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1. 发明授权

US5348015A Method and apparatus for ultrasonically detecting, counting and/or characterizing emboli 失效
标题翻译：用于超声检测，计数和/或表征栓塞的方法和装置
公开(公告)号：US5348015A
公开(公告)日：1994-09-20
申请号：US947038
申请日：1992-09-17
申请人： Mark A. Moehring , Mark A. Curry , Merrill P. Spencer , John R. Klepper
发明人： Mark A. Moehring , Mark A. Curry , Merrill P. Spencer , John R. Klepper
IPC分类号： A61B8/06 , G01S7/52
CPC分类号： G01S7/52038 , A61B8/06 , A61B8/488
摘要： This disclosure relates to a noninvasive means for detecting, counting and characterizing emboli moving through the arterial or venous circulation. An ultrasonic transducer is applied to the skin or other tissues of the subject at sites such as over the temporal bone on either side of the head of the subject, on the neck, on the chest, the abdomen, arm, leg, within the esophagus, or surgically exposed organs or blood vessels. Using standard ultrasonic Doppler techniques, Doppler-shifted signals are located which are proportional to the blood flow velocity in the blood vessel(s) of interest. Spectral analysis is performed on the received signal using the fast Fourier transform or other appropriate technique to determine the frequency components in the Doppler shift spectrum. Further analysis of the spectra is used to delineate and characterize Doppler shift signals due to blood from Doppler shift signals due to emboli having a variety of compositions.
摘要翻译：本公开涉及用于检测，计数和表征通过动脉或静脉循环移动的栓塞的无创手段。将超声波换能器施加到受试者的皮肤或其他组织的位置，例如在受试者头部，颈部，胸部，腹部，手臂，腿部，食管内的颞骨上方，或手术暴露的器官或血管。使用标准的超声多普勒技术，定位多普勒频移信号，其与感兴趣的血管中的血流速度成比例。使用快速傅立叶变换或其他适当的技术对接收到的信号执行频谱分析以确定多普勒频移频谱中的频率分量。光谱的进一步分析用于描绘和表征多普勒频移信号，因为由于栓塞具有各种组成，多普勒频移信号的血液。

2. 发明授权

US06635017B1 Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis 有权
标题翻译：将诊断超声与治疗超声相结合以增强溶栓的方法和设备
公开(公告)号：US06635017B1
公开(公告)日：2003-10-21
申请号：US09500708
申请日：2000-02-09
申请人： Mark A. Moehring , Arne H. Voie , Merrill P. Spencer
发明人： Mark A. Moehring , Arne H. Voie , Merrill P. Spencer
IPC分类号： A61B806
CPC分类号： A61B8/0808 , A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/463 , A61B8/481 , A61B17/22004 , A61B17/2256 , A61B2090/378 , A61N7/00
摘要： A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can have the same or different frequency ranges in the diagnostic and therapeutic modes. The pulsed or continuous-wave ultrasound in the therapeutic mode enhances a lysing effect of a thrombolytic agent. The pulsed ultrasound in the diagnostic mode allows monitoring of blood flow to locate a thrombus, to determine an optimal window to administer the therapeutic pulsed ultrasound, and to detect when recanalization has occurred. If an operator attends the device, a graphical display operates during the diagnostic mode to display an image representative of the blood flow.
摘要翻译：描述了将治疗性脉冲或连续波超声与诊断脉冲超声相结合的方法和装置。在治疗模式和诊断模式中，超声从单个探针施用于患有血栓形成的患者。超声波可以在诊断和治疗模式中具有相同或不同的频率范围。治疗方式中的脉冲或连续波超声增强溶栓剂的溶解作用。在诊断模式中的脉冲超声波允许监测血流以定位血栓，以确定施用治疗性脉冲超声的最佳窗口，以及何时发生再通化检测。如果操作员参加该设备，则在诊断模式期间操作图形显示以显示代表血流的图像。

3. 发明授权

US07771358B2 System and method for grading microemboli monitored by a multi-gate doppler ultrasound system 有权
标题翻译：由多栅多普勒超声系统监测的微栓子分级系统和方法
公开(公告)号：US07771358B2
公开(公告)日：2010-08-10
申请号：US11134862
申请日：2005-05-20
申请人： Mark A. Moehring , Asanka S. Dewaraja , Thomas O. Mera , Merrill P. Spencer
发明人： Mark A. Moehring , Asanka S. Dewaraja , Thomas O. Mera , Merrill P. Spencer
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： A61B8/06 , A61B8/0808
摘要： Systems and methods for grading signals from microemboli in blood flow monitored using a Doppler ultrasound system. Signals from microemboli in blood flow are graded by calculating a value related to a power for the signals from microemboli in blood flow and categorizing the signals into one of at least two grades based on the calculated value. Alternatively, signals can be categorized by assessing a power value for the microemboli in blood flow during a period of monitoring. In response to the power value being greater than or equal to a threshold value, the microemboli in blood flow are categorized based on the power value, and in response to the power value being less than the threshold value, a number of microemboli are counted during at least a portion of the period of monitoring and the microemboli are categorized based on the number.
摘要翻译：使用多普勒超声系统监测血流中微栓子信号的分级系统和方法。通过计算与血液中的微栓塞信号的功率相关的值，根据计算值将信号分类为至少两个等级，将血流中的微栓子信号分级。或者，可以通过在监测期间评估血流中微栓子的功率值来分类信号。响应于功率值大于或等于阈值，血流中的微栓子基于功率值被分类，并且响应于功率值小于阈值，在多个微栓子期间计数微栓子至少监测期间的一部分和微栓子根据数量进行分类。

4. 发明授权

US07425198B2 Method and apparatus for automatic location of blood flow with Doppler ultrasound 有权
标题翻译：用多普勒超声自动定位血流的方法和装置
公开(公告)号：US07425198B2
公开(公告)日：2008-09-16
申请号：US10691122
申请日：2003-10-21
申请人： Mark A. Moehring , Arne H. Voie , Merrill P. Spencer
发明人： Mark A. Moehring , Arne H. Voie , Merrill P. Spencer
IPC分类号： A61B8/06
CPC分类号： A61B8/0808 , A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/463 , A61B8/481 , A61B17/22004 , A61B17/2256 , A61B2090/378 , A61N7/00
摘要： A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can have the same or different frequency ranges in the diagnostic and therapeutic modes. The pulsed or continuous-wave ultrasound in the therapeutic mode enhances a lysing effect of a thrombolytic agent. The pulsed ultrasound in the diagnostic mode allows monitoring of blood flow to locate a thrombus, to determine an optimal window to administer the therapeutic pulsed ultrasound, and to detect when recanalization has occurred. If an operator attends the device, a graphical display operates during the diagnostic mode to display an image representative of the blood flow.
摘要翻译：描述了将治疗性脉冲或连续波超声与诊断脉冲超声相结合的方法和装置。在治疗模式和诊断模式中，超声从单个探针施用于患有血栓形成的患者。超声波可以在诊断和治疗模式中具有相同或不同的频率范围。治疗方式中的脉冲或连续波超声增强溶栓剂的溶解作用。在诊断模式中的脉冲超声波允许监测血流以定位血栓，以确定施用治疗性脉冲超声的最佳窗口，以及何时发生再通化检测。如果操作员参加该设备，则在诊断模式期间操作图形显示以显示代表血流的图像。

5. 发明授权

US5052395A Non-invasive ultrasonic pulse doppler cardiac output monitor 失效
标题翻译：非侵入性超声波脉冲多普勒心输出量监测仪
公开(公告)号：US5052395A
公开(公告)日：1991-10-01
申请号：US499292
申请日：1990-05-16
申请人： Thomas A. Burton , George F. Sedivy , John R. Klepper , Mark A. Moehring , Richard F. Ferraro , Donald L. Davis
发明人： Thomas A. Burton , George F. Sedivy , John R. Klepper , Mark A. Moehring , Richard F. Ferraro , Donald L. Davis
IPC分类号： A61B8/06
CPC分类号： A61B8/467 , A61B8/065 , A61B8/461
摘要： A cardiac output measurement device for the real-time, non-invasive measurement of cardiac output that can be effectively operated by relatively unskilled personnel on a routine monitoring basis in a wide variety of office and hospital conditions. To accomplish this task, the system utilizes a pulsed Doppler ultrasound transducer directed through the suprasternal notch of a patient axially towards the blood flow in the ascending aorta. The device automatically searches the ascending aorta at various predetermined depths to find the depth at which the greatest quality blood velocity reading is detected. An examination is performed at that chosen depth and the device automatically calculates a patient's cardiac output from the Doppler measured velocity combined with an aortic diameter estimation made from the patient's height, weight, and age. The device automatically calculates cardiac velocity, cardiac index, stroke distance, heart rate, and stroke volume.
摘要翻译： PCT No.PCT / US88 / 04084 Sec。 371日期：1990年5月16日 102（e）日期1990年5月16日PCT提交1988年11月16日PCT公布。出版物WO89 / 04634 日期1989年6月1日。用于实时，无创测量心输出量的心输出量测量装置，其可以在各种办公室和医院条件下在日常监测的基础上由相对不熟练的人员有效地操作。为了完成这个任务，该系统利用脉冲多普勒超声换能器，引导穿过患者的超中间切口轴向朝向升主动脉中的血流。该装置以各种预定深度自动搜索升主动脉，以找到检测最高质量血液速度读数的深度。在所选择的深度进行检查，并且装置根据患者的身高，体重和年龄结合主动脉直径估计自动计算多普勒测量速度的患者心输出量。该装置自动计算心脏速度，心脏指数，行程距离，心率和行程体积。

6. 发明申请

US20120226163A1 MEDICAL DOPPLER ULTRASOUND SYSTEM FOR LOCATING AND TRACKING BLOOD FLOW 审中-公开
标题翻译：用于定位和跟踪血液流量的医用多普勒超声系统
公开(公告)号：US20120226163A1
公开(公告)日：2012-09-06
申请号：US13453851
申请日：2012-04-23
申请人： Mark A. Moehring , Mark A. Curry
发明人： Mark A. Moehring , Mark A. Curry
IPC分类号： A61B8/06
CPC分类号： A61B8/488 , A61B5/725 , A61B8/06 , A61B8/0816 , A61B8/4483 , A61B8/4488 , A61B8/4494 , A61B8/461 , A61B8/5223 , A61B8/54 , G01S7/5202 , G01S7/52028 , G01S7/52047 , G01S7/52066 , G01S15/8925 , G01S15/8979 , G01S15/8988
摘要： Systems and methods for processing echo signals in a Doppler ultrasound system from a region of interest. An ultrasound beam is electronically steered to deliver ultrasound to and receive echo signals from a plurality of sample locations in the region of interest. The echo signals for each sample location are processed to extract Doppler shift signals and Doppler shift data representing the Doppler shift signals are generated. The Doppler shift data accumulated for the sample locations can be used to detect the presence of blood flow in the region of interest, and identify the location in the region of interest at which the presence of blood flow is detected. The blood flow can be tracked by updating the location of the detected blood flow in the region of interest. The blood flow can be further monitored by combining the locating and tracking functionality with an m-mode ultrasound image.
摘要翻译：用于在多普勒超声系统中从感兴趣区域处理回波信号的系统和方法。电子控制超声波束以将超声波传送到感兴趣区域中的多个样本位置并从其接收回波信号。处理每个采样位置的回波信号以提取多普勒频移信号，并且生成表示多普勒频移信号的多普勒频移数据。可以使用针对样本位置累积的多普勒频移数据来检测感兴趣区域中的血流的存在，并且识别检测出血流存在的感兴趣区域中的位置。可以通过更新感兴趣区域中检测到的血流的位置来跟踪血流量。可以通过将定位和跟踪功能与m模式超声图像组合来进一步监测血流。

7. 发明授权

US08162837B2 Medical doppler ultrasound system for locating and tracking blood flow 有权
标题翻译：医用多普勒超声系统用于定位和跟踪血流
公开(公告)号：US08162837B2
公开(公告)日：2012-04-24
申请号：US11152666
申请日：2005-06-13
申请人： Mark A. Moehring , Mark A. Curry
发明人： Mark A. Moehring , Mark A. Curry
IPC分类号： A61B8/00
CPC分类号： A61B8/488 , A61B5/725 , A61B8/06 , A61B8/0816 , A61B8/4483 , A61B8/4488 , A61B8/4494 , A61B8/461 , A61B8/5223 , A61B8/54 , G01S7/5202 , G01S7/52028 , G01S7/52047 , G01S7/52066 , G01S15/8925 , G01S15/8979 , G01S15/8988
摘要： Systems and methods for processing echo signals in a Doppler ultrasound system from a region of interest. An ultrasound beam is electronically steered to deliver ultrasound to and receive echo signals from a plurality of sample locations in the region of interest. The echo signals for each sample location are processed to extract Doppler shift signals and Doppler shift data representing the Doppler shift signals are generated. The Doppler shift data accumulated for the sample locations can be used to detect the presence of blood flow in the region of interest, and identify the location in the region of interest at which the presence of blood flow is detected. The blood flow can be tracked by updating the location of the detected blood flow in the region of interest. The blood flow can be further monitored by combining the locating and tracking functionality with an m-mode ultrasound image.
摘要翻译：用于在多普勒超声系统中从感兴趣区域处理回波信号的系统和方法。电子控制超声波束以将超声波传送到感兴趣区域中的多个样本位置并从其接收回波信号。处理每个采样位置的回波信号以提取多普勒频移信号，并且生成表示多普勒频移信号的多普勒频移数据。可以使用针对样本位置累积的多普勒频移数据来检测感兴趣区域中血流的存在，并且识别检测到血流存在的感兴趣区域中的位置。可以通过更新感兴趣区域中检测到的血流的位置来跟踪血流量。可以通过将定位和跟踪功能与m模式超声图像组合来进一步监测血流。

8. 发明授权

US07771356B2 Ultrasound tympanoscope 有权
标题翻译：超声鼓膜镜
公开(公告)号：US07771356B2
公开(公告)日：2010-08-10
申请号：US11274729
申请日：2005-11-14
申请人： Arne H. Voie , Mark A. Moehring , George A. Gates , Eugene A. Saxon , Mailee J. Hess
发明人： Arne H. Voie , Mark A. Moehring , George A. Gates , Eugene A. Saxon , Mailee J. Hess
IPC分类号： A61B8/00
CPC分类号： A61B8/12 , A61B5/6817 , A61B8/4455 , A61B8/4483
摘要： A system and method for examining a patient for an ear disorder. Reflectance ultrasound is applied to a portion of the ear to determine the presence of ear effusion in a middle ear. If ear effusion is present, motion of the tympanic membrane is induced and ultrasound is further applied to the moving tympanic membrane. Echo signals resulting from the ultrasound applied to the moving tympanic membrane are analyzed to obtain information regarding the motion of the tympanic membrane and is used to characterize the ear effusion.
摘要翻译：一种用于检查患者耳朵疾病的系统和方法。反射超声应用于耳朵的一部分以确定中耳中的耳积液的存在。如果存在耳积液，则诱发鼓膜的运动，并且将超声波进一步施加到移动的鼓膜。分析了应用于移动式鼓膜的超声波产生的回波信号，以获得关于鼓膜运动的信息，并用于表征耳积液。

9. 发明授权

US07537568B2 Doppler ultrasound method and apparatus for monitoring blood flow 失效
标题翻译：用于监测血流量的多普勒超声方法和装置
公开(公告)号：US07537568B2
公开(公告)日：2009-05-26
申请号：US10612822
申请日：2003-07-01
申请人： Mark A. Moehring
发明人： Mark A. Moehring
IPC分类号： A61B8/06
CPC分类号： A61B8/463 , A61B8/06 , A61B8/0816 , A61B8/488 , G01S7/52036 , G01S7/52046 , G01S7/52071 , G01S7/52073 , G01S15/8984 , G01S15/8988
摘要： A pulse Doppler ultrasound system and associated methods are described for monitoring blood flow. A graphical information display includes simultaneously displayed depth-mode and spectrogram displays. The depth-mode display indicates the various positions along the ultrasound beam axis at which blood flow is detected. These positions are indicated as one or more colored regions, with the color indicating direction of blood flow and varying in intensity as a function of detected Doppler ultrasound signal amplitude or detected blood flow velocity. The depth-mode display also includes a pointer whose position may be selected by a user. The spectrogram displayed corresponds to the location identified by the pointer. Embolus detection and characterization are also provided.
摘要翻译：描述脉搏多普勒超声系统及相关方法来监测血流量。图形信息显示包括同时显示的深度模式和频谱图显示。深度模式显示指示沿着检测血流的超声波束轴的各种位置。这些位置被指示为一个或多个着色区域，其颜色指示血流的方向并且作为检测到的多普勒超声信号幅度或检测到的血流速度的函数而变化。深度模式显示还包括其位置可由用户选择的指针。显示的频谱图对应于由指针识别的位置。还提供了栓塞检测和表征。

10. 发明授权

US06524249B2 Doppler ultrasound method and apparatus for monitoring blood flow and detecting emboli 有权
公开(公告)号：US06524249B2
公开(公告)日：2003-02-25
申请号：US09731645
申请日：2000-12-06
申请人： Mark A. Moehring , Timothy R. Myers
发明人： Mark A. Moehring , Timothy R. Myers
IPC分类号： A61B806
CPC分类号： G01S15/8988 , A61B8/06 , A61B8/0816 , A61B8/463 , G01S7/52036 , G01S7/52046 , G01S7/52071 , G01S7/52073 , G01S15/8984
摘要： A pulse Doppler ultrasound system and associated methods are described for monitoring blood flow and detecting emboli. A graphical information display includes simultaneously displayed depth-mode and spectrogram displays. The depth-mode display indicates the various positions along the ultrasound beam axis at which blood flow is detected. These positions are indicated as one or more colored regions, with the color indicating direction of blood flow and varying in intensity as a function of detected Doppler ultrasound signal amplitude or detected blood flow velocity. The depth-mode display also includes a pointer whose position may be selected by a user. The spectrogram displayed corresponds to the location identified by the pointer. Embolus detection is also provided.

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