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1. 发明授权

US5873861A Plunger systems 失效
公开(公告)号：US5873861A
公开(公告)日：1999-02-23
申请号：US748258
申请日：1996-11-12
申请人： Mark W. Hitchins , Edward J. Rhinehart , David M. Reilly , Anthony S. McCoppin , Robert J. Masarik
发明人： Mark W. Hitchins , Edward J. Rhinehart , David M. Reilly , Anthony S. McCoppin , Robert J. Masarik
IPC分类号： A61M5/145 , A61M25/18 , A61M5/00
CPC分类号： A61M5/14546 , A61M5/14566 , A61M5/31515
摘要： The plunger systems for use in an injector-actuated syringe of the present invention include a dynamic wedge seal which improves the sealing engagement between the plunger cover and syringe barrel, and flexible capture members extending from the rear surface of the plunger which permit the engagement and disengagement of the plunger from the injector drive means at any plunger position within the syringe. Further, the plunger systems include a contrast saving tip which expells the injection liquid from the syringe tip.

2. 发明授权

US06984222B1 Plunger systems 失效
公开(公告)号：US06984222B1
公开(公告)日：2006-01-10
申请号：US09436612
申请日：1999-11-09
申请人： Mark W. Hitchins , Edward J. Rhinehart , David M. Reilly , Anthony S. McCoppin , Thomas L. Dufalla , Robert J. Masarik
发明人： Mark W. Hitchins , Edward J. Rhinehart , David M. Reilly , Anthony S. McCoppin , Thomas L. Dufalla , Robert J. Masarik
IPC分类号： A61M5/315
CPC分类号： A61M5/14546 , A61M5/14566 , A61M5/1458
摘要： The plunger systems for use in an injector-actuated syringe of the present invention include a dynamic wedge seal which improves the sealing engagement between the plunger cover and syringe barrel, and flexible capture members extending from the rear surface of the plunger which permit the engagement and disengagement of the plunger from the injector drive means at any plunger position within the syringe. Further, the plunger systems include a contrast saving tip which expells the injection liquid from the syringe tip.

3. 发明授权

US5944694A Prefillable syringes and injectors for use therewith 失效
标题翻译：预先使用的注射器和注射器
公开(公告)号：US5944694A
公开(公告)日：1999-08-31
申请号：US748230
申请日：1996-11-12
申请人： Mark W. Hitchins , Edward J. Rhinehart , Robert J. Masarik
发明人： Mark W. Hitchins , Edward J. Rhinehart , Robert J. Masarik
IPC分类号： A61M5/145 , A61M37/00
CPC分类号： A61M5/14546 , A61M5/14566
摘要： The present invention provides prefillable syringes and injectors for use therewith that expand and/or facilitate a variety of medical procedures involving the injection of a liquid medium. In several embodiments, the present syringes and injectors enable the use of current syringe materials at higher pressures than previously attainable or the use of other materials not previously usable with current high pressure-syringe and injector designs. In one embodiment, a syringe comprises an elongated cylindrical main body having a first pair and a second pair of mounting flanges encompassing collectively an arcuate length equal to at least approximately 180.degree. of the circumference of the rear portion of the cylindrical main body for releasably mounting the syringe in a desired position relative to the front wall of the injector housing. Injectors for use with such syringes comprise a housing having a front wall and a retainer on the front wall which cooperates with the first and second pairs of mounting flanges of the syringe to releasably mount the syringe on the injector.
摘要翻译：本发明提供了可与之一起使用的可预充注射器和注射器，其扩展和/或促进涉及注射液体介质的各种医疗过程。在几个实施例中，本发明的注射器和注射器使得能够以比先前可获得的更高的压力使用当前的注射器材料，或者使用以前不能用于当前高压注射器和注射器设计的其它材料。在一个实施例中，注射器包括细长的圆柱形主体，其具有第一对和第二对安装凸缘，其共同包含等于圆柱形主体的后部的圆周的至少大约180度的弓形长度，用于可释放地安装注射器相对于注射器壳体的前壁处于期望的位置。用于这种注射器的注射器包括具有在前壁上的前壁和保持器的壳体，其与注射器的第一和第二对安装凸缘配合以将注射器可释放地安装在注射器上。

4. 发明授权

US06322535B1 Prefillable syringes and injectors for use therewith 失效
标题翻译：预先使用的注射器和注射器
公开(公告)号：US06322535B1
公开(公告)日：2001-11-27
申请号：US09282941
申请日：1999-04-01
申请人： Mark W. Hitchins , Edward J. Rhinehart , Robert J. Masarik
发明人： Mark W. Hitchins , Edward J. Rhinehart , Robert J. Masarik
IPC分类号： A61M3700
CPC分类号： A61M5/14546 , A61M5/14566
摘要： The present invention provides prefillable syringes and injectors for use therewith that expand and/or facilitate a variety of medical procedures involving the injection of a liquid medium. In several embodiments, the present syringes and injectors enable the use of current syringe materials at higher pressures than previously attainable or the use of other materials not previously usable with current high pressure-syringe and injector designs. In one embodiment, a syringe comprises an elongated cylindrical main body having a first pair and a second pair of mounting flanges encompassing collectively an arcuate length equal to at least approximately 180° of the circumference of the rear portion of the cylindrical main body for releasably mounting the syringe in a desired position relative to the front wall of the injector housing. Injectors for use with such syringes comprise a housing having a front wall and a retainer on the front wall which cooperates with the first and second pairs of mounting flanges of the syringe to releasably mount the syringe on the injector.
摘要翻译：本发明提供了可与之一起使用的可预充注射器和注射器，其扩展和/或促进涉及注射液体介质的各种医疗过程。在几个实施例中，本发明的注射器和注射器使得能够以比先前可获得的更高的压力使用当前的注射器材料，或者使用以前不能用于当前高压注射器和注射器设计的其它材料。在一个实施例中，注射器包括细长的圆柱形主体，其具有第一对和第二对安装凸缘，其共同包含等于圆柱形主体的后部的圆周的至少约180°的弓形长度，用于可释放地安装注射器相对于注射器壳体的前壁处于期望的位置。用于这种注射器的注射器包括具有在前壁上的前壁和保持器的壳体，其与注射器的第一和第二对安装凸缘配合以将注射器可释放地安装在注射器上。

5. 发明授权

US6017330A Plunger systems 有权
标题翻译：柱塞系统
公开(公告)号：US6017330A
公开(公告)日：2000-01-25
申请号：US239164
申请日：1999-01-28
申请人： Mark W. Hitchins , Edward J. Rhinehart , David M. Reilly , Anthony S. McCoppin , Thomas L. Dufalla , Robert J. Masarik
发明人： Mark W. Hitchins , Edward J. Rhinehart , David M. Reilly , Anthony S. McCoppin , Thomas L. Dufalla , Robert J. Masarik
IPC分类号： A61M5/145 , A61M25/18 , A61M5/00
CPC分类号： A61M5/14546 , A61M5/14566 , A61M5/31515
摘要： The plunger systems for use in an injector-actuated syringe of the present invention include a dynamic wedge seal which improves the sealing engagement between the plunger cover and syringe barrel, and flexible capture members extending from the rear surface of the plunger which permit the engagement and disengagement of the plunger from the injector drive means at any plunger position within the syringe. Further, the plunger systems include a contrast saving tip which expells the injection liquid from the syringe tip.
摘要翻译：用于本发明的注射器致动注射器的柱塞系统包括动态楔形密封件，其改善了柱塞盖和注射器筒之间的密封接合，以及从柱塞的后表面延伸的柔性捕获构件，其允许接合和在注射器内的任何柱塞位置处，柱塞从喷射器驱动装置脱离。此外，柱塞系统包括从注射器末端排出注射液体的对比度保存尖端。

6. 发明授权

US08721596B2 Front-loading syringe adapted to releasably engage a medical injector regardless of the orientation of the syringe with respect to the injector 有权
标题翻译：适于可释放地接合医疗注射器的前装载注射器，而不管注射器相对于注射器的取向如何
公开(公告)号：US08721596B2
公开(公告)日：2014-05-13
申请号：US10668643
申请日：2003-09-23
申请人： Mark Trocki , Mark W. Hitchins , Kevin P. Cowan , Edward J. Rhinehart
发明人： Mark Trocki , Mark W. Hitchins , Kevin P. Cowan , Edward J. Rhinehart
IPC分类号： A61M37/00
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2205/60 , A61M2205/6063 , A61M2205/6072
摘要： A syringe for use with an injector includes a body having a rear end and a front end, a plunger movably disposed within the body, an attachment member associated with the body and adapted to releasably engage a syringe retaining mechanism of the injector regardless of the orientation of the syringe with respect to the injector, and an encoding device operable to provide syringe information to the injector.
摘要翻译：用于注射器的注射器包括具有后端和前端的主体，可移动地设置在主体内的柱塞，与主体相关联并适于可释放地接合注射器的注射器保持机构而不管取向如何相对于注射器的注射器，以及可操作以向注射器提供注射器信息的编码装置。

7. 发明授权

US5947935A Syringes, syringe plungers and injector systems 失效
标题翻译：注射器，注射器柱塞和注射器系统
公开(公告)号：US5947935A
公开(公告)日：1999-09-07
申请号：US978226
申请日：1997-11-25
申请人： Edward J. Rhinehart , David M. Reilly , Mark W. Hitchins , Anthony S. McCoppin
发明人： Edward J. Rhinehart , David M. Reilly , Mark W. Hitchins , Anthony S. McCoppin
IPC分类号： A61M5/145 , A61M25/18 , A61M25/00
CPC分类号： A61M5/14546 , A61M5/14566 , A61M5/31515
摘要： The present invention provides a connection mechanism adapted to make a releasable connection between a syringe plunger and a drive member of an injector. The drive member is preferably movable in a generally reciprocal linear manner to control movement of the plunger within the syringe. The connection mechanism comprises at least one capture member attached to the plunger. The capture member forms a releasable connection with the drive member upon contact of the drive member during linear forward motion of the drive member when the capture member is rotated relative to the drive member to an engagement position. The capture member is further adapted to disconnect from the drive member upon rotation of the capture member relative to the drive member to a disengagement position.
摘要翻译：本发明提供了一种适于在注射器柱塞和注射器的驱动构件之间进行可释放连接的连接机构。驱动构件优选地以大致往复的线性方式移动以控制柱塞在注射器内的移动。连接机构包括附接到柱塞的至少一个捕获构件。当捕获构件相对于驱动构件旋转到接合位置时，捕获构件在驱动构件的线性向前运动期间与驱动构件接触时形成与驱动构件的可释放连接。捕获构件还适于在捕获构件相对于驱动构件旋转到脱离位置时与驱动构件断开连接。

8. 发明授权

US06652489B2 Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith 有权
标题翻译：前部装药医用注射器和注射器，注射器接口，注射器适配器和与其一起使用的注射器柱塞
公开(公告)号：US06652489B2
公开(公告)日：2003-11-25
申请号：US09777020
申请日：2001-02-05
申请人： Mark Trocki , Mark W. Hitchins , Kevin P. Cowan , James A. Dedig , Francis J. Sciulli , Steven C. Rygg , Larry J. Fuchs , Edward J. Rhinehart , Robert D. Parks
发明人： Mark Trocki , Mark W. Hitchins , Kevin P. Cowan , James A. Dedig , Francis J. Sciulli , Steven C. Rygg , Larry J. Fuchs , Edward J. Rhinehart , Robert D. Parks
IPC分类号： A61M3700
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2205/60 , A61M2205/6063 , A61M2205/6072
摘要： Embodiments of an injector, syringe, syringe interface, and piston/plunger assembly for an injector (of contrast medium, for example) are described. Preferably, the syringe is adapted to engage a syringe interface mechanism such that the syringe may be connected to an injector without regard to any particular orientation of the syringe to the injector or to the piston/plunger assembly.
摘要翻译：描述了用于注射器（例如造影剂）的注射器，注射器，注射器接口和活塞/柱塞组件的实施例。优选地，注射器适于接合注射器接口机构，使得注射器可以连接到注射器，而不考虑注射器对于注射器或活塞/柱塞组件的任何特定取向。

9. 发明授权

US06189195B1 Manufacture of prefilled syringes 失效
标题翻译：制造预充式注射器
公开(公告)号：US06189195B1
公开(公告)日：2001-02-20
申请号：US08517645
申请日：1995-08-22
申请人： David M. Reilly , Edward J. Rhinehart , Eugene A. Gelblum , Mark W. Hitchins , Michelle Robinson
发明人： David M. Reilly , Edward J. Rhinehart , Eugene A. Gelblum , Mark W. Hitchins , Michelle Robinson
IPC分类号： B23P1500
CPC分类号： B65B3/003 , Y10T29/49808 , Y10T29/4984
摘要： This invention relates to a process for manufacturing prefilled syringes where at least one of the syringe components is manufactured in at least a class 100 environment. The process includes the steps of manufacturing syringe components, such as the barrel and plunger substrate, within at least a class 100 and MCB-3 environment; manufacturing syringe components, such as the plunger cover and tip seal in an environment less clean than a class 100 environment; decontaminating the plunger cover and tip seal; lubricating at least one of the barrel, plunger substrate, plunger cover and tip seal; assembling the barrel and tip seal to form a barrel/tip seal combination; assembling the plunger cover and plunger substrate to form a plunger; filling the barrel/tip seal combination with a predetermined amount of fluid; and final assembling of the prefilled syringe by inserting the plunger into the barrel/tip seal combination. When the syringe components are manufactured at different locations, each component is tripled-bagged to maintain the component substantially free from contaminants, and transported to an assembly site where the components are unpackaged and assembled into the barrel/tip seal combination and plunger. When filling and final assembly of the barrel/tip seal combination takes place at a location separate from its assembly site, the barrel/tip seal combination is tripled-bagged to maintain it substantially free from contaminants, and transported to a filling and final assembling site for filling and final assembling into a prefilled syringe.
摘要翻译：本发明涉及一种用于制造预充式注射器的方法，其中至少一个注射器组件在至少100级环境中制造。该方法包括在至少100级和MCB-3环境中制造注射器部件（例如筒体和柱塞基底）的步骤; 在比100级环境更干净的环境中制造注射器部件，例如柱塞盖和末端密封; 净化柱塞盖和顶端密封; 润滑桶，柱塞基板，柱塞盖和端盖密封件中的至少一个; 组装筒和尖端密封以形成筒/尖端密封组合; 组装柱塞盖和柱塞基板以形成柱塞; 用预定量的流体填充桶/尖端密封组合; 以及通过将柱塞插入筒/尖端密封组合中来预填充注射器的最终组装。当注射器组件在不同位置制造时，每个组件被三倍重装，以保持组件基本上没有污染物，并被运输到组件的未被包装并组装到筒/尖端密封组合和柱塞中的组装位置。当筒/尖端密封组合的填充和最终组装在与其组装位置分离的位置处发生时，筒/尖端密封组合被三倍重装，以使其基本上不含污染物，并被运送到填充和最终组装位置用于填充和最终组装成预充式注射器。

10. 发明授权

US07691085B2 Syringe interfaces and adapters for use with medical injectors 有权
标题翻译：用于医疗注射器的注射器接口和适配器
公开(公告)号：US07691085B2
公开(公告)日：2010-04-06
申请号：US10295297
申请日：2002-11-15
申请人： James Albert Dedig , Frank A. Lazzaro , Kevin P. Cowan , Mark W. Hitchins , Charles J. Mutschler , James R. Neill
发明人： James Albert Dedig , Frank A. Lazzaro , Kevin P. Cowan , Mark W. Hitchins , Charles J. Mutschler , James R. Neill
IPC分类号： A61M5/20
CPC分类号： A61M5/14546 , A61M5/1456 , A61M5/1458 , A61M2205/58 , Y10S128/01
摘要： A syringe interface includes a top opening into which a syringe can be loaded, a first retaining member positioned on one side of the opening and a second retaining member positioned on a second side of the opening. The first retaining member and the second retaining member abut a forward facing abutment surface of a syringe flange on the syringe generally symmetrically. The syringe interface further includes a cradle, at least one engagement member to abut a forward facing abutment surface of a syringe flange, and a carriage slidably disposed within the cradle. The carriage includes a connector to form a releasable connection with a plunger or plunger extension of the syringe and a drive member of the injector. The connector includes a plurality of flexing capture members that flex radially outward to connect to a flange on the rear of the plunger or plunger extension of the syringe when the carriage is moved forward within the syringe interface. The syringe interface may further include a connector on a rear portion thereof to connect to the injector.
摘要翻译：注射器接口包括可以装载注射器的顶部开口，位于开口的一侧上的第一保持构件和位于开口的第二侧上的第二保持构件。第一保持构件和第二保持构件大致对称地抵靠注射器凸缘的朝前的抵靠表面。注射器接口还包括支架，至少一个接合构件以抵靠注射器凸缘的前向对置的表面，以及可滑动地设置在支架内的托架。托架包括连接器，以形成与注射器的柱塞或柱塞延伸部和注射器的驱动构件的可释放连接。连接器包括多个弯曲捕获构件，当滑架在注射器接口内向前移动时，径向向外弯曲以连接到注射器的柱塞或柱塞延伸部的后部上的凸缘。注射器接口还可以包括在其后部分上连接到喷射器的连接器。

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