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1. 发明申请

US20060287676A1 Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use 审中-公开
标题翻译：术中将治疗剂涂覆在缝合线上的方法，复合缝合线和使用方法
公开(公告)号：US20060287676A1
公开(公告)日：2006-12-21
申请号：US11315905
申请日：2005-12-22
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61L17/00
CPC分类号： A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent, methods of repairing soft tissue defects with coated sutures and composite sutures coated with therapeutic agents.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括使缝合线与包含治疗剂的装置接触，用涂覆的缝合线修复软组织缺陷的方法以及用治疗剂涂覆的复合缝合线。

2. 发明申请

US20060287675A1 Method of intra-operative coating therapeutic agents onto sutures composite sutures and methods of use 审中-公开
标题翻译：术中将治疗剂涂覆在缝线复合缝合线上的方法及使用方法
公开(公告)号：US20060287675A1
公开(公告)日：2006-12-21
申请号：US11315793
申请日：2005-12-22
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Dyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61L17/00
CPC分类号： A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent, methods of repairing soft tissue defects with coated sutures and composite sutures coated with therapeutic agents.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括使缝合线与包含治疗剂的装置接触，用涂覆的缝合线修复软组织缺陷的方法以及用治疗剂涂覆的复合缝合线。

3. 发明申请

US20060286289A1 Method of intraoperative coating therapeutic agents onto sutures 审中-公开
标题翻译：术中将治疗剂涂在缝合线上的方法
公开(公告)号：US20060286289A1
公开(公告)日：2006-12-21
申请号：US11153285
申请日：2005-06-15
申请人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Deyne , Joseph Hammer , Chunlin Yang
发明人： Rita Prajapati , Steven Bowman , Mark Timmer , Patrick De Deyne , Joseph Hammer , Chunlin Yang
IPC分类号： A61F13/02
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/145
摘要： Intra-operative coating of sutures with therapeutic proteins, particularly growth factors such as rhGDF-5. including contacting a suture to a device containing a therapeutic agent.
摘要翻译：用治疗性蛋白质，特别是生长因子例如rhGDF-5进行术中包衣。包括将缝合线接触含有治疗剂的装置。

4. 发明申请

US20100152530A1 Biocompatible Fiber Based Device for Guided Tissue Regeneration 审中-公开
标题翻译：用于引导组织再生的生物相容性纤维装置
公开(公告)号：US20100152530A1
公开(公告)日：2010-06-17
申请号：US12335169
申请日：2008-12-15
申请人： Mark Timmer , Chunlin Yang , Clifford G. Volpe , Joseph J. Hammer , Dhanuraj Shetty , Daniel J. Keeley , Jackie J. Donners
发明人： Mark Timmer , Chunlin Yang , Clifford G. Volpe , Joseph J. Hammer , Dhanuraj Shetty , Daniel J. Keeley , Jackie J. Donners
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2/0063 , A61F2210/0004 , A61F2250/0067 , B32B5/022 , B32B5/026 , B32B5/08 , B32B5/26 , B32B7/12 , B32B2250/20 , B32B2262/0253 , B32B2262/0261 , B32B2262/0276 , B32B2262/06 , B32B2262/14 , B32B2307/72 , B32B2535/00 , D04H1/492 , D04H3/11
摘要： Tissue engineering devices for pelvic floor repair are disclosed. More specifically, tissue engineering devices made of an implant, having a central portion at least partially embedded within a nonwoven felt are disclosed.
摘要翻译：公开了用于盆底修复的组织工程装置。更具体地，公开了由植入物制成的组织工程装置，其具有至少部分地嵌入非织造织物毡内的中心部分。

5. 发明申请

US20070190101A1 Flowable bone grafts 审中-公开
标题翻译：可流动的骨移植物
公开(公告)号：US20070190101A1
公开(公告)日：2007-08-16
申请号：US10815000
申请日：2004-03-31
申请人： Chunlin Yang , Jacky Au-Yeung , Iksoo Chun , Mark Davis , Lu Liu , Aruna Nathan , Vivek Shenoy , Mark Timmer
发明人： Chunlin Yang , Jacky Au-Yeung , Iksoo Chun , Mark Davis , Lu Liu , Aruna Nathan , Vivek Shenoy , Mark Timmer
IPC分类号： A61K35/32 , A61K38/17 , A61K38/18
CPC分类号： A61K38/39 , A61K35/28 , A61K38/00 , A61L27/26 , A61L27/3608 , A61L27/365 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L89/06
摘要： The present invention is directed to bone graft compositions suitable for administration to the body via a cannula, where the compositions contain mineralized collagen particles and a fluid biocompatible carrier having the mineralized collagen particles substantially uniformly distributed there through, which particles contain bound mineralized collagen fibrils substantially uniformly distributed there through and a binder for the fibrils; and to methods of making such particles.
摘要翻译：本发明涉及适于通过插管向身体施用的骨移植组合物，其中组合物含有矿化胶原颗粒和具有基本均匀分布在其中的矿化胶原颗粒的流体生物相容性载体，该颗粒基本上包含结合的矿化胶原原纤维均匀地分布在那里，以及用于原纤维的粘合剂; 以及制备这种颗粒的方法。

6. 发明申请

US20060222680A1 Method of preparing crosslinked collagen microspheres 审中-公开
标题翻译：制备交联胶原微球的方法
公开(公告)号：US20060222680A1
公开(公告)日：2006-10-05
申请号：US11095802
申请日：2005-03-31
申请人： Chunlin Yang , Mark Timmer
发明人： Chunlin Yang , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： B01J13/14
摘要： The present invention is drawn to methods of preparing crosslinked collagen microspheres and microparticles, where a solution of soluble collagen in an aqueous acidic medium is combined with an emulsifying agent to form a first mixture of the soluble collagen solution and the emulsifying agent, the first mixture then is combined with a hydrophobic liquid under conditions effective to form water-in-oil emulsion of the hydrophobic liquid and the first mixture, the water-in-oil emulsion then is added to a buffered alcohol solution under conditions effective to form a dispersion of a continuous liquid phase and a dispersed solid phase of collagen fibers reconstituted from the soluble collagen solution, the liquid phase then is removed from the dispersion to provide collagen microspheres, the collagen microspheres then are crosslinked to form crosslinked collagen microspheres, and the crosslinked collagen microspheres then are optionally dried to form crosslinked collagen microparticles.
摘要翻译：本发明涉及制备交联胶原微球和微粒的方法，其中可溶性胶原在酸性介质中的溶液与乳化剂结合形成可溶性胶原溶液和乳化剂的第一混合物，第一混合物然后在有效形成疏水性液体和第一混合物的油包水乳液的条件下与疏水性液体混合，然后在有效形成分散体的条件下将油包水乳液加入缓冲的醇溶液中从可溶性胶原溶液中重新构成胶原纤维的连续液相和分散固相，然后从分散体中除去液相，提供胶原微球，然后将胶原微球交联形成交联胶原微球，并将交联的胶原微球然后任选地干燥以形成交联的胶原微粒。

7. 发明申请

US20070112360A1 Bioprosthetic device 审中-公开
标题翻译：生物假体装置
公开(公告)号：US20070112360A1
公开(公告)日：2007-05-17
申请号：US11273745
申请日：2005-11-15
申请人： Patrick De Deyne , Dhanuraj Shetty , Steven Bowman , Mark Timmer , Mora Melican , Shana Azri-Meehan , Joseph Contiliano
发明人： Patrick De Deyne , Dhanuraj Shetty , Steven Bowman , Mark Timmer , Mora Melican , Shana Azri-Meehan , Joseph Contiliano
IPC分类号： A61F2/02 , A61F2/08
CPC分类号： A61F2/08
摘要： The present disclosure relates to bioprosthetics. For example, to the use of bioprosthetics for the repair and replacement of connective tissue.
摘要翻译：本公开涉及生物假体。例如，使用生物假体来修复和更换结缔组织。

8. 发明申请

US20070031470A1 NONWOVEN TISSUE SCAFFOLD 有权
标题翻译：非金属组织SCAFFOLD
公开(公告)号：US20070031470A1
公开(公告)日：2007-02-08
申请号：US11427477
申请日：2006-06-29
申请人： Stephanie Kladakis , Joseph Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
发明人： Stephanie Kladakis , Joseph Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

9. 发明授权

US08221780B2 Nonwoven tissue scaffold 有权
标题翻译：无纺布组织支架
公开(公告)号：US08221780B2
公开(公告)日：2012-07-17
申请号：US11427477
申请日：2006-06-29
申请人： Sridevi Dhanaraj , Stephanie M. Kladakis , Joseph J. Hammer , Dhanuraj Shetty , Mark Timmer
发明人： Sridevi Dhanaraj , Stephanie M. Kladakis , Joseph J. Hammer , Dhanuraj Shetty , Mark Timmer
IPC分类号： A61F2/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

10. 发明申请

US20120165939A1 NONWOVEN TISSUE SCAFFOLD 审中-公开
标题翻译：非金属组织SCAFFOLD
公开(公告)号：US20120165939A1
公开(公告)日：2012-06-28
申请号：US13341366
申请日：2011-12-30
申请人： Stephanie M. Kladakis , Joseph J. Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
发明人： Stephanie M. Kladakis , Joseph J. Hammer , Shetty Dhanuraj , Sridevi Dhanaraj , Mark Timmer
IPC分类号： A61F2/08 , A61K35/12 , A61K38/18 , A61K35/16 , A61K38/00
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/3872 , A61F2002/30766 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.
摘要翻译：公开了一种生物相容性半月板修复装置。所述组织修复装置包括适于与弯液面中的缺陷接触的支架，所述支架包括高密度干法铺设的非织造聚合物材料和生物相容性泡沫。支架提供增加的缝线拉拔强度。

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