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1. 发明申请

US20120256632A1 NMR measuring configuration with optimized sample container geometry and method for calculating the shape of the sample container 有权
标题翻译： NMR测量配置，具有优化的样品容器几何形状和计算样品容器形状的方法
公开(公告)号：US20120256632A1
公开(公告)日：2012-10-11
申请号：US13417260
申请日：2012-03-11
申请人： Dirk Wilhelm , Thomas Speck , Oskar Schett
发明人： Dirk Wilhelm , Thomas Speck , Oskar Schett
IPC分类号： G01R33/30 , G06F17/10
CPC分类号： G01R33/30 , G01R33/56536
摘要： A sample container (2) for NMR measurements defines a volume (V) of sample substance. The sample container (2) has a first interface (G1) towards an environment (1) and a second interface (G2) towards the sample substance (3). A susceptibility jump at the second interface G2 is sufficiently large that the maximum value of |B′G2/B0| within the volume (V) is at least 0.5 ppm. The geometry of the sample container (2) is selected in such a fashion that, when a homogeneous magnetic field B0 has been applied, a location-dependent relative field change F is present in the volume (V), which is larger than 20 ppb at least at one point in a center partial volume (V1) and a first residual field (R1) in the center partial volume (V1) is smaller than 1.6 ppb. A second residual field (R2a) in the lower partial volume (V2a) is smaller than 30 ppb.
摘要翻译：用于NMR测量的样品容器（2）定义了样品物质的体积（V）。样品容器（2）具有朝向环境（1）的第一界面（G1）和朝向样品物质（3）的第二界面（G2）。在第二接口G2处的磁敏度跳跃足够大，使得| B'G2 / B0 |的最大值在体积（V）内至少为0.5ppm。选择样品容器（2）的几何形状，使得当已经施加均匀磁场B0时，位置相关的相对场变化F存在于体积（V）中，其大于20ppb 至少中心部分体积（V1）中的一点和中心部分体积（V1）中的第一残留场（R1）小于1.6ppb。较低部分体积（V2a）中的第二残留场（R2a）小于30ppb。

2. 发明授权

US08912796B2 NMR measuring configuration with optimized sample container geometry and method for calculating the shape of the sample container 有权
标题翻译： NMR测量配置，具有优化的样品容器几何形状和计算样品容器形状的方法
公开(公告)号：US08912796B2
公开(公告)日：2014-12-16
申请号：US13417260
申请日：2012-03-11
申请人： Dirk Wilhelm , Thomas Speck , Oskar Schett
发明人： Dirk Wilhelm , Thomas Speck , Oskar Schett
IPC分类号： G01R33/30 , G06F17/10 , G01R33/565
CPC分类号： G01R33/30 , G01R33/56536
摘要： A sample container (2) for NMR measurements defines a volume (V) of sample substance. The sample container (2) has a first interface (G1) towards an environment (1) and a second interface (G2) towards the sample substance (3). A susceptibility jump at the second interface G2 is sufficiently large that the maximum value of |B′G2/B0| within the volume (V) is at least 0.5 ppm. The geometry of the sample container (2) is selected in such a fashion that, when a homogeneous magnetic field B0 has been applied, a location-dependent relative field change F is present in the volume (V), which is larger than 20 ppb at least at one point in a center partial volume (V1) and a first residual field (R1) in the center partial volume (V1) is smaller than 1.6 ppb. A second residual field (R2a) in the lower partial volume (V2a) is smaller than 30 ppb.
摘要翻译：用于NMR测量的样品容器（2）定义了样品物质的体积（V）。样品容器（2）具有朝向环境（1）的第一界面（G1）和朝向样品物质（3）的第二界面（G2）。在第二接口G2处的磁敏度跳跃足够大，使得| B'G2 / B0 |的最大值在体积（V）内至少为0.5ppm。选择样品容器（2）的几何形状，使得当已经施加均匀磁场B0时，位置相关的相对场变化F存在于体积（V）中，其大于20ppb 至少中心部分体积（V1）中的一点和中心部分体积（V1）中的第一残留场（R1）小于1.6ppb。较低部分体积（V2a）中的第二残留场（R2a）小于30ppb。

3. 发明授权

US08250020B2 Method and system for automated analysis of nuclear magnetic resonance spectra 有权
标题翻译：核磁共振谱自动分析方法与系统
公开(公告)号：US08250020B2
公开(公告)日：2012-08-21
申请号：US12461834
申请日：2009-08-26
申请人： Jiwen Li , Abraham Bernstein , Bjoern Heitmann , Michael Fey , Till Kuehn , Sandra Loss , James Masse , Konstantin Pervushin , Oskar Schett
发明人： Jiwen Li , Abraham Bernstein , Bjoern Heitmann , Michael Fey , Till Kuehn , Sandra Loss , James Masse , Konstantin Pervushin , Oskar Schett
IPC分类号： G06N5/00
CPC分类号： G01R33/4625 , G01N24/087 , G01R33/5608 , G06F19/703 , G06F19/707 , G06N5/046
摘要： A fully automatic, parameter free MR interpretation system is based on human logic emulation. Information is derived mainly from an MR spectrum with maximum confidence and in a similar way as a human expert. This is achieved by the combination of different expert systems that interpret certain MR spectral features as well as features from a proposed structure. The expert systems are dynamically linked to each other and the analysis is performed iteratively in all directions in a way that the expert systems can utilize all of the interpretations of all expert systems at all times. The expert system may generate not just a single result but rather lists of probability weighted hypotheses.
摘要翻译：全自动，无参数的MR解释系统基于人为逻辑仿真。信息主要来自具有最大信度的MR谱，与人类专家类似。这是通过解释某些MR谱特征以及来自所提出的结构的特征的不同专家系统的组合来实现的。专家系统彼此动态链接，并且分析在所有方向上迭代地执行，专家系统可以始终利用所有专家系统的所有解释。专家系统不仅可以产生单一的结果，而且可能产生概率加权假说的列表。

4. 发明授权

US06204665B1 NMR probe head with integrated remote tuning 有权
标题翻译： NMR探头与集成远程调谐
公开(公告)号：US06204665B1
公开(公告)日：2001-03-20
申请号：US09161298
申请日：1998-09-28
申请人： René Triebe , Jürg Fenner , Oskar Schett
发明人： René Triebe , Jürg Fenner , Oskar Schett
IPC分类号： G01R3320
CPC分类号： G01R33/28 , G01R33/3628
摘要： A nuclear magnetic resonance (NMR) spectrometer probe head having one or more drive units, one or more transmission units and one or more drive shafts which are coupled to adjustment rods and a means for directly mounting and fastening the drive unit, transmission unit, and drive shaft to the lower portion of the probe head during operation of the NMR spectrometer, which increases user comfort and freedom of motion below the magnet. The probe head also having an actuator for remote control adjustment of electrical and/or mechanical units, e.g. trimmer capacitors, variable resistors, and adjustable inductors within the probe head. The probe head is characterized in that the amount of space needed for the actuator is minimized, access to the region below the magnet is optimized, and installation of the actuator is simplified because the actuator is an integral part of the NMR-probe head within an NMR-spectrometer.
摘要翻译：具有一个或多个驱动单元，一个或多个传动单元和连接到调节杆的一个或多个驱动轴的核磁共振（NMR）光谱仪探针头和用于直接安装和紧固驱动单元，传动单元和在NMR光谱仪的操作期间驱动轴到探头的下部，这增加了使用者在磁体下方的舒适性和运动自由度。探头还具有用于电气和/或机械单元的远程控制调节的致动器。微调电容器，可变电阻器和探头内的可调电感器。探头的特征在于致动器所需的空间量被最小化，对磁体下方区域的访问被优化，并且致动器的安装被简化，因为致动器是NMR探针头内部的一部分 NMR光谱仪。

5. 发明申请

US20100063955A1 Method and system for automated analysis of nuclear magnetic resonance spectra 有权
标题翻译：核磁共振谱自动分析方法与系统
公开(公告)号：US20100063955A1
公开(公告)日：2010-03-11
申请号：US12461834
申请日：2009-08-26
申请人： Jiwen Li , Abraham Bernstein , Bjoern Heitmann , Michael Fey , Till Kuehn , Sandra Loss , James Masse , Konstantin Pervushin , Oskar Schett
发明人： Jiwen Li , Abraham Bernstein , Bjoern Heitmann , Michael Fey , Till Kuehn , Sandra Loss , James Masse , Konstantin Pervushin , Oskar Schett
IPC分类号： G06N5/02
CPC分类号： G01R33/4625 , G01N24/087 , G01R33/5608 , G06F19/703 , G06F19/707 , G06N5/046
摘要： A fully automatic, parameter free MR interpretation system is based on human logic emulation. Information is derived mainly from an MR spectrum with maximum confidence and in a similar way as a human expert. This is achieved by the combination of different expert systems that interpret certain MR spectral features as well as features from a proposed structure. The expert systems are dynamically linked to each other and the analysis is performed iteratively in all directions in a way that the expert systems can utilize all of the interpretations of all expert systems at all times. The expert system may generate not just a single result but rather lists of probability weighted hypotheses.
摘要翻译：全自动，无参数的MR解释系统基于人体逻辑仿真。信息主要来自具有最大信度的MR谱，与人类专家类似。这是通过解释某些MR谱特征以及来自所提出的结构的特征的不同专家系统的组合来实现的。专家系统彼此动态链接，并且分析在所有方向上迭代地执行，专家系统可以始终利用所有专家系统的所有解释。专家系统不仅可以产生单一的结果，而且可能产生概率加权假说的列表。

6. 发明授权

US07222490B2 NMR spectrometer with refrigerator cooling 有权
标题翻译： NMR光谱仪带冰箱冷却
公开(公告)号：US07222490B2
公开(公告)日：2007-05-29
申请号：US11236555
申请日：2005-09-28
申请人： René Triebe , Daniel Marek , Oskar Schett , Daniel Guy Baumann
发明人： René Triebe , Daniel Marek , Oskar Schett , Daniel Guy Baumann
IPC分类号： F25B9/00
CPC分类号： F25D19/006 , F25B9/10 , G01R33/34023 , G01R33/34092 , G01R33/3804
摘要： An NMR spectrometer comprising an NMR magnet system (27) disposed in a helium tank of a cryostat and an NMR probe head (11) disposed in a room temperature bore of the cryostat, which contains a cooled RF resonator (9) for receiving NMR signals from a sample to be investigated, and a cooled pre-amplifier (10), wherein the NMR probe head (11) is cooled by a common multi-stage compressor-operated refrigerator (2), wherein the refrigerator (2) comprises a cold head and several heat exchangers (5, 6) at different temperature levels, wherein the refrigerator (2) is disposed at a spatial separation from the cryostat in a separate, evacuated and thermally insulated housing (1) and wherein at least one cooling circuit with cooling lines, which are thermally insulated by a transfer line (13, 14) is disposed between the housing (1) containing the heat exchangers (5, 6) and the NMR probe head (11), is characterized in that additional cooling lines to an LN2 tank (18) or radiation shield (21) disposed in the cryostat and surrounding the helium tank are provided, and the refrigerator (2) also cools the LN2 tank (18) or the radiation shield (21). The inventive NMR spectrometer comprises a simple and inexpensive device for matching the holding time of LN2 to that of LHe through cooling the LN2 tank using the refrigerator provided for cooling the NMR probe head and without great expense.
摘要翻译：一种NMR光谱仪，其包括设置在低温恒温器的氦气罐中的NMR磁体系统（27）和设置在低温恒温器的室温孔中的NMR探头（11），其包含用于接收NMR信号的冷却的RF谐振器（9）来自待研究的样品和冷却的前置放大器（10），其中NMR探针头（11）由公共的多级压缩机操作的冰箱（2）冷却，其中冰箱（2）包括冷头部和多个热交换器（5,6），其中所述冰箱（2）在分开的抽真空和隔热的壳体（1）中与所述低温恒温器空间间隔地设置，并且其中至少一个冷却回路具有在包含热交换器（5,6）和NMR探头（11）的壳体（1）之间设置由传输管线（13,14）进行绝热的冷却管线，其特征在于，附加的冷却管线一个LN 2＆lt; 2＆gt; t 提供设置在低温恒温器中并围绕氦气箱的散热片（18）或辐射屏蔽（21），并且冰箱（2）还冷却LN 2 2（18）或辐射屏蔽（21））。本发明的NMR光谱仪包括一种简单且便宜的装置，用于通过使用用于冷却NMR的冷藏器来冷却LN 2 2罐，使LN 2的保持时间与LHe的保持时间相匹配探头不费大费。

7. 发明授权

US5192910A Temperature-control device for samples 失效
标题翻译：样品温度控制装置
公开(公告)号：US5192910A
公开(公告)日：1993-03-09
申请号：US715107
申请日：1991-06-10
申请人： Phillip Hepp , Werner H. Tschopp , Martin Rindlisbacher , Oskar Schett
发明人： Phillip Hepp , Werner H. Tschopp , Martin Rindlisbacher , Oskar Schett
IPC分类号： G01R33/32 , B01L7/00 , G01R33/31
CPC分类号： G01R33/307 , B01L7/00 , G01R33/31
摘要： In a temperature-control device for samples, in particular for NMR spectroscopy, comprising a vessel (20) provided with an opening (19) for receiving a measuring sample (1), an inlet opening (10) for introduction of the fluid, an outlet opening (15) for the outflow of the fluid and a flow channel (18) through which at least a partial flow of the fluid is guided past the sample (1), as direct fluid flow, from the bottom to the top, there is provided at least one by-pass channel (17) which is arranged in such a way that an additional partial fluid flow can be guided past the upper area of the said sample (1) in the form of a by-pass fluid flow (7). This enables also the upper area of the sample (1) to be temperature-controlled in an efficient way so as to minimize the temperature gradient in the sample (1). The temperature-control device may comprise, in the upper area of the sample (1), a heat-exchanger system (14) which concentrates the direct fluid flow ( 8), after it has been combined with the by-pass fluid flow (8), around the sample (1). One achieves in this manner efficient temperature control of the upper section of the sample by the fluid flow, without any disturbing thermal obstacles.
摘要翻译：在用于样品的温度控制装置中，特别是用于NMR光谱，包括容器（20），其设置有用于接收测量样品（1）的开口（19），用于引入流体的入口（10）用于流体流出的出口开口（15）和流动通道（18），流体的至少部分流动通过所述流动通道（18）从所述底部到顶部被引导通过样品（1）作为直接流体流动设置有至少一个旁通通道（17），其被布置成使得附加的部分流体流可以以旁路流体流的形式被引导通过所述样品（1）的上部区域 7）。这也使得样品（1）的上部区域能够以有效的方式进行温度控制，以使样品（1）中的温度梯度最小化。温度控制装置可以在样品（1）的上部区域中包括热交换器系统（14），其在直接流体流（8）已经与旁路流体流（ 8），样品（1）周围。以这种方式实现了通过流体流动对样品的上部部分进行有效的温度控制，而没有任何干扰的热障碍物。

8. 发明申请

US20120242335A1 Cryogenic probehead cooler in a nuclear magnetic resonance apparatus 有权
标题翻译：核磁共振装置中的低温探针头冷却器
公开(公告)号：US20120242335A1
公开(公告)日：2012-09-27
申请号：US13407819
申请日：2012-02-29
申请人： Oskar Schett , Daniel Guy Baumann , Marc Schnell , Cengiz Cetrefli , Daniel Marek , Klemens Kessler , Philippe Stauffenegger
发明人： Oskar Schett , Daniel Guy Baumann , Marc Schnell , Cengiz Cetrefli , Daniel Marek , Klemens Kessler , Philippe Stauffenegger
IPC分类号： G01R33/31
CPC分类号： G01R33/3403
摘要： An NMR (nuclear magnetic resonance) apparatus has a magnet system disposed in a cryostat (1), the cryostat having at least one nitrogen tank (3b) for receiving liquid nitrogen (5b) and a room temperature bore (7) for receiving an NMR probehead (8), wherein part(s) of the probehead or the overall probehead can be cooled to cryogenic temperatures by supplying liquid nitrogen (5b) via a supply line (14). The nitrogen tank (3b) of the cryostat (1) is connected to the NMR probehead (8) by means of a supply line (14) in such a fashion that liquid nitrogen (5b) is removed from the nitrogen tank (3b) and guided to the NMR probehead (8). The overall apparatus is therefore more compact, the operating comfort of the apparatus is increased, and the costs for acquisition, operation and maintenance are considerably reduced compared to previous comparable devices.
摘要翻译： NMR（核磁共振）装置具有设置在低温恒温器（1）中的磁体系统，低温恒温器具有用于接收液氮的至少一个氮气罐（3b）和用于接收NMR的室温孔（7）探头（8），其中通过经由供应管线（14）供应液氮（5b），探针头或整个探针头的部分可被冷却至低温。低温恒温器（1）的氮气罐（3b）借助于供应管线（14）与NMR探针头（8）连接，使氮气（5b）从氮气罐（3b）中取出，引导到NMR探针头（8）。因此，整体装置更紧凑，装置的操作舒适性增加，并且与先前的可比装置相比，采集，操作和维护的成本大大降低。

9. 发明申请

US20100156422A1 Automated transport device for NMR measuring samples, cryo-magnetic system with automated transport device, transport container for an automated transport device and method for conveying an NMR measuring sample 有权
标题翻译：用于NMR测量样品的自动运送装置，具有自动运输装置的冷冻磁系统，用于自动运输装置的运输容器和用于输送NMR测量样品的方法
公开(公告)号：US20100156422A1
公开(公告)日：2010-06-24
申请号：US12637791
申请日：2009-12-15
申请人： Jonathan de Vries , Daniel Guy Baumann , Oskar Schett , Werner Maas
发明人： Jonathan de Vries , Daniel Guy Baumann , Oskar Schett , Werner Maas
IPC分类号： G01R33/30 , G01N24/08
CPC分类号： G01R33/307
摘要： A transport device for conveying an object to be transported (18) between an input point (A) and a supply point (Z), where the object to be transported (18) can be supplied to an RT tube (4) of a cryostat (1), wherein the input point (A) is both horizontally and also vertically spaced apart from the supply point (Z), wherein a transport tube (14) is provided for pneumatically conveying the object to be transported within the transport tube (14) from a first transfer point (B) to a second transfer point (C), is characterized in that the transport tube (14) is vertically arranged, a first transport container (TB1) and a second transport container (TB2) are provided for receiving the object to be transported (18), a first transfer device is disposed between the input point (A) and the first transfer point (B), and a second transfer device is provided between the second transfer point (C) and the supply point (Z).
摘要翻译：一种用于在输入点（A）和供给点（Z）之间输送待运输物体（18）的输送装置，其中待运送物体（18）可被供给到低温恒温器的RT管（4）（1），其中所述输入点（A）水平地并且还与所述供应点（Z）垂直间隔开，其中设置有输送管（14），用于在所述输送管（14）内气动输送待运输的物体）从第一转印点（B）到第二转印点（C）的特征在于，输送管（14）垂直布置，设置有第一输送容器（TB1）和第二输送容器（TB2）接收待运送物体（18），第一传送装置设置在输入点（A）和第一传送点（B）之间，第二传送装置设置在第二传送点（C）和电源点（Z）。

10. 发明申请

US20070128086A1 Reduction in eddy current losses in electrically conducting sample materials with the assistance of special NMR sample tubes 有权
标题翻译：借助特殊的NMR样品管，减少导电样品中的涡流损耗
公开(公告)号：US20070128086A1
公开(公告)日：2007-06-07
申请号：US11603882
申请日：2006-11-24
申请人： Philippe Stauffenegger , Oskar Schett
发明人： Philippe Stauffenegger , Oskar Schett
IPC分类号： B01L3/00
CPC分类号： G01R33/30 , B01L3/5082 , B01L2300/0858
摘要： A sample tube for an NMR probe head, which extends along a z axis and has an internal cavity that extends in an axial direction of the z axis, is open to the outside at the axially upper end, is closed at the axially lower end and contains a liquid NMR sample substance during operation, wherein the cross-sectional surface of this cavity extending perpendicularly to the z axis and parallel to the xy coordinate plane has an elongated shape in the direction of the x axis with maximum dimensions a in the y direction and b in the x direction, wherein a
摘要翻译：用于NMR探针头的样品管沿着z轴延伸并且具有在z轴的轴向方向上延伸的内腔，在轴向上端处向外部开口，在轴向下端处封闭，并且包含在操作期间的液体NMR样品物质，其中该空腔的垂直于z轴延伸并且平行于xy坐标平面的横截面在x轴的方向上具有细长形状，并且在y方向具有最大尺寸a， b在x方向上，其中a

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