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1. 发明申请

US20120165794A1 Pill Catchers 审中-公开
公开(公告)号：US20120165794A1
公开(公告)日：2012-06-28
申请号：US12976761
申请日：2010-12-22
申请人： Mark S. Ortiz , Christopher J. Hess , Jason L. Harris , James W. Voegele , Mark S. Zeiner , Mark D. Overmyer , Joseph B. Kraimer , Jeff Shimizu , Rocco Crivelli , Yanik Tardy , Thierry Utard , Juergen Burger , Toralf Bork , Martin Pfleiderer , Olivier Chossat
发明人： Mark S. Ortiz , Christopher J. Hess , Jason L. Harris , James W. Voegele , Mark S. Zeiner , Mark D. Overmyer , Joseph B. Kraimer , Jeff Shimizu , Rocco Crivelli , Yanik Tardy , Thierry Utard , Juergen Burger , Toralf Bork , Martin Pfleiderer , Olivier Chossat
IPC分类号： A61M31/00
CPC分类号： A61B1/041 , A61B1/00147 , A61F5/0013 , A61M31/002
摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

2. 发明授权

US10046109B2 Drug delivery device with compressible drug reservoir 有权
公开(公告)号：US10046109B2
公开(公告)日：2018-08-14
申请号：US13390111
申请日：2010-08-10
申请人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
发明人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
IPC分类号： A61M5/145 , A61M31/00
摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).

3. 发明授权

US09687638B2 Swallowable medication capsule 有权
公开(公告)号：US09687638B2
公开(公告)日：2017-06-27
申请号：US14006901
申请日：2012-03-23
申请人： Hans Zou , Jeff Shimizu
发明人： Hans Zou , Jeff Shimizu
IPC分类号： A61M31/00 , A61K9/48
CPC分类号： A61M31/00 , A61K9/4808 , A61M31/002
摘要： The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.

4. 发明授权

US09227011B2 Miniaturized threshold sensor 有权
标题翻译：小型阈值传感器
公开(公告)号：US09227011B2
公开(公告)日：2016-01-05
申请号：US12442961
申请日：2007-09-27
申请人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman , Anke Pierik , Judith Margaret Rensen
发明人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman , Anke Pierik , Judith Margaret Rensen
IPC分类号： G08B1/08 , A61M5/142 , A61B5/07 , A61M5/172
CPC分类号： A61M5/14276 , A61B5/073 , A61B2562/0214 , A61M5/1723 , A61M2005/1726 , A61M2210/1053
摘要： A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.
摘要翻译：一种传感器，包括具有微小尺寸和较低功率消耗的多个电极以及电极外部的涂层，其中所述涂层与目标条件相互作用，从而产生电极的电性能的变化，其中所述变化被转换成电极的电信号。另外，用于药物输送的系统包括这种传感器和丸剂。

5. 发明申请

US20110092959A1 ELECTRONIC PILL COMPRISING A PLURALITY OF MEDICINE RESERVOIRS 有权
标题翻译：包含多种药物储存的电子药丸
公开(公告)号：US20110092959A1
公开(公告)日：2011-04-21
申请号：US12992613
申请日：2009-06-18
申请人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
发明人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
IPC分类号： A61M37/00 , B65B3/04
CPC分类号： A61M31/002
摘要： Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.
摘要翻译：包括多个药物储存器（2,12,22）的电子药丸（1,11,21），每个储存器包括由可移除的盖（6,16,26）覆盖的排出口（3,13,33）。所述药丸包括响应于控制电路的至少一个致动器，用于从所述排放开口（3,13,33）移除所述盖。致动器可以例如是在分配药物时破坏箔盖的弹簧加载的活塞（4）。或者，盖可以是具有开口（17,27）的可旋转盘（16）或圆筒（26），该开口可在致动器的作用下与储存器的排出口一致。

6. 发明授权

US09744139B2 Modular ingestible drug delivery capsule 有权
公开(公告)号：US09744139B2
公开(公告)日：2017-08-29
申请号：US13262841
申请日：2010-04-02
申请人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
发明人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
IPC分类号： A61K9/48 , A61K9/00 , A61M31/00
CPC分类号： A61K9/4808 , A61K9/0009 , A61K9/0097 , A61M31/002
摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

7. 发明申请

US20110089050A1 METHOD AND APPARATUS FOR CHEMICAL ANALYSIS OF FLUIDS 有权
标题翻译：流体化学分析方法与装置
公开(公告)号：US20110089050A1
公开(公告)日：2011-04-21
申请号：US12673845
申请日：2008-08-29
申请人： Lucian R. Albu , Hans Zou , Jeff Shimizu
发明人： Lucian R. Albu , Hans Zou , Jeff Shimizu
IPC分类号： G01N27/413 , G01N27/416
CPC分类号： A63B69/0002 , A63B69/3641 , A63B2069/0008 , A63B2209/00 , A63B2210/50 , A63B2225/09 , A63B2225/093
摘要： An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.
摘要翻译：用于电化学流体分析的装置和方法包括具有用于容纳待测流体体积的深度尺寸的腔室（1202），设置在腔室内的第一和第二电极（A1），并且沿与所述腔室间隔开的深度尺寸延伸另一种和可溶性固体，例如退火的聚合物，例如 EUDRAGIT占据第一和第二电极之间的横向间隙。通过流体中可溶性固体的电化学阻抗谱（EIS）监测的溶解速率取决于流体中溶液中存在的相应分析物的化学浓度。在一个实施例中，限定上边缘的硅基集成电路器件包括沿着所述上边缘设置的电极阵列，以允许电极阵列直接暴露于待测流体。该器件采用CMOS技术构建。

8. 发明申请

US20110017612A1 METHOD OF PREPARING A SWALLOWABLE CAPSULE COMPRISING A SENSOR 有权
标题翻译：制备包含传感器的易碎胶囊的方法
公开(公告)号：US20110017612A1
公开(公告)日：2011-01-27
申请号：US12933891
申请日：2009-03-24
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Petrus Leonardus Adrianus Van Der Made , Michel Gerardus Pardoel , Frits Tobi De Jongh , Johan Gerard Kleibeuker
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Petrus Leonardus Adrianus Van Der Made , Michel Gerardus Pardoel , Frits Tobi De Jongh , Johan Gerard Kleibeuker
IPC分类号： G01N33/487 , G01N27/26
CPC分类号： A61B5/073 , A61B5/14539 , A61B5/1495 , A61B2560/0223
摘要： The inventions relates to a kit comprising a swallowable capsule (1, 45) with a potentiometric sensor (3), such as a pH sensor, with an unfilled electrolyte cell (31). The kit further includes a separate container (46) containing a liquid electrolyte. The kit can, e.g., be packed in a blister package. After unpacking the capsule the electrolyte cell (31) is filled with the electrolyte.
摘要翻译：本发明涉及一种试剂盒，其包括具有电位传感器（3）的可吞咽胶囊（1,45），例如具有未填充电解质电池（31）的pH传感器。该试剂盒还包括含有液体电解质的单独的容器（46）。试剂盒可以例如包装在泡罩包装中。在拆开胶囊之后，电解质电池（31）充满电解质。

9. 发明申请

US20100171820A1 LENS SYSTEM 审中-公开
标题翻译：镜头系统
公开(公告)号：US20100171820A1
公开(公告)日：2010-07-08
申请号：US12666545
申请日：2008-06-25
申请人： Bernardus Hendrikus Wihelmu Hendriks , Jeff Shimizu , Stein Kuiper
发明人： Bernardus Hendrikus Wihelmu Hendriks , Jeff Shimizu , Stein Kuiper
IPC分类号： H04N7/18 , G02B15/00 , G02B21/02 , G02B23/24
CPC分类号： G02B23/243 , G02B26/103
摘要： A lens system comprises a first lens group and a second lens group, and is configured to form an image at a first magnification and at a second magnification. The lens system has a common optical axis in both magnifications. The lens system is further configured to form an intermediate image between the first lens group and the second lens group at the first magnification. The intermediate image formed in the first magnification is further imaged onto an optical detector. In the first magnification, the second lens group acts as a relay lens imaging the intermediate image onto the optical detector. In the second magnification, the first and second lens groups together form an image on the optical detector without forming an intermediate image.
摘要翻译：透镜系统包括第一透镜组和第二透镜组，并且被配置为以第一放大率和第二放大率形成图像。透镜系统具有两个放大倍率的共同光轴。透镜系统还被配置为在第一放大率下在第一透镜组和第二透镜组之间形成中间图像。在第一放大率中形成的中间图像进一步成像到光学检测器上。在第一放大率中，第二透镜组用作将中间图像成像到中间透镜到光学检测器。在第二放大倍数中，第一和第二透镜组一起在光学检测器上形成图像，而不形成中间图像。

10. 发明申请

US20100056874A1 MEDICAMENT DELIVERY DEVICE, CAPSULE AND IN VIVO MEDICINE DELIVERY OR DIAGNOSTIC SYSTEM 有权
标题翻译：药物输送装置，胶囊和体内药物递送或诊断系统
公开(公告)号：US20100056874A1
公开(公告)日：2010-03-04
申请号：US12515383
申请日：2007-11-06
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61M5/14593 , A61B1/041 , A61B5/01 , A61B5/073 , A61B5/14539 , A61B5/4839 , A61M5/14276 , A61M31/002 , A61M2005/14204 , A61M2205/3561
摘要： A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.
摘要翻译：一种药物输送装置，其包括驱动机构和具有储存器（2）的壳体（1），其至少部分地填充有物质，并且至少在一侧上用柔性壁（21）密封。驱动机构适于将活塞（23）压靠在柔性壁（21）上，从而通过储存器（2）中的开口（25）将物质从储存器（2）释放。这提供了一种安全可靠的药物输送装置。

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