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1. 发明授权

US06864054B1 Polypeptides from CREB binding protein and related protein p300 for use in transcriptional regulation 失效
标题翻译：来自CREB结合蛋白和相关蛋白p300的多肽用于转录调节
公开(公告)号：US06864054B1
公开(公告)日：2005-03-08
申请号：US09701080
申请日：1999-05-26
申请人： Mark J. O'Connor , Holger Zimmermann
发明人： Mark J. O'Connor , Holger Zimmermann
IPC分类号： G01N33/566 , A61K38/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N15/09 , G01N33/15 , G01N33/68 , C12Q1/68 , C12N7/00
CPC分类号： C07K14/475 , A61K38/00 , C07K14/4702
摘要： A method for determining whether a compound inhibits or disrupts an interaction between a first polypeptide comprising a transcriptional adaptor motif (TRAM) and a second polypeptide comprising a TRAM-interaction motif. The first polypeptide and/or second polypeptide may be Mdm-2, p53, TBP, E2F, YY1, CBP/p300 or TF11B, or a viral polypeptide such as a human papillomavirus (HPV) E6 polypeptide from HPV strain (16) or (18).
摘要翻译：用于确定化合物是否抑制或破坏包含转录衔接子基序（TRAM）的第一多肽与包含TRAM相互作用基序的第二多肽之间的相互作用的方法。第一多肽和/或第二多肽可以是Mdm-2，p53，TBP，E2F，YY1，CBP / p300或TF11B，或来自HPV株（16）或（16）的病毒多肽，例如人乳头状瘤病毒（HPV） 18）。

2. 发明授权

US08198282B2 Substituted azaquinazolines having an antiviral action 有权
标题翻译：取代的具有抗病毒作用的氮杂喹啉
公开(公告)号：US08198282B2
公开(公告)日：2012-06-12
申请号：US12647210
申请日：2009-12-24
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Suessmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Suessmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
IPC分类号： A61K31/497 , A61P31/12
CPC分类号： C07D471/04
摘要： This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

3. 发明授权

US07867992B2 Substituted quinolones 有权
标题翻译：取代喹诺酮类
公开(公告)号：US07867992B2
公开(公告)日：2011-01-11
申请号：US11655589
申请日：2007-01-19
申请人： Holger Zimmermann , Rudolf Schohe-Loop , Kerstin Henninger , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Daniela Paulsen , Thomas Roelle , Johannes Koebberling , Marcus Bauser
发明人： Holger Zimmermann , Rudolf Schohe-Loop , Kerstin Henninger , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Daniela Paulsen , Thomas Roelle , Johannes Koebberling , Marcus Bauser
IPC分类号： A01N43/62 , A61K31/55 , C07D413/00
CPC分类号： C07D215/56 , C07D401/04
摘要： The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及取代的喹诺酮及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

4. 发明授权

US07767704B2 Antiviral 4-aminocarbonylamino-substituted imidazole compounds 有权
标题翻译：抗病毒4-氨基羰基氨基取代的咪唑化合物
公开(公告)号：US07767704B2
公开(公告)日：2010-08-03
申请号：US10594343
申请日：2005-03-11
申请人： Holger Zimmermann , David Brueckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Joerg Keldenich , Dieter Lang , Martin Radtke
发明人： Holger Zimmermann , David Brueckner , Dirk Heimbach , Martin Hendrix , Kerstin Henninger , Guy Hewlett , Ulrich Rosentreter , Joerg Keldenich , Dieter Lang , Martin Radtke
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07D233/90 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的取代的咪唑及其制备方法，用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途特别是用作抗病毒剂，特别是抗巨细胞病毒。

5. 发明授权

US07662822B2 Substituted azaquinazolines having an antiviral action 有权
标题翻译：取代的具有抗病毒作用的氮杂喹啉
公开(公告)号：US07662822B2
公开(公告)日：2010-02-16
申请号：US11579919
申请日：2005-04-23
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Süβmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Frank Süβmeier , Holger Zimmermann , Kerstin Henninger , Dieter Lang
IPC分类号： C07D471/04 , A61K31/497 , C07D213/75 , C07D213/73 , C07F9/06 , C07F9/28 , C07C265/12 , A61P31/12
CPC分类号： C07D471/04
摘要： This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的氮杂喹唑啉，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的疾病。

6. 发明申请

US20080214512A1 PHARMACEUTICAL PREPARATION CONTAINING A GESTAGEN, AND KIT AND METHOD FOR TREATING ENDOMETRIOSIS USING THE PREPARATION 审中-公开
标题翻译：含有Gestagen的药物制剂，以及使用制剂治疗子宫内膜异位的药盒和方法
公开(公告)号：US20080214512A1
公开(公告)日：2008-09-04
申请号：US12037990
申请日：2008-02-27
申请人： Christian Seitz , Annemarie Wasserfall , Holger Zimmermann
发明人： Christian Seitz , Annemarie Wasserfall , Holger Zimmermann
IPC分类号： A61K31/57 , A61P43/00
CPC分类号： A61K31/57
摘要： The pharmaceutical preparation for treating endometriosis contains at least 28, preferably 30, daily dose units, each of which contain dienogest, cyproterone acetate, or chlormadinone acetate at a daily dose that is at most twice that required to inhibit ovulation together with one or more pharmaceutical aids and/or carriers. The daily dose units are administered in a method of prophylaxis and/or therapy of endometriosis continuously during a time interval of at least 169 days or 25 weeks, preferably more than two years. The method effectively reduces endometriosis and associated pain, while undesirable side effects including bone density decrease are reduced or eliminated.
摘要翻译：用于治疗子宫内膜异位症的药物制剂含有至少28个，优选30个日剂量单位，每个剂量单位含有依那诺酯，乙酸环丙孕酮或醋酸氯美他尼酮，其日剂量为抑制排卵所需的一种或多种药物的两倍辅助工具和/或承运人。日剂量单位是在至少169天或25周，优选多于两年的时间间隔内连续预防和/或治疗子宫内膜异位症的方法施用的。该方法有效地减少了子宫内膜异位症和相关的疼痛，而减少或消除包括骨密度降低在内的不期望的副作用。

7. 发明申请

US20070185121A1 Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents 有权
标题翻译：杂环取代的二氢喹唑啉及其作为抗病毒剂的用途
公开(公告)号：US20070185121A1
公开(公告)日：2007-08-09
申请号：US10556198
申请日：2004-04-28
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang
IPC分类号： A61K31/4985 , C07D403/14
CPC分类号： C07D487/04
摘要： The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的杂环基取代的二氢喹唑啉，其制备方法，含有它们的药物，以及用于治疗和/或预防疾病，特别是用作抗病毒剂的方法特别是针对巨细胞病毒。

8. 发明申请

US20070088011A1 Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same 审中-公开
标题翻译：口服避孕和口服治疗功能障碍性子宫出血的组合制剂，含有戊酸雌二醇和dienogest及其使用方法
公开(公告)号：US20070088011A1
公开(公告)日：2007-04-19
申请号：US11377693
申请日：2006-03-16
申请人： Susan Zeun , Pol Boudes , Angelo Secci , Jan Endrikat , Holger Zimmermann
发明人： Susan Zeun , Pol Boudes , Angelo Secci , Jan Endrikat , Holger Zimmermann
IPC分类号： A61K31/57 , A61K31/56
CPC分类号： A61K31/56 , A61K31/57
摘要： The multiphase combination preparation for oral therapy of dysfunctional uterine bleeding and for oral contraception contains a first phase of 2 daily dosage units, each consisting of 3 mg of estradiol valerate; a second phase of two groups of daily dosage units, which consist of a first group containing 5 daily dosage units, each of which consist of a combination of 2 mg of estradiol valerate and 2 mg of dienogest, and a second group containing 17 daily dosage units, each of which consist of a combination of 2 mg of estradiol valerate and 3 mg of dienogest; a third phase of 2 daily dosage units each consisting of 1 mg of estradiol valerate; and another phase of 2 daily dosage units of a pharmaceutically harmless placebo; so that the multiphase combination preparation consists of a total number of 28 daily dosage units.
摘要翻译：用于口服功能障碍性子宫出血和口服避孕药物的多相组合制剂含有2个日剂量单位的第一阶段，每个剂量单位由3mg戊酸雌二醇组成; 两组每日剂量单位的第二期，由含有5个日剂量单位的第一组组成，每组含有2mg戊酸雌二醇和2mg的二烯酸的组合，第二组含有17个日剂量单位，其中每一个由2mg戊酸雌二醇和3mg的二烯酸的组合组成; 第三阶段为每日2剂量单位，每组1公斤戊酸雌二醇; 另一阶段是药物无害安慰剂的2个日剂量单位; 使多相组合制剂共计28个日剂量单位。

9. 发明授权

US07065007B2 Method and a playback device for performing a track slip 失效
标题翻译：方法和用于执行轨道滑移的回放装置
公开(公告)号：US07065007B2
公开(公告)日：2006-06-20
申请号：US09937006
申请日：2001-01-18
申请人： Holger Zimmermann , Volker Becker , Jens Maier , Dieter Baas
发明人： Holger Zimmermann , Volker Becker , Jens Maier , Dieter Baas
IPC分类号： G11B21/08
CPC分类号： G11B7/08588 , G11B7/08505
摘要： A method for performing a track skip and a playback device for optical storage disks enable an accelerated track skip in the case of a non-moving storage disk in which a time is determined for the track skip of a read device between a current track and a selected track of a storage disk inserted in the playback device, as a function of the tracks to be skipped in this instance, and the read device is moved in the direction of the selected track for the determined time. In response to a track skip request, the read device is moved in the direction of a lead-in area of the optical storage disk until a starting position is detected. The time necessary for the track skip from starting position to the selected track is determined from this track.
摘要翻译：用于执行光盘存储盘的轨道跳过和重放装置的方法使得能够在不移动存储盘的情况下加速轨道跳跃，其中确定了当前轨道和当前轨道之间的读取装置的轨迹跳过时间根据在这种情况下要跳过的轨道的功能，插入回放设备中的存储盘的所选轨道，并且读取设备沿所选择的轨道的方向移动所确定的时间。响应于轨道跳过请求，读取设备沿光存储盘的导入区域的方向移动，直到检测到起始位置。从该轨迹确定轨道从起始位置跳到所选轨道所需的时间。

10. 发明授权

US6063404A Bioadhesive tablet 失效
标题翻译：生物粘合剂片剂
公开(公告)号：US6063404A
公开(公告)日：2000-05-16
申请号：US124577
申请日：1998-07-29
申请人： Carsten Timpe , Michael Dittgen , Detlef Grawe , Jochen Schumacher , Holger Zimmermann , Herbert Hoffmann
发明人： Carsten Timpe , Michael Dittgen , Detlef Grawe , Jochen Schumacher , Holger Zimmermann , Herbert Hoffmann
IPC分类号： A61K9/00 , A61K9/20 , A61K47/30 , A61K47/38 , A61K9/44
CPC分类号： A61K9/006 , A61K9/2072 , A61K9/2086
摘要： This invention relates to a bioadhesive tablet containing at least one bioadhesive adjuvant and at least one lubricant, with at least one surface of the tablet comprising concentric or parallel, straight and/or curved depressions, and to a method for producing the bioadhesive tablets as well as to pharmaceuticals in the form of the bioadhesive tablets.
摘要翻译：本发明涉及包含至少一种生物粘附剂佐剂和至少一种润滑剂的生物粘附片剂，片剂的至少一个表面包含同心或平行的直的和/或弯曲的凹陷部分，以及用于生产生物粘附片剂的方法关于生物粘附片形式的药物。

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