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1. 发明申请

US20060089336A1 4-Dedimethylamino tetracycline compounds 审中-公开
标题翻译： 4-二甲氨基四环素化合物
公开(公告)号：US20060089336A1
公开(公告)日：2006-04-27
申请号：US11283571
申请日：2005-11-18
申请人： Mark Nelson , Kwasi Ohemeng
发明人： Mark Nelson , Kwasi Ohemeng
IPC分类号： A61K31/65 , C07D221/18 , C07D311/78 , C07C237/26
CPC分类号： A61K31/65 , C07C235/70 , C07C237/26 , C07C251/48 , C07C255/41 , C07C271/22 , C07C271/54 , C07C271/58 , C07C275/42 , C07C275/54 , C07C279/18 , C07C311/06 , C07C311/08 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07D295/185 , C07D317/60 , C07F9/2475 , C07F9/4006
摘要： The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分地涉及新的取代的4-脱二甲基氨基四环素化合物。这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。

2. 发明申请

US20050288262A1 3, 10, and 12a Substituted tetracycline compounds 失效
标题翻译： 3,10和12a取代的四环素化合物
公开(公告)号：US20050288262A1
公开(公告)日：2005-12-29
申请号：US11069197
申请日：2005-02-28
申请人： Upul Bandarage , Jackson Chen , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng
发明人： Upul Bandarage , Jackson Chen , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng
IPC分类号： A61K31/36 , A61K31/536 , A61K31/65 , A61P9/10 , A61P11/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07C237/26 , C07D265/12 , C07D317/54
CPC分类号： C07C237/26 , A61K31/65 , C07D265/12 , C07D317/54 , Y02A50/411
摘要： The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明涉及新的3,10和/或12a取代的四环素化合物。这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。

3. 发明申请

US20050143352A1 Substituted tetracycline compounds 审中-公开
标题翻译：取代四环素化合物
公开(公告)号：US20050143352A1
公开(公告)日：2005-06-30
申请号：US10877928
申请日：2004-06-25
申请人： Mark Nelson , Kwasi Ohemeng , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Oak Kim , Jude Mathews , Rachid Mechiche
发明人： Mark Nelson , Kwasi Ohemeng , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Oak Kim , Jude Mathews , Rachid Mechiche
IPC分类号： C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , A61K31/65 , C07D221/18
CPC分类号： C07C237/48 , A61K31/65 , C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2603/46 , Y02A50/411 , Y02A50/473
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分地涉及新的取代的四环素化合物。这些四环素化合物可用于治疗许多四环素化合物反应状态，例如细菌感染和肿瘤，以及四环素化合物的其它已知应用，例如阻断四环素外排和调节基因表达。

5. 发明申请

US20060166945A1 Substituted tetracycline compounds 有权
公开(公告)号：US20060166945A1
公开(公告)日：2006-07-27
申请号：US11258622
申请日：2005-10-25
申请人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng , Jingwen Pan
发明人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng , Jingwen Pan
IPC分类号： C07C237/26 , A61K31/65
CPC分类号： C07D471/04 , C07C237/26 , C07C251/48 , C07C255/59 , C07C259/10 , C07C271/18 , C07C271/22 , C07C271/24 , C07C2601/02 , C07C2603/46 , C07D207/335 , C07D207/337 , C07D211/70 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/30 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/14 , C07D333/20 , C07D333/24 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

7. 发明申请

US20050038002A1 Substituted tetracycline compounds 有权
标题翻译：取代四环素化合物
公开(公告)号：US20050038002A1
公开(公告)日：2005-02-17
申请号：US10740961
申请日：2003-12-18
申请人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Nagavelli , Paul Sheahan , Atul Verma , Peter Viski , Tadeusz Warchol
发明人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Nagavelli , Paul Sheahan , Atul Verma , Peter Viski , Tadeusz Warchol
IPC分类号： C07D295/20 , A61K31/65 , A61P31/04 , A61P43/00 , C07C237/26 , C07C239/18 , C07C245/20 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/06 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/52 , C07D307/54 , C07D307/68 , C07D317/54 , C07D317/60 , C07D401/04 , C07F7/10
CPC分类号： C07D307/52 , C07C237/26 , C07C239/18 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07C2603/46 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/68 , C07D317/54 , C07D401/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分地涉及新的取代的四环素化合物。这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。

8. 发明申请

US20170181393A1 ASSEMBLY FOR VERTICAL PLANT ARRAY 审中-公开
公开(公告)号：US20170181393A1
公开(公告)日：2017-06-29
申请号：US15327591
申请日：2015-07-28
申请人： Mark Nelson
发明人： Mark Nelson
IPC分类号： A01G31/06 , A01G27/00 , A01G9/02
CPC分类号： A01G31/06 , A01G9/023 , A01G27/00
摘要： A modular array for growing plants consisting of horizontally extending tubes with plant openings, downspouts for conveying water from an upper tube to a lower tube and means for adjusting the height of water in each tube. Preferably, each downspout is movable within a mounting in the uppertube and the water height is adjusted by altering the height by which the downspout projects into the tube interior.

9. 发明授权

US09612803B2 System and method for use of a virtual assembly builder 有权
公开(公告)号：US09612803B2
公开(公告)日：2017-04-04
申请号：US13448111
申请日：2012-04-16
申请人： Richard P. Mousseau , Mark Nelson , Jon Richards , Troy Schulz , Keith Kelleman , Mark Spotswood , Jeff Berkowitz
发明人： Richard P. Mousseau , Mark Nelson , Jon Richards , Troy Schulz , Keith Kelleman , Mark Spotswood , Jeff Berkowitz
IPC分类号： G06F9/455 , G06F9/44
CPC分类号： G06F8/34 , G06F9/45558 , G06F2009/45562 , G06F2009/4557
摘要： A virtual assembly builder for use in virtualization environments, which can be used as a tool for virtualizing installed components in a reference environment, modifying those components if necessary, and then deploying them into another/target environment. Using the virtual assembly builder, a user (e.g., an administrator) can capture the configuration and product/component binaries of existing software components into software appliance artifacts. Appliances can be grouped, and their relationships defined, into software assembly artifacts. Logical connections between appliances within an assembly can be reconfigured by a process of assembly editing. When a desired assembly configuration has been achieved, the assembly can be prepared for, and deployed into, the target environment.

10. 发明授权

US08986606B2 Chemistry for effective microbe control with reduced gas phase corrosiveness in pulp and paper processing systems 有权
标题翻译：用于在纸浆和纸张处理系统中降低气相腐蚀性的有效微生物控制的化学
公开(公告)号：US08986606B2
公开(公告)日：2015-03-24
申请号：US12472058
申请日：2009-05-26
申请人： Mark Nelson , Marko Kolari , Juhana Ahola
发明人： Mark Nelson , Marko Kolari , Juhana Ahola
IPC分类号： A61L2/18 , D21F1/66 , C02F1/76 , C02F1/50 , C02F103/28
CPC分类号： D21F1/66 , C02F1/50 , C02F1/76 , C02F2103/28 , C02F2303/08 , C02F2303/20
摘要： Processes for biofilm or microorganism growth control in an aqueous system such as a pulp, paper or board manufacturing system are described in which a halogenated hydantoin is added to the aqueous system in combination with haloamine, chlorine dioxide or a combination thereof. The halogenated hydantoin is preferably a fully or partially halogenated dialkyl hydantoin, and more preferably 5,5-dimethyl hydantoin or 5-methyl-5-ethyl hydantoin. The haloamine is preferably a monohaloamine, dihaloamine, trihaloamine, or a combination thereof, and more preferably monochloramine, monobromamine, bromochloroamine or a combination thereof. The halogenated hydantoin is preferably added to the aqueous system in portions of the system susceptible to gas phase corrosion, such as the short loop of the system, and the haloamine and chlorine dioxide are preferably added to other portions of the system. The halogenated hydantoin and haloamine and/or chlorine dioxide maintain good compatibility with each other in the absence of excess free chlorine.
摘要翻译：描述了在水系统如纸浆，纸或板制造系统中的生物膜或微生物生长控制的方法，其中将卤代乙内酰脲与卤胺，二氧化氯或其组合组合加入到水系统中。卤化乙内酰脲优选为完全或部分卤化的二烷基乙内酰脲，更优选为5,5-二甲基乙内酰脲或5-甲基-5-乙基乙内酰脲。卤代胺优选为单卤代胺，二卤代胺，三卤代胺或其组合，更优选一氯胺，一溴胺，溴氯胺或其组合。卤化乙内酰脲优选在易于气相腐蚀的系统的部分系统中加入到水系统中，例如系统的短路，并且卤胺和二氧化氯优选加入系统的其它部分。卤代乙内酰脲和卤代胺和/或二氧化氯在不存在过量游离氯的情况下保持彼此良好的相容性。

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