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1. 发明授权

US09028851B2 Hemostatic materials and devices with galvanic particulates 有权
标题翻译：止血材料和具有电偶颗粒的装置
公开(公告)号：US09028851B2
公开(公告)日：2015-05-12
申请号：US13333136
申请日：2011-12-21
申请人： Yi-Lan Wang , Ying Sun , Guanghui Zhang , Chunlin Yang
发明人： Yi-Lan Wang , Ying Sun , Guanghui Zhang , Chunlin Yang
IPC分类号： A61K9/70 , A61P7/04 , A61K9/00 , A61K33/00 , A61K33/34 , A61L24/00 , A61L24/02 , A61L24/08 , A61K33/30
CPC分类号： A61L24/0036 , A61K33/30 , A61K33/34 , A61L24/02 , A61L24/08 , A61L26/0004 , A61L26/0023 , A61L2300/102 , A61L2300/418 , A61L2400/04 , C08L5/08 , C08L1/02 , A61K2300/00 , C08L1/04
摘要： The present invention is directed to a hemostatic material comprising a scaffold and a galvanic particulate. The galvanic particulate comprises particles made of at least two dissimilar metals. The scaffold is preferably a biocompatible polysaccharide-based hemostatic, such as a chitosan or cellulosic based hemostatic like ORC.
摘要翻译：本发明涉及包含支架和电流颗粒的止血材料。电偶颗粒包含由至少两种不同金属制成的颗粒。支架优选为生物相容性多糖类止血剂，例如壳聚糖或基于纤维素的止血剂，如ORC。

2. 发明申请

US20130164360A1 Hemostatic Materials and Devices with Galvanic Particulates 有权
标题翻译：止血材料和器件与电镀微粒
公开(公告)号：US20130164360A1
公开(公告)日：2013-06-27
申请号：US13333136
申请日：2011-12-21
申请人： Yi-Lan Wang , Ying Sun , Guanghui Zhang , Chunlin Yang
发明人： Yi-Lan Wang , Ying Sun , Guanghui Zhang , Chunlin Yang
IPC分类号： A61K9/70 , A61P7/04 , A61K9/00 , A61K33/00 , A61K33/34
CPC分类号： A61L24/0036 , A61K33/30 , A61K33/34 , A61L24/02 , A61L24/08 , A61L26/0004 , A61L26/0023 , A61L2300/102 , A61L2300/418 , A61L2400/04 , C08L5/08 , C08L1/02 , A61K2300/00 , C08L1/04
摘要： The present invention is directed to a hemostatic material comprising a scaffold and a galvanic particulate. The galvanic particulate comprises particles made of at least two dissimilar metals. The scaffold is preferably a biocompatible polysaccharide-based hemostatic, such as a chitosan or cellulosic based hemostatic like ORC.
摘要翻译：本发明涉及包含支架和电流颗粒的止血材料。电偶颗粒包含由至少两种不同金属制成的颗粒。支架优选为生物相容性多糖类止血剂，例如壳聚糖或基于纤维素的止血剂，如ORC。

3. 发明申请

US20130316974A1 OXIDIZED REGENERATED CELLULOSE HEMOSTATIC POWDERS AND METHODS OF MAKING 有权
标题翻译：氧化再生纤维素HEMOSTATIC POWDERS及其制备方法
公开(公告)号：US20130316974A1
公开(公告)日：2013-11-28
申请号：US13480842
申请日：2012-05-25
申请人： Yi-Lan Wang , Guanghui Zhang
发明人： Yi-Lan Wang , Guanghui Zhang
IPC分类号： C08B16/00 , A61P7/04 , A61P17/02 , A61K31/717
CPC分类号： A61L26/0023 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/404 , A61L2300/418 , A61L2400/04 , Y10T428/2982 , C08L1/04
摘要： The present invention is directed to hemostatic material containing compacted ORC powder comprising particles having an average aspect ratio from about 1 to about 18, wherein said compacted ORC powder have preferably been processed in a compaction device, such as a ball milled ORC powder. The present invention further relates to methods of making the hemostatic material and a method of treating a wound by applying the hemostatic powder onto and/or into the wound of a patient.
摘要翻译：本发明涉及包含压实的ORC粉末的止血材料，其包含平均纵横比为约1至约18的颗粒，其中所述压实的ORC粉末优选在压实装置如球磨的ORC粉末中加工。本发明还涉及制止止血材料的方法以及通过将止血粉末施用于患者的伤口和/或进入伤口来治疗伤口的方法。

4. 发明申请

US20130004478A1 Procoagulant Peptides and Their Derivatives and Uses Therefor 有权
公开(公告)号：US20130004478A1
公开(公告)日：2013-01-03
申请号：US13173013
申请日：2011-06-30
申请人： Yi-Lan Wang , Guanghui Zhang
发明人： Yi-Lan Wang , Guanghui Zhang
IPC分类号： A61K38/08 , A61K38/17 , A61P17/02 , A61K38/36 , A61K38/38 , A61P7/04 , A61K38/51
CPC分类号： A61L26/0052 , A61K38/39 , A61L24/0015 , A61L24/108 , A61L26/009 , A61L2300/25 , A61L2300/252 , A61L2300/418 , A61L2400/04
摘要： The present invention is directed to a hemostatic or tissue sealing material having (a) a peptide having a sequence SEQ ID NO: 1 or an amino acid analog sequence thereof, and (b) a scaffold for said peptide or amino acid analogue sequence. The scaffold is preferably hemostatic, such as a natural or genetically engineered absorbable polymer, a synthetic absorbable polymer, or combinations thereof. The natural or genetically engineered absorbable polymers can be selected from the group consisting of a protein, a polysaccharide, or combinations thereof.

5. 发明授权

US09149511B2 Procoagulant peptides and their derivatives and uses therefor 有权
标题翻译：促凝肽及其衍生物及其用途
公开(公告)号：US09149511B2
公开(公告)日：2015-10-06
申请号：US13173013
申请日：2011-06-30
申请人： Yi-Lan Wang , Guanghui Zhang
发明人： Yi-Lan Wang , Guanghui Zhang
IPC分类号： A61K38/08 , A61K38/17 , A61K38/38 , A61P17/02 , A61K38/39 , A61L24/00 , A61L24/10
CPC分类号： A61L26/0052 , A61K38/39 , A61L24/0015 , A61L24/108 , A61L26/009 , A61L2300/25 , A61L2300/252 , A61L2300/418 , A61L2400/04
摘要： The present invention is directed to a hemostatic or tissue sealing material having (a) a peptide having a sequence SEQ ID NO: 1 or an amino acid analog sequence thereof, and (b) a scaffold for said peptide or amino acid analog sequence. The scaffold is preferably hemostatic, such as a natural or genetically engineered absorbable polymer, a synthetic absorbable polymer, or combinations thereof. The natural or genetically engineered absorbable polymers can be selected from the group consisting of a protein, a polysaccharide, or combinations thereof.
摘要翻译：本发明涉及一种止血或组织密封材料，其具有（a）具有序列SEQ ID NO：1或其氨基酸类似物序列的肽，和（b）所述肽或氨基酸类似物序列的支架。支架优选为止血剂，例如天然或遗传工程可吸收聚合物，合成可吸收聚合物或其组合。天然或遗传工程可吸收聚合物可以选自蛋白质，多糖或其组合。

6. 发明授权

US08815832B2 Oxidized regenerated cellulose hemostatic powders and methods of making 有权
标题翻译：氧化再生纤维素止血粉及其制备方法
公开(公告)号：US08815832B2
公开(公告)日：2014-08-26
申请号：US13480842
申请日：2012-05-25
申请人： Yi-Lan Wang , Guanghui Zhang
发明人： Yi-Lan Wang , Guanghui Zhang
IPC分类号： A61K31/717 , C08B16/00 , A61P17/02 , A61P7/04
CPC分类号： A61L26/0023 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/404 , A61L2300/418 , A61L2400/04 , Y10T428/2982 , C08L1/04
摘要： The present invention is directed to hemostatic material containing compacted ORC powder comprising particles having an average aspect ratio from about 1 to about 18, wherein said compacted ORC powder have preferably been processed in a compaction device, such as a ball milled ORC powder. The present invention further relates to methods of making the hemostatic material and a method of treating a wound by applying the hemostatic powder onto and/or into the wound of a patient.
摘要翻译：本发明涉及包含压实的ORC粉末的止血材料，其包含平均纵横比为约1至约18的颗粒，其中所述压实的ORC粉末优选在压实装置如球磨的ORC粉末中加工。本发明还涉及制止止血材料的方法以及通过将止血粉末施用于患者的伤口和/或进入伤口来治疗伤口的方法。

7. 发明授权

US08985429B2 Surgical stapling device with adjunct material application feature 有权
标题翻译：具有附加材料应用功能的手术吻合装置
公开(公告)号：US08985429B2
公开(公告)日：2015-03-24
申请号：US13242164
申请日：2011-09-23
申请人： Stephen J. Balek , Chad P. Boudreaux , Matthew D. Holcomb , Thomas W. Lytle, IV , Matthew C. Miller , Charles J. Scheib , Bret W. Smith , Yi-Lan Wang , Donald F. Wilson, Jr. , Edward A. Rhad , Kreena R. Modi , Joseph Zavatsky , Aron O. Zingman
发明人： Stephen J. Balek , Chad P. Boudreaux , Matthew D. Holcomb , Thomas W. Lytle, IV , Matthew C. Miller , Charles J. Scheib , Bret W. Smith , Yi-Lan Wang , Donald F. Wilson, Jr. , Edward A. Rhad , Kreena R. Modi , Joseph Zavatsky , Aron O. Zingman
IPC分类号： A61B17/068 , A61B17/00 , A61B17/072 , A61B17/32
CPC分类号： A61B17/00491 , A61B17/07207 , A61B2017/07271 , A61B2017/07285 , A61B2017/320052
摘要： A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a removable cartridge. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further includes an agent. The firing bar is operable to assist with releasing the agent onto a severed line of tissue when the firing bar is advanced.
摘要翻译：手术器械包括手柄部分，容纳击球杆的轴，包括砧座的末端执行器，下颚和响应于由手柄部分和轴产生的纵向关闭运动的装订和切割组件。下颌构造成接收可移除的盒。盒包括壳体，设置在壳体中的多个钉，以及设置在多个钉上的甲板。甲板限定孔，每个孔基本上设置在每个钉上。该盒还包括一个代理。射击杆可操作以帮助当射击杆前进时将药剂释放到组织切断线上。

8. 发明授权

US09393018B2 Surgical staple assembly with hemostatic feature 有权
标题翻译：具有止血功能的外科手术组装
公开(公告)号：US09393018B2
公开(公告)日：2016-07-19
申请号：US13240074
申请日：2011-09-22
申请人： Yi-Lan Wang , Matthew C. Miller , Aron O. Zingman
发明人： Yi-Lan Wang , Matthew C. Miller , Aron O. Zingman
IPC分类号： A61B17/068 , A61B17/072
CPC分类号： A61B17/07292 , A61B17/068
摘要： A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a removable cartridge. The cartridge includes a housing, a plurality of staples disposed in the housing, a deck disposed over the plurality of staples, and a fastener insert tip including a plurality of hooks. The deck defines apertures, with each aperture being substantially disposed over each staple. The instrument includes a fastener insert including hooks, and the fastener insert is removably received in the anvil. A buttress is attached to one or both of the anvil and the cartridge via the hooks.
摘要翻译：手术器械包括手柄部分，容纳击球杆的轴，包括砧座的末端执行器，下颚和响应于由手柄部分和轴产生的纵向关闭运动的装订和切割组件。下颌构造成接收可移除的盒。盒包括壳体，设置在壳体中的多个订书钉，设置在多个订书钉上的台面，以及包括多个钩子的紧固件插入件尖端。甲板限定孔，每个孔基本上设置在每个钉上。仪器包括具有钩的紧固件插入件，并且紧固件插件可移除地容纳在砧座中。支撑件通过钩连接到砧座和盒子中的一个或两个。

9. 发明授权

US09731076B2 Multi-compartment pre-filled mixing syringes with bypass 有权
公开(公告)号：US09731076B2
公开(公告)日：2017-08-15
申请号：US13537202
申请日：2012-06-29
申请人： Yi-Lan Wang , Leo B. Kriksunov
发明人： Yi-Lan Wang , Leo B. Kriksunov
IPC分类号： A61M5/28 , A61M5/315 , A61M5/31
CPC分类号： A61M5/284 , A61M5/3129 , A61M5/31511
摘要： The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.

10. 发明申请

US20120164224A1 Hemostatic Preparation Containing an Extract of Golden Moss 有权
标题翻译：包含金黄色提取物的止血剂
公开(公告)号：US20120164224A1
公开(公告)日：2012-06-28
申请号：US12975589
申请日：2010-12-22
申请人： Yi-Lan Wang , Xintian Ming
发明人： Yi-Lan Wang , Xintian Ming
IPC分类号： A61K36/10 , A61P7/04 , A61K9/00
CPC分类号： A61K36/12 , A61K9/0014 , A61K36/287 , A61K38/39 , A61L26/0038 , A61L26/0057 , A61L2400/04 , A61K2300/00
摘要： The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to an extract of a plant-based “Traditional Chinese Medicinal” product and devices incorporating such agents for the delivery thereof to bleeding wounds.
摘要翻译：本发明一般涉及用于促进止血的药剂和装置，更具体地，涉及植物性“中药”产品的提取物和包含用于将其输送给出血伤口的药剂的提取物。

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