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1. 发明申请

US20210033602A1 Simplifying Solid-Phase Microextraction (SPME)-Based Analytical Measurements of Exceedingly Small-Volume Samples by Application of Negligible Depletion 有权
公开(公告)号：US20210033602A1
公开(公告)日：2021-02-04
申请号：US16940824
申请日：2020-07-28
申请人： Marc David Porter , Jennifer Harnisch Granger , Robert Joseph Soto , Lorriane Marie Siperko
发明人： Marc David Porter , Jennifer Harnisch Granger , Robert Joseph Soto , Lorriane Marie Siperko
IPC分类号： G01N33/543
摘要： This invention discloses an approach regarding the use of solid-phase microextractions (SPMEs) in the analytical, bioanalytical, combinatorial sciences, and all other applicable areas of measurement science. The approach applies to the analysis of exceedingly small volumes of a liquid specimen (10s-100s of μL), and how the concepts of negligible depletion (ND) can be used within the context of tradeoff between extractive (reaction) kinetics, extractive capacity, and sample flow rate as a means to obviate the need to deliver accurately a small volume sample for SPME analysis, improving the ease-of-use for a number of different SPME-based measurements including, for example, disease markers in immunoassays for health care.

2. 发明申请

US20210031191A1 Smart Microplates and Microarrays 有权
公开(公告)号：US20210031191A1
公开(公告)日：2021-02-04
申请号：US16934102
申请日：2020-07-21
申请人： Marc David Porter , Anton Sergeyevich Klimenko , Aleksander Skuratovsky , Jennifer Harnisch Granger
发明人： Marc David Porter , Anton Sergeyevich Klimenko , Aleksander Skuratovsky , Jennifer Harnisch Granger
IPC分类号： B01L3/00
摘要： This invention discloses a design of microplates and microarrays to improve utility. The new design constructs a physical flux barrier that limits thermocapillary and other mass transfer contributions to the heterogeneous accumulation of reactant at the surface of a well or array address. The improved control of reactant delivery results in a much more uniform distribution of reactant across an address, thereby improving the accuracy of the measured response.

3. 发明申请

US20210031166A1 Solid Phase Microextraction Membranes Impregnated with Gold Nanoparticles: Creation of Novel SERS-Enhancing Substrates 有权
公开(公告)号：US20210031166A1
公开(公告)日：2021-02-04
申请号：US16942274
申请日：2020-07-29
申请人： Marc David Porter , Jennifer Harnisch Granger , Anton Sergeyevich Klimenko
发明人： Marc David Porter , Jennifer Harnisch Granger , Anton Sergeyevich Klimenko
IPC分类号： B01J20/02 , B01J20/32
摘要： This invention discloses an approach is improve the strength and reproducibility of the signal generated in FTAs using solid-phase microextraction (SPME) through the design of an approach to generate the plasmonically-enhanced signal for SERS, surface-enhanced infrared (SEIRA), and other enhanced spectroscopies. The design incorporates: (1) a particle-particle coupling strategy that is triggered by the selective capture of an analyte to a particle that has been immobilized on a membrane and has been modified to act as a capture substrate; (2) the selective tagging of the captured analyte by a nanoparticle also designed to generate an amplified plasmonic signal upon tagging; and (3) the incorporation of an internal nanoparticle standard to account for fluctuations in flow rates and flow paths. Collectively, these developments improve the accuracy and precision of the analysis as well as the SPME analysis accurately, improving the ease-of-use for a number of different SPME-based measurements, including, for example, those focused on disease markers using immunoassays and a range of other assay formats.

4. 发明授权

US08685239B2 Separation device with integral guard column 有权
标题翻译：带集成保护柱的分离装置
公开(公告)号：US08685239B2
公开(公告)日：2014-04-01
申请号：US11329759
申请日：2006-01-11
申请人： Jennifer Harnisch Granger , Robert Plumb
发明人： Jennifer Harnisch Granger , Robert Plumb
IPC分类号： B01D15/22 , G01N30/60
CPC分类号： B01D15/22 , G01N30/60 , G01N30/6039 , G01N30/6065 , G01N30/6069 , G01N2030/085
摘要： A separation device is formed of a first tube with a cylindrical wall enclosing a chamber having a first diameter, where the device has a first end for discharging a fluid and a second end for receiving a fluid. At least two stationary phase medias are packed into the chamber with separating frits between the medias. At least one end frit element, secured to an inner surface of the first tube contains the media in its section of the chamber and allows the beds formed of the media to be formed and packed. When the separation device so constructed forms a nanocolumn with a guard bed, the guard bed may be cleaved from the separation device extending the useful life of the nanocolumn. When the separation device so constructed comprises two analytical sections, and a plurality of guard beds, complex analysis may be performed on a column having an extended useful life.
摘要翻译：分离装置由具有包围具有第一直径的室的圆柱形壁的第一管形成，其中该装置具有用于排出流体的第一端和用于接收流体的第二端。至少两个固定相介质被填充到室内，分离介质之间的玻璃料。固定到第一管的内表面的至少一个端部玻璃料元件在其腔室的部分中包含介质，并允许形成和包装由介质形成的床。当如此构造的分离装置形成具有保护床的纳米柱时，保护床可以从延长纳米柱的使用寿命的分离装置断裂。当如此构造的分离装置包括两个分析部分和多个保护床时，可以对具有延长的使用寿命的柱进行复杂分析。

5. 发明申请

US20120052522A1 Apparatus And Method For The Study Of Metabolism 审中-公开
标题翻译：代谢研究的装置与方法
公开(公告)号：US20120052522A1
公开(公告)日：2012-03-01
申请号：US13128720
申请日：2009-11-17
申请人： Jose Castro-Perez , Robert S. Plumb , Jennifer Harnisch Granger
发明人： Jose Castro-Perez , Robert S. Plumb , Jennifer Harnisch Granger
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： C12M41/38 , C12M23/06
摘要： Embodiments of the present invention feature methods and apparatus in which fluids circulating between a plurality of vessels containing different cell types or tissues are monitored for metabolites following the introduction of a sample.
摘要翻译：本发明的实施方案的特征在于在引入样品之后监测在含有不同细胞类型或组织的多个血管之间循环的液体代谢物的方法和装置。

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