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1. 发明申请

US20080269249A2 AMINOPYRAZINE ANALOGS FOR TREATING GLAUCOMA AND OTHER RHO KINASE-MEDIATED DISEASES AND CONDITIONS 审中-公开
标题翻译：用于治疗葡萄球菌和其他RHO激酶介导的疾病和病症的氨基吡嗪类似物
公开(公告)号：US20080269249A2
公开(公告)日：2008-10-30
申请号：US11302825
申请日：2005-12-14
申请人： Mark Hellberg , Andrew Rusinko , Alan Henderson , Cheng Guo , Mark Hadden , Helene Decornez
发明人： Mark Hellberg , Andrew Rusinko , Alan Henderson , Cheng Guo , Mark Hadden , Helene Decornez
IPC分类号： A61K31/497 , C07D403/02 , A61K31/4965
CPC分类号： C07D471/04 , A61K31/4965 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14
摘要： Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.
摘要翻译：公开了使用氨基吡嗪类似物治疗rho激酶介导的疾病或rho激酶介导的病症（包括控制眼内压和治疗青光眼）的方法。还公开了可用于治疗眼睛疾病例如青光眼并且还可用于控制眼内压的眼用药物组合物，所述组合物包含有效量的氨基吡嗪类似物。

2. 发明授权

US07820670B2 6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions 有权
标题翻译： 6-氨基咪唑并[1,2-b]哒嗪类似物作为rho激酶抑制剂，用于治疗rho激酶介导的疾病和病症
公开(公告)号：US07820670B2
公开(公告)日：2010-10-26
申请号：US11960476
申请日：2007-12-19
申请人： Hwang-Hsing Chen , Andrew Rusinko , Mark R. Hellberg , Bryon S. Severns , Alan J. Henderson , Cheng Guo , Mark Hadden
发明人： Hwang-Hsing Chen , Andrew Rusinko , Mark R. Hellberg , Bryon S. Severns , Alan J. Henderson , Cheng Guo , Mark Hadden
IPC分类号： A61K31/501
CPC分类号： A61K31/5025 , A61K9/0048
摘要： Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.
摘要翻译：本文公开了使用6-氨基咪唑并[1,2-b]哒嗪类似物的方法，用于治疗rho激酶介导的疾病或rho激酶介导的病症，包括控制眼内压和治疗青光眼。用于治疗眼睛疾病如青光眼的眼用药物组合物，另外可用于控制眼内压，本文公开了包含有效量的6-氨基咪唑并[1,2-b]哒嗪类似物的组合物。

3. 发明申请

US20100216777A1 AMINOPYRAZINE ANALOGS FOR TREATING GLAUCOMA AND OTHER RHO KINASE-MEDIATED DISEASES AND CONDITIONS 审中-公开
标题翻译：用于治疗葡萄球菌和其他RHO激酶介导的疾病和病症的氨基吡嗪类似物
公开(公告)号：US20100216777A1
公开(公告)日：2010-08-26
申请号：US12774399
申请日：2010-05-05
申请人： Mark R. Hellberg , Andrew Rusinko , Alan J. Henderson , Cheng Guo , Mark Hadden , Hélène Y. Decornez
发明人： Mark R. Hellberg , Andrew Rusinko , Alan J. Henderson , Cheng Guo , Mark Hadden , Hélène Y. Decornez
IPC分类号： A61K31/551 , A61K31/55 , A61K31/497 , C07D401/14 , C07D401/04 , A61P27/06 , C07D403/14 , C07D471/04 , A61P27/02
CPC分类号： C07D471/04 , A61K31/4965 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14
摘要： Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.
摘要翻译：公开了使用氨基吡嗪类似物治疗rho激酶介导的疾病或rho激酶介导的病症（包括控制眼内压和治疗青光眼）的方法。还公开了可用于治疗眼睛疾病例如青光眼并且还可用于控制眼内压的眼用药物组合物，所述组合物包含有效量的氨基吡嗪类似物。

4. 发明授权

US08183275B2 Substituted imidazoles as bombesin receptor subtype-3 modulators 失效
公开(公告)号：US08183275B2
公开(公告)日：2012-05-22
申请号：US12311672
申请日：2007-10-16
申请人： Peter H. Dobbelaar , Christopher L. Franklin , Allan Goodman , Cheng Guo , Peter R. Guzzo , Mark Hadden , Shuwen He , Alan J. Henderson , Tianying Jian , Linus S. Lin , Jian Liu , Ravi P. Nargund , Megan Ruenz , Bruce J. Sargent , Iyassu K. Sebhat , Larry Yet
发明人： Peter H. Dobbelaar , Christopher L. Franklin , Allan Goodman , Cheng Guo , Peter R. Guzzo , Mark Hadden , Shuwen He , Alan J. Henderson , Tianying Jian , Linus S. Lin , Jian Liu , Ravi P. Nargund , Megan Ruenz , Bruce J. Sargent , Iyassu K. Sebhat , Larry Yet
IPC分类号： A61K31/4178 , A61K31/4164 , C07D471/04 , C07D401/10 , C07D403/10 , C07D233/64
CPC分类号： C07D401/10 , C07D233/64 , C07D403/10 , C07D403/12 , C07D405/04 , C07D409/10 , C07D413/06 , C07D417/06 , C07D417/10 , C07D471/04
摘要： Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

5. 发明申请

US20100204236A1 Substituted imidazoles as bombesin receptor subtype-3 modulators 失效
公开(公告)号：US20100204236A1
公开(公告)日：2010-08-12
申请号：US12311672
申请日：2007-10-16
申请人： Peter H. Dobbelaar , Christopher L. Franklin , Allan Goodman , Cheng Guo , Peter R. Guzzo , Mark Hadden , Shuwen He , Alan J. Henderson , Tianying Jian , Linus S. Lin , Jian Liu , Ravi P. Nargund , Megan Ruenz , Bruce J. Sargent , Iyassu K. Sebhat , Larry Yet
发明人： Peter H. Dobbelaar , Christopher L. Franklin , Allan Goodman , Cheng Guo , Peter R. Guzzo , Mark Hadden , Shuwen He , Alan J. Henderson , Tianying Jian , Linus S. Lin , Jian Liu , Ravi P. Nargund , Megan Ruenz , Bruce J. Sargent , Iyassu K. Sebhat , Larry Yet
IPC分类号： A61K31/4178 , A61K31/4985 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/4439 , A61K31/427 , A61K31/425 , A61K31/4196 , A61K31/4164 , C07D471/04 , C07D401/10 , C07D417/10 , C07D405/10 , C07D403/10 , C07D409/06 , C07D233/64 , A61P9/10 , A61P3/04
CPC分类号： C07D401/10 , C07D233/64 , C07D403/10 , C07D403/12 , C07D405/04 , C07D409/10 , C07D413/06 , C07D417/06 , C07D417/10 , C07D471/04
摘要： Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

6. 发明授权

US11085076B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 有权
公开(公告)号：US11085076B2
公开(公告)日：2021-08-10
申请号：US15763364
申请日：2016-09-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

7. 发明授权

US5599846A Phenylephrine tannate compositions 失效
标题翻译：去氧肾上腺素鞣酸盐组成
公开(公告)号：US5599846A
公开(公告)日：1997-02-04
申请号：US671160
申请日：1996-06-28
申请人： Vilas M. Chopdekar , James R. Schleck , Vernon A. Brown , Cheng Guo
发明人： Vilas M. Chopdekar , James R. Schleck , Vernon A. Brown , Cheng Guo
IPC分类号： A61K31/137 , A61K31/135
CPC分类号： A61K31/137
摘要： Phenylephrine tannate compositions are disclosed wherein the phenylephrine tannate has a minimum purity level of at least 95%. The composition also contains a minor amount of water, but no significant quantities of organic compounds or solvents other than water are present. The phenylephrine tannate will have a density of at least 0.6 g/cc.
摘要翻译：公开了其中苯肾上腺素丹宁酸具有至少95％的最低纯度水平的鞣酸去氧肾上腺素组合物。该组合物还含有少量的水，但不存在显着量的除水以外的有机化合物或溶剂。丹宁苯肾上腺素的密度至少为0.6g / cc。

8. 发明申请

US20180274024A1 DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开
公开(公告)号：US20180274024A1
公开(公告)日：2018-09-27
申请号：US15763364
申请日：2016-09-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/6869 , C07H19/20 , C07H19/10 , C07H19/14
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q2525/117 , C12Q2563/107
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

9. 发明授权

US09109156B2 Chemiluminescent system 有权
标题翻译：化学发光体系
公开(公告)号：US09109156B2
公开(公告)日：2015-08-18
申请号：US13998715
申请日：2013-11-26
申请人： Cheng Guo
发明人： Cheng Guo
IPC分类号： C09K11/07 , A63H33/28 , F21K2/06
CPC分类号： C09K11/07 , C09K2211/1007 , C09K2211/1011 , F21K2/06
摘要： An aqueous-based self-illuminating bubble-forming composition is provided. The composition comprises an oxalate component comprising an oxalate ester and a solvent; an activator component comprising a peroxide, a catalyst, and water; a surfactant; and a fluorescer in admixture with an aqueous bubble-forming solution. One or more of the same or different surfactants may be present in the activator component; the oxalate component; the activator component and the oxalate component; the aqueous bubble-forming solution; the activator component and the aqueous bubble-forming solution; the oxalate component and the aqueous bubble-forming solution; or in the oxalate component, the activator component and the aqueous bubble-forming solution.
摘要翻译：提供一种水性自发泡形成组合物。该组合物包含草酸酯组分，其包含草酸酯和溶剂; 包含过氧化物，催化剂和水的活化剂组分; 表面活性剂; 和与水泡形成溶液混合的荧光剂。一种或多种相同或不同的表面活性剂可以存在于活化剂组分中; 草酸盐成分; 活化剂组分和草酸盐组分; 水气泡形成溶液; 活化剂组分和含水气泡形成溶液; 草酸盐组分和含水气泡形成溶液; 或在草酸盐组分中，活化剂组分和含水气泡形成溶液。

10. 发明授权

US09081486B2 Method, device and system for acquiring virtual keyboard 有权
标题翻译：用于获取虚拟键盘的方法，设备和系统
公开(公告)号：US09081486B2
公开(公告)日：2015-07-14
申请号：US13981510
申请日：2011-12-23
申请人： Zhiqiang He , Chunhua Luo , Yuankun Zheng , Cheng Guo , Yu Tian , Liang Ma
发明人： Zhiqiang He , Chunhua Luo , Yuankun Zheng , Cheng Guo , Yu Tian , Liang Ma
IPC分类号： G06F13/38 , G06F15/16 , G06F3/048 , G06F3/0484
CPC分类号： G06F3/0484 , G06F3/048 , G06F3/04886
摘要： Embodiments, relating to the field of virtual keyboard technologies, of the present invention provide a method for acquiring a virtual keyboard key. The method includes: receiving layout of a universal virtual keyboard and a mapping relationship between terminals and universal virtual keyboard key value mapping tables from a server; acquiring a corresponding universal virtual keyboard key value mapping table according to the identifier of the terminal and the mapping relationship between terminals and universal virtual keyboard key value mapping tables; and acquiring a universal virtual keyboard according to the layout of the universal virtual keyboard and the universal virtual keyboard key value mapping table of the terminal. According to the embodiments of the present invention, a universal virtual keyboard key value mapping table of a terminal is acquired according to the identifier of the terminal and a mapping relationship between terminals and universal virtual keyboard key value mapping tables, and a universal virtual keyboard is acquired according to layout of the universal virtual keyboard and the universal virtual keyboard key value mapping table of the terminal. In this way, virtual keyboards of different terminals have uniform user interface display, thereby reducing operation costs of users to adapt different virtual keyboards due to use of different terminals, and improving user experience.
摘要翻译：本发明的虚拟键盘技术领域的实施例提供了一种用于获取虚拟键盘键的方法。该方法包括：从服务器接收通用虚拟键盘的布局和终端与通用虚拟键盘键值映射表之间的映射关系; 根据终端的标识符和终端与通用虚拟键盘密钥值映射表之间的映射关系，获取相应的通用虚拟键盘密钥值映射表; 并根据通用虚拟键盘的布局和终端的通用虚拟键盘键值映射表获取通用虚拟键盘。根据本发明的实施例，根据终端的标识符和终端与通用虚拟键盘键值映射表之间的映射关系，获取终端的通用虚拟键盘键值映射表，通用虚拟键盘根据通用虚拟键盘的布局和终端的通用虚拟键盘键值映射表获取。这样，不同终端的虚拟键盘具有统一的用户界面显示，从而降低用户使用不同终端的不同虚拟键盘的操作成本，提高用户体验。

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