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1. 发明申请

US20100152530A1 Biocompatible Fiber Based Device for Guided Tissue Regeneration 审中-公开
标题翻译：用于引导组织再生的生物相容性纤维装置
公开(公告)号：US20100152530A1
公开(公告)日：2010-06-17
申请号：US12335169
申请日：2008-12-15
申请人： Mark Timmer , Chunlin Yang , Clifford G. Volpe , Joseph J. Hammer , Dhanuraj Shetty , Daniel J. Keeley , Jackie J. Donners
发明人： Mark Timmer , Chunlin Yang , Clifford G. Volpe , Joseph J. Hammer , Dhanuraj Shetty , Daniel J. Keeley , Jackie J. Donners
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2/0063 , A61F2210/0004 , A61F2250/0067 , B32B5/022 , B32B5/026 , B32B5/08 , B32B5/26 , B32B7/12 , B32B2250/20 , B32B2262/0253 , B32B2262/0261 , B32B2262/0276 , B32B2262/06 , B32B2262/14 , B32B2307/72 , B32B2535/00 , D04H1/492 , D04H3/11
摘要： Tissue engineering devices for pelvic floor repair are disclosed. More specifically, tissue engineering devices made of an implant, having a central portion at least partially embedded within a nonwoven felt are disclosed.
摘要翻译：公开了用于盆底修复的组织工程装置。更具体地，公开了由植入物制成的组织工程装置，其具有至少部分地嵌入非织造织物毡内的中心部分。

2. 发明申请

US20060287676A1 Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use 审中-公开
标题翻译：术中将治疗剂涂覆在缝合线上的方法，复合缝合线和使用方法
公开(公告)号：US20060287676A1
公开(公告)日：2006-12-21
申请号：US11315905
申请日：2005-12-22
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61L17/00
CPC分类号： A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent, methods of repairing soft tissue defects with coated sutures and composite sutures coated with therapeutic agents.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括使缝合线与包含治疗剂的装置接触，用涂覆的缝合线修复软组织缺陷的方法以及用治疗剂涂覆的复合缝合线。

3. 发明申请

US20060287675A1 Method of intra-operative coating therapeutic agents onto sutures composite sutures and methods of use 审中-公开
标题翻译：术中将治疗剂涂覆在缝线复合缝合线上的方法及使用方法
公开(公告)号：US20060287675A1
公开(公告)日：2006-12-21
申请号：US11315793
申请日：2005-12-22
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61L17/00
CPC分类号： A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent, methods of repairing soft tissue defects with coated sutures and composite sutures coated with therapeutic agents.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括使缝合线与包含治疗剂的装置接触，用涂覆的缝合线修复软组织缺陷的方法以及用治疗剂涂覆的复合缝合线。

4. 发明申请

US20060286289A1 Method of intraoperative coating therapeutic agents onto sutures 审中-公开
标题翻译：术中将治疗剂涂在缝合线上的方法
公开(公告)号：US20060286289A1
公开(公告)日：2006-12-21
申请号：US11153285
申请日：2005-06-15
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Deyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Deyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61F13/02
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括将缝合线接触含有治疗剂的装置。

5. 发明申请

US20060222680A1 Method of preparing crosslinked collagen microspheres 审中-公开
标题翻译：制备交联胶原微球的方法
公开(公告)号：US20060222680A1
公开(公告)日：2006-10-05
申请号：US11095802
申请日：2005-03-31
申请人： Chunlin Yang , Mark Timmer
发明人： Chunlin Yang , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： B01J13/14
摘要： The present invention is drawn to methods of preparing crosslinked collagen microspheres and microparticles, where a solution of soluble collagen in an aqueous acidic medium is combined with an emulsifying agent to form a first mixture of the soluble collagen solution and the emulsifying agent, the first mixture then is combined with a hydrophobic liquid under conditions effective to form water-in-oil emulsion of the hydrophobic liquid and the first mixture, the water-in-oil emulsion then is added to a buffered alcohol solution under conditions effective to form a dispersion of a continuous liquid phase and a dispersed solid phase of collagen fibers reconstituted from the soluble collagen solution, the liquid phase then is removed from the dispersion to provide collagen microspheres, the collagen microspheres then are crosslinked to form crosslinked collagen microspheres, and the crosslinked collagen microspheres then are optionally dried to form crosslinked collagen microparticles.
摘要翻译：本发明涉及制备交联胶原微球和微粒的方法，其中可溶性胶原在酸性介质中的溶液与乳化剂结合形成可溶性胶原溶液和乳化剂的第一混合物，第一混合物然后在有效形成疏水性液体和第一混合物的油包水乳液的条件下与疏水性液体混合，然后在有效形成分散体的条件下将油包水乳液加入缓冲的醇溶液中从可溶性胶原溶液中重新构成胶原纤维的连续液相和分散固相，然后从分散体中除去液相，提供胶原微球，然后将胶原微球交联形成交联胶原微球，并将交联的胶原微球然后任选地干燥以形成交联的胶原微粒。

6. 发明申请

US20070190101A1 Flowable bone grafts 审中-公开
标题翻译：可流动的骨移植物
公开(公告)号：US20070190101A1
公开(公告)日：2007-08-16
申请号：US10815000
申请日：2004-03-31
申请人： Chunlin Yang , Jacky Au-Yeung , Iksoo Chun , Mark Davis , Lu Liu , Aruna Nathan , Vivek Shenoy , Mark Timmer
发明人： Chunlin Yang , Jacky Au-Yeung , Iksoo Chun , Mark Davis , Lu Liu , Aruna Nathan , Vivek Shenoy , Mark Timmer
IPC分类号： A61K35/32 , A61K38/17 , A61K38/18
CPC分类号： A61K38/39 , A61K35/28 , A61K38/00 , A61L27/26 , A61L27/3608 , A61L27/365 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L89/06
摘要： The present invention is directed to bone graft compositions suitable for administration to the body via a cannula, where the compositions contain mineralized collagen particles and a fluid biocompatible carrier having the mineralized collagen particles substantially uniformly distributed there through, which particles contain bound mineralized collagen fibrils substantially uniformly distributed there through and a binder for the fibrils; and to methods of making such particles.
摘要翻译：本发明涉及适于通过插管向身体施用的骨移植组合物，其中组合物含有矿化胶原颗粒和具有基本均匀分布在其中的矿化胶原颗粒的流体生物相容性载体，该颗粒基本上包含结合的矿化胶原原纤维均匀地分布在那里，以及用于原纤维的粘合剂; 以及制备这种颗粒的方法。

7. 发明授权

US09028851B2 Hemostatic materials and devices with galvanic particulates 有权
标题翻译：止血材料和具有电偶颗粒的装置
公开(公告)号：US09028851B2
公开(公告)日：2015-05-12
申请号：US13333136
申请日：2011-12-21
申请人： Yi-Lan Wang , Ying Sun , Guanghui Zhang , Chunlin Yang
发明人： Yi-Lan Wang , Ying Sun , Guanghui Zhang , Chunlin Yang
IPC分类号： A61K9/70 , A61P7/04 , A61K9/00 , A61K33/00 , A61K33/34 , A61L24/00 , A61L24/02 , A61L24/08 , A61K33/30
CPC分类号： A61L24/0036 , A61K33/30 , A61K33/34 , A61L24/02 , A61L24/08 , A61L26/0004 , A61L26/0023 , A61L2300/102 , A61L2300/418 , A61L2400/04 , C08L5/08 , C08L1/02 , A61K2300/00 , C08L1/04
摘要： The present invention is directed to a hemostatic material comprising a scaffold and a galvanic particulate. The galvanic particulate comprises particles made of at least two dissimilar metals. The scaffold is preferably a biocompatible polysaccharide-based hemostatic, such as a chitosan or cellulosic based hemostatic like ORC.
摘要翻译：本发明涉及包含支架和电流颗粒的止血材料。电偶颗粒包含由至少两种不同金属制成的颗粒。支架优选为生物相容性多糖类止血剂，例如壳聚糖或基于纤维素的止血剂，如ORC。

8. 发明授权

US08197838B2 Sustained release systems of ascorbic acid phosphate 有权
标题翻译：抗坏血酸磷酸盐缓释体系
公开(公告)号：US08197838B2
公开(公告)日：2012-06-12
申请号：US13006586
申请日：2011-01-14
申请人： Yufu Li , Stephen Wohlert , Chunlin Yang
发明人： Yufu Li , Stephen Wohlert , Chunlin Yang
IPC分类号： A61K31/665 , A61K9/70 , A61K35/12 , A61P17/02 , A61P19/00
CPC分类号： A61K31/375 , A61K9/7007 , A61L31/16
摘要： A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.
摘要翻译：公开了制备控释组合物的新方法。具体地说，本发明涉及一种制备抗坏血酸磷酸盐和可吸收聚合物的控释组合物的方法。还公开了通过本发明的方法制备的抗坏血酸磷酸盐的新型控释组合物。

9. 发明授权

US08034363B2 Sustained release systems of ascorbic acid phosphate 有权
标题翻译：抗坏血酸磷酸盐缓释体系
公开(公告)号：US08034363B2
公开(公告)日：2011-10-11
申请号：US12332414
申请日：2008-12-11
申请人： Yufu Li , Stephen Wohlert , Chunlin Yang
发明人： Yufu Li , Stephen Wohlert , Chunlin Yang
IPC分类号： A61F2/04 , A61K47/34 , A61K9/00 , A61K35/12
CPC分类号： A61K31/375 , A61K9/7007 , A61L31/16
摘要： A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.
摘要翻译：公开了制备控释组合物的新方法。具体地说，本发明涉及一种制备抗坏血酸磷酸盐和可吸收聚合物的控释组合物的方法。还公开了通过本发明的方法制备的抗坏血酸磷酸盐的新型控释组合物。

10. 发明授权

US07927676B2 Plasma-treated vascular occlusion devices and methods 有权
标题翻译：血浆治疗血管闭塞装置及方法
公开(公告)号：US07927676B2
公开(公告)日：2011-04-19
申请号：US11395474
申请日：2006-03-31
申请人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Champion Davis, III , Darren R. Sherman
发明人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Champion Davis, III , Darren R. Sherman
IPC分类号： B65D39/00 , B32B15/08 , A61D1/00
CPC分类号： A61L31/14 , A61L31/10 , A61L31/146 , A61L2400/18 , A61L2430/36 , Y10T428/1355 , Y10T428/1376 , C08L27/20
摘要： Vaso-occlusive devices are provided that have a polymer foam disposed about them. The polymer is treated with a plasma to facilitate thrombogenicity. A method for making and using such devices also is provided. The preferred polymer is a copolymer of a halogenated vinylidene and a halogenated alkene.
摘要翻译：提供具有围绕它们设置聚合物泡沫的血管闭塞装置。用等离子体处理聚合物以促进血栓形成。还提供了制造和使用这种装置的方法。优选的聚合物是卤代亚乙烯基和卤代烯烃的共聚物。

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