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1. 发明授权

US5052395A Non-invasive ultrasonic pulse doppler cardiac output monitor 失效
标题翻译：非侵入性超声波脉冲多普勒心输出量监测仪
公开(公告)号：US5052395A
公开(公告)日：1991-10-01
申请号：US499292
申请日：1990-05-16
申请人： Thomas A. Burton , George F. Sedivy , John R. Klepper , Mark A. Moehring , Richard F. Ferraro , Donald L. Davis
发明人： Thomas A. Burton , George F. Sedivy , John R. Klepper , Mark A. Moehring , Richard F. Ferraro , Donald L. Davis
IPC分类号： A61B8/06
CPC分类号： A61B8/467 , A61B8/065 , A61B8/461
摘要： A cardiac output measurement device for the real-time, non-invasive measurement of cardiac output that can be effectively operated by relatively unskilled personnel on a routine monitoring basis in a wide variety of office and hospital conditions. To accomplish this task, the system utilizes a pulsed Doppler ultrasound transducer directed through the suprasternal notch of a patient axially towards the blood flow in the ascending aorta. The device automatically searches the ascending aorta at various predetermined depths to find the depth at which the greatest quality blood velocity reading is detected. An examination is performed at that chosen depth and the device automatically calculates a patient's cardiac output from the Doppler measured velocity combined with an aortic diameter estimation made from the patient's height, weight, and age. The device automatically calculates cardiac velocity, cardiac index, stroke distance, heart rate, and stroke volume.
摘要翻译： PCT No.PCT / US88 / 04084 Sec。 371日期：1990年5月16日 102（e）日期1990年5月16日PCT提交1988年11月16日PCT公布。出版物WO89 / 04634 日期1989年6月1日。用于实时，无创测量心输出量的心输出量测量装置，其可以在各种办公室和医院条件下在日常监测的基础上由相对不熟练的人员有效地操作。为了完成这个任务，该系统利用脉冲多普勒超声换能器，引导穿过患者的超中间切口轴向朝向升主动脉中的血流。该装置以各种预定深度自动搜索升主动脉，以找到检测最高质量血液速度读数的深度。在所选择的深度进行检查，并且装置根据患者的身高，体重和年龄结合主动脉直径估计自动计算多普勒测量速度的患者心输出量。该装置自动计算心脏速度，心脏指数，行程距离，心率和行程体积。

2. 发明授权

US5348015A Method and apparatus for ultrasonically detecting, counting and/or characterizing emboli 失效
标题翻译：用于超声检测，计数和/或表征栓塞的方法和装置
公开(公告)号：US5348015A
公开(公告)日：1994-09-20
申请号：US947038
申请日：1992-09-17
申请人： Mark A. Moehring , Mark A. Curry , Merrill P. Spencer , John R. Klepper
发明人： Mark A. Moehring , Mark A. Curry , Merrill P. Spencer , John R. Klepper
IPC分类号： A61B8/06 , G01S7/52
CPC分类号： G01S7/52038 , A61B8/06 , A61B8/488
摘要： This disclosure relates to a noninvasive means for detecting, counting and characterizing emboli moving through the arterial or venous circulation. An ultrasonic transducer is applied to the skin or other tissues of the subject at sites such as over the temporal bone on either side of the head of the subject, on the neck, on the chest, the abdomen, arm, leg, within the esophagus, or surgically exposed organs or blood vessels. Using standard ultrasonic Doppler techniques, Doppler-shifted signals are located which are proportional to the blood flow velocity in the blood vessel(s) of interest. Spectral analysis is performed on the received signal using the fast Fourier transform or other appropriate technique to determine the frequency components in the Doppler shift spectrum. Further analysis of the spectra is used to delineate and characterize Doppler shift signals due to blood from Doppler shift signals due to emboli having a variety of compositions.
摘要翻译：本公开涉及用于检测，计数和表征通过动脉或静脉循环移动的栓塞的无创手段。将超声波换能器施加到受试者的皮肤或其他组织的位置，例如在受试者头部，颈部，胸部，腹部，手臂，腿部，食管内的颞骨上方，或手术暴露的器官或血管。使用标准的超声多普勒技术，定位多普勒频移信号，其与感兴趣的血管中的血流速度成比例。使用快速傅立叶变换或其他适当的技术对接收到的信号执行频谱分析以确定多普勒频移频谱中的频率分量。光谱的进一步分析用于描绘和表征多普勒频移信号，因为由于栓塞具有各种组成，多普勒频移信号的血液。

3. 发明授权

US5517995A 2D array for phase aberration correction 失效
标题翻译：用于相位校正的2D阵列
公开(公告)号：US5517995A
公开(公告)日：1996-05-21
申请号：US315786
申请日：1994-09-30
申请人： John R. Klepper , Levin F. Nock
发明人： John R. Klepper , Levin F. Nock
IPC分类号： B06B1/06 , G01S7/52 , G01S15/89 , A61B8/00
CPC分类号： G01S15/8925 , B06B1/0629 , G01S15/8927 , G01S7/52049
摘要： A vibratory energy (ultrasonic) imaging system of the type including a transducer array having a plurality of transducer elements for generating pulses of vibratory energy which are directed towards reflectors and which receive reflections of said vibratory energy and develop echo signals in response thereto. The array comprises a two-dimensional array of transducer elements arranged in a plurality of rows extending in a lateral dimension of the array and a plurality of columns extending in an elevation dimension of the array, at least one of a first type of said columns having elements of a first height in the elevation dimension and at least one of a second type of column having elements of a second height in the elevation dimension which is greater than the first height. In a preferred embodiment of the invention, the first height is an integral fraction of the second height.
摘要翻译：一种振动能量（超声波）成像系统，其类型包括具有多个换能器元件的换能器阵列，所述换能器阵列用于产生指向反射器的振动能量的脉冲，并且响应于此产生回波信号并产生所述振动能量的反射。所述阵列包括以阵列的横向尺寸延伸的多列布置的换能器元件的二维阵列，以及以所述阵列的高度尺寸延伸的多个列，所述列的第一类型中的至少一个具有在高度尺寸中的第一高度的元件和具有大于第一高度的高度尺寸中具有第二高度的元件的第二类型列中的至少一个。在本发明的优选实施例中，第一高度是第二高度的积分分数。

4. 发明授权

US4648276A Apparatus for measuring the characteristics of an ultrasonic wave medium 失效
标题翻译：用于测量超声波介质特性的装置
公开(公告)号：US4648276A
公开(公告)日：1987-03-10
申请号：US616472
申请日：1984-06-01
申请人： John R. Klepper , John M. Reid , Hirohide Miwa , Takaki Shimura , Keiichi Murakami
发明人： John R. Klepper , John M. Reid , Hirohide Miwa , Takaki Shimura , Keiichi Murakami
IPC分类号： G01S7/52 , G01S15/89 , G01N29/00
CPC分类号： G01S7/52036 , G01S15/8954 , G01S7/52025
摘要： The present invention relates to an apparatus which determines the distribution of the attenuation slope coefficient on a real-time basis using the center frequency shift. In one embodiment, the phase difference between a received signal and a reference signal is determined using EXCLUSIVE OR gates or an inverse trigonometric relation stored in a ROM. The phase difference is input to a differentiator which outputs the center frequency shift of the received signal on a real-time basis. The center frequency shift is input to another differentiator which outputs the attenuation slope coefficient. In other embodiments, the received signal is distributed into received signal bands, having different center frequencies, and signal characteristics of the received signal bands are averaged to remove virtually all effects of spectrum scalloping in the time domain. Thus, the attenuation slope coefficient is obtained without the effects of spectrum scalloping using simple hardware and without Fourier transformation.
摘要翻译：本发明涉及使用中心频移来实时地确定衰减斜率系数的分布的装置。在一个实施例中，接收信号和参考信号之间的相位差是使用存储在ROM中的独占或门或逆三角关系来确定的。相位差被输入到实时地输出接收信号的中心频移的微分器。中心频移被输入到输出衰减斜率系数的另一个微分器。在其他实施例中，接收的信号被分配到具有不同中心频率的接收信号频带中，并且接收信号频带的信号特性被平均以消除时域中的频谱扇贝的几乎所有的影响。因此，衰减斜率系数在没有使用简单的硬件并且没有傅立叶变换的频谱扇贝的影响下获得。

5. 发明授权

US4534220A Apparatus for measuring the characteristics of an ultrasonic wave medium 失效
标题翻译：用于测量超声波介质特性的装置
公开(公告)号：US4534220A
公开(公告)日：1985-08-13
申请号：US574690
申请日：1984-01-27
申请人： John R. Klepper , John M. Reid , Hirohide Miwa , Takaki Shimura , Keiichi Murakami
发明人： John R. Klepper , John M. Reid , Hirohide Miwa , Takaki Shimura , Keiichi Murakami
IPC分类号： A61B8/08 , A61B8/00 , G01N27/90 , G01N29/00 , G01S15/02 , G01S15/89
CPC分类号： G01S15/89 , G01N27/9046 , G01S15/02
摘要： The present invention relates to an apparatus which determines the distribution of the attenuation slope coefficient on a real time basis using the center frequency shift. The phase difference between a received signal and a reference signal is determined using EXCLUSIVE OR gates or an inverse trigonometric relation stored in a ROM. The phase difference is input to a differentiator which outputs the center frequency shift of the received signal on a real time basis. The center frequency shift is input to another differentiator which outputs the attenuation slope coefficient. Thus, the attenuation slope coefficient is determined using simple hardware and without calculating the power spectrum and the first moment.
摘要翻译：本发明涉及使用中心频率移位实时地确定衰减斜率系数的分布的装置。接收信号和参考信号之间的相位差使用存储在ROM中的独占或门或逆三角关系来确定。相位差输入到实时地输出接收信号的中心频移的微分器。中心频移被输入到输出衰减斜率系数的另一个微分器。因此，使用简单的硬件来确定衰减斜率系数，并且不计算功率谱和第一时刻。

6. 发明授权

US5575290A Coarse-fine ultrasound transducer array for medical imaging 失效
标题翻译：用于医学成像的粗细超声换能器阵列
公开(公告)号：US5575290A
公开(公告)日：1996-11-19
申请号：US497627
申请日：1995-06-30
申请人： Tat-Jin Teo , John R. Klepper
发明人： Tat-Jin Teo , John R. Klepper
IPC分类号： G01S15/89 , G10K11/34 , A61B8/00
CPC分类号： G01S15/8925 , G10K11/34 , G01S15/8913
摘要： The ultrasound transducer array defines an average row spacing along the elevation for receiving transducer elements that differs from an average row spacing along the elevation for transmitting transducer elements. In one embodiment a relatively "coarse" row spacing is used for reception and a relatively "fine" row spacing is used for transmission. The differing spacings lead to different transmit-elevation and receive-elevation beam-patterns. In one configuration the number of transducer elements, and correspondingly the number of ultrasound processing channels, is reduced. In an alternative configuration the beam-pattern "footprint" is increased without increasing the number of transducer elements or processing channels. The array includes dedicated transmit-only elements and/or dedicated receive-only elements, together with coincident, time-shared transmit/receive elements. The coarse-fine spacings enable improved elevational focus without substantially increasing side lobe levels in a focal plane and far field portion of a resulting beam-pattern.
摘要翻译：超声换能器阵列定义沿着仰角的平均行距，用于接收换能器元件，其不同于沿着仰角的平均行间距，用于发射换能器元件。在一个实施例中，相对“粗”行间距用于接收，并且相对“精细”的行间隔用于传输。不同的间距导致不同的透射仰角和接收仰角波束图案。在一种配置中，减少了换能器元件的数量，并且相应地减少了超声波处理通道的数量。在替代配置中，波束图案“覆盖区”增加而不增加换能器元件或处理通道的数量。该阵列包括专用的仅发送元件和/或专用的仅接收元件，以及重合的时间共享的发送/接收元件。粗细间距使得能够改善高程聚焦，而不会在所得到的波束图案的焦平面和远场部分中基本上增加旁瓣电平。

7. 发明授权

US5460180A Connection arrangement and method of operation of a 2D array for phase aberration correction 失效
标题翻译：用于相位差校正的2D阵列的连接布置和操作方法
公开(公告)号：US5460180A
公开(公告)日：1995-10-24
申请号：US316603
申请日：1994-09-30
申请人： John R. Klepper , Levin F. Nock
发明人： John R. Klepper , Levin F. Nock
IPC分类号： G01N29/06 , A61B8/00 , B06B1/02 , B06B1/06 , G01N29/24 , G01N29/44 , G01S15/89
CPC分类号： B06B1/0622 , B06B2201/20 , B06B2201/40
摘要： An ultrasound imaging system of the type including a 2D transducer array which has first and second types of transducer elements. Each element of the first type occupies an area of the array which is an integral fraction of the area occupied by each element of the second type. A connection arrangement comprising a plurality of multiplexer/summation circuits is provided for electrically connecting the array elements to the remainder of the ultrasound imaging system. Each multiplexer/summation circuit has a plurality of signal inputs individually connected to a respective plurality of the elements of the first type for selectively combining a given number of the elements of the first type together, the given number being an inverse of the integral fraction. In a preferred embodiment of the invention the 2D array is generally rectangular in shape and has elements arranged into rows along its lateral dimension and columns along its elevational dimension, with a first lateral portion of the array including at least one column of elements of the first type and a second lateral portion of the array including columns of elements of the second type. The multiplexer/summation circuit has signal inputs connected individually to each of the elements of a column of the elements of the first type, for selecting the given number of elements to be combined.
摘要翻译：该类型的超声成像系统包括具有第一和第二类型的换能器元件的2D换能器阵列。第一类型的每个元件占据阵列的区域，该区域是第二类型的每个元件所占据的区域的整体分数。提供了包括多个多路复用器/求和电路的连接装置，用于将阵列元件电连接到超声成像系统的其余部分。每个多路复用器/求和电路具有分别连接到第一类型的相应多个元件的多个信号输入，用于选择性地将给定数量的第一类型的元件组合在一起，给定数量是积分分数的倒数。在本发明的优选实施例中，2D阵列的形状大致为矩形，并且具有沿其横向尺寸排列的元件和沿着它的垂直尺寸的列，阵列的第一侧向部分包括至少一列第一类型和包括第二类型元素列的阵列的第二横向部分。多路复用器/求和电路具有单独地连接到第一类型的元件的列的每个元件的信号输入，用于选择要组合的给定数量的元件。

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