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1. 发明申请

US20080116894A1 Method for automatic shimming for nuclear magnetic resonance spectroscopy 有权
公开(公告)号：US20080116894A1
公开(公告)日：2008-05-22
申请号：US11975207
申请日：2007-10-18
申请人： Markus Weiger , Michael Fey , Thomas Speck
发明人： Markus Weiger , Michael Fey , Thomas Speck
IPC分类号： G01R33/38 , G06F19/00
CPC分类号： G01R33/3875 , G01R33/243 , G01R33/4625 , G01R33/56572
摘要： A method for homogenizing a static magnetic field with a magnetic field distribution B0(r) for nuclear magnetic resonance spectroscopy by adjusting the currents Ci through the shim coils, thus creating spatial field distributions Ci·Si(r), where r stands for one, two, or three of the spatial dimensions x, y, and z, and said magnetic field distribution B0(r) has only a field component along z, in a working volume of a magnetic resonance apparatus with one or more radio frequency (=RF) coils (5) for inducing RF pulses and receiving RF signals within a working volume, said RF coils having a spatial sensitivity distribution of magnitudes B1k(r), and with shim coils (6) for homogenizing the magnetic field within the working volume, said shim coils (6) being characterized by their magnetic field distributions per unit current Si(r) and having components only along z, includes the following steps: (a) Mapping the magnetic field distribution B0(r) of the main magnetic field, (b) calculating a simulated spectrum IS(f) based on the sum of the magnetic field distribution B0(r) and the additional field distributions Ci·Si(r) generated by the shim coils (6), and on the sensitivity distributions B1k(r) of the RF coils(5), (c) optimising a quality criterion derived from the simulated spectrum IS(f) by using an optimisation procedure within a search range with the shim currents Ci as a set of parameters, whereby for each new set of parameter values step (b) has to be repeated, (d) realising the found optimum of the quality criterion of step (c) by generating the associated target field distribution B0T(r). In this way a direct one-to-one link is obtained between a set of shim currents and the associated NMR spectrum The quality of the desired NMR spectra can be improved with this method.

2. 发明申请

US20060197526A1 METHOD FOR AUTOMATIC SHIMMING FOR NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY 有权
公开(公告)号：US20060197526A1
公开(公告)日：2006-09-07
申请号：US11279149
申请日：2006-04-10
申请人： Markus Weiger , Michael Fey , Thomas Speck
发明人： Markus Weiger , Michael Fey , Thomas Speck
IPC分类号： G01V3/00 , A61B5/05
CPC分类号： G01R33/3875 , G01R33/46
摘要： A method for homogenizing a static magnetic field with a magnetic field distribution B0(r) for nuclear magnetic resonance spectroscopy by adjusting the currents Ci through the shim coils, thus creating spatial field distributions Ci·Si(r), where r stands for one, two, or three of the spatial dimensions x, y, and z, and said magnetic field distribution B0(r) has only a field component along z, in a working volume of a magnetic resonance apparatus with one or more radio frequency (=RF) coils (5) for inducing RF pulses and receiving RF signals within a working volume, said RF coils having a spatial sensitivity distribution of magnitudes B1k(r), and with shim coils (6) for homogenizing the magnetic field within the working volume, said shim coils (6) being characterized by their magnetic field distributions per unit current Si(r) and having components only along z, includes the following steps: (a) Mapping the magnetic field distribution B0(r) of the main magnetic field, (b) calculating a simulated spectrum IS(f) based on the sum of the magnetic field distribution B0(r) and the additional field distributions Ci·Si(r) generated by the shim coils (6), and on the sensitivity distributions B1k(r) of the RF coils (5), (c) optimising a quality criterion derived from the simulated spectrum IS(f) by using an optimisation procedure within a search range with the shim currents Ci as a set of parameters, whereby for each new set of parameter values step (b) has to be repeated, (d) realising the found optimum of the quality criterion of step (c) by generating the associated target field distribution B0T(r). In this way a direct one-to-one link is obtained between a set of shim currents and the associated NMR spectrum The quality of the desired NMR spectra can be improved with this method.

3. 发明授权

US07605589B2 Method for automatic shimming for nuclear magnetic resonance spectroscopy 有权
标题翻译：核磁共振波谱自动匀场方法
公开(公告)号：US07605589B2
公开(公告)日：2009-10-20
申请号：US11975207
申请日：2007-10-18
申请人： Markus Weiger , Michael Fey , Thomas Speck
发明人： Markus Weiger , Michael Fey , Thomas Speck
IPC分类号： G01V3/00
CPC分类号： G01R33/3875 , G01R33/243 , G01R33/4625 , G01R33/56572
摘要： A method for homogenizing a static magnetic field with a magnetic field distribution B0(r) for nuclear magnetic resonance spectroscopy by adjusting the currents Ci through the shim coils, thus creating spatial field distributions Ci·Si(r), where r stands for one, two, or three of the spatial dimensions x, y, and z, and said magnetic field distribution B0(r) has only a field component along z, in a working volume of a magnetic resonance apparatus with one or more radio frequency (=RF) coils (5) for inducing RF pulses and receiving RF signals within a working volume, said RF coils having a spatial sensitivity distribution of magnitudes B1k(r), and with shim coils (6) for homogenizing the magnetic field within the working volume, said shim coils (6) being characterized by their magnetic field distributions per unit current Si(r) and having components only along z, includes the following steps: (a) Mapping the magnetic field distribution B0(r) of the main magnetic field, (b) calculating a simulated spectrum IS(f) based on the sum of the magnetic field distribution B0(r) and the additional field distributions Ci·Si(r) generated by the shim coils (6), and on the sensitivity distributions B1k(r) of the RF coils(5), (c) optimising a quality criterion derived from the simulated spectrum IS(f) by using an optimisation procedure within a search range with the shim currents Ci as a set of parameters, whereby for each new set of parameter values step (b) has to be repeated, (d) realising the found optimum of the quality criterion of step (c) by generating the associated target field distribution B0T(r). In this way a direct one-to-one link is obtained between a set of shim currents and the associated NMR spectrum The quality of the desired NMR spectra can be improved with this method.
摘要翻译：一种用于核磁共振光谱的磁场分布B0（r）使静态磁场均匀化的方法，通过调整通过垫片线圈的电流Ci，从而产生空间场分布Ci.Si（r），其中r表示一个，空间尺寸x，y和z中的两个或三个，并且所述磁场分布B0（r）在具有一个或多个射频（= RF）的磁共振装置的工作体积中仅具有z的场分量）线圈（5），用于感应RF脉冲并在工作体积内接收RF信号，所述RF线圈具有大小B1k（r）的空间灵敏度分布，以及用于使工作体积内的磁场均匀化的垫片线圈（6）所述垫片线圈（6）的特征在于它们每单位电流Si（r）的磁场分布并且仅沿着z具有分量，包括以下步骤：（a）映射主磁场的磁场分布B0（r）（b）计算a 基于磁场分布B0（r）和由垫片线圈（6）产生的附加场分布Ci.Si（r）之和的和（f）的灵敏度分布B1k（r）的模拟频谱IS（f） RF线圈（5），（c）通过使用以电流Ci为一组参数的搜索范围内的优化程序来优化从模拟频谱IS（f）导出的质量标准，由此对于每组新的参数值集必须重复步骤（b），（d）通过产生相关的目标场分布B0T（r）来实现步骤（c）的质量标准的找到最佳。以这种方式，在一组垫片电流和相关的NMR光谱之间获得直接的一对一链接。可以通过该方法改善期望NMR光谱的质量。

4. 发明授权

US07348775B2 Method for automatic shimming for nuclear magnetic resonance spectroscopy 有权
公开(公告)号：US07348775B2
公开(公告)日：2008-03-25
申请号：US11279149
申请日：2006-04-10
申请人： Markus Weiger , Michael Fey , Thomas Speck
发明人： Markus Weiger , Michael Fey , Thomas Speck
IPC分类号： G01V3/00
CPC分类号： G01R33/3875 , G01R33/46
摘要： A method for homogenizing a static magnetic field with a magnetic field distribution B0(r) for nuclear magnetic resonance spectroscopy by adjusting the currents Ci through the shim coils, thus creating spatial field distributions Ci·Si(r), where r stands for one, two, or three of the spatial dimensions x, y, and z, and said magnetic field distribution B0(r) has only a field component along z, in a working volume of a magnetic resonance apparatus with one or more radio frequency (=RF) coils (5) for inducing RF pulses and receiving RF signals within a working volume, said RF coils having a spatial sensitivity distribution of magnitudes B1k(r), and with shim coils (6) for homogenizing the magnetic field within the working volume, said shim coils (6) being characterized by their magnetic field distributions per unit current Si(r) and having components only along z, includes the following steps: (a) Mapping the magnetic field distribution B0(r) of the main magnetic field, (b) calculating a simulated spectrum IS(f) based on the sum of the magnetic field distribution B0(r) and the additional field distributions Ci·Si(r) generated by the shim coils (6), and on the sensitivity distributions B1k(r) of the RF coils (5), (c) optimising a quality criterion derived from the simulated spectrum IS(f) by using an optimisation procedure within a search range with the shim currents Ci as a set of parameters, whereby for each new set of parameter values step (b) has to be repeated, (d) realising the found optimum of the quality criterion of step (c) by generating the associated target field distribution B0T(r). In this way a direct one-to-one link is obtained between a set of shim currents and the associated NMR spectrum The quality of the desired NMR spectra can be improved with this method.

5. 发明授权

US07656158B2 Sample holder for NMR measurements with field homogenization in the sample volume by means of the bordering surfaces of the sample holder 有权
标题翻译：用于通过样品架的边界表面在样品体积中进行现场均匀化的NMR测量的样品架
公开(公告)号：US07656158B2
公开(公告)日：2010-02-02
申请号：US11907417
申请日：2007-10-12
申请人： Michael Fey , Thomas Speck
发明人： Michael Fey , Thomas Speck
IPC分类号： G01V3/00
CPC分类号： G01R33/30 , G01R33/56536
摘要： A sample vessel (80) made of material with magnetic susceptibility χ2, for containing a sample substance (87) with magnetic susceptibility χ3≠χ2 to be analyzed in a nuclear magnetic resonance (NMR) spectrometer, has an inner interface G2 toward the sample substance and an outer interface G1 toward the environment (85) that exhibits magnetic susceptibility χ1. The shape of the interface toward the sample substance and the interface toward the environment are coordinated to match the discontinuities in susceptibility at the interfaces in such a way that on introduction of the sample tube filled with sample substance into the previously homogeneous magnetic field of an NMR spectrometer, the magnetic field inside the sample substance remains largely homogeneous.
摘要翻译：由核磁共振（NMR）光谱仪分析的含有磁化率chi3chi2的样品物质（87）由具有磁化率chi2的材料制成的样品容器（80）具有朝向样品物质的内界面G2和外界面G1朝向呈现磁化率chi1的环境（85）。配合朝向样品物质的界面的形状和朝向环境的界面进行协调以匹配界面处的敏感性的不连续性，使得在将样品物质填充到先前均匀的NMR磁场中的样品管光谱仪，样品物质内的磁场保持很大程度上均匀。

6. 发明申请

US20080106263A1 Sample holder for NMR measurements with field homogenization in the sample volume by means of the bordering surfaces of the sample holder 有权
标题翻译：用于通过样品架的边界表面在样品体积中进行现场均匀化的NMR测量的样品架
公开(公告)号：US20080106263A1
公开(公告)日：2008-05-08
申请号：US11907417
申请日：2007-10-12
申请人： Michael Fey , Thomas Speck
发明人： Michael Fey , Thomas Speck
IPC分类号： G01R33/30
CPC分类号： G01R33/30 , G01R33/56536
摘要： A sample vessel (80) made of material with magnetic susceptibility χ2, for containing a sample substance (87) with magnetic susceptibility χ3≠χ2 to be analyzed in a nuclear magnetic resonance (NMR) spectrometer, has an inner interface G2 toward the sample substance and an outer interface G1 toward the environment (85) that exhibits magnetic susceptibility χ1. The shape of the interface toward the sample substance and the interface toward the environment are coordinated to match the discontinuities in susceptibility at the interfaces in such a way that on introduction of the sample tube filled with sample substance into the previously homogeneous magnetic field of an NMR spectrometer, the magnetic field inside the sample substance remains largely homogeneous.
摘要翻译：由具有磁化率的材料制成的样品容器（80）用于容纳具有磁化率的样品物质（87），其具有磁化率ki < 在核磁共振（NMR）光谱仪中进行分析时，具有朝向样品物质的内部界面G 2 2和朝向环境的外部界面G 1（＆lt; 1＆gt; 85），其显示磁化率为1/2。配合朝向样品物质的界面的形状和朝向环境的界面进行协调以匹配界面处的敏感性的不连续性，使得在将样品物质填充到先前均匀的NMR磁场中的样品管光谱仪，样品物质内的磁场保持很大程度上均匀。

7. 发明申请

US20080087203A1 Pallet 失效
标题翻译：托盘
公开(公告)号：US20080087203A1
公开(公告)日：2008-04-17
申请号：US11891051
申请日：2007-08-08
申请人： Marc Hartel , Thomas Speck , Tina Steinbrecher , Deane Harder
发明人： Marc Hartel , Thomas Speck , Tina Steinbrecher , Deane Harder
IPC分类号： B65D19/38
CPC分类号： B65D19/04 , B65D19/0012 , B65D19/0026 , B65D19/40 , B65D2519/00034 , B65D2519/00069 , B65D2519/00079 , B65D2519/00114 , B65D2519/00268 , B65D2519/00273 , B65D2519/00278 , B65D2519/00288 , B65D2519/00333 , B65D2519/00343 , B65D2519/00388 , B65D2519/00666
摘要： A pallet for receiving and transporting loads, having an upper platform for receiving the loads and block-like or strip-like support elements which are attached to or can be attached to its underside by connecting sections. At least the support elements are made of plastic with fiber material embedded therein. Advantageous shock absorbing properties, along with an advantageous structure, are achieved because the fiber material consists of natural fibers.
摘要翻译：用于接收和运输负载的托盘，具有用于接收负载的上部平台和通过连接部分连接到或可以附接到其下侧的块状或带状支撑元件。至少支撑元件由塑料制成，纤维材料嵌入其中。由于纤维材料由天然纤维组成，因此有利的冲击吸收性能以及有利的结构被实现。

8. 发明申请

US20070052420A1 Matrix shim system with grouped coils 有权
公开(公告)号：US20070052420A1
公开(公告)日：2007-03-08
申请号：US11506799
申请日：2006-08-21
申请人： Thomas Speck , Werner Tschopp
发明人： Thomas Speck , Werner Tschopp
IPC分类号： G01V3/00
CPC分类号： G01R33/3875
摘要： A matrix shim system for generating magnetic field components superimposed on a main static magnetic field, comprising a plurality of annular coils, is characterized in that it comprises g groups G1 . . . Gg of coils, with g being a natural number ≧1, wherein each group Gi consists of at least two single annular coils connected in series, wherein each group Gi is designed to generate, in use, a magnetic field B z ⁡ ( G i ) = ∑ n = 0 ∞ ⁢ A n ⁢ ⁢ 0 ⁡ ( G i ) · T n ⁢ ⁢ 0 . For each group Gi, there are at least two values of n for which  A n ⁢ ⁢ 0 ⁡ ( G i ) · R n  {  A 20 ⁡ ( G i ) · R 2  , … ⁢ ,  A N ⁢ ⁢ 0 ⁡ ( G i ) · R N  } ≥ 0.5 ⁢ ⁢ and ⁢ ⁢ N ≥ n ≥ 2 , with N: the total number of current supplies of the matrix shim system, and R: smallest inside radius of any of the annular coils of the matrix shim system. An individual, adjustable electrical current supply is provided for each group Gi of coils. The inventive matrix shim system is both simple in design and stable against current fluctuations.

9. 发明申请

US20120256632A1 NMR measuring configuration with optimized sample container geometry and method for calculating the shape of the sample container 有权
标题翻译： NMR测量配置，具有优化的样品容器几何形状和计算样品容器形状的方法
公开(公告)号：US20120256632A1
公开(公告)日：2012-10-11
申请号：US13417260
申请日：2012-03-11
申请人： Dirk Wilhelm , Thomas Speck , Oskar Schett
发明人： Dirk Wilhelm , Thomas Speck , Oskar Schett
IPC分类号： G01R33/30 , G06F17/10
CPC分类号： G01R33/30 , G01R33/56536
摘要： A sample container (2) for NMR measurements defines a volume (V) of sample substance. The sample container (2) has a first interface (G1) towards an environment (1) and a second interface (G2) towards the sample substance (3). A susceptibility jump at the second interface G2 is sufficiently large that the maximum value of |B′G2/B0| within the volume (V) is at least 0.5 ppm. The geometry of the sample container (2) is selected in such a fashion that, when a homogeneous magnetic field B0 has been applied, a location-dependent relative field change F is present in the volume (V), which is larger than 20 ppb at least at one point in a center partial volume (V1) and a first residual field (R1) in the center partial volume (V1) is smaller than 1.6 ppb. A second residual field (R2a) in the lower partial volume (V2a) is smaller than 30 ppb.
摘要翻译：用于NMR测量的样品容器（2）定义了样品物质的体积（V）。样品容器（2）具有朝向环境（1）的第一界面（G1）和朝向样品物质（3）的第二界面（G2）。在第二接口G2处的磁敏度跳跃足够大，使得| B'G2 / B0 |的最大值在体积（V）内至少为0.5ppm。选择样品容器（2）的几何形状，使得当已经施加均匀磁场B0时，位置相关的相对场变化F存在于体积（V）中，其大于20ppb 至少中心部分体积（V1）中的一点和中心部分体积（V1）中的第一残留场（R1）小于1.6ppb。较低部分体积（V2a）中的第二残留场（R2a）小于30ppb。

10. 发明授权

US07330031B2 Matrix shim system with grouped coils 有权
公开(公告)号：US07330031B2
公开(公告)日：2008-02-12
申请号：US11506799
申请日：2006-08-21
申请人： Thomas Speck , Werner Tschopp
发明人： Thomas Speck , Werner Tschopp
IPC分类号： G01V3/00
CPC分类号： G01R33/3875
摘要： A matrix shim system for generating magnetic field components superimposed on a main static magnetic field, comprising a plurality of annular coils, is characterized in that it comprises g groups G1 . . . Gg of coils, with g being a natural number ≧1, wherein each group Gi consists of at least two single annular coils connected in series, wherein each group Gi is designed to generate, in use, a magnetic field B z ⁡ ( G i ) = ∑ n = 0 ∞ ⁢ A n ⁢ ⁢ 0 ⁡ ( G i ) · T n ⁢ ⁢ 0 . For each group Gi, there are at least two values of n for which  A n ⁢ ⁢ 0 ⁡ ( G i ) · R n  max ⁢ {  A 20 ⁡ ( G i ) · R 2  , … ⁢ ,  A N ⁢ ⁢ 0 ⁡ ( G i ) · R N  } ≥ 0.5 ⁢ ⁢ and ⁢ ⁢ N ≥ n ≥ 2 , with N: the total number of current supplies of the matrix shim system, and R: smallest inside radius of any of the annular coils of the matrix shim system. An individual, adjustable electrical current supply is provided for each group Gi of coils. The inventive matrix shim system is both simple in design and stable against current fluctuations.

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