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1. 发明授权

US08802031B2 Liquid dispensing device with a cap and a diaphragm 有权
标题翻译：具有盖和隔膜的液体分配装置
公开(公告)号：US08802031B2
公开(公告)日：2014-08-12
申请号：US12065659
申请日：2006-09-05
申请人： Martin Alan Lee , David James Squirrell , Georgina Martin
发明人： Martin Alan Lee , David James Squirrell , Georgina Martin
IPC分类号： B01L3/02 , B01L3/00
CPC分类号： B01L3/021 , B01L2400/0481 , G01N35/1002 , G01N2035/103
摘要： A liquid dispensing device comprising a hollow body having an opening in a lower end thereof for receiving liquid, and an integrated cap member arranged to sealingly close the body, said cap member comprising a resilient diaphragm which is deformable in a downwards direction. The device is suitable for use in automated apparatus.
摘要翻译：一种液体分配装置，包括在其下端具有用于接收液体的开口的中空本体，以及设置成密封地封闭所述主体的集成的盖构件，所述盖构件包括可沿向下方向变形的弹性隔膜。该设备适用于自动化设备。

2. 发明申请

US20080314855A1 Liquid Dispensing Device with a Cap and a Diaphragm 有权
标题翻译：具有盖和隔膜的液体分配装置
公开(公告)号：US20080314855A1
公开(公告)日：2008-12-25
申请号：US12065659
申请日：2006-09-05
申请人： Martin Alan Lee , David James Squirrell , Georgina Martin
发明人： Martin Alan Lee , David James Squirrell , Georgina Martin
IPC分类号： B65D39/00 , B67D5/06 , B67B7/00
CPC分类号： B01L3/021 , B01L2400/0481 , G01N35/1002 , G01N2035/103
摘要： A liquid dispensing device comprising a hollow body having an opening in a lower end thereof for receiving liquid, and an integrated cap member arranged to sealingly close the body, said cap member comprising a resilient diaphragm which is deformable in a downwards direction. The device is suitable for use in automated apparatus.
摘要翻译：一种液体分配装置，包括在其下端具有用于接收液体的开口的中空本体，以及设置成密封地封闭所述主体的集成的盖构件，所述盖构件包括可沿向下方向变形的弹性隔膜。该设备适用于自动化设备。

3. 发明授权

US09138748B2 Reaction vessel comprising conductive layer and inner non-metallic layer 有权
标题翻译：反应容器包括导电层和内部非金属层
公开(公告)号：US09138748B2
公开(公告)日：2015-09-22
申请号：US12671272
申请日：2008-08-01
申请人： Martin Alan Lee , David James Squirrell , Ross Peter Jones , Roger James Williamson , George Richard Gregory , Graham Gutsell
发明人： Martin Alan Lee , David James Squirrell , Ross Peter Jones , Roger James Williamson , George Richard Gregory , Graham Gutsell
IPC分类号： C12P19/34 , C12M1/00 , B01L7/00 , B01L3/00 , G01N21/03
CPC分类号： B01L7/52 , B01L3/50851 , B01L2300/0858 , B01L2300/0887 , B01L2300/16 , B01L2300/1827 , B01L2300/1883 , G01N21/0332
摘要： A reaction vessel for conducting a chemical or biochemical reaction, such as a polymerase chain reaction wherein at least one wall of said vessel comprises a metallic layer and an inner non-metallic layer. Reaction systems comprising combinations of vessels of the invention and apparatus for heating them, as well as particular reactions vessels are also described and claimed.
摘要翻译：一种用于进行化学或生物化学反应（例如聚合酶链式反应）的反应容器，其中所述容器的至少一个壁包括金属层和内部非金属层。还描述和要求保护包括本发明的容器和用于加热它们的装置的组合的反应系统以及特定的反应容器。

4. 发明申请

US20100210010A1 SAMPLE PROCESSOR 审中-公开
标题翻译：样品处理器
公开(公告)号：US20100210010A1
公开(公告)日：2010-08-19
申请号：US12671257
申请日：2008-08-01
申请人： Martin Alan Lee , David James Squirrell , Michael John Withers , Trevor John Beckett , Christopher John Silk
发明人： Martin Alan Lee , David James Squirrell , Michael John Withers , Trevor John Beckett , Christopher John Silk
IPC分类号： C12M1/34 , H05B3/10
CPC分类号： G01N35/1079 , B01L3/5029 , B01L9/00 , B01L2200/025 , B01L2200/141 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0867 , G01N2035/00376 , G01N2035/00534 , G01N2035/103
摘要： An integral magnet and heater device comprising a heating element with integral permanent magnet for use in a sample preparation or analysis apparatus. Also disclosed is a sheath adapted to cover a reusable processing component, such as a heater or sonicator, of an apparatus during use. Other associated aspects of the system are described and claimed.
摘要翻译：一种集成的磁体和加热器装置，其包括用于样品制备或分析装置的具有一体永磁体的加热元件。还公开了适于在使用期间覆盖设备的可重复使用的处理部件（例如加热器或超声波器）的护套。描述和要求保护系统的其它相关方面。

5. 发明申请

US20090325278A1 Reaction System for Performing in the Amplification of Nucleic Acids 有权
标题翻译：用于核酸扩增的反应体系
公开(公告)号：US20090325278A1
公开(公告)日：2009-12-31
申请号：US12553367
申请日：2009-09-03
申请人： Martin Alan Lee , Hilary Bird , Dario Lyall Leslie , David James Squirrell , John Shaw , David Wenn , Julie Deacon
发明人： Martin Alan Lee , Hilary Bird , Dario Lyall Leslie , David James Squirrell , John Shaw , David Wenn , Julie Deacon
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , B01L3/52 , B01L3/523
摘要： A method of carrying out an amplification reaction, said method comprising supplying to a well in a disposable unit (a) a sample which contains or is suspected of containing a target nucleic acid sequence (b) primers, nucleotides and enzymes required to effect said amplification reaction and (c) a buffer system, and subjecting the unit to thermal cycling conditions such that any target nucleic acid present within the sample is amplified; wherein the disposable unit comprises a thermally conducting layer and a facing layer having one or more reagent wells of up to 1000 microns in depth defined therebetween; and the reaction mixture comprises at least one of the following: A) a buffer system wherein the pH is above 8.3; B) a detergent; and/or C) a blocking agent. Apparatus for effecting the method as well as disposable units for use in the method are described. The method is particularly suitable for rapid PCR reactions.
摘要翻译：一种进行扩增反应的方法，所述方法包括向一次性单元（a）中的井提供含有或怀疑含有靶核酸序列的样品（b）实现所述扩增所需的引物，核苷酸和酶反应和（c）缓冲系统，并使该单元经受热循环条件，使得存在于样品中的任何靶核酸被扩增; 其中所述一次性单元包括导热层和面对层，其具有在其间限定的深度达1000微米的一个或多个试剂阱; 并且反应混合物包含以下至少一种：A）其中pH高于8.3的缓冲体系; B）洗涤剂; 和/或C）封端剂。描述了用于实现该方法的装置以及用于该方法的一次性单元。该方法特别适用于快速PCR反应。

6. 发明申请

US20080206751A1 Method For Carrying Out A Multi-Step Reaction, Breakable Container For Storing Reagents And Method For Transferring Solid Reagent Using An Electrostatically Charged Wand 审中-公开
标题翻译：用于进行多步反应的方法，用于储存试剂的易碎容器和使用静电充电棒转移固体试剂的方法
公开(公告)号：US20080206751A1
公开(公告)日：2008-08-28
申请号：US11814726
申请日：2006-01-26
申请人： David James Squirrell , Martin Alan Lee
发明人： David James Squirrell , Martin Alan Lee
IPC分类号： C12Q1/68 , B01L3/00 , C12P19/34 , B65G61/00 , B65H29/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00335 , B01J2219/00344 , B01J2219/00421 , B01J2219/00468 , B01J2219/00704 , B01J2219/00722 , B01L3/502 , B01L3/5021 , B01L7/52 , B01L2200/16 , B01L2300/0838 , B01L2300/087 , B01L2400/0409 , C40B40/06 , G01N35/0098
摘要： The application relates to a method of performing a multi-step reaction vessel (68) having at least two compartments (685, 680). The reagents are placed in the first compartment (685) and moved to second one (680) by centrifugation, after which another set of reagents may be placed in the first compartment (685) while the reaction in the lower chamber takes place. Once the reaction is complete, the reagents that were in the first compartment (685) may be moved to the lower one (680) by centrifugation. The application also claims a container having a pierceable lower surface and an upper surface with either a pierceable component or a lid. A wand capable of being electrostatically charged, an apparatus comprising such a wand and a method of transferring solid reagents using such a wand is also claimed.
摘要翻译：本申请涉及执行具有至少两个隔室（685,680）的多步骤反应容器（68）的方法。将试剂置于第一隔室（685）中，并通过离心移至第二隔室（680），之后另外一组试剂可放置在第一隔室（685）中，同时在下室中发生反应。一旦反应完成，通过离心可将第一隔室（685）中的试剂移至较低的试剂（680）。本申请还要求具有可刺穿的下表面的容器和具有可刺破的部件或盖子的上表面。一种能够被静电充电的魔杖，包括这种魔杖的装置以及使用这种魔杖传送固体试剂的方法也被要求保护。

7. 发明授权

US07176003B2 Method for determining the length of a nucleic acid molecule 失效
标题翻译：确定核酸分子长度的方法
公开(公告)号：US07176003B2
公开(公告)日：2007-02-13
申请号：US10220330
申请日：2001-03-06
申请人： David James Squirrell , Martin Alan Lee
发明人： David James Squirrell , Martin Alan Lee
IPC分类号： C12P19/34 , C12Q1/68 , C07H21/04 , G01N21/64
CPC分类号： C12Q1/68
摘要： A method of determining the length of a particular region within a nucleic acid, the method comprising a) subjecting a sample of the nucleic acid to a plurality of amplification reactions in which the region is amplified, wherein the time of the extension phase in each of the reactions is varied; b) monitoring the progress of the amplification reactions; c) determining the minimum time during which extension phase of the amplification is completed within each reaction mixture and relating that to the length of the sequence undergoing extension. The method, combined with melting point analysis, will allow percentage GC content of a sequence to be determined. Length analysis of this type can be used in diagnosis or analysis as well as in recombinant DNA technology to check for the presence of concatamers, and in taxonomic classification or forensics. Apparatus for use in the method is also described and claimed.
摘要翻译：一种确定核酸内特定区域的长度的方法，所述方法包括：a）使所述核酸样品经受其中扩增所述区域的多个扩增反应，其中每个反应是多种多样的; b）监测扩增反应的进展情况; c）确定在每个反应混合物内完成扩增的延伸期的最短时间，并将其与经历延伸的序列的长度相关联。该方法与熔点分析相结合，可以确定序列的GC含量百分比。这种类型的长度分析可用于诊断或分析以及重组DNA技术，以检查连接体的存在，以及分类分类或取证。还描述并要求保护该方法中使用的装置。

8. 发明申请

US20080290292A1 Fluorescence-Based Detection Methods and Apparatus 失效
标题翻译：基于荧光的检测方法和装置
公开(公告)号：US20080290292A1
公开(公告)日：2008-11-27
申请号：US12095444
申请日：2006-12-11
申请人： David James Squirrell , Martin Alan Lee
发明人： David James Squirrell , Martin Alan Lee
IPC分类号： G01J1/58
CPC分类号： G01N21/6428 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6441 , G01N2201/0691
摘要： In apparatus for detecting the emission of fluorescent radiation from a sample in response to excitation by two or more different radiation sources (145, 160) over the same time period, each radiation source (145, 160) is imprinted with a modulation regime which can then be separately detected in the emitted fluorescent radiation. For instance in techniques based on fluorescent resonant energy transfer (“FRET”), the drive current to two or more different LED sources (145, 160) may be frequency modulated, or pulse width modulated, according to different modulation regimes. Responses of the sample, for instance of different donor/acceptor probes contained in the sample, to each of the sources (145, 160) can then be separately detected by means of the different modulation regimes, even where the wavelengths or wavelength ranges of the responses are the same or overlapping.
摘要翻译：在用于响应于两个或更多个不同的辐射源（145,160）在相同时间段的激发来检测来自样品的荧光辐射的发射的装置中，每个辐射源（145,160）被印刷有调制方式，其可以然后在发射的荧光辐射中单独检测。例如，在基于荧光共振能量转移（“FRET”）的技术中，可以根据不同的调制方式对两个或更多个不同的LED源（145,160）的驱动电流进行频率调制或脉冲宽度调制。然后可以通过不同的调制方式单独地检测样品（例如包含在样品中的不同施主/受体探针）到每个源（145,160）的响应，即使其中波长或波长范围回应是相同或重叠的。

9. 发明授权

US08986927B2 Reaction system for performing in the amplification of nucleic acids 有权
标题翻译：用于在核酸扩增中进行的反应体系
公开(公告)号：US08986927B2
公开(公告)日：2015-03-24
申请号：US12553367
申请日：2009-09-03
申请人： Martin Alan Lee , Hilary Bird , Dario Lyall Leslie , David James Squirrell , John Shaw , David Wenn , Julie Deacon
发明人： Martin Alan Lee , Hilary Bird , Dario Lyall Leslie , David James Squirrell , John Shaw , David Wenn , Julie Deacon
IPC分类号： B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/52 , B01L3/523
摘要： A method of carrying out an amplification reaction, said method comprising supplying to a well in a disposable unit (a) a sample which contains or is suspected of containing a target nucleic acid sequence (b) primers, nucleotides and enzymes required to effect said amplification reaction and (c) a buffer system, and subjecting the unit to thermal cycling conditions such that any target nucleic acid present within the sample is amplified; wherein the disposable unit comprises a thermally conducting layer and a facing layer having one or more reagent wells of up to 1000 microns in depth defined therebetween; and the reaction mixture comprises at least one of the following: A) a buffer system wherein the pH is above 8.3; B) a detergent; and/or C) a blocking agent. Apparatus for effecting the method as well as disposable units for use in the method are described. The method is particularly suitable for rapid PCR reactions.
摘要翻译：一种进行扩增反应的方法，所述方法包括向一次性单元（a）中的井提供含有或怀疑含有靶核酸序列的样品（b）实现所述扩增所需的引物，核苷酸和酶反应和（c）缓冲系统，并使该单元经受热循环条件，使得存在于样品中的任何靶核酸被扩增; 其中所述一次性单元包括导热层和面对层，其具有在其间限定的深度达1000微米的一个或多个试剂阱; 并且反应混合物包含以下至少一种：A）其中pH高于8.3的缓冲体系; B）洗涤剂; 和/或C）封端剂。描述了用于实现该方法的装置以及用于该方法的一次性单元。该方法特别适用于快速PCR反应。

10. 发明申请

US20110212491A1 REACTION VESSEL 审中-公开
标题翻译：反应容器
公开(公告)号：US20110212491A1
公开(公告)日：2011-09-01
申请号：US12671777
申请日：2008-08-01
申请人： Martin Alan Lee , David James Squirrell , Ross Peter Jones , Andrea Hamilton
发明人： Martin Alan Lee , David James Squirrell , Ross Peter Jones , Andrea Hamilton
IPC分类号： C12P19/34 , C12M1/00 , C08G61/10
CPC分类号： B01L3/5082 , B01L3/508 , B01L3/50825 , B01L3/50851 , B01L7/52 , B01L2300/0654 , B01L2300/0838 , B01L2300/163 , B01L2300/1827
摘要： A reaction vessel for carrying out a chemical or biochemical reaction, such as a polymerase chain reaction, said vessel having a coating of parylene or a derivative thereof, on at least the surface which contacts reactants.
摘要翻译：用于进行化学或生物化学反应（例如聚合酶链式反应）的反应容器，所述容器在至少与反应物接触的表面上具有聚对二甲苯或其衍生物的涂层。

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