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1. 发明授权

US06898463B2 Current monitor for an implantable medical device 有权
标题翻译：可植入医疗器械的电流监视器
公开(公告)号：US06898463B2
公开(公告)日：2005-05-24
申请号：US10102076
申请日：2002-03-19
申请人： Frank R. Dropps , Dennis A. Brumwell
发明人： Frank R. Dropps , Dennis A. Brumwell
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3706 , A61N1/3925
摘要： A method and an apparatus for performing a device component failure analysis in an implantable medical device using current consumption data. A current consumption signal relating to current consumption in an implantable medical device is generated. The current consumption signal is then processed. A defect of a component in the implantable medical device is assessed in response to the processing of the current consumption signal and appropriate action is taken, such as selecting alternate therapies, generating an alert signal, and turning off circuits corresponding to the assessed defect.
摘要翻译：一种使用电流消耗数据在可植入医疗装置中执行装置部件故障分析的方法和装置。产生与植入式医疗装置中的电流消耗相关的电流消耗信号。然后处理电流消耗信号。响应于电流消耗信号的处理来评估可植入医疗装置中的部件的缺陷，并采取适当的动作，例如选择替代治疗，产生警报信号，以及关闭对应于所评估的缺陷的电路。

2. 发明授权

US4428378A Rate adaptive pacer 失效
标题翻译：速率自适应起搏器
公开(公告)号：US4428378A
公开(公告)日：1984-01-31
申请号：US322815
申请日：1981-11-19
申请人： Kenneth M. Anderson , Dennis A. Brumwell
发明人： Kenneth M. Anderson , Dennis A. Brumwell
IPC分类号： A61B5/11 , A61N1/365 , A61N1/372 , A61N1/36
CPC分类号： A61N1/36542 , A61B5/1118 , A61B5/721 , A61N1/37252
摘要： An activity sensor mounted within the pacer detects the general activity level of the patient and alters the escape interval of the pacer between a preset minimum and maximum in response to the detected activity level of the patient.
摘要翻译：安装在起搏器内的活动传感器检测患者的一般活动水平，并响应于检测到的患者的活动水平，改变起搏器在预设最小和最大值之间的逃脱间隔。

3. 发明授权

US5620464A System and method for delivering multiple closely spaced defibrillation pulses 失效
标题翻译：用于递送多个紧密间隔的除颤脉冲的系统和方法
公开(公告)号：US5620464A
公开(公告)日：1997-04-15
申请号：US376353
申请日：1995-01-23
申请人： Mark W. Kroll , Dennis A. Brumwell , Ann M. Donohoo
发明人： Mark W. Kroll , Dennis A. Brumwell , Ann M. Donohoo
IPC分类号： A61N1/39 , H01M2/10 , H01M16/00
CPC分类号： H01M16/00 , A61N1/3956 , A61N1/3906 , A61N1/3912 , A61N1/3975 , H01M2/1066
摘要： A main energy delivery electrical circuit for use in an implantable cardioverter defibrillator device comprises a low power output primary defibrillator battery, a high power output intermediate power intensifying capacitor system, a switch for permitting the intermediate power intensifying capacitor system to rapidly charge a main energy delivery capacitor, and a main energy delivery capacitor. The main energy delivery capacitor is configured for discharging, in a first pulse, an electrical charge derived from the primary battery, and for discharging certain subsequent pulses of electrical charge derived from the intermediate power intensifying capacitor system. The circuit permits the implantable cardioverter defibrillator device to deliver multiple closely spaced defibrillation pulses to a heart.
摘要翻译：用于植入式心律转复除颤器装置的主能量输送电路包括低功率输出初级除颤器电池，高功率输出中间功率增强电容器系统，用于允许中间功率增强电容器系统快速充电主能量输送的开关电容器和主能量输送电容器。主能量输送电容器被配置为在第一脉冲中放电源自一次电池的电荷，并且用于放出从中间功率增强电容器系统导出的某些后续的电荷脉冲。电路允许植入式心律转复除颤器装置向心脏递送多个紧密间隔的除颤脉冲。

4. 发明授权

US5312454A Apparatus and method of automatically adjusting a sensor signal comparator threshold for an oxygen sensing pacemaker 失效
标题翻译：自动调节氧气感应起搏器的传感器信号比较器阈值的装置和方法
公开(公告)号：US5312454A
公开(公告)日：1994-05-17
申请号：US947859
申请日：1992-12-14
申请人： Glenn M. Roline , Dennis A. Brumwell
发明人： Glenn M. Roline , Dennis A. Brumwell
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36557
摘要： A monitoring system for an oxygen sensing, dual-wavelength, reflectance oximetry based, rate responsive cardiac pacemaker, is capable of automatically and continually adjusting an oxygen sensor signal comparator threshold such that the effects of noise, sensitivity and drift on oximeter output signals sent to the pacemaker are minimized. A comparator and related circuitry are configured to sample and compare supply excitations for multiple oxygen sensor light sources. The comparator threshold is adjusted as a function of supply excitation for each light source independently of one another, thereby providing an oxygen sensing pacemaker with optimal noise immunity since one of the more vulnerable portions of the pacing system is the transfer of the light source signals which are susceptible to noise.
摘要翻译：一种用于氧气感测双波长，基于反射率血糖测定法的速率响应心脏起搏器的监测系统能够自动和连续地调节氧传感器信号比较器阈值，使得噪声，灵敏度和漂移对血氧计输出信号的影响被发送到起搏器最小化。比较器和相关电路被配置为对多个氧传感器光源的电源激励进行采样和比较。比较器阈值作为每个光源的供应激励的函数被彼此独立地调整，从而提供具有最佳抗噪声能力的氧感应起搏器，因为起搏系统的较脆弱部分之一是光源信号的传送，容易受到噪音的影响。

5. 发明授权

US5129393A Dual chamber rate responsive pacemaker with variable refractory period 失效
$Dual chamber rate responsive pacemaker with variable refractory period$
标题翻译：具有可变耐用期的双层反应堆
公开(公告)号：US5129393A
公开(公告)日：1992-07-14
申请号：US567433
申请日：1990-08-14
申请人： Dennis A. Brumwell
发明人： Dennis A. Brumwell
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/3622
摘要： An improved atrial synchronous, dual chamber pacemaker provided with a variable refractory period during which the pacemaker is not responsive to the sensed atrial contractions. The atrial refractory period is varied as a function of measured atrial and ventricular rates, and corresponds to a predetermined proportion of the lesser of the average interval separating the ventricular contractions and the average interval separating atrial contractions. The invention is particularly beneficial in the context of a VDD type pacemaker.
摘要翻译：改进的心房同步双室心脏起搏器，其具有可变不应期，在此期间起搏器不能对感觉到的心房收缩作出反应。心房不应期作为测量的心房和心室率的函数而变化，并且对应于分离心室收缩的平均间隔和分离心房收缩的平均间隔中较小的预定比例。本发明在VDD型心脏起搏器的上下文中是特别有益的。

6. 发明授权

US4485813A Implantable dynamic pressure transducer system 失效
标题翻译：植入式动态压力传感器系统
公开(公告)号：US4485813A
公开(公告)日：1984-12-04
申请号：US322814
申请日：1981-11-19
申请人： Kenneth M. Anderson , Dennis A. Brumwell
发明人： Kenneth M. Anderson , Dennis A. Brumwell
IPC分类号： A61B5/0215 , A61N1/05 , A61N1/365 , A61B5/02
CPC分类号： A61B5/0215 , A61N1/056 , A61N1/36564
摘要： Pressure and motion transducer, and cooperating circuitry for an implantable medical device is disclosed. The system includes a clock for the pulse excitation of a dynamic motion transducer and further includes circuitry for recovering the modulated signal from the transducer.
摘要翻译：公开了用于可植入医疗装置的压力和运动传感器以及协作电路。该系统包括用于动态运动换能器的脉冲激励的时钟，并且还包括用于从换能器恢复调制信号的电路。

7. 再颁专利

USRE38777E1 Dual battery power system for an implantable cardioverter defibrillator with voltage booster 失效
标题翻译：双电池电源系统，用于具有升压器的可植入式心律转复除颤器
公开(公告)号：USRE38777E1
公开(公告)日：2005-08-16
申请号：US08766634
申请日：1996-12-13
申请人： Theodore P. Adams , Dennis A. Brumwell , Joseph S. Perttu , Charles G. Supino
发明人： Theodore P. Adams , Dennis A. Brumwell , Joseph S. Perttu , Charles G. Supino
IPC分类号： A61N1/39
摘要： An improved dual battery power system uses two separate battery power sources for an implantable cardioverter defibrillator, each having optimized characteristics for monitoring functions and for output energy delivery functions, respectively. The monitoring functions are supplied electrical power by a first battery source, such as a conventional pacemaker power source in the form of a lithium iodide battery which is optimized for long life at very low current levels. The output energy delivery functions are supplied by a separate second battery source, such as a pair of lithium vanadium pentoxide batteries, which is optimized for high current drain capability and low self-discharge for long shelf life. The first battery source provides electrical power only to the monitoring functions of the implantable cardioverter defibrillator, and the second battery source provides all of the electrical power for the output energy delivery functions.
摘要翻译：改进的双电池电力系统使用两个单独的电池电源用于可植入式心律转复除颤器，每个除颤器分别具有用于监测功能和输出能量传递功能的优化特性。监测功能由第一电池源提供电力，例如碘化锂电池形式的常规起搏器电源，其以非常低的电流水平被优化用于长寿命。输出能量传递功能由单独的第二电池源提供，例如一对锂五氧化二钒电池，其针对高电流漏极能力和低自放电优化以保持长期保存期限。第一电池源仅向可植入式心律转复除颤器的监视功能提供电力，并且第二电池源为输出能量传递功能提供所有电力。

8. 发明授权

US5749910A Shield for implantable cardioverter defibrillator 失效
标题翻译：用于植入式心律转复除颤器的护盾
公开(公告)号：US5749910A
公开(公告)日：1998-05-12
申请号：US486759
申请日：1995-06-07
申请人： Dennis A. Brumwell , Joseph S. Perttu , Mark W. Kroll , Randall S. Nelson
发明人： Dennis A. Brumwell , Joseph S. Perttu , Mark W. Kroll , Randall S. Nelson
IPC分类号： A61N1/375 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/375 , A61N1/3758
摘要： An implantable cardioverter defibrillator capable of subcutaneous positioning within a patient delivers at least one electrical cardioversion/defibrillation countershocks to the heart of the patient. The implantable cardioverter defibrillator includes a housing, circuitry positioned within the housing to control delivery of the countershocks, and an energy source coupled with the circuitry to provide electrical energy to a capacitor in the circuitry that stores the electrical energy for delivery of the countershocks. Because the circuitry is susceptible to undesirable electromagnetic coupling effects of origin external to the circuitry, particularly the capacitive coupling effects between the circuitry and the housing of the device when at least a portion of the housing is utilized as an electrode, the implantable cardioverter defibrillator also includes a conductive shield, disposed between the housing and the circuitry, to shield the circuitry against such undesired coupling effects.
摘要翻译：能够在患者体内皮下定位的植入式心律转复除颤器将至少一个电复律/去颤颤颤抗原递送至患者的心脏。植入式心律转复除颤器包括壳体，位于壳体内的电路，用于控制反射的传送，以及与该电路耦合的能量源，以将电能提供给电路中的电容器，该电路存储用于递送该反射的电能。因为当至少一部分壳体被用作电极时，电路容易受到电路外部原点的不期望的电磁耦合影响，特别是电路和器件壳体之间的电容耦合效应，所以可植入的心律转复除颤器也包括设置在外壳和电路之间的导电屏蔽，以屏蔽电路免受这种不期望的耦合影响。

9. 发明授权

US5709215A R-wave detection method for implantable cardioverter defibrillators 失效
标题翻译：用于植入式心律转复除颤器的R波检测方法
公开(公告)号：US5709215A
公开(公告)日：1998-01-20
申请号：US524391
申请日：1995-09-06
申请人： Joseph S. Perttu , Dennis A. Brumwell , James E. Brewer , Theodore P. Adams
发明人： Joseph S. Perttu , Dennis A. Brumwell , James E. Brewer , Theodore P. Adams
IPC分类号： A61B5/0456 , A61N1/39
CPC分类号： A61B5/0456 , A61B5/7207 , A61N1/3931
摘要： An ICD detection method for sensing the occurrence of an R-wave improves the ability to distinguish R-waves from noise through the use of variable declining sensitivity thresholds. The method includes the consideration of the amplitude of at least the previous most recent R-wave to determine a declining threshold of sensitivity used to recognize a subsequent electrical signal as an R-wave. In the method, the amplitude of the previous R-wave may be classified, based upon amplitude, and based upon the classification, a desirable time constant for the declining threshold of sensitivity is provided as an exponential or reverse exponential decay. Alternatively, a piece wise use of various decay formulas may be combined and used to avoid false recognition of noise as an R-wave.
摘要翻译：用于感测R波的发生的ICD检测方法通过使用可变下降的灵敏度阈值来提高区分R波与噪声的能力。该方法包括考虑至少先前最近的R波的振幅，以确定用于将后续电信号识别为R波的灵敏度下降阈值。在该方法中，先前R波的振幅可以基于振幅进行分类，并且基于分类，灵敏度下降阈值的期望时间常数被提供为指数或反指数衰减。或者，可以组合并且使用各种衰减公式的分段使用来避免作为R波的噪声的错误识别。

10. 发明授权

US5674248A Staged energy concentration for an implantable biomedical device 失效
标题翻译：植入式生物医学装置的分阶段能量集中
公开(公告)号：US5674248A
公开(公告)日：1997-10-07
申请号：US486760
申请日：1995-06-07
申请人： Mark W. Kroll , Dennis A. Brumwell , Ann M. Donohoo
发明人： Mark W. Kroll , Dennis A. Brumwell , Ann M. Donohoo
IPC分类号： A61N1/39
CPC分类号： H01M16/00 , A61N1/3956 , H01M10/052 , H01M10/425 , H01M6/16 , A61N1/3912 , A61N1/3975
摘要： A staged energy storage system provides electrical energy to an implantable biomedical device by using the combination of a first stage energy source and a second stage energy concentration system. The second stage energy concentration system allows a lower density and/or lower voltage energy source to be used as the first stage energy source, thereby decreasing the battery cost, size and weight. In one embodiment, the second stage energy concentration system comprises a rechargeable battery. In another embodiment, the second stage energy capacitor system comprises a high energy density capacitor system. The staged energy storage system is ideal for internally charging a pulse-generating capacitor system within an implantable cardioverter defibrillator. In this embodiment, a high voltage transformer has a secondary side that is electrically connected to the pulse-generating capacitor system. A second stage concentration system is electrically connected between a first stage energy source and a primary side of the high voltage transformer to store at least a portion of an electrical charge that is delivered from the first stage energy source and to the high voltage transformer.
摘要翻译：分阶段能量存储系统通过使用第一级能量源和第二级能量集中系统的组合向可植入的生物医学装置提供电能。第二级能量集中系统允许将较低密度和/或较低电压能量源用作第一级能量源，从而降低电池成本，尺寸和重量。在一个实施例中，第二级能量集中系统包括可充电电池。在另一实施例中，第二级能量电容器系统包括高能量密度电容器系统。分级储能系统非常适用于在植入式心律转复除颤器内进行脉冲发生电容系统的内部充电。在本实施例中，高压变压器具有与脉冲发生电容器系统电连接的次级侧。第二级集中系统电连接在高压变压器的第一级能量源和初级侧之间，以存储从第一级能源和高电压变压器传送的电荷的至少一部分。

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