
IPC分类号： G01N15/14 , G01N21/27 , G01N21/59 , G01N33/50 , G01N33/72 , G01N35/04 , G06T7/40 , G01N33/48 , G01N33/00 , G06F15/00
CPC分类号： G01N21/27 , G01N2035/0446 , Y10S436/909
摘要： In a stained particle analyzing method and apparatus for staining a test sample containing suspended particles, shooting an image of the stained sample, and classifying the particles and computing the density from the shot image of the sample, the sample, which may not be analyzed precisely, is detected before the start of an image analyzing process. Only the sample, which will be analyzed precisely, is stained and subjected to the image analysis. Color information of the sample before the staining is detected and stored. Color information of an image of the sample shot after the staining is compensated based on the color information of the sample detected before the staining. The sort and density of the particles are classified and computed on the basis of the image after the color compensation.
摘要翻译：在用于染色含有悬浮颗粒的测试样品的染色颗粒分析方法和装置中，拍摄染色样品的图像，并对颗粒进行分类并从样品的拍摄图像计算密度，样品可能没有被精确分析在图像分析处理开始之前被检测到。只有将精确分析的样品染色并进行图像分析。检测并存储染色前样品的颜色信息。基于在染色前检测到的样品的颜色信息来补偿染色后的样品的图像的颜色信息。基于颜色补偿后的图像对颗粒的分类和密度进行分类和计算。

6. 发明授权

US4653078A Method and apparatus for detecting occurrence of clogging conditions by counting particles suspended in a liquid method 失效
标题翻译：通过计算悬浮在液体方法中的颗粒来检测堵塞条件的发生的方法和装置
公开(公告)号：US4653078A
公开(公告)日：1987-03-24
申请号：US721468
申请日：1985-04-09
申请人： Toshiaki Aritomi , Hatsue Shinohara , Shinichi Sakuraba
发明人： Toshiaki Aritomi , Hatsue Shinohara , Shinichi Sakuraba
IPC分类号： G01N15/14 , G01N27/00
CPC分类号： G01N15/1459 , G01N2015/0073 , G01N2015/1415 , G01N2015/1486
摘要： A method of counting red blood cells suspended in a blood sample is disclosed which can judge the presence or absence of clogging in the sample passage system of a blood cell counting apparatus. In this method, for example, the counting of red blood cells for a period of 200 msec is repeated 50 times, the means value X and standard deviation SD of 50 red blood cell counts each indicating the number of red blood cells per unit time (equal to 200 msec) are calculated, and when one of the red blood cell counts deviates from the mean value X by more than 3SD, such deviation is judged to presage clogging in the sample passage system. Further, each of the red blood cell counts can be displayed on the fluorescent screen of a CRT display.
摘要翻译：公开了一种计数悬浮在血液样品中的红细胞的方法，其可以判断血细胞计数装置的样品通道系统中是否存在堵塞。在该方法中，例如，将200毫秒的红细胞计数重复50次，将50次红细胞计数的平均值＆Upbar＆X和标准差SD计数为每单位时间内的红细胞数（等于200毫秒），当红细胞计数之一偏离平均值＆upbar＆X超过3SD时，这种偏差被判断为在样品通道系统中预示着堵塞。此外，每个红细胞计数可以显示在CRT显示器的荧光屏上。

7. 发明授权

US4847910A Automatic cell sample classifying apparatus 失效
标题翻译：自动细胞样品分选装置
公开(公告)号：US4847910A
公开(公告)日：1989-07-11
申请号：US67003
申请日：1987-06-29
申请人： Shinichi Sakuraba , Hajime Matsushita , Masaaki Kurimura
发明人： Shinichi Sakuraba , Hajime Matsushita , Masaaki Kurimura
IPC分类号： G01N33/48 , G01N1/28 , G01N1/30 , G01N15/14 , G01N21/25 , G01N21/85 , G01N35/02 , G06K9/00
CPC分类号： G06K9/00127 , G01N15/1468 , G01N1/30 , G01N21/25 , G01N2201/0492
摘要： A stain discriminating apparatus in which light rays having at least light component having a wavelength in a predetermined range are projected to a cell sample to discriminate the staining method by which the cell sample has been stained on the basis of the light intensity of the light component transmitted through the sample and having the wavelength (530 nm) in the predetermined range. An automatic cell sample classifying apparatus in which a plurality of cell sample slides are sequentially fed to the stain discriminating apparatus is used to determine the staining method by which the cell samples have been stained, respectively. One of the examination/classification programs previously stored in a memory is read out according to the staining method as discriminated and the cell samples are processed in accordance with the program as read out.
摘要翻译：一种污染鉴别装置，其中具有至少具有预定范围波长的光成分的光线投射到细胞样品，以基于光成分的光强度来鉴别细胞样品已被染色的染色方法透过样品并具有预定范围的波长（530nm）。使用其中将多个细胞样品载片依次送入染色鉴别装置的自动细胞样品分选装置来确定细胞样品已被染色的染色方法。先前存储在存储器中的检查/分类程序之一根据所识别的染色方法读出，并且根据读出的程序按照程序处理单元样本。

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