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1. 发明授权

US06596776B2 High molecular weight primary aliphatic alcohols obtained from natural products and uses thereof 有权
公开(公告)号：US06596776B2
公开(公告)日：2003-07-22
申请号：US10133986
申请日：2002-04-25
申请人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
发明人： William R. Gamble , Zhengjie Liu , David T. Bailey , Pedro P. Perez , Dean P. Stull , Steven L. Richheimer , Rebecca L. Nichols , Rod Lenoble
IPC分类号： A61K31045
CPC分类号： C07C29/76 , C07C29/86 , C07C31/125 , C07C33/025
摘要： The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia. Consequently the composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis) and also to act as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.

2. 发明授权

US06545058B2 Ophthalmic compositions for soft contact lens, method of enhancing wettability of soft contact lens, and method of inhibiting terpenoid adsorption 有权
标题翻译：用于软性隐形眼镜的眼用组合物，增强软性隐形眼镜的润湿性的方法以及抑制萜类吸附的方法
公开(公告)号：US06545058B2
公开(公告)日：2003-04-08
申请号：US09486212
申请日：2000-02-24
申请人： Koji Doi , Hisayuki Nakayama , Takuya Nakajima , Noriko Sakai
发明人： Koji Doi , Hisayuki Nakayama , Takuya Nakajima , Noriko Sakai
IPC分类号： A61K31045
CPC分类号： A61K31/125 , A61K9/0048 , A61K31/045 , Y10S514/912
摘要： The present invention provides an ophthalmic composition for soft contact lenses (SCL), which contains a terpenoid as an active ingredient, an ophthalmic composition for SCL, which contains polyoxyethylene sorbitan ester, a method of enhancing the wettability of soft contact lenses, which comprises bringing terpenoid into contact with SCL and a method of inhibiting adsorption of terpenoid onto SCL, which comprises adding polyoxyethylene sorbitan ester to an ophthalmic composition containing a terpenoid. The ophthalmic composition containing a terpenoid improves, for example, the wettability of SCL, thereby to inhibit decrease in the water content of SCL. As a result, it can inhibit a dry feeling and an uncomfortable feeling during wearing SCL and is useful for enhancing the wettability of SCL. Further, addition of polyoxyethylene sorbitan ester leads to the inhibition of adsorption of terpenoid onto SCL.
摘要翻译：本发明提供一种含有萜类化合物作为活性成分的软性隐形眼镜（SCL）用眼用组合物，含有聚氧乙烯山梨聚糖酯的SCL用眼用组合物，增强软性隐形眼镜的润湿性的方法，萜类化合物与SCL接触以及抑制萜类化合物在SCL上吸附的方法，其包括将聚氧乙烯失水山梨醇酯加入到含有萜类化合物的眼用组合物中。包含萜类化合物的眼用组合物可改善例如SCL的润湿性，从而抑制SCL的水分含量降低。结果，可以抑制穿着SCL时的干燥感和不适感，并且对于提高SCL的润湿性是有用的。此外，加入聚氧乙烯脱水山梨糖醇酯导致抑制萜类化合物在SCL上的吸附。

3. 发明授权

US06403652B1 Method and composition 失效
标题翻译：方法和组成
公开(公告)号：US06403652B1
公开(公告)日：2002-06-11
申请号：US09608366
申请日：2000-06-30
申请人： John Brahms , Bruce Nascimbeni , Sukhvinder Sandhu
发明人： John Brahms , Bruce Nascimbeni , Sukhvinder Sandhu
IPC分类号： A61K31045
CPC分类号： A61K31/05
摘要： A method for inhibiting methicillin drug resistant bacteria using a phenolic compound.
摘要翻译：使用酚类化合物抑制甲氧西林耐药细菌的方法

4. 发明授权

US06369115B1 Stabilized powder formulations 失效
标题翻译：稳定粉末配方
公开(公告)号：US06369115B1
公开(公告)日：2002-04-09
申请号：US09528519
申请日：2000-03-20
申请人： Gary Ward
发明人： Gary Ward
IPC分类号： A61K31045
CPC分类号： A61K9/0075 , A61K31/167 , A61K31/56 , Y10S514/826 , Y10S514/951 , Y10S514/97 , A61K2300/00
摘要： A dry powder formulation for treatment of pulmonary conditions, via inhalation, includes an effective amount of formoterol or a salt or solvate thereof, in a dry powder form, an effective amount of fluticasone, in a dry powder form, and an excipient. A method for preparing a physically stable dry powder formulation for inhalation includes the steps of micronizing a first active polar drug, a second active non-polar drug, and a polar excipient. The second non-polar active drug is first blended with the excipient to form an intermediate mixture. The intermediate mixture is then blended with the first active polar drug. The increased separation of the polar drug and polar excipient stabilizes the formulation.
摘要翻译：用于通过吸入治疗肺部病症的干粉制剂包括有效量的福莫特罗或其盐或溶剂合物，干粉形式，有效量的氟替卡松，干粉形式和赋形剂。制备用于吸入的物理稳定的干粉制剂的方法包括使第一活性极性药物，第二活性非极性药物和极性赋形剂微粉化的步骤。首先将第二种非极性活性药物与赋形剂混合以形成中间体混合物。然后将中间体混合物与第一活性极性药物混合。极性药物和极性赋形剂的分离增加使制剂稳定。

5. 发明授权

US06204289B1 Cembranoid inhibitors of nicotinic acetylcholine receptors 失效
标题翻译：烟碱乙酰胆碱受体的类块抑制剂
公开(公告)号：US06204289B1
公开(公告)日：2001-03-20
申请号：US09092407
申请日：1998-06-04
申请人： Vesna A. Eterovic , Abimael D. Rodriguez , Richard M. Hann , Pedro A. Ferchmin , One R. Pagan , Misty J. Eaton
发明人： Vesna A. Eterovic , Abimael D. Rodriguez , Richard M. Hann , Pedro A. Ferchmin , One R. Pagan , Misty J. Eaton
IPC分类号： A61K31045
CPC分类号： A61K31/366 , A61K31/045 , A61K31/336 , A61K31/343 , A61K31/365 , Y10S514/813
摘要： The present invention relates to the use of cembranoids to inhibit nicotinic acetylcholine receptors.
摘要翻译：本发明涉及使用类块抑制烟碱乙酰胆碱受体。

6. 发明授权

US06723755B2 Method of treating rosacea 有权
标题翻译：治疗酒渣鼻的方法
公开(公告)号：US06723755B2
公开(公告)日：2004-04-20
申请号：US10430917
申请日：2003-05-07
申请人： Piotr Chomczynski
发明人： Piotr Chomczynski
IPC分类号： A61K31045
CPC分类号： A61K31/047 , A61K31/045
摘要： A method for topically treating rosacea is disclosed. In this method, an active material having the formula given below is applied to the patient at the site of said rosacea: wherein R1 is selected from —OH and C1-C3 alkyl OH; and R2, R3, R4, R5 and R6 are independently selected from —H, —OH, C1-C6 alkyl, and C3-C6 cycloalkyl. Preferred active materials include 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures of those materials. Methods for treating acne vulgaris, as well as colds, flu, sinusitis, and ear infections, using these actives are also disclosed.
摘要翻译：公开了一种局部治疗酒渣鼻的方法。在该方法中，在所述红斑痤疮的部位将具有下式的活性物质施用于患者：其中R 1选自-OH和C 1 -C 3烷基OH; R 2，R 3，R 4，R 5和R 6独立地选自-H，-OH，C 1 -C 6烷基和C 3 -C 6环烷基。优选的活性物质包括1,2-环己二醇，1,3-环己二醇，1,4-环己二醇以及这些物质的混合物。还公开了使用这些活性物质治疗寻常型痤疮以及感冒，流感，鼻窦炎和耳朵感染的方法。

7. 发明授权

US06723754B2 Use of COMT inhibitors as analgesics 有权
标题翻译：使用COMT抑制剂作为镇痛药
公开(公告)号：US06723754B2
公开(公告)日：2004-04-20
申请号：US10221497
申请日：2002-09-13
申请人： Päivi Aho , Inge-Britt Lindén
发明人： Päivi Aho , Inge-Britt Lindén
IPC分类号： A61K31045
CPC分类号： A61K31/277 , A61K31/00 , A61K31/12
摘要： The use of COMT inhibitors in the treatment of control of pain in mammals, for example in animals and humans.
摘要翻译：使用COMT抑制剂治疗哺乳动物疼痛的控制，例如在动物和人体中。

8. 发明授权

US06664297B1 Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol 失效
标题翻译：通过施用包含2,4-二硝基苯酚的组合物来抑制和溶解淀粉样变性的方法
公开(公告)号：US06664297B1
公开(公告)日：2003-12-16
申请号：US09692743
申请日：2000-10-18
申请人： Sergio Teixeira Ferreira , Fernanda Guarino De Felice , Paulo Roberto Ferreira Louzada, Jr.
发明人： Sergio Teixeira Ferreira , Fernanda Guarino De Felice , Paulo Roberto Ferreira Louzada, Jr.
IPC分类号： A61K31045
CPC分类号： A61K31/06
摘要： The inhibition of the formation and development of amyloidoses, as well as the dissolution of amyloidoses in organisms is claimed. Methods for the diagnosis of amyloidoses using aromatic and heteroaromatic compounds having at least one electron-withdrawing groups are claimed.
摘要翻译：要求保护淀粉样变性的形成和发展的抑制以及淀粉样变性在生物体中的溶解。要求使用具有至少一个吸电子基团的芳族和杂芳族化合物诊断淀粉样变性的方法。

9. 发明授权

US06569906B1 Composition containing a precursor capable of being hydrolysed by glucocerebrosidase 有权
标题翻译：含有能够被葡糖脑苷脂酶水解的前体的组合物
公开(公告)号：US06569906B1
公开(公告)日：2003-05-27
申请号：US09856220
申请日：2001-05-18
申请人： Daniel Redoules , Roger Tarroux , Jean-Jacques Perie
发明人： Daniel Redoules , Roger Tarroux , Jean-Jacques Perie
IPC分类号： A61K31045
CPC分类号： C07H17/065 , A61K8/602 , A61K2800/70 , A61Q17/00 , A61Q19/00 , A61Q19/004 , A61Q19/007 , A61Q19/08 , C07H15/203
摘要： The invention concerns a composition capable of being hydrolyzed by a cutaneous enzyme, glucocerebrosidase. The active precursor is advantageously a gluco-conjugate derived from phenol whereof the two &agr; carbons are free. The invention also concerns the use of such compositions against light-induced skin ageing or for making a medicine for treating certain skin diseases. The invention further concerns novel glucosylated compounds.
摘要翻译：本发明涉及能够被皮肤酶，葡糖脑苷脂酶水解的组合物。活性前体有利地是衍生自苯酚的葡糖共轭体，其中两个α碳是自由基。本发明还涉及这种组合物对光诱导的皮肤老化或用于制备用于治疗某些皮肤疾病的药物的用途。本发明还涉及新的葡糖基化化合物。

10. 发明授权

US06515029B1 Absorbent article having a hydrophilic lotionized bodyside liner 有权
标题翻译：吸收制品具有亲水洗剂体内衬
公开(公告)号：US06515029B1
公开(公告)日：2003-02-04
申请号：US09298313
申请日：1999-04-23
申请人： Duane Gerard Krzysik , David Charles Musil , Frank Andrew Rosch, III , Gordon Allen Shaw , Diane Michele Underhill , Jeffrey Michael Hockersmith
发明人： Duane Gerard Krzysik , David Charles Musil , Frank Andrew Rosch, III , Gordon Allen Shaw , Diane Michele Underhill , Jeffrey Michael Hockersmith
IPC分类号： A61K31045
CPC分类号： A61L15/50 , A61L15/26 , Y10S514/969 , C08L71/02
摘要： An absorbent article having a bodyside liner includes a hydrophilic lotion formulation on the outer bodyfacing surface thereof. The hydrophilic lotion formulation comprises from about 10 to about 90 weight percent of a hydrophilic solvent, from about 5 to about 90 weight percent of a high molecular weight polyethylene glycol, and from about 0 to about 60 weight percent of a fatty alcohol. The hydrophilic lotion formulation has a reduced adverse effect on the absorbent and liquid uptake properties of the liner and the absorbent body when compared to conventional lipophilic or hydrophobic lotion formulations. The hydrophilic lotion formulation acts as a lubricant to reduce the abrasion of the skin caused by the liner and also transfers to the skin to provide improved skin health.
摘要翻译：具有体侧衬里的吸收制品包括在其外表面上的亲水洗剂制剂。亲水洗剂制剂包含约10至约90重量％的亲水溶剂，约5至约90重量％的高分子量聚乙二醇和约0至约60重量％的脂肪醇。当与常规亲脂性或疏水性洗剂制剂相比时，亲水洗剂制剂对衬垫和吸收体的吸收和液体吸收性能具有减小的不利影响。亲水性乳液制剂用作润滑剂以减少由衬里引起的皮肤磨损，并且还转移到皮肤以提供改善的皮肤健康。

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