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1. 发明申请

US20070232621A1 Linear dicationic terphenyls and their aza analogues as antiparasitic agents 失效
标题翻译：线性双阳离子三联苯及其氮杂类似物作为抗寄生虫剂
公开(公告)号：US20070232621A1
公开(公告)日：2007-10-04
申请号：US11698257
申请日：2007-01-25
申请人： Richard Tidwell , David Boykin , W. Wilson , Reto Brun , Karl Werbovetz , Mohamed Ismail , Reem Arafa , Laixing Hu
发明人： Richard Tidwell , David Boykin , W. Wilson , Reto Brun , Karl Werbovetz , Mohamed Ismail , Reem Arafa , Laixing Hu
IPC分类号： A61K31/34 , A61K31/16 , A61K31/4164 , A61K31/435 , C07D213/00 , C07D239/00 , C07D307/00
CPC分类号： C07C257/18 , C07C259/18 , C07C279/18 , C07C279/24 , C07D213/58 , C07D239/26 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14
摘要： Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.
摘要翻译：新型的二联三联苯化合物及其杂环类似物。用新型双极化三联苯化合物及其氮杂类似物对抗微生物感染的方法。合成新型双线性三联苯化合物及其氮杂类似物的方法。

2. 发明申请

US20060166945A1 Substituted tetracycline compounds 有权
公开(公告)号：US20060166945A1
公开(公告)日：2006-07-27
申请号：US11258622
申请日：2005-10-25
申请人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng , Jingwen Pan
发明人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng , Jingwen Pan
IPC分类号： C07C237/26 , A61K31/65
CPC分类号： C07D471/04 , C07C237/26 , C07C251/48 , C07C255/59 , C07C259/10 , C07C271/18 , C07C271/22 , C07C271/24 , C07C2601/02 , C07C2603/46 , C07D207/335 , C07D207/337 , C07D211/70 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/30 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/14 , C07D333/20 , C07D333/24 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

3. 发明申请

US20050213529A1 Channel estimation in a CDMA receiver 审中-公开
标题翻译： CDMA接收机中的信道估计
公开(公告)号：US20050213529A1
公开(公告)日：2005-09-29
申请号：US11033752
申请日：2005-01-13
申请人： Yuk Chow , Michael Fitton , Khurram Rizvi , Mohamed Ismail , Yan Bian
发明人： Yuk Chow , Michael Fitton , Khurram Rizvi , Mohamed Ismail , Yan Bian
IPC分类号： H04B1/707 , H04B7/216
CPC分类号： H04B1/711 , H04B2201/70701
摘要： A receiver for receiving a CDMA signal comprises a common channel interference cancellation facility operable to cancel common channel interference by applying a common channel interference estimate to the received signal through a weighted hybrid of parallel and serial interference cancellation, and a physical channel self-interference cancellation facility operable to cancel physical channel self-interference by applying an interference estimate to the received signal through a weighted hybrid of parallel and serial interference cancellation.
摘要翻译：用于接收CDMA信号的接收机包括公共信道干扰消除设备，其可操作以通过并行和串行干扰消除的加权混合以及物理信道自干扰消除对接收到的信号应用公共信道干扰估计来消除共同信道干扰该设施可操作以通过并行和串行干扰消除的加权混合来对接收的信号应用干扰估计来消除物理信道自身干扰。

4. 发明授权

US06172226B2 Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions 失效
标题翻译：用于在温和条件下合成和去保护肽核酸的合成子
公开(公告)号：US06172226B2
公开(公告)日：2001-01-09
申请号：US09116793
申请日：1998-07-16
申请人： James M. Coull , Michael Egholm , Richard P. Hodge , Mohamed Ismail , S. B. Rajur
发明人： James M. Coull , Michael Egholm , Richard P. Hodge , Mohamed Ismail , S. B. Rajur
IPC分类号： C07D23910
CPC分类号： C07D239/47 , C07D473/18 , C07D473/34 , C07D473/40 , C07K14/003 , Y02P20/55
摘要： A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed.
摘要翻译：公开了一种制备具有能够在温和条件下去除的保护基的新型PNA合成子的方法。通过将具有杂环的外环氨基的氨基甲酸酯保护的新的N-取代的核碱基中间体与氨基酸N-（2-氨基乙基） - 甘氨酸的氨基保护的主链或氨基保护的主链酯偶联来制备PNA合成子。通过本发明的方法，所得的PNA合成子可以具有氨基甲酸酯保护的核碱基和氨基保护的主链的正交保护。 PNA合成子可用于合成肽核酸（PNA）和其他寡聚体如PNA-DNA嵌合体，并可用于自动合成仪中。还公开了新的组合物。此外，公开了具有不受保护的C6羰基的环外2-氨基的选择性氨基甲酸酯保护的鸟嘌呤PNA合成子。

5. 发明授权

US10112730B2 System and methods for remote monitoring drones and aerial vehicles for security and health monitoring purposes 有权
公开(公告)号：US10112730B2
公开(公告)日：2018-10-30
申请号：US15918416
申请日：2018-03-12
申请人： Mohamed Alsayed Ahmed Mohamed Ismail
发明人： Mohamed Alsayed Ahmed Mohamed Ismail
IPC分类号： G08B21/00 , B64F5/60 , G07C5/00 , G06N3/02 , B64D45/00
摘要： One or more methods for remotely estimating a drone's weight during flying are contemplated. It is possible to utilize a long range laser Doppler Vibrometer or a remote optical surveillance system. In addition, it is possible to employ a method disclosed herein using physical signatures for identifying flight characteristics and manufacturers of different drones and for monitoring drones' degradation prior to failures as a condition based maintenance system. The present teachings are applicable to drones, helicopters, and all manned and unmanned aerial vehicles.

6. 发明授权

US08288374B2 Medicinal composition containing benzo[a]phenoxazine compound as the active ingredient for prevention or treatment of protozoal disease 有权
标题翻译：含有苯并[a]吩恶嗪化合物作为预防或治疗原生动物疾病的有效成分的药物组合物
公开(公告)号：US08288374B2
公开(公告)日：2012-10-16
申请号：US12921569
申请日：2009-03-11
申请人： Masataka Ihara , Jian-Feng Ge , Chika Arai , Nasser Saad Mohamed Ismail , Mei Yang , Isamu Itoh , Reto Brun
发明人： Masataka Ihara , Jian-Feng Ge , Chika Arai , Nasser Saad Mohamed Ismail , Mei Yang , Isamu Itoh , Reto Brun
IPC分类号： C07D413/12 , C07D417/12 , A61K31/538
CPC分类号： A61K31/538 , C07D265/34 , C07D413/12 , C07D417/12 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/421
摘要： Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-prolonging effect and so on. A medicinal composition which contains as the active ingredient a benzo[a]phenoxazine compound represented by General formula (1) or a salt compound of the same, in particular, an agent for treating and/or preventing infection with a protozoa such as malaria, leishmaniasis, African trypanosomiasis, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidium disease; and a novel compound which is contained therein as the active ingredient.
摘要翻译：本发明提供一种药物组合物，特别是用于治疗和/或预防的药物组合物，其对寄生原虫感染和对其的选择性毒性具有高治疗效果并且具有延长寿命等。作为活性成分含有由通式（1）表示的苯并[a]吩恶嗪化合物或其盐化合物的药物组合物，特别是用于治疗和/或预防感染原虫如疟疾的药剂，利什曼病，非洲锥虫病，恰加斯病，弓形虫病，淋巴丝虫病，宝贝病或球虫病; 和作为活性成分含有的新化合物。

7. 发明申请

US20060293540A1 Novel bichalcophenes and their prodrugs as antiprotozoal agents 有权
标题翻译：新颖的双螯合物及其前药作为抗原虫药
公开(公告)号：US20060293540A1
公开(公告)日：2006-12-28
申请号：US11435323
申请日：2006-05-16
申请人： Richard Tidwell , David Boykin , Chad Stephens , Mohamed Ismail , W. Wilson , Reto Brun , Karl Werbovetz
发明人： Richard Tidwell , David Boykin , Chad Stephens , Mohamed Ismail , W. Wilson , Reto Brun , Karl Werbovetz
IPC分类号： C07C211/00
CPC分类号： C07D307/68 , C07D307/54 , C07D333/24 , C07D333/38 , C07D345/00 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D421/14
摘要： Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
摘要翻译：描述了新型双阳离子双生烯烃化合物。目前公开的新型双阳离子双生烯烃化合物显示体外活性与罗氏黑斑病，恶性疟原虫或杜氏不动症相当，与戊脒和呋脒相当。一些新型双阳离子双生命烯化合物在罗氏黑斑病感染的鼠模型中在体内表现出良好的活性。

8. 发明申请

US20050282853A1 Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8,-tetrahydro-imidazo[1,2,-a]pyridines as antiprotozoal agents 有权
标题翻译：新型二环咪唑并[1,2-a]吡啶和5,6,7,8-四氢 - 咪唑并[1,2-a]吡啶作为抗原虫剂
公开(公告)号：US20050282853A1
公开(公告)日：2005-12-22
申请号：US11074565
申请日：2005-03-08
申请人： David Boykin , Richard Tidwell , W. Wilson , Mohamed Ismail
发明人： David Boykin , Richard Tidwell , W. Wilson , Mohamed Ismail
IPC分类号： A61K31/4745 , C07D471/02 , C07D471/04
CPC分类号： C07D471/04
摘要： A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.
摘要翻译：一种用于治疗微生物感染的方法，包括通过向受试者施用有效量的双阳离子咪唑并吡啶化合物或双阳离子四氢 - 咪唑并吡啶化合物，在有需要的受试者中治疗来自原生动物病原体（例如，罗氏黑曲霉和恶性疟原虫）的感染复合。双阳离子咪唑并吡啶和双阳离子四氢 - 咪唑并吡啶的合成方法以及新型的双阳离子咪唑并吡啶和双阳离子四氢 - 咪唑并吡啶化合物本身。

9. 发明申请

US20050148646A1 Dicationic triaryl analogs as anti-protozoan agents 审中-公开
标题翻译：起始的三芳基类似物作为抗原生动物
公开(公告)号：US20050148646A1
公开(公告)日：2005-07-07
申请号：US10972715
申请日：2004-10-25
申请人： David Boykin , Richard Tidwell , W. David Wilson , Reto Brun , Mohamed Ismail
发明人： David Boykin , Richard Tidwell , W. David Wilson , Reto Brun , Mohamed Ismail
IPC分类号： A61K31/4184 , C07D235/18 , C07D235/24 , C07D307/71 , C07D401/10 , C07D405/10 , C07D405/12
CPC分类号： C07D235/18 , C07D307/71 , C07D401/10 , C07D405/10 , C07D405/12
摘要： Novel dicationic, heterocyclic triaryl compounds are useful in the treatment of microbial infections, such as Trypanosoma brucei rhodesiense infection and Plasmodium falciparum infection. These compounds are accordingly useful in treating second-stage human African trypanosomiasis. Pharmaceutical formulations comprising these compounds can be used in methods of treating microbial infections.
摘要翻译：新型双阳离子，杂环三芳基化合物可用于治疗微生物感染，如罗氏黑斑病菌感染和恶性疟原虫感染。因此，这些化合物可用于治疗第二阶段的非洲锥虫病。包含这些化合物的药物制剂可用于治疗微生物感染的方法。

10. 发明申请

US20190011180A1 Sales Gas Enrichment with Propane and Butanes By IDS Process 审中-公开
公开(公告)号：US20190011180A1
公开(公告)日：2019-01-10
申请号：US15641437
申请日：2017-07-05
申请人： Hussein Mohamed Ismail Mostafa
发明人： Hussein Mohamed Ismail Mostafa
IPC分类号： F25J3/02
摘要： The present invention is a separation unit process in which a high pressure section of a separation unit operates at a relatively high pressure to initially process and separate a high pressure feed stream and a low pressure section of the separation unit to initially process and separate a low pressure feed stream, where the high pressure section and the low pressure section are integral with and exchange streams to accomplish a desired separation of a wellhead fluid feed which typically includes a heavier portion of pentanes and heavier components

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