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1. 发明授权

US09463169B2 Human gastrointestinal microbiome modulating food supplement for improving blood glucose regulation 有权
标题翻译：人类胃肠微生物调节食物补充剂，用于改善血糖调节
公开(公告)号：US09463169B2
公开(公告)日：2016-10-11
申请号：US14238980
申请日：2012-08-17
申请人： Mark L. Heiman , Dean P. Stull , Justin W. Peno
发明人： Mark L. Heiman , Dean P. Stull , Justin W. Peno
IPC分类号： A01N65/00 , A61K31/155 , A61K31/733 , A61K31/047 , A61K31/716 , A61K31/718 , A61K36/45 , A61K36/00 , A61K38/28 , A61K9/00 , A61K9/10
CPC分类号： A61K31/733 , A23L29/212 , A23L33/00 , A23L33/105 , A23L33/21 , A23L33/30 , A23V2002/00 , A61K9/0031 , A61K9/0095 , A61K9/10 , A61K31/047 , A61K31/05 , A61K31/155 , A61K31/716 , A61K31/718 , A61K36/00 , A61K36/45 , A61K36/88 , A61K36/899 , A61K38/28 , A61K2300/00 , A23V2200/32 , A23V2200/328 , A23V2200/332 , A23V2250/21 , A23V2250/2104 , A23V2250/282 , A23V2250/284 , A23V2250/5034 , A23V2250/5062 , A23V2250/5116 , A23V2250/5118
摘要： A formulation to increase the ratio of gastrointestinal microbiota in phylum Bacteroidetes to microbiota of Firmicutes phylum preferably includes about 20-60 mg/kg of body weight of fermentable fiber, about 10-30 mg/kg of body weight of beta glucan and about 20-60 mg/kg of body weight of blueberry extracts or any fruit or berry ingredient preparation containing similar phenolics. This formulation is preferably used to control body weight, body composition, and blood glucose regulation, preferably in humans, and is preferably administered orally, preferably twice per day.
摘要翻译：用于增加细菌类菌属中的胃肠道微生物比例与Firmicutes门的微生物群比例的配方优选包括约20-60mg / kg体重的可发酵纤维，约10-30mg / kg体重的β-葡聚糖和约20- 蓝莓提取物60毫克/公斤体重或含相似酚类物质的任何水果或浆果成分制剂。该制剂优选用于控制体重，身体组成和血糖调节，优选在人中，并且优选口服施用，优选每天两次。

2. 发明申请

US20140294997A1 COMPOSITION AND USE OF A FORMULATION TO INCREASE THE RATIO OF GASTROINTESTINAL MICROBIOTA IN PHYLUM BACTERIODITES TO MICROBIOTA OF FIRMUCTES PHYLUM 有权
标题翻译：组合物和使用制剂将生物细胞中的胃肠微生物比例增加到烟草微生物中的比例
公开(公告)号：US20140294997A1
公开(公告)日：2014-10-02
申请号：US14238980
申请日：2012-08-17
申请人： Mark L. Heiman , Dean P. Stull , Justin W. Peno
发明人： Mark L. Heiman , Dean P. Stull , Justin W. Peno
IPC分类号： A61K36/45 , A61K31/733 , A23L1/30 , A61K31/716
CPC分类号： A61K31/733 , A23L29/212 , A23L33/00 , A23L33/105 , A23L33/21 , A23L33/30 , A23V2002/00 , A61K9/0031 , A61K9/0095 , A61K9/10 , A61K31/047 , A61K31/05 , A61K31/155 , A61K31/716 , A61K31/718 , A61K36/00 , A61K36/45 , A61K36/88 , A61K36/899 , A61K38/28 , A61K2300/00 , A23V2200/32 , A23V2200/328 , A23V2200/332 , A23V2250/21 , A23V2250/2104 , A23V2250/282 , A23V2250/284 , A23V2250/5034 , A23V2250/5062 , A23V2250/5116 , A23V2250/5118
摘要： A formulation to increase the ratio of gastrointestinal microbiota in phylum Bacteroidetes to microbiota of Firmicutes phylum preferably includes about 20-60 mg/kg of body weight of fermentable fiber, about 10-30 mg/kg of body weight of beta glucan and about 20-60 mg/kg of body weight of blueberry extracts or any fruit or berry ingredient preparation containing similar phenolics. This formulation is preferably used to control body weight, body composition, and blood glucose regulation, preferably in humans, and is preferably administered orally, preferably twice per day.
摘要翻译：用于增加细菌类菌属中的胃肠道微生物比例与Firmicutes门的微生物群比例的配方优选包括约20-60mg / kg体重可发酵纤维，约10-30mg / kg体重的β-葡聚糖和约20- 蓝莓提取物60毫克/公斤体重或含相似酚类物质的任何水果或浆果成分制剂。该制剂优选用于控制体重，身体组成和血糖调节，优选在人中，并且优选口服施用，优选每天两次。

3. 发明授权

US06596776B2 High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof 有权
公开(公告)号：US06596776B2
公开(公告)日：2003-07-22
申请号：US10133986
申请日：2002-04-25
申请人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
发明人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
IPC分类号： A61K31045
CPC分类号： C07C29/76 , C07C29/86 , C07C31/125 , C07C33/025
摘要： The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia. Consequently the composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis) and also to act as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.

4. 发明授权

US4623472A Thermoset microporous polymer lubricating composition and method for forming the same 失效
标题翻译：热固性微孔聚合物润滑组合物及其形成方法
公开(公告)号：US4623472A
公开(公告)日：1986-11-18
申请号：US720518
申请日：1985-04-05
申请人： Warren E. Jamison , Dean P. Stull , Franklin H. Guzzetta
发明人： Warren E. Jamison , Dean P. Stull , Franklin H. Guzzetta
IPC分类号： C08L75/04 , B29C39/00 , C08L75/00 , C10M107/44 , C10M177/00 , C10N40/02 , F02F7/00 , F16C33/66 , C10M149/20
CPC分类号： F16C33/6648 , B29C39/003 , C10M177/00 , F02F7/0085 , F16C33/6688 , B29C2037/92 , B29L2031/04
摘要： Thermoset microporous polymer lubricating compositions and methods for forming the same are disclosed. Each thermoset composition disclosed includes a thermosetting polymer that is formed into a microporous matrix capable of receiving a lubricating oil in the interconnected microscopic pores of the matrix during formation thereof, with the lubricating oil being thereafter retained in the pores until released through capillary draw, externally applied forces or elevated temperatures. Thermosetting polymers are set forth utilizing a number of different thermosetting resins, among which are polyurethanes that include an isocyanate (such as a diisocyanate), a polyol (such as a polyether-based polyol or a polyester-based polyol), and a catalyst (such as an amine or a metal salt) for forming a polyurethane polymer matrix the pores of which are filled with lubricating oil (such as a mineral oil or an ester-based synthetic oil), with surface energy modifiers (such as emulsifiers and foaming agents) also being utilized in some formulations to promote interconnected pore formation. The polyurethane matrix is formed by mixing the lubricating oil, catalyst and surface energy modifiers (if used) with the polyol to form an initial mixture, thereafter mixing the initial mixture with the isocyanate to form a final mixture, and then pouring the final mixture into a mold or utilization device (such as a bearing) where the final mixture is allowed to cure to thus form the polyurethane polymer matrix the pores of which are filled with the lubricating oil.
摘要翻译：公开了热固性微孔聚合物润滑组合物及其形成方法。所公开的每种热固性组合物包括形成微孔基质的热固性聚合物，该微孔基体能够在其形成期间在基体的相互连接的微孔中接收润滑油，随后润滑油保留在孔中，直到通过毛细管吸附释放施加的力或升高的温度。使用许多不同的热固性树脂制备热固性聚合物，其中包括异氰酸酯（如二异氰酸酯），多元醇（如聚醚基多元醇或聚酯基多元醇）和催化剂（例如胺或金属盐），用于形成聚氨酯聚合物基质，孔的孔用润滑油（例如矿物油或酯基合成油）填充，表面能改进剂（例如乳化剂和发泡剂）也用于一些制剂以促进相互连通的孔形成。通过将润滑油，催化剂和表面能改进剂（如果使用）与多元醇混合以形成初始混合物形成聚氨酯基质，然后将初始混合物与异氰酸酯混合以形成最终混合物，然后将最终混合物倒入模具或利用装置（例如轴承），其中允许最终混合物固化，从而形成聚氨酯聚合物基质，其孔被润滑油填充。

5. 发明申请

US20080175888A1 Combination Therapy Comprising Actinidia and Steroids and Uses Thereof 审中-公开
标题翻译：包括猕猴桃和类固醇的组合疗法及其用途
公开(公告)号：US20080175888A1
公开(公告)日：2008-07-24
申请号：US12015193
申请日：2008-01-16
申请人： Julie Lindemann , Nancy Ellen Fogg-Johnson , Patti Cronin , Gil Belofsky , Dean P. Stull
发明人： Julie Lindemann , Nancy Ellen Fogg-Johnson , Patti Cronin , Gil Belofsky , Dean P. Stull
IPC分类号： A61K9/00 , A61K36/00 , A61K9/46 , A61P37/02 , A61K9/14
CPC分类号： A61K31/56 , A61K36/185 , A61K2300/00
摘要： Disclosed is a combination of an Actinidia preparation and one or more steroids, and the use of such a combination to prevent and/or treat allergic and non-allergic inflammatory conditions or diseases, to alleviate at least one symptom of such conditions or diseases, and/or to regulate an immune response in a mammal.
摘要翻译：公开了猕猴桃制剂和一种或多种类固醇的组合，以及使用这种组合来预防和/或治疗过敏性和非过敏性炎性病症或疾病，以减轻这种病症或疾病的至少一种症状，以及 /或调节哺乳动物的免疫反应。

6. 发明授权

US07141611B2 High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof 有权
标题翻译：由天然产物获得的高分子量伯脂肪醇及其用途
公开(公告)号：US07141611B2
公开(公告)日：2006-11-28
申请号：US10622249
申请日：2003-07-18
申请人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
发明人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
IPC分类号： A61K31/045 , C07C29/76 , C07C29/28 , C07C29/86
CPC分类号： C07C29/76 , C07C29/86 , C07C31/125 , C07C33/025
摘要： This invention provides an isolated mixture of higher molecular weight primary aliphatic alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms and having enhanced purity. This invention also provides a process for obtaining the alcohol mixture by extracting a natural product with organic solvents with or without saponification of the natural product. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering total cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels and therefore is effective in treating hypercholesterolemia. The composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis), and can be used as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.
摘要翻译：本发明提供了具有20,22,24,26,27,28,30,32和34个碳原子的较高分子量伯脂肪醇的分离混合物，并且具有增强的纯度。本发明还提供了一种通过在天然产物皂化或不皂化的情况下用有机溶剂萃取天然产物来获得醇混合物的方法。酒精混合物可用于药物组合物，食品和膳食补充剂中，并有效降低总胆固醇和低密度脂蛋白胆固醇并增加HDL-胆固醇水平，因此有效治疗高胆固醇血症。该组合物可用于降低冠心病的风险，抑制动脉粥样硬化过程（血小板超聚集，缺血和血栓形成），并可用作抗炎和抗血栓形成剂。该组合物还具有神经营养性质，可用于改善男性的性活动。

7. 发明授权

US4563973A Heat detection apparatus 失效
标题翻译：热检测装置
公开(公告)号：US4563973A
公开(公告)日：1986-01-14
申请号：US630030
申请日：1984-07-12
申请人： Dean P. Stull , Raymond E. Bennett
发明人： Dean P. Stull , Raymond E. Bennett
IPC分类号： G01K11/06 , G01K1/02 , G01K1/14
CPC分类号： G01K11/06
摘要： A heat detection apparatus comprising a display face having a protruding member extending therefrom disposed in a fixed frame means and connected to a tension means in a tensioned mode, said protruding member and display face maintained in a first position under tension by a solid retention means disposed with the distal end of said protruding member in communication with said protruding member and frame means with said retention means meltable at an elevated temperature, and wherein melting of said retention means permits relaxation of said tension means resulting in said protruding member and display face moving to a second position under relaxation, and further wherein said display face displays a first indicator of non-elevated temperature in the first position and a second indicator of elevated temperature in the second position. Also disclosed is the heat detection apparatus above described in combination with a barrier, as well as a method of determining at a first side of a barrier the presence of an elevated temperature at a second side of said barrier through utilization of said heat detection apparatus.
摘要翻译：一种热检测装置，包括：显示面，其具有从其延伸的突出构件，设置在固定框架装置中并以张紧模式连接到张紧装置，所述突出构件和显示面通过固定保持装置在张力下保持在第一位置，所述突出构件的远端与所述突出构件和框架装置连通，所述保持装置在升高的温度下可熔化，并且其中所述保持装置的熔化允许松弛所述张紧装置，导致所述突出构件和显示面移动在松弛下的第二位置，并且其中所述显示面在第一位置显示不升高的温度的第一指示器和在第二位置显示高温的第二指示器。还公开了上述与隔离屏相结合的热检测装置，以及通过利用所述热检测装置在所述阻挡层的第二侧处确定屏障的第一侧存在升高温度的方法。

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