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1. 发明授权

US06368658B1 Coating medical devices using air suspension 有权
标题翻译：使用空气悬浮的涂层医疗设备
公开(公告)号：US06368658B1
公开(公告)日：2002-04-09
申请号：US09551614
申请日：2000-04-17
申请人： Marlene Schwarz , Kathleen Miller , Kalpana Kamath
发明人： Marlene Schwarz , Kathleen Miller , Kalpana Kamath
IPC分类号： B01J1300
CPC分类号： A61L27/28 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/606 , A61L2300/608 , A61L2420/02 , B05B13/02 , B05B13/0221 , B05B13/025 , B05B13/0257 , B05C13/00 , B05D1/22 , C23C14/50 , C23C16/458
摘要： Methods and apparatuses for coating medical devices and the devices thereby produced are disclosed. In one embodiment, the invention includes a method comprising the steps of suspending the medical device in an air stream and introducing a coating material into the air stream such that the coating material is dispersed therein and coats at least a portion of the medical device. In another embodiment, the medical devices are suspended in an air stream and a coating apparatus coats at least a portion of the medical device with a coating material. The coating apparatus may include a device that utilizes any number of alternative coating techniques for coating the medical devices. This process is used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats. By using air suspensions to coat medical devices, the methods of the present invention result in coatings having minimal defects and uniform thicknesses and mechanical properties. Further, the methods of the present invention are time efficient and cost effective because they facilitate the coating of numerous medical devices in a single batch, resulting in numerous medical device units containing substantially the same coating.
摘要翻译：公开了用于涂覆医疗装置的方法和装置以及由此制造的装置。在一个实施方案中，本发明包括一种方法，其包括以下步骤：将医疗装置悬浮在空气流中并将涂料引入空气流中，使得涂层材料分散在其中并涂覆医疗装置的至少一部分。在另一个实施方案中，医疗装置悬浮在空气流中，并且涂覆装置用涂料涂覆医疗装置的至少一部分。涂覆设备可以包括利用任何数量的替代涂覆技术来涂覆医疗装置的装置。该方法用于同时或按顺序施用一种或多种涂料。在本发明的某些实施方案中，涂层材料包括治疗剂，聚合物，糖，蜡或脂肪。通过使用空气悬浮液来涂覆医疗装置，本发明的方法产生具有最小缺陷和均匀厚度和机械性能的涂层。此外，本发明的方法是时间有效和成本有效的，因为它们有助于单批次涂覆许多医疗装置，导致许多医疗装置单元含有基本上相同的涂层。

2. 发明申请

US20110034993A1 COATED MEDICAL IMPLANTS 审中-公开
标题翻译：涂层医用植绒
公开(公告)号：US20110034993A1
公开(公告)日：2011-02-10
申请号：US12856431
申请日：2010-08-13
申请人： Marlene Schwarz , Kathleen Miller , Kalpana Kamath
发明人： Marlene Schwarz , Kathleen Miller , Kalpana Kamath
IPC分类号： A61L27/54 , A61L29/16
CPC分类号： A61L27/28 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/606 , A61L2300/608 , A61L2420/02 , B05B13/02 , B05B13/0221 , B05B13/025 , B05B13/0257 , B05C13/00 , B05D1/22 , C23C14/50 , C23C16/458
摘要： Coated medical devices are disclosed. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats. In certain embodiments of the invention, a medical device is coated on at least a portion of its surface with a first coating comprising a therapeutic agent and a wax or fat. The coated medical device may be a stent or catheter.
摘要翻译：公开了涂覆的医疗装置。在本发明的某些实施方案中，涂层材料包括治疗剂，聚合物，糖，蜡或脂肪。在本发明的某些实施方案中，医疗装置在其表面的至少一部分上涂覆有包含治疗剂和蜡或脂肪的第一涂层。涂覆的医疗装置可以是支架或导管。

3. 发明授权

US06855770B2 Drug delivery compositions and medical devices containing block copolymer 有权
标题翻译：药物输送组合物和含有嵌段共聚物的医疗器械
公开(公告)号：US06855770B2
公开(公告)日：2005-02-15
申请号：US10319802
申请日：2002-12-13
申请人： Leonard Pinchuk , Sepideh Nott , Marlene Schwarz , Kalpana Kamath
发明人： Leonard Pinchuk , Sepideh Nott , Marlene Schwarz , Kalpana Kamath
IPC分类号： A61K47/32 , A61K9/22 , A61K31/337 , A61K35/12 , A61K45/00 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K48/00 , A61L27/16 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/16 , A61M37/00 , C08F2/00 , C08F293/00 , C08F297/00 , C08F297/04 , C08L53/00 , C08L53/02 , C09D153/00 , C09D153/02 , C08L23/00 , C08L23/04
CPC分类号： C08L53/00 , A61L27/16 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08F293/005 , C08F297/00 , C08F297/04 , C08L53/02 , C09D153/00 , C09D153/02 , C08L2666/02
摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.
摘要翻译：提供了用于递送治疗剂的组合物。所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。嵌段共聚物优选为式X-（AB）n，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。根据本发明的另一方面，提供一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内医疗装置的至少一部分上的涂层，其中所述涂层包括上述生物相容性嵌段共聚物。

4. 发明申请

US20050215722A1 Drug delivery compositions and medical devices containing block copolymer 有权
标题翻译：药物输送组合物和含有嵌段共聚物的医疗器械
公开(公告)号：US20050215722A1
公开(公告)日：2005-09-29
申请号：US11057870
申请日：2005-02-14
申请人： Leonard Pinchunk , Sepideh Hashemi , Marlene Schwarz , Kalpana Kamath , Ni Ding
发明人： Leonard Pinchunk , Sepideh Hashemi , Marlene Schwarz , Kalpana Kamath , Ni Ding
IPC分类号： A61K47/32 , A61K9/22 , A61K31/337 , A61K35/12 , A61K45/00 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K48/00 , A61L27/16 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/16 , A61M37/00 , C08F2/00 , C08F293/00 , C08F297/00 , C08F297/04 , C08L53/00 , C08L53/02 , C09D153/00 , C09D153/02
CPC分类号： C08L53/00 , A61L27/16 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08F293/005 , C08F297/00 , C08F297/04 , C08L53/02 , C09D153/00 , C09D153/02 , C08L2666/02
摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.
摘要翻译：提供了用于递送治疗剂的组合物。所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。嵌段共聚物优选为式X-（AB）n N，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层包括上述生物相容性嵌段共聚物。

5. 发明授权

US06545097B2 Drug delivery compositions and medical devices containing block copolymer 有权
公开(公告)号：US06545097B2
公开(公告)日：2003-04-08
申请号：US09734639
申请日：2000-12-12
申请人： Leonard Pinchuk , Sepideh Nott , Marlene Schwarz , Kalpana Kamath
发明人： Leonard Pinchuk , Sepideh Nott , Marlene Schwarz , Kalpana Kamath
IPC分类号： C08L2300
CPC分类号： C08L53/00 , A61L27/16 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08F293/005 , C08F297/00 , C08F297/04 , C08L53/02 , C09D153/00 , C09D153/02 , C08L2666/02
摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.

6. 发明申请

US20050025802A1 Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent 有权
标题翻译：含有丙烯酸共聚物的可植入或可插入的医疗器械用于治疗剂的控制递送
公开(公告)号：US20050025802A1
公开(公告)日：2005-02-03
申请号：US10632061
申请日：2003-07-31
申请人： Robert Richard , Marlene Schwarz
发明人： Robert Richard , Marlene Schwarz
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M31/00 , A61F13/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , C08L53/02
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises an acrylic copolymer, which comprises (i) a plurality of rubbery acrylic units and (ii) a plurality of hard units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）聚合物释放区域，其在施用于患者时控制治疗剂的释放。聚合物释放区还包括丙烯酸共聚物，其包含（i）多个橡胶状丙烯酸单元和（ii）多个硬单元。还描述了使用上述可植入或可插入医疗装置向患者施用治疗剂的方法以及制备上述装置的方法。

7. 发明授权

US06607598B2 Device for protecting medical devices during a coating process 失效
标题翻译：用于在涂覆过程中保护医疗装置的装置
公开(公告)号：US06607598B2
公开(公告)日：2003-08-19
申请号：US09804040
申请日：2001-03-13
申请人： Marlene Schwarz , Jan Weber , Henrik Hansen , Paul Lubinsky
发明人： Marlene Schwarz , Jan Weber , Henrik Hansen , Paul Lubinsky
IPC分类号： B05C1302
CPC分类号： B05B13/025 , A61L27/28 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/10 , A61L2300/252 , A61L2300/258 , A61L2300/606 , B05B13/02 , B05B13/0257 , B05D1/22 , C23C14/50 , C23C16/458
摘要： Methods and devices for protecting and/or coating medical devices are disclosed. In one embodiment, a method is disclosed that includes surrounding a medical device with a cage, the medical device having a surface. The method further includes attaching the medical device to the cage with at least one securement, suspending the medical device in an air stream, the air stream substantially devoid of suspending particles, and coating at least a portion of said surface of said suspended medical device with a first coating material.
摘要翻译：公开了用于保护和/或涂覆医疗器械的方法和装置。在一个实施例中，公开了一种包括用保持架围绕医疗装置的方法，该医疗装置具有表面。该方法还包括将医疗装置连接到具有至少一个固定件的保持器，将医疗装置悬挂在空气流中，空气流基本上没有悬浮颗粒，并且将所述悬挂的医疗装置的所述表面的至少一部分涂覆到第一涂料。

8. 发明申请

US20050025801A1 Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent 失效
标题翻译：含有辐射处理聚合物的植入式或可插入医疗装置，用于改善治疗剂的递送
公开(公告)号：US20050025801A1
公开(公告)日：2005-02-03
申请号：US10632054
申请日：2003-07-31
申请人： Robert Richard , Marlene Schwarz
发明人： Robert Richard , Marlene Schwarz
IPC分类号： A61L27/16 , A61L27/34 , A61L27/54 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61N1/08 , A61N1/10
CPC分类号： A61L31/16 , A61L27/16 , A61L27/34 , A61L27/54 , A61L29/041 , A61L29/085 , A61L29/16 , A61L31/048 , A61L31/10 , A61L2300/602 , C08L33/12 , C08L53/02 , C08L25/10 , C08L23/22
摘要： An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region comprising a polymer. The polymeric release region is treated with a radiation dose that is effective to substantially increase the cumulative release of the therapeutic agent subsequent to administration to a patient. The polymeric release region can be, for example, (a) a carrier region that comprises the therapeutic agent or (b) a barrier region that is disposed over a therapeutic-agent-containing region that comprises the therapeutic agent. The present invention is further directed to methods of forming such medical devices, methods of releasing a therapeutic agent within a patient using such medical devices, and methods of modulating the release of a therapeutic agent from such medical devices.
摘要翻译：一种可植入或可插入的医疗装置，其包括（a）治疗剂和（b）包含聚合物的聚合物释放区域。用辐射剂量处理聚合物释放区域，其有效地大大增加给予患者后治疗剂的累积释放。聚合物释放区可以是例如（a）包含治疗剂的载体区域或（b）设置在包含治疗剂的包含治疗剂的区域上的屏障区域。本发明进一步涉及形成这种医疗装置的方法，使用这种医疗装置在患者体内释放治疗剂的方法，以及调节治疗剂从这些医疗装置释放的方法。

9. 发明申请

US20050015142A1 Coated medical device and method for manufacturing the same 有权
标题翻译：涂覆医疗器械及其制造方法
公开(公告)号：US20050015142A1
公开(公告)日：2005-01-20
申请号：US10797704
申请日：2004-03-09
申请人： Michael Austin , Don Robinson , Dennis Boulais , Praveen Kulkarni , Toby Freyman , Samuel Epstein , Wendy Naimark , Marlene Schwarz
发明人： Michael Austin , Don Robinson , Dennis Boulais , Praveen Kulkarni , Toby Freyman , Samuel Epstein , Wendy Naimark , Marlene Schwarz
IPC分类号： A61F2/00 , A61F2/06 , A61F2/90 , B05C1/02 , B05C1/08 , B05C1/14 , B05D1/28
CPC分类号： B05C1/0813 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2250/0068 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/606 , A61L2420/08 , B05C1/022 , B05C1/08 , B05C1/0817 , B05C1/14 , B05D1/28
摘要： The medical device of the invention comprises a surface comprising at least one outermost portion and a plurality of depressions. The depressions occupy at least about 80% of the surface area of the surface. The depressions contain a coating material that preferably comprises a biologically active material and/or polymer, and the outermost portion is substantially free of any coating material. The invention is also directed to a method for manufacturing a medical device. The method comprises applying a coating material to the surface of the medical device by using at least one roller.
摘要翻译：本发明的医疗装置包括包括至少一个最外部分和多个凹陷的表面。凹陷占表面表面积的至少约80％。凹陷包含优选包含生物活性材料和/或聚合物的涂层材料，并且最外部分基本上不含任何涂层材料。本发明还涉及一种用于制造医疗装置的方法。该方法包括通过使用至少一个辊将涂层材料施加到医疗装置的表面上。

10. 发明授权

US08097291B2 Methods for coating workpieces 失效
标题翻译：涂装工件的方法
公开(公告)号：US08097291B2
公开(公告)日：2012-01-17
申请号：US11446262
申请日：2006-06-05
申请人： Gerald Fredrickson , Lan Pham , Marlene Schwarz , Todd Robida
发明人： Gerald Fredrickson , Lan Pham , Marlene Schwarz , Todd Robida
IPC分类号： B05D3/04 , B05D3/14 , B05D1/32
CPC分类号： B05D3/042 , A61L2420/02 , B05B5/082 , B05B12/18 , B05B13/02 , B05B13/0228 , B05B14/00 , B05D1/002 , B05D1/04
摘要： The present invention is directed to methods, processes, and systems for coating portions of a workpiece as well as to workpieces that have themselves been coated in accord with the invention. Under these methods and processes of the invention, a means to repel may be positioned on a mandrel prior to applying a coating to the workpiece. The means to repel may prevent the coating of a target surface of the workpiece.
摘要翻译：本发明涉及用于涂覆工件的部分以及本身已经根据本发明进行了涂覆的工件的方法，工艺和系统。在本发明的这些方法和方法下，在将涂层施加到工件之前，排斥装置可以定位在心轴上。排斥的方法可以防止工件的目标表面的涂覆。

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