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1. 发明授权

US5411526A Improved implantable defibrillator system for producing true-voltage-pulse waveforms 失效
标题翻译：改进的植入式除颤器系统，用于产生真正的电压脉冲波形
公开(公告)号：US5411526A
公开(公告)日：1995-05-02
申请号：US856733
申请日：1992-03-24
申请人： Mark W. Kroll , Charles G. Supino , Theodore P. Adams , Dennis A. Brumwell
发明人： Mark W. Kroll , Charles G. Supino , Theodore P. Adams , Dennis A. Brumwell
IPC分类号： A61N1/39 , A61N1/00
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912
摘要： The first embodiment of the present invention repositions the shunt thyristor used in the monophasic-waveform generator of the prior art so that it discharges the main capacitor through a series thyristor, thus increasing current through it briefly, rather than reducing current through it. The result of this arrangement is that the node between the series thyristor and the heart is pulled rapidly to a low voltage, causing the shunt switch to discharge the cardiac capacitance, as well as the main capacitance. The consequence is that discharging the cardiac capacitance requires a reversal of current in the heart, which enhances the heart-stimulating effect of the defibrillating waveform. The resulting true-voltage-pulse waveform has an efficacy approximating that of a biphasic waveform and is achieved with a circuit no more complex than that used to generate a monophasic waveform. A second and alternative embodiment of the present invention is a defibrillation system comprising a switching-bridge circuit, augmented by a zener diode and a rectifier diode, that is capable of delivering on demand any one of the waveforms known as monophasic, biphasic, and true-voltage-pulse waveforms.
摘要翻译：本发明的第一实施例重新使用现有技术的单相波形发生器中使用的分流晶闸管，使得其通过串联晶闸管放电主电容器，从而短暂地增加电流，而不是减少通过其的电流。这种安排的结果是串联晶闸管和心脏之间的节点被迅速拉到低电压，导致并联开关放电心电容以及主电容。结果是，放电心脏电容需要心脏中的电流反转，这增强了除颤波形的心脏刺激作用。所得到的真实电压脉冲波形的效果近似于双相波形，并且通过不比用于产生单相波形的电路更复杂的电路来实现。本发明的第二和替代实施例是一种除颤系统，其包括由齐纳二极管和整流二极管增强的开关桥式电路，其能够根据需要输送任何一种已知为单相，双相和真实的波形电压脉冲波形。

2. 再颁专利

USRE38777E1 Dual battery power system for an implantable cardioverter defibrillator with voltage booster 失效
标题翻译：双电池电源系统，用于具有升压器的可植入式心律转复除颤器
公开(公告)号：USRE38777E1
公开(公告)日：2005-08-16
申请号：US08766634
申请日：1996-12-13
申请人： Theodore P. Adams , Dennis A. Brumwell , Joseph S. Perttu , Charles G. Supino
发明人： Theodore P. Adams , Dennis A. Brumwell , Joseph S. Perttu , Charles G. Supino
IPC分类号： A61N1/39
摘要： An improved dual battery power system uses two separate battery power sources for an implantable cardioverter defibrillator, each having optimized characteristics for monitoring functions and for output energy delivery functions, respectively. The monitoring functions are supplied electrical power by a first battery source, such as a conventional pacemaker power source in the form of a lithium iodide battery which is optimized for long life at very low current levels. The output energy delivery functions are supplied by a separate second battery source, such as a pair of lithium vanadium pentoxide batteries, which is optimized for high current drain capability and low self-discharge for long shelf life. The first battery source provides electrical power only to the monitoring functions of the implantable cardioverter defibrillator, and the second battery source provides all of the electrical power for the output energy delivery functions.
摘要翻译：改进的双电池电力系统使用两个单独的电池电源用于可植入式心律转复除颤器，每个除颤器分别具有用于监测功能和输出能量传递功能的优化特性。监测功能由第一电池源提供电力，例如碘化锂电池形式的常规起搏器电源，其以非常低的电流水平被优化用于长寿命。输出能量传递功能由单独的第二电池源提供，例如一对锂五氧化二钒电池，其针对高电流漏极能力和低自放电优化以保持长期保存期限。第一电池源仅向可植入式心律转复除颤器的监视功能提供电力，并且第二电池源为输出能量传递功能提供所有电力。

3. 发明授权

US5372605A Dual battery power system for an implantable cardioverter defibrillator 失效
标题翻译：用于植入式心律转复除颤器的双电池电源系统
公开(公告)号：US5372605A
公开(公告)日：1994-12-13
申请号：US108130
申请日：1993-08-16
申请人： Theodore P. Adams , Dennis A. Brumwell , Joseph S. Perttu , Charles G. Supino
发明人： Theodore P. Adams , Dennis A. Brumwell , Joseph S. Perttu , Charles G. Supino
IPC分类号： A61N1/378 , A61N1/39 , H01M2/10 , H01M6/50 , H01M16/00
CPC分类号： A61N1/3975 , A61N1/3787 , A61N1/3931 , A61N1/3956 , H01M16/00 , H01M2/1066 , H01M6/5016
摘要： An improved dual battery power system uses two separate battery power sources for an implantable cardioverter defibrillator, each having optimized characteristics for monitoring functions and for output energy delivery functions, respectively. The monitoring functions are supplied electrical power by a first battery source, such as a conventional pacemaker power source in the form of a lithium iodide battery which is optimized for long life at very low current levels. The output energy delivery functions are supplied by a separate second battery source, such as a pair of lithium vanadium pentoxide batteries, which is optimized for high current drain capability and low self-discharge for long shelf life. The first battery source provides electrical power only to the monitoring functions of the implantable cardioverter defibrillator, and the second battery source provides all of the electrical power for the output energy delivery functions.
摘要翻译：改进的双电池电力系统使用两个单独的电池电源用于可植入式心律转复除颤器，每个除颤器分别具有用于监测功能和输出能量传递功能的优化特性。监测功能由第一电池源提供电力，例如碘化锂电池形式的常规起搏器电源，其以非常低的电流水平被优化用于长寿命。输出能量传递功能由单独的第二电池源提供，例如一对锂五氧化二钒电池，其针对高电流漏极能力和低自放电优化以保持长期保存期限。第一电池源仅向可植入式心律转复除颤器的监视功能提供电力，并且第二电池源为输出能量传递功能提供所有电力。

4. 发明授权

US5507781A Implantable defibrillator system with capacitor switching circuitry 失效
标题翻译：具有电容开关电路的可植入除颤器系统
公开(公告)号：US5507781A
公开(公告)日：1996-04-16
申请号：US292354
申请日：1994-08-18
申请人： Mark W. Kroll , Theodore P. Adams , Dennis A. Brumwell
发明人： Mark W. Kroll , Theodore P. Adams , Dennis A. Brumwell
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912
摘要： The present invention uses switches to set the topology and polarity of a circuit that includes capacitors to deliver an electric pulse to a heart during a defibrillation procedure. The waveform of the electric pulse is biphasic, in that it is a positive portion of the pulse followed by a negative portion of the pulse. The topology and polarity of the circuit are utilized to produce a waveform that approximates the ideal waveform for the specific situation. The circuit provides for combinations of capacitors variously in series and in parallel and changing the topology and polarity of the circuit during discharge of the capacitors.
摘要翻译：本发明使用开关来设置包括电容器的电路的拓扑和极性，以在除颤过程期间将电脉冲输送到心脏。电脉冲的波形是双相的，因为它是脉冲的正部分，后面是脉冲的负部分。电路的拓扑结构和极性被用于产生一个近似于特定情况的理想波形的波形。该电路提供串联和并联的电容器的组合，并且在电容器放电期间改变电路的拓扑和极性。

5. 发明授权

US5620464A System and method for delivering multiple closely spaced defibrillation pulses 失效
标题翻译：用于递送多个紧密间隔的除颤脉冲的系统和方法
公开(公告)号：US5620464A
公开(公告)日：1997-04-15
申请号：US376353
申请日：1995-01-23
申请人： Mark W. Kroll , Dennis A. Brumwell , Ann M. Donohoo
发明人： Mark W. Kroll , Dennis A. Brumwell , Ann M. Donohoo
IPC分类号： A61N1/39 , H01M2/10 , H01M16/00
CPC分类号： H01M16/00 , A61N1/3956 , A61N1/3906 , A61N1/3912 , A61N1/3975 , H01M2/1066
摘要： A main energy delivery electrical circuit for use in an implantable cardioverter defibrillator device comprises a low power output primary defibrillator battery, a high power output intermediate power intensifying capacitor system, a switch for permitting the intermediate power intensifying capacitor system to rapidly charge a main energy delivery capacitor, and a main energy delivery capacitor. The main energy delivery capacitor is configured for discharging, in a first pulse, an electrical charge derived from the primary battery, and for discharging certain subsequent pulses of electrical charge derived from the intermediate power intensifying capacitor system. The circuit permits the implantable cardioverter defibrillator device to deliver multiple closely spaced defibrillation pulses to a heart.
摘要翻译：用于植入式心律转复除颤器装置的主能量输送电路包括低功率输出初级除颤器电池，高功率输出中间功率增强电容器系统，用于允许中间功率增强电容器系统快速充电主能量输送的开关电容器和主能量输送电容器。主能量输送电容器被配置为在第一脉冲中放电源自一次电池的电荷，并且用于放出从中间功率增强电容器系统导出的某些后续的电荷脉冲。电路允许植入式心律转复除颤器装置向心脏递送多个紧密间隔的除颤脉冲。

6. 发明授权

US5709215A R-wave detection method for implantable cardioverter defibrillators 失效
标题翻译：用于植入式心律转复除颤器的R波检测方法
公开(公告)号：US5709215A
公开(公告)日：1998-01-20
申请号：US524391
申请日：1995-09-06
申请人： Joseph S. Perttu , Dennis A. Brumwell , James E. Brewer , Theodore P. Adams
发明人： Joseph S. Perttu , Dennis A. Brumwell , James E. Brewer , Theodore P. Adams
IPC分类号： A61B5/0456 , A61N1/39
CPC分类号： A61B5/0456 , A61B5/7207 , A61N1/3931
摘要： An ICD detection method for sensing the occurrence of an R-wave improves the ability to distinguish R-waves from noise through the use of variable declining sensitivity thresholds. The method includes the consideration of the amplitude of at least the previous most recent R-wave to determine a declining threshold of sensitivity used to recognize a subsequent electrical signal as an R-wave. In the method, the amplitude of the previous R-wave may be classified, based upon amplitude, and based upon the classification, a desirable time constant for the declining threshold of sensitivity is provided as an exponential or reverse exponential decay. Alternatively, a piece wise use of various decay formulas may be combined and used to avoid false recognition of noise as an R-wave.
摘要翻译：用于感测R波的发生的ICD检测方法通过使用可变下降的灵敏度阈值来提高区分R波与噪声的能力。该方法包括考虑至少先前最近的R波的振幅，以确定用于将后续电信号识别为R波的灵敏度下降阈值。在该方法中，先前R波的振幅可以基于振幅进行分类，并且基于分类，灵敏度下降阈值的期望时间常数被提供为指数或反指数衰减。或者，可以组合并且使用各种衰减公式的分段使用来避免作为R波的噪声的错误识别。

7. 发明授权

US5749910A Shield for implantable cardioverter defibrillator 失效
标题翻译：用于植入式心律转复除颤器的护盾
公开(公告)号：US5749910A
公开(公告)日：1998-05-12
申请号：US486759
申请日：1995-06-07
申请人： Dennis A. Brumwell , Joseph S. Perttu , Mark W. Kroll , Randall S. Nelson
发明人： Dennis A. Brumwell , Joseph S. Perttu , Mark W. Kroll , Randall S. Nelson
IPC分类号： A61N1/375 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/375 , A61N1/3758
摘要： An implantable cardioverter defibrillator capable of subcutaneous positioning within a patient delivers at least one electrical cardioversion/defibrillation countershocks to the heart of the patient. The implantable cardioverter defibrillator includes a housing, circuitry positioned within the housing to control delivery of the countershocks, and an energy source coupled with the circuitry to provide electrical energy to a capacitor in the circuitry that stores the electrical energy for delivery of the countershocks. Because the circuitry is susceptible to undesirable electromagnetic coupling effects of origin external to the circuitry, particularly the capacitive coupling effects between the circuitry and the housing of the device when at least a portion of the housing is utilized as an electrode, the implantable cardioverter defibrillator also includes a conductive shield, disposed between the housing and the circuitry, to shield the circuitry against such undesired coupling effects.
摘要翻译：能够在患者体内皮下定位的植入式心律转复除颤器将至少一个电复律/去颤颤颤抗原递送至患者的心脏。植入式心律转复除颤器包括壳体，位于壳体内的电路，用于控制反射的传送，以及与该电路耦合的能量源，以将电能提供给电路中的电容器，该电路存储用于递送该反射的电能。因为当至少一部分壳体被用作电极时，电路容易受到电路外部原点的不期望的电磁耦合影响，特别是电路和器件壳体之间的电容耦合效应，所以可植入的心律转复除颤器也包括设置在外壳和电路之间的导电屏蔽，以屏蔽电路免受这种不期望的耦合影响。

8. 发明授权

US5674248A Staged energy concentration for an implantable biomedical device 失效
标题翻译：植入式生物医学装置的分阶段能量集中
公开(公告)号：US5674248A
公开(公告)日：1997-10-07
申请号：US486760
申请日：1995-06-07
申请人： Mark W. Kroll , Dennis A. Brumwell , Ann M. Donohoo
发明人： Mark W. Kroll , Dennis A. Brumwell , Ann M. Donohoo
IPC分类号： A61N1/39
CPC分类号： H01M16/00 , A61N1/3956 , H01M10/052 , H01M10/425 , H01M6/16 , A61N1/3912 , A61N1/3975
摘要： A staged energy storage system provides electrical energy to an implantable biomedical device by using the combination of a first stage energy source and a second stage energy concentration system. The second stage energy concentration system allows a lower density and/or lower voltage energy source to be used as the first stage energy source, thereby decreasing the battery cost, size and weight. In one embodiment, the second stage energy concentration system comprises a rechargeable battery. In another embodiment, the second stage energy capacitor system comprises a high energy density capacitor system. The staged energy storage system is ideal for internally charging a pulse-generating capacitor system within an implantable cardioverter defibrillator. In this embodiment, a high voltage transformer has a secondary side that is electrically connected to the pulse-generating capacitor system. A second stage concentration system is electrically connected between a first stage energy source and a primary side of the high voltage transformer to store at least a portion of an electrical charge that is delivered from the first stage energy source and to the high voltage transformer.
摘要翻译：分阶段能量存储系统通过使用第一级能量源和第二级能量集中系统的组合向可植入的生物医学装置提供电能。第二级能量集中系统允许将较低密度和/或较低电压能量源用作第一级能量源，从而降低电池成本，尺寸和重量。在一个实施例中，第二级能量集中系统包括可充电电池。在另一实施例中，第二级能量电容器系统包括高能量密度电容器系统。分级储能系统非常适用于在植入式心律转复除颤器内进行脉冲发生电容系统的内部充电。在本实施例中，高压变压器具有与脉冲发生电容器系统电连接的次级侧。第二级集中系统电连接在高压变压器的第一级能量源和初级侧之间，以存储从第一级能源和高电压变压器传送的电荷的至少一部分。

9. 发明授权

US4428378A Rate adaptive pacer 失效
标题翻译：速率自适应起搏器
公开(公告)号：US4428378A
公开(公告)日：1984-01-31
申请号：US322815
申请日：1981-11-19
申请人： Kenneth M. Anderson , Dennis A. Brumwell
发明人： Kenneth M. Anderson , Dennis A. Brumwell
IPC分类号： A61B5/11 , A61N1/365 , A61N1/372 , A61N1/36
CPC分类号： A61N1/36542 , A61B5/1118 , A61B5/721 , A61N1/37252
摘要： An activity sensor mounted within the pacer detects the general activity level of the patient and alters the escape interval of the pacer between a preset minimum and maximum in response to the detected activity level of the patient.
摘要翻译：安装在起搏器内的活动传感器检测患者的一般活动水平，并响应于检测到的患者的活动水平，改变起搏器在预设最小和最大值之间的逃脱间隔。

10. 发明授权

US06898463B2 Current monitor for an implantable medical device 有权
标题翻译：可植入医疗器械的电流监视器
公开(公告)号：US06898463B2
公开(公告)日：2005-05-24
申请号：US10102076
申请日：2002-03-19
申请人： Frank R. Dropps , Dennis A. Brumwell
发明人： Frank R. Dropps , Dennis A. Brumwell
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3706 , A61N1/3925
摘要： A method and an apparatus for performing a device component failure analysis in an implantable medical device using current consumption data. A current consumption signal relating to current consumption in an implantable medical device is generated. The current consumption signal is then processed. A defect of a component in the implantable medical device is assessed in response to the processing of the current consumption signal and appropriate action is taken, such as selecting alternate therapies, generating an alert signal, and turning off circuits corresponding to the assessed defect.
摘要翻译：一种使用电流消耗数据在可植入医疗装置中执行装置部件故障分析的方法和装置。产生与植入式医疗装置中的电流消耗相关的电流消耗信号。然后处理电流消耗信号。响应于电流消耗信号的处理来评估可植入医疗装置中的部件的缺陷，并采取适当的动作，例如选择替代治疗，产生警报信号，以及关闭对应于所评估的缺陷的电路。

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