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    • 2. 发明授权
    • Microfluidic droplet queuing network
    • 微流控液滴排队网络
    • US07993911B2
    • 2011-08-09
    • US12097455
    • 2007-02-07
    • Mark DaviesTara DaltonJulie GarveyKieran CurranDamian Curtin
    • Mark DaviesTara DaltonJulie GarveyKieran CurranDamian Curtin
    • C12M1/34
    • B01J19/0046B01F13/0071B01F15/0201B01F15/0232B01J2219/00313B01J2219/00353B01J2219/00479B01J2219/00587B01J2219/00608B01L3/5025B01L3/502784B01L2200/0673B01L2300/0829B01L2400/0487Y10T436/25
    • A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
    • 多端口液体桥(1)将包含油相载体液体(11)中的水相液滴(10)加入到通风道(4,6)。 室(3)连接四个端口,在使用时永久充满油(11)。 油相在进气口(4)的进料流中进料,并通过排气口(6)和补偿流通口(7)排出。 油载体和样品液滴(“水相”)以相当的流体流通过入口端口(5)流过补偿口(7)。 桥梁(1)的端口由保持在塑料壳体中的位置的毛细管的端部形成。 这些阶段是密度匹配的,以创造引力几乎可忽略的环境。 这导致当从毛细管尖端悬浮时,液滴(10)采用球形。 此外,质量流量的相等性等于体积流量的相等。 入口流(从液滴入口端口5和进气口4)的相位用于确定出口(6)的流动相位。