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1. 发明授权

US07771358B2 System and method for grading microemboli monitored by a multi-gate doppler ultrasound system 有权
标题翻译：由多栅多普勒超声系统监测的微栓子分级系统和方法
公开(公告)号：US07771358B2
公开(公告)日：2010-08-10
申请号：US11134862
申请日：2005-05-20
申请人： Mark A. Moehring , Asanka S. Dewaraja , Thomas O. Mera , Merrill P. Spencer
发明人： Mark A. Moehring , Asanka S. Dewaraja , Thomas O. Mera , Merrill P. Spencer
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： A61B8/06 , A61B8/0808
摘要： Systems and methods for grading signals from microemboli in blood flow monitored using a Doppler ultrasound system. Signals from microemboli in blood flow are graded by calculating a value related to a power for the signals from microemboli in blood flow and categorizing the signals into one of at least two grades based on the calculated value. Alternatively, signals can be categorized by assessing a power value for the microemboli in blood flow during a period of monitoring. In response to the power value being greater than or equal to a threshold value, the microemboli in blood flow are categorized based on the power value, and in response to the power value being less than the threshold value, a number of microemboli are counted during at least a portion of the period of monitoring and the microemboli are categorized based on the number.
摘要翻译：使用多普勒超声系统监测血流中微栓子信号的分级系统和方法。通过计算与血液中的微栓塞信号的功率相关的值，根据计算值将信号分类为至少两个等级，将血流中的微栓子信号分级。或者，可以通过在监测期间评估血流中微栓子的功率值来分类信号。响应于功率值大于或等于阈值，血流中的微栓子基于功率值被分类，并且响应于功率值小于阈值，在多个微栓子期间计数微栓子至少监测期间的一部分和微栓子根据数量进行分类。

2. 发明授权

US06635017B1 Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis 有权
标题翻译：将诊断超声与治疗超声相结合以增强溶栓的方法和设备
公开(公告)号：US06635017B1
公开(公告)日：2003-10-21
申请号：US09500708
申请日：2000-02-09
申请人： Mark A. Moehring , Arne H. Voie , Merrill P. Spencer
发明人： Mark A. Moehring , Arne H. Voie , Merrill P. Spencer
IPC分类号： A61B806
CPC分类号： A61B8/0808 , A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/463 , A61B8/481 , A61B17/22004 , A61B17/2256 , A61B2090/378 , A61N7/00
摘要： A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can have the same or different frequency ranges in the diagnostic and therapeutic modes. The pulsed or continuous-wave ultrasound in the therapeutic mode enhances a lysing effect of a thrombolytic agent. The pulsed ultrasound in the diagnostic mode allows monitoring of blood flow to locate a thrombus, to determine an optimal window to administer the therapeutic pulsed ultrasound, and to detect when recanalization has occurred. If an operator attends the device, a graphical display operates during the diagnostic mode to display an image representative of the blood flow.
摘要翻译：描述了将治疗性脉冲或连续波超声与诊断脉冲超声相结合的方法和装置。在治疗模式和诊断模式中，超声从单个探针施用于患有血栓形成的患者。超声波可以在诊断和治疗模式中具有相同或不同的频率范围。治疗方式中的脉冲或连续波超声增强溶栓剂的溶解作用。在诊断模式中的脉冲超声波允许监测血流以定位血栓，以确定施用治疗性脉冲超声的最佳窗口，以及何时发生再通化检测。如果操作员参加该设备，则在诊断模式期间操作图形显示以显示代表血流的图像。

3. 发明授权

US5348015A Method and apparatus for ultrasonically detecting, counting and/or characterizing emboli 失效
标题翻译：用于超声检测，计数和/或表征栓塞的方法和装置
公开(公告)号：US5348015A
公开(公告)日：1994-09-20
申请号：US947038
申请日：1992-09-17
申请人： Mark A. Moehring , Mark A. Curry , Merrill P. Spencer , John R. Klepper
发明人： Mark A. Moehring , Mark A. Curry , Merrill P. Spencer , John R. Klepper
IPC分类号： A61B8/06 , G01S7/52
CPC分类号： G01S7/52038 , A61B8/06 , A61B8/488
摘要： This disclosure relates to a noninvasive means for detecting, counting and characterizing emboli moving through the arterial or venous circulation. An ultrasonic transducer is applied to the skin or other tissues of the subject at sites such as over the temporal bone on either side of the head of the subject, on the neck, on the chest, the abdomen, arm, leg, within the esophagus, or surgically exposed organs or blood vessels. Using standard ultrasonic Doppler techniques, Doppler-shifted signals are located which are proportional to the blood flow velocity in the blood vessel(s) of interest. Spectral analysis is performed on the received signal using the fast Fourier transform or other appropriate technique to determine the frequency components in the Doppler shift spectrum. Further analysis of the spectra is used to delineate and characterize Doppler shift signals due to blood from Doppler shift signals due to emboli having a variety of compositions.
摘要翻译：本公开涉及用于检测，计数和表征通过动脉或静脉循环移动的栓塞的无创手段。将超声波换能器施加到受试者的皮肤或其他组织的位置，例如在受试者头部，颈部，胸部，腹部，手臂，腿部，食管内的颞骨上方，或手术暴露的器官或血管。使用标准的超声多普勒技术，定位多普勒频移信号，其与感兴趣的血管中的血流速度成比例。使用快速傅立叶变换或其他适当的技术对接收到的信号执行频谱分析以确定多普勒频移频谱中的频率分量。光谱的进一步分析用于描绘和表征多普勒频移信号，因为由于栓塞具有各种组成，多普勒频移信号的血液。

4. 发明授权

US07425198B2 Method and apparatus for automatic location of blood flow with Doppler ultrasound 有权
标题翻译：用多普勒超声自动定位血流的方法和装置
公开(公告)号：US07425198B2
公开(公告)日：2008-09-16
申请号：US10691122
申请日：2003-10-21
申请人： Mark A. Moehring , Arne H. Voie , Merrill P. Spencer
发明人： Mark A. Moehring , Arne H. Voie , Merrill P. Spencer
IPC分类号： A61B8/06
CPC分类号： A61B8/0808 , A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/463 , A61B8/481 , A61B17/22004 , A61B17/2256 , A61B2090/378 , A61N7/00
摘要： A method and apparatus for combining therapeutic pulsed or continuous-wave ultrasound with diagnostic pulsed ultrasound are described. In both a therapeutic mode and in a diagnostic mode, the ultrasound is administered from a single probe to a patient suffering from thrombosis. The ultrasound can have the same or different frequency ranges in the diagnostic and therapeutic modes. The pulsed or continuous-wave ultrasound in the therapeutic mode enhances a lysing effect of a thrombolytic agent. The pulsed ultrasound in the diagnostic mode allows monitoring of blood flow to locate a thrombus, to determine an optimal window to administer the therapeutic pulsed ultrasound, and to detect when recanalization has occurred. If an operator attends the device, a graphical display operates during the diagnostic mode to display an image representative of the blood flow.
摘要翻译：描述了将治疗性脉冲或连续波超声与诊断脉冲超声相结合的方法和装置。在治疗模式和诊断模式中，超声从单个探针施用于患有血栓形成的患者。超声波可以在诊断和治疗模式中具有相同或不同的频率范围。治疗方式中的脉冲或连续波超声增强溶栓剂的溶解作用。在诊断模式中的脉冲超声波允许监测血流以定位血栓，以确定施用治疗性脉冲超声的最佳窗口，以及何时发生再通化检测。如果操作员参加该设备，则在诊断模式期间操作图形显示以显示代表血流的图像。

5. 发明授权

US5042490A Method for diagnosis of early stage of optic nerve blood supply disturbance 失效
标题翻译：诊断视神经供血障碍早期的方法
公开(公告)号：US5042490A
公开(公告)日：1991-08-27
申请号：US405549
申请日：1989-09-11
申请人： Svyatoslav N. Fedorov , Merrill P. Spencer , Gertruda D. Mikhailova , Dina I. Ioffe
发明人： Svyatoslav N. Fedorov , Merrill P. Spencer , Gertruda D. Mikhailova , Dina I. Ioffe
IPC分类号： A61F9/00 , A61B8/06 , A61B18/10
CPC分类号： A61B8/06 , A61B18/10
摘要： The invention is a method for diagnosis of early stage of optic nerve blood supply disturbance resides in that the state and localization of the optic nerve is determined by virtue of ultrasonic scanning, then a distance from the eyelid anterior surface of the ciliary arteries supplying said optic nerve is measured, whereupon the state of hemodynamics in said ciliary arteries is determined on the thus-measured distance with the aid of ultrasonic pulse-dopplerography, by measuring the linear and volumetric blood flow velocities in said arteries, a value of said linear blood flow velocity below 9 cm/s and of said volumetric blood flow below 5 ml/min are indicative of an early stage of optic nerve blood supply disturbance.
摘要翻译：本发明是用于诊断视神经供血障碍早期的方法，其原因在于，通过超声波扫描来确定视神经的状态和定位，然后从提供所述视神经的睫状体动脉的眼睑前表面的距离通过测量所述动脉中的线性和体积血流速度，借助于超声波脉冲 - 多普勒影像在所测量的距离上确定所述睫状动脉中的血液动力学状态，所述线性血流量低于9cm / s的速度和低于5ml / min的体积血流量指示视神经供血障碍的早期阶段。

6. 发明授权

US4109642A Apparatus for ultrasonic arteriography 失效
标题翻译：超声动脉造影仪
公开(公告)号：US4109642A
公开(公告)日：1978-08-29
申请号：US454423
申请日：1974-03-25
申请人： John M. Reid , Merrill P. Spencer
发明人： John M. Reid , Merrill P. Spencer
IPC分类号： A61B8/06 , G01F1/66 , G01S15/50 , G01S15/89 , A61B10/00
CPC分类号： A61B8/4218 , A61B8/06 , G01F1/66 , G01S15/50 , G01S15/8979 , G01S15/8993 , G01N2291/02836
摘要： Continuous wave ultrasonic sound waves from a transmitter and receiver are highly focused to a width of approximately 1 millimeter or less and are transmitted and received through intersecting paths within the tissue of a patient. A doppler flow detector produces an image of the moving blood within the vessel. The transmitter and receiver are systematically scanned over the subject and the detected images are converted into visually intelligible pictures.An improved circuit for more clearly defining the flow picture of the moving blood particles utilizes a conventional directional doppler circuit plus a multiplier-differentiator-low pass filter circuit to automatically eliminate venous flow signals. A grey scale oscilloscope provides brightness intensity on the visual picture proportional to the velocity and direction of the blood flow for detecting stenosis in the vessel.A recording technique is disclosed for detecting atherosclerotic thickening of the artery wall.A multiple beam scanner is disclosed which requires movement only in the longitudinal direction of the vessel.
摘要翻译：来自发射器和接收器的连续波超声波被高度聚焦到大约1毫米或更小的宽度，并且通过患者组织内的相交路径被传送和接收。多普勒流量检测器产生血管内移动血液的图像。发射机和接收机被系统地扫描主体，并将检测到的图像转换成视觉上可理解的图像。

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