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1. 发明授权

US08318761B2 Substituted arylsulfonamides as antiviral agents 有权
标题翻译：取代的芳基磺酰胺作为抗病毒剂
公开(公告)号：US08318761B2
公开(公告)日：2012-11-27
申请号：US12203793
申请日：2008-09-03
申请人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
发明人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
IPC分类号： A01N43/40 , A61K31/435 , A61K31/44
CPC分类号： C07D413/04 , C07D213/73
摘要： The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的取代芳基磺酰胺及其制备方法及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

2. 发明申请

US20090176842A1 SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS 有权
标题翻译：作为抗病毒剂的取代的芳香烃化物
公开(公告)号：US20090176842A1
公开(公告)日：2009-07-09
申请号：US12203793
申请日：2008-09-03
申请人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
发明人： Niels Svenstrup , Holger Zimmermann , Dagmar Karthaus , Andreas Goeller , Dirk Heimbach , Kerstin Henninger , Dieter Lang , Daniela Paulsen , Bernd Riedl , Rudolf Schohe-Loop , Joachim Schuhmacher , Tobias Wunberg
IPC分类号： A61K31/4439 , C07D413/04 , C07D213/73 , A61P31/12
CPC分类号： C07D413/04 , C07D213/73
摘要： The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的取代芳基磺酰胺及其制备方法及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

3. 发明申请

US20070293478A1 Substituted quinolones 有权
标题翻译：取代喹诺酮类
公开(公告)号：US20070293478A1
公开(公告)日：2007-12-20
申请号：US11655589
申请日：2007-01-19
申请人： Holger Zimmermann , Rudolph Schohe-loop , Kerstin Henninger , Daniela Paulsen , Thomas Roelle , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Johannes Koebberling , Marcus Bauser
发明人： Holger Zimmermann , Rudolph Schohe-loop , Kerstin Henninger , Daniela Paulsen , Thomas Roelle , Dieter Lang , Kai Thede , Chantal Fuerstner , David Brueckner , Johannes Koebberling , Marcus Bauser
IPC分类号： A61K31/497 , A61K31/5377 , A61K31/5513 , A61P31/22 , C07D243/08 , C07D401/02 , C07D413/14
CPC分类号： C07D215/56 , C07D401/04
摘要： The invention relates to substituted quinolones and to processes for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及取代的喹诺酮及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

4. 发明授权

US07196086B2 Substituted dihydroquinazolines 有权
公开(公告)号：US07196086B2
公开(公告)日：2007-03-27
申请号：US10832109
申请日：2004-04-26
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jürgen Reefschläger , Rudolf Schohe-Loop , Frank Süssmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Dieter Lang , Peter Nell
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jürgen Reefschläger , Rudolf Schohe-Loop , Frank Süssmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jörg Keldenich , Dieter Lang , Peter Nell
IPC分类号： A61K31/517 , C07D43/04
CPC分类号： C07D239/84
摘要： The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.

5. 发明申请

US20070066622A1 2-(3-Phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses 有权
标题翻译： 2-（3-苯基-2-哌嗪基-3,4-二氢喹唑啉-4-基）乙酸作为抗病毒剂，特别是针对巨细胞病毒
公开(公告)号：US20070066622A1
公开(公告)日：2007-03-22
申请号：US10545453
申请日：2004-01-29
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefshlager , Rudolf Schohe-Loop , Frank Submeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Thomas Kramer , Peter Nell , Tse-I Lin
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefshlager , Rudolf Schohe-Loop , Frank Submeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Thomas Kramer , Peter Nell , Tse-I Lin
IPC分类号： A61K31/517 , C07D405/14 , C07D403/02
CPC分类号： C07D239/84
摘要： The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.
摘要翻译：本发明涉及二氢喹唑啉及其制备方法，其用于治疗和/或预防疾病的用途，除了在制备药物中用于治疗和/或预防疾病，特别是用作抗病毒剂，特别是针对巨细胞病毒。

6. 发明申请

US20050065160A1 Substituted dihydroquinazolines 有权
标题翻译：取代的二氢喹唑啉
公开(公告)号：US20050065160A1
公开(公告)日：2005-03-24
申请号：US10832109
申请日：2004-04-26
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Rudolf Schohe-Loop , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang , Peter Nell
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Rudolf Schohe-Loop , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang , Peter Nell
IPC分类号： A61P31/22 , C07D239/84 , A61K31/517 , C07D43/04
CPC分类号： C07D239/84
摘要： The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
摘要翻译：本发明涉及取代的二氢喹唑啉及其制备方法，也涉及其用于制备用于治疗和/或预防疾病，特别是用作抗病毒剂，特别是针对巨细胞病毒的药物的用途。

7. 发明申请

US20050059658A1 Pyridazinone 审中-公开
标题翻译：哒嗪酮
公开(公告)号：US20050059658A1
公开(公告)日：2005-03-17
申请号：US10482520
申请日：2002-06-17
申请人： Tobias Wunberg , Ulrich Betz , Sabine Hallenberger , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Franz Zumpe , Marcus Bauser , Wolfgang Bender , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Axel Jensen , Jorg Keldenich , Holger Zimmermann
发明人： Tobias Wunberg , Ulrich Betz , Sabine Hallenberger , Gerald Kleymann , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Franz Zumpe , Marcus Bauser , Wolfgang Bender , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Axel Jensen , Jorg Keldenich , Holger Zimmermann
IPC分类号： A61K31/50 , A61K31/501 , A61P31/12 , C07D237/04 , C07D237/32 , C07D417/12
CPC分类号： C07D417/12 , C07D237/04 , C07D237/32
摘要： The invention relates to novel compounds, to a method for the production of said compounds and to the use thereof as medicaments, more particularly as antiviral agents, especially against cytomegalovirus.
摘要翻译：本发明涉及新化合物，所述化合物的制备方法及其作为药物的用途，更特别地涉及抗病毒剂，特别是抗巨细胞病毒。

8. 发明授权

US06864054B1 Polypeptides from CREB binding protein and related protein p300 for use in transcriptional regulation 失效
标题翻译：来自CREB结合蛋白和相关蛋白p300的多肽用于转录调节
公开(公告)号：US06864054B1
公开(公告)日：2005-03-08
申请号：US09701080
申请日：1999-05-26
申请人： Mark J. O'Connor , Holger Zimmermann
发明人： Mark J. O'Connor , Holger Zimmermann
IPC分类号： G01N33/566 , A61K38/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N15/09 , G01N33/15 , G01N33/68 , C12Q1/68 , C12N7/00
CPC分类号： C07K14/475 , A61K38/00 , C07K14/4702
摘要： A method for determining whether a compound inhibits or disrupts an interaction between a first polypeptide comprising a transcriptional adaptor motif (TRAM) and a second polypeptide comprising a TRAM-interaction motif. The first polypeptide and/or second polypeptide may be Mdm-2, p53, TBP, E2F, YY1, CBP/p300 or TF11B, or a viral polypeptide such as a human papillomavirus (HPV) E6 polypeptide from HPV strain (16) or (18).
摘要翻译：用于确定化合物是否抑制或破坏包含转录衔接子基序（TRAM）的第一多肽与包含TRAM相互作用基序的第二多肽之间的相互作用的方法。第一多肽和/或第二多肽可以是Mdm-2，p53，TBP，E2F，YY1，CBP / p300或TF11B，或来自HPV株（16）或（16）的病毒多肽，例如人乳头状瘤病毒（HPV） 18）。

9. 发明授权

US06459673B1 Apparatus for holding in readiness and selecting at least one storage disk 失效
标题翻译：用于保持准备并选择至少一个存储盘的装置
公开(公告)号：US06459673B1
公开(公告)日：2002-10-01
申请号：US09271533
申请日：1999-03-18
申请人： Volker Becker , Holger Zimmermann
发明人： Volker Becker , Holger Zimmermann
IPC分类号： G11B1704
CPC分类号： G11B17/22 , G11B33/0472
摘要： An apparatus for holding in readiness and selecting at least one storage disk is provided. The apparatus includes threaded rods, each having external threads. The at least one storage disk can be guided in the external threads of the threaded rods. Flights of the external threads coact with individual edge regions of at least one inserted storage disk. The at least one storage disk is displaceable along the threaded rods by rotation of the threaded rods.
摘要翻译：提供一种用于保持准备并选择至少一个存储盘的装置。该装置包括螺纹杆，每个具有外螺纹。可以在螺杆的外螺纹中引导至少一个存储盘。外部线程的航班与至少一个插入的存储盘的各个边缘区域共同作用。所述至少一个存储盘可以通过所述螺杆的旋转沿所述螺杆移动。

10. 发明授权

US06178152B1 Device for playing compact disks 失效
标题翻译：播放光盘的设备
公开(公告)号：US06178152B1
公开(公告)日：2001-01-23
申请号：US09171276
申请日：1999-08-18
申请人： Volker Becker , Anton Mindl , Thomas Westendorf , Holger Zimmermann
发明人： Volker Becker , Anton Mindl , Thomas Westendorf , Holger Zimmermann
IPC分类号： G11B1726
CPC分类号： G11B17/22 , G11B17/021 , G11B17/12
摘要： A device for playing compact disks, particularly for motor vehicles, including a magazine for a plurality of compact disks that is arranged in and is removable from a housing, and a playback unit for playing a compact disk from the magazine, the playback unit being swing-mounted in the housing separately from the magazine and being adjustable by an adjusting mechanism, is characterized in that the magazine includes a swivel mechanism, which enables at least a portion of the compact disks located in holding compartments of the magazine to swivel away from a compact disk positioned on the playback unit, to form an unencumbered swing space between the compact disk to be played that is positioned on the playback unit and the compact disks arranged in the holding compartments of the magazine.
摘要翻译：一种用于播放光盘的装置，特别是用于机动车辆的装置，包括布置在壳体中并可从壳体移除的多个光盘的盒子，以及用于从盒子播放光盘的回放单元，回放单元摆动 - 安装在壳体中，并且可通过调节机构调节，其特征在于，所述盒包括旋转机构，所述旋转机构使得位于所述盒的保持隔间中的至少一部分光盘能够远离定位在重放单元上的光盘，以便在放置在播放单元上的要播放的光盘之间形成一个不受阻碍的摆动空间，以及布置在盒的保持隔间中的光盘。

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