专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08492365B2 7-substituted tetracycline compounds 有权
公开(公告)号：US08492365B2
公开(公告)日：2013-07-23
申请号：US12481368
申请日：2009-06-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , A61K31/42 , A61K31/426 , A61K31/4402 , A61K31/505 , A61K31/5375 , C07C237/26 , C07D239/26 , C07D295/104 , C07D261/08 , C07D277/42
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

2. 发明申请

US20090306022A1 7-SUBSTITUTED TETRACYCLINE COMPOUNDS 有权
标题翻译： 7-取代的四环素化合物
公开(公告)号：US20090306022A1
公开(公告)日：2009-12-10
申请号：US12481368
申请日：2009-06-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , C07C237/26 , C07D277/38 , C07D333/24 , C07D213/56 , C07D307/54 , C07D239/52 , C07D413/06 , C07D239/34
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分地涉及新的7-取代四环素化合物。这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。

3. 发明申请

US20050038002A1 Substituted tetracycline compounds 有权
标题翻译：取代四环素化合物
公开(公告)号：US20050038002A1
公开(公告)日：2005-02-17
申请号：US10740961
申请日：2003-12-18
申请人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Nagavelli , Paul Sheahan , Atul Verma , Peter Viski , Tadeusz Warchol
发明人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Nagavelli , Paul Sheahan , Atul Verma , Peter Viski , Tadeusz Warchol
IPC分类号： C07D295/20 , A61K31/65 , A61P31/04 , A61P43/00 , C07C237/26 , C07C239/18 , C07C245/20 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/06 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/52 , C07D307/54 , C07D307/68 , C07D317/54 , C07D317/60 , C07D401/04 , C07F7/10
CPC分类号： C07D307/52 , C07C237/26 , C07C239/18 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07C2603/46 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/68 , C07D317/54 , C07D401/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分地涉及新的取代的四环素化合物。这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。

6. 发明申请

US20050124678A1 Transcription factor modulating compounds and methods of use thereof 有权
标题翻译：转录因子调节化合物及其使用方法
公开(公告)号：US20050124678A1
公开(公告)日：2005-06-09
申请号：US10700661
申请日：2003-11-03
申请人： Stuart Levy , Michael Alekshun , Brent Podlogar , Kwasi Ohemeng , Atul Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
发明人： Stuart Levy , Michael Alekshun , Brent Podlogar , Kwasi Ohemeng , Atul Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
IPC分类号： A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , A61K31/4184
CPC分类号： A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
摘要翻译：提供了可用作降低微生物的抗性，毒力或生长的抗感染药物的取代的苯并咪唑化合物。制备和使用取代的苯并咪唑化合物的方法，以及其药物制剂，例如降低抗生素抗性和抑制生物膜。

7. 发明申请

US20070111069A1 Method and materials for bonding electrodes to interconnect layers in solid oxide fuel cell stacks 有权
标题翻译：用于将电极连接到固体氧化物燃料电池堆中的互连层的方法和材料
公开(公告)号：US20070111069A1
公开(公告)日：2007-05-17
申请号：US11271946
申请日：2005-11-14
申请人： Timothy Rehg , Jil Guan , Kurtis Montgomery , Atul Verma , Gregory Lear
发明人： Timothy Rehg , Jil Guan , Kurtis Montgomery , Atul Verma , Gregory Lear
IPC分类号： H01M8/12 , C04B35/64
CPC分类号： H01M8/2404 , C04B37/005 , C04B37/006 , C04B37/025 , C04B37/026 , C04B2237/04 , C04B2237/06 , C04B2237/066 , C04B2237/123 , C04B2237/124 , C04B2237/125 , H01M8/0228 , H01M8/028 , H01M8/0286 , H01M8/0297 , H01M8/2425 , H01M2008/1293
摘要： A method and related bonding compositions for use in assembling a solid oxide fuel cell (“SOFC”) stack having thermally and chemically stable and electrically conductive bonds between alternating fuel cells and interconnect components in the stack. The improved method and materials allow for the assembly of solid oxide fuel cells having a stronger and more reliable bond with good electrical contact in situ between the SOFC interconnect layers (plates) and the electrodes. The bonding materials and method according to the invention provide good electrical performance while maintaining the mechanical and electrical integrity of SOFC stacks without requiring excessive mechanical compression of the stack as exemplified by prior art systems. The preferred bonding agents comprise a primary phase that provides the electrical conduction path during fuel cell operation, as well as the mechanical strength necessary to insure a reliable connection between the interconnect and the relevant anode or cathode surfaces of the fuel cell. Secondary phases can be added in small amounts to the primary phase to improve adhesion. An exemplary method according to the invention also contemplates various different steps for pre-treating the surfaces of the interconnect plates and electrodes to improve their surface bonding properties.
摘要翻译：一种用于组装固体氧化物燃料电池（“SOFC”）堆叠的方法和相关的粘合组合物，其在交替的燃料电池和叠层中的互连部件之间具有热和化学稳定且导电的结合。改进的方法和材料允许组装固体氧化物燃料电池，其具有更强和更可靠的结合，在SOFC互连层（板）和电极之间原位具有良好的电接触。根据本发明的接合材料和方法提供良好的电性能，同时保持SOFC堆叠的机械和电气完整性，而不需要堆叠的过度机械压缩，如现有技术系统所示。优选的粘合剂包括在燃料电池操作期间提供导电路径的主相以及确保在互连和燃料电池的相关阳极或阴极表面之间的可靠连接所必需的机械强度。次相可以少量添加到主相以改善粘附性。根据本发明的示例性方法还考虑了用于预处理互连板和电极的表面以改善其表面粘合性质的各种不同步骤。

8. 发明授权

US09583778B2 Chemically sintered composite electrodes and manufacturing processes 有权
标题翻译：化学烧结复合电极及制造工艺
公开(公告)号：US09583778B2
公开(公告)日：2017-02-28
申请号：US11888943
申请日：2007-08-03
申请人： Samuel B. Schaevitz , Zachary Byars , Ramanan Ganeshananthan , Atul Verma , John Rule
发明人： Samuel B. Schaevitz , Zachary Byars , Ramanan Ganeshananthan , Atul Verma , Vladimir Petrovsky , John Rule
IPC分类号： H01M8/1213 , H01M8/1286 , H01M8/1004 , H01M8/1097 , H01M8/1246 , H01M8/12 , H01M4/86 , H01M4/88 , H01M8/10
CPC分类号： H01M8/1213 , H01M4/8652 , H01M4/8657 , H01M4/8828 , H01M4/8885 , H01M8/1004 , H01M8/1097 , H01M8/1246 , H01M8/1286 , Y02E60/521 , Y02E60/525 , Y02P70/56 , Y10T428/25
摘要： An iterative process of depositing on a solid electrolyte a coating of unconnected particles composed of an ionically conductive material. A liquid solution is also applied. The liquid solution includes an inorganic component. The deposited liquid is heated to a temperature sufficient to evaporate or otherwise remove some or all of the volatile components of the liquid solution. Typically the temperature is below 1000° and often at about 850° C. The effect of heating the solution is to cause ion conducting material in the solution to adhere to the surface of the existing ion conducting particles and form connections between these particles. This is understood to create an ion conducting skeletal support structure. Within the intrestices of this skeletal support structure, the step of heating is also understood to result in the deposition of the inorganic component that will begin to form a electron conducting structure. The process of applying the liquid solution and heating may be repeated until a sufficiently thick layer of material is laid over the solid electrolyte to provide the composite electrode structure desired.
摘要翻译：在固体电解质上沉积由离子导电材料组成的未连接颗粒的涂层的迭代过程。还应用液体溶液。液体溶液包含无机成分。将沉积的液体加热到足以蒸发或以其它方式除去液体溶液的一些或全部挥发性组分的温度。通常，温度低于1000°，通常在约850℃。加热溶液的效果是使溶液中的离子传导材料粘附到现有离子传导颗粒的表面上并形成这些颗粒之间的连接。这被理解为产生离子导电骨架支撑结构。在该骨骼支撑结构的内部，加热步骤也被理解为导致开始形成电子传导结构的无机组分的沉积。可以重复施加液体溶液和加热的过程，直到将足够厚的材料层铺在固体电解质上以提供所需的复合电极结构。

9. 发明授权

US07681012B2 Method, system and device for handling a memory management fault in a multiple processor device 有权
标题翻译：用于处理多处理器设备中的存储器管理故障的方法，系统和设备
公开(公告)号：US07681012B2
公开(公告)日：2010-03-16
申请号：US11699562
申请日：2007-01-30
申请人： Atul Verma , Samant Kumar
发明人： Atul Verma , Samant Kumar
IPC分类号： G06F13/00
CPC分类号： G06F12/10 , G06F2212/1032
摘要： A method or device handles memory management faults in a device having a digital signal processor (“DSP”) and a microprocessor. The DSP includes a memory management unit (“DSP MMU”) to manage memory access by the DSP, and the DSP and the microprocessor access shared physical memory. Upon the DSP executing an instruction attempting to access a virtual address wherein the virtual address is invalid, a page fault interrupt is generated by the DSP MMU. A microprocessor interrupt handler in the microprocessor is activated in direct response to the page fault interrupt. Thereafter in the microprocessor, a translation lookaside buffer (“TLB”) entry is created in the DSP MMU, which includes a valid mapping between the virtual address and a page of physical memory. After creating the TLB entry, the microprocessor indicates to the DSP that the access by the DSP of the virtual address is completed.
摘要翻译：方法或设备处理具有数字信号处理器（“DSP”）和微处理器的设备中的存储器管理故障。 DSP包括一个内存管理单元（“DSP MMU”），用于管理DSP的存储器访问，DSP和微处理器访问共享的物理内存。在DSP执行试图访问虚拟地址无效的虚拟地址的指令时，由DSP MMU产生寻呼故障中断。微处理器中的微处理器中断处理程序是直接响应页错误中断而被激活的。此后在微处理器中，在DSP MMU中创建翻译后备缓冲器（“TLB”）条目，其包括虚拟地址和物理存储器页之间的有效映射。在创建TLB条目之后，微处理器向DSP指示DSP访问虚拟地址。

10. 发明申请

US20060160799A1 Transcription factor modulating compounds and methods of use thereof 审中-公开
公开(公告)号：US20060160799A1
公开(公告)日：2006-07-20
申请号：US11115024
申请日：2005-04-25
申请人： Michael Alekshun , Victor Amoo , Oak Kim , Atul Verma
发明人： Michael Alekshun , Victor Amoo , Oak Kim , Atul Verma
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , A61K31/4439 , A61K31/42 , A61K31/427 , A61K31/4184
CPC分类号： A61K31/5377 , A61K31/4184 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/496 , C07D235/18 , C07D235/22 , C07D235/24 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式