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1. 发明授权

US07186843B2 Aminomethylpyrrolidine derivatives having aromatic substituents 失效
公开(公告)号：US07186843B2
公开(公告)日：2007-03-06
申请号：US10834079
申请日：2004-04-29
申请人： Makoto Takemura , Hisashi Takahashi , Katsuhiro Kawakami , Toshiyuki Takeda , Rie Miyauchi
发明人： Makoto Takemura , Hisashi Takahashi , Katsuhiro Kawakami , Toshiyuki Takeda , Rie Miyauchi
IPC分类号： C07D207/09 , C07D401/12 , C07D403/12
CPC分类号： C07D401/04 , C07D405/14
摘要： This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of the same or a hydrate of both. In the formula, R2, R3: hydrogen atom, an alkyl group; R4, R5, R6: hydrogen atom, hydroxyl group, a halogen atom, carbamoyl group, an alkyl group, an alkoxyl group, an alkylthio group; R7, R8: hydrogen atom, an alkyl group; R9: an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, an aryl group, a heteroaryl group, an alkoxyl group having from 1 to 6 carbon atoms, an alkylamino group; R10:hydrogen atom, an alkylthio group; R11: hydrogen atom, amino group, hydroxyl group, thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; X1: halogen atom, a hydrogen atom; A1: nitrogen atom, C—X2; X2: hydrogen atom, amino group, a halogen atom, cyano group, an halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; A2, A3:>C═C (—A1═)—N(—R9)—, >N—C (—A1>)═C(—R9)—; R10 and R9 or R9 and X2 may be integrated to form a ring structure; and Y: hydrogen atom, ester forming group.

2. 发明授权

US06762181B1 Aminomethylpyrrolidine derivatives having aromatic substituents 失效
标题翻译：具有芳香取代基的氨基甲基吡咯烷衍生物
公开(公告)号：US06762181B1
公开(公告)日：2004-07-13
申请号：US09936050
申请日：2001-09-07
申请人： Makoto Takemura , Hisashi Takahashi , Katsuhiro Kawakami , Toshiyuki Takeda , Rie Miyauchi
发明人： Makoto Takemura , Hisashi Takahashi , Katsuhiro Kawakami , Toshiyuki Takeda , Rie Miyauchi
IPC分类号： A61K314375
CPC分类号： C07D401/04 , C07D405/14
摘要： This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of the same or a hydrate of both. In the formula, R2, R3: hydrogen atom, an alkyl group; R4, R5, R6: hydrogen atoms, hydroxyl group, a halogen atom, carbamoyl group, an alkyl group, an alkoxyl group, an alkylthio group; R7, R8: hydrogen atom, an alkyl group; R9: an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, an aryl group, a heteroaryl group, an alkoxyl group having from 1 to 6 carbon atoms, an alkylamino group; R10: hydrogen atom, an alkylthio group; R11: hydrogen atom, amino group, hydroxyl group, thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; X1: halogen atom, a hydrogen atom; A1: nitrogen atom, C—X2; X2: hydrogen atom, amino group, a halogen atom, cyano group, an halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; A2, A3: >C═C(—A1═)—N(—R9)—, >N—C(—A1═)═C(—R9)—; R10 and R9 or R9 and X2 may be integrated to form a ring structure; and Y: hydrogen atom, ester forming group.
摘要翻译：本发明提供了一种喹诺酮衍生物，其具有对各种细菌的抗菌活性，包括耐药菌株，其为下式的化合物，其中R 1为任选取代的芳族基团，其两者的盐或两者的水合物。式R 2，R 3：氢原子，烷基; R 4，R 5，R 6：氢原子，羟基，卤素原子，氨基甲酰基，烷基，烷氧基，烷硫基; R 7，R 8：氢原子，烷基; R 9：烷基，烯基，卤代烷基，环状烷基，芳基，杂芳基，碳原子数1〜6的烷氧基，烷基氨基， R 10：氢原子，烷硫基; R 11：氢原子，氨基，羟基，硫醇基，卤代甲基，烷基，烯基，炔基，烷氧基; X 1：卤素原子，氢原子; A 1：氮原子，C-X 2; X 2：氢原子，氨基，卤原子，氰基，卤代甲基，卤代甲氧基，烷基，烯基，炔基，烷氧基; A 2，A 3：C = C（-A 1 =）-N（-R 9） - ，> NC（-A 1）= C（-R 9） >） - ; R 10和R 9或R 9和X 2可以一体形成环结构; 和Y：氢原子，酯形成基团。

3. 发明授权

US06656952B2 Cis-substituted fluoromethylpyrrolidine derivative 失效
标题翻译：顺式取代的氟甲基吡咯烷衍生物
公开(公告)号：US06656952B2
公开(公告)日：2003-12-02
申请号：US09446696
申请日：1999-12-23
申请人： Makoto Takemura , Hisashi Takahashi , Hitoshi Ohki , Kenichi Kimura , Rie Miyauchi , Toshiyuki Takeda
发明人： Makoto Takemura , Hisashi Takahashi , Hitoshi Ohki , Kenichi Kimura , Rie Miyauchi , Toshiyuki Takeda
IPC分类号： A61K3147
CPC分类号： C07D401/04
摘要： An antibacterial drug having potent antibacterial activities upon various bacteria including resistant strains and high safety is disclosed, which comprises as an active ingredient, quinolone derivatives represented by the following formula (I), its salts or hydrates thereof: wherein R1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R2 represents a halogenomethoxyl group or an alkoxyl group, R3 represents an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, a heteroaryl group, an alkoxyl group or an alkylamino group, and R4 represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, 3-acetoxy-2-oxobutyl group, an alkyl group, an alkoxylmethyl group or a phenylalkyl group. These substituents may further have additional substituents.
摘要翻译：本发明公开了一种对各种细菌（包括耐药菌株）和高度安全性具有有效抗菌活性的抗菌药物，其包含作为活性成分的由下式（I）表示的喹诺酮衍生物，其盐或水合物：其中R 1表示氢原子或碳原子数1〜6的烷基，R 2表示卤代甲氧基或烷氧基，R 3表示烷基，链烯基，卤代烷基，环状烷基，杂芳基基团，烷氧基或烷基氨基，R 4表示氢原子，苯基，乙酰氧基甲基，新戊酰氧基甲基，乙氧基羰基，胆碱基，二甲基氨基乙基，5-二氢化茚基， 5-烷基-2-氧代-1,3-二氧杂环戊烯-4-基甲基，3-乙酰氧基-2-氧代丁基，烷基，烷氧基甲基或苯基烷基。这些取代基还可以具有另外的取代基。

4. 发明授权

US06573260B1 Cycloalkyl-substituted aminomethylpyrrolidine derivatives 失效
标题翻译：环烷基取代的氨基甲基吡咯烷衍生物
公开(公告)号：US06573260B1
公开(公告)日：2003-06-03
申请号：US09856631
申请日：2001-05-24
申请人： Makoto Takemura , Hisashi Takahashi , Rie Miyauchi , Toshiyuki Takeda , Isao Hayakawa
发明人： Makoto Takemura , Hisashi Takahashi , Rie Miyauchi , Toshiyuki Takeda , Isao Hayakawa
IPC分类号： A61K314709
CPC分类号： C07D401/04
摘要： This invention provides a quinolone derivative which exerts strong antibacterial action upon various bacteria and has high safety, and it relates to a compound having a structure of formula (I), its salts and hydrates thereof: {R1 and R2: hydrogen, alkyl; n: 1 to 4; Q: following structure (Ia): [R3: alkyl, alkenyl, halogenoalkyl, cyclic alkyl, aryl, heteroaryl, alkoxyl, alkylamino; R4: hydrogen, alkylthio; R5: hydrogen, amino, hydroxyl, thiol, halogenomethyl, alkyl, alkenyl, alkynyl, alkoxyl; X1: halogen, hydrogen, A1: nitrogen, structure of formula (II): (X2: hydrogen, amino, halogen, cyano, halogenomethyl, halogenomethyl, alkyl, alkenyl, alkynyl, alkoxyl; R4 and R3 or X2 and R3 may together form a cyclic structure; Y: hydrogen, various ester forming groups]}.
摘要翻译：本发明提供了一种喹诺酮衍生物，其对各种细菌具有强烈的抗菌作用并具有高度的安全性，它涉及具有式（I）结构的化合物及其盐和水合物：{R1和R2：氢，烷基; n：1到4; Q：以下结构（Ia）：[R3：烷基，烯基，卤代烷基，环烷基，芳基，杂芳基，烷氧基，烷基氨基; R4：氢，烷硫基; R5：氢，氨基，羟基，硫醇，卤代甲基，烷基，烯基，炔基，烷氧基; X1：卤素，氢，A1：氮，式（II）的结构：（X2：氢，氨基，卤素，氰基，卤代甲基，卤代甲基，烷基，烯基，炔基，烷氧基; R4和R3或X2和R3可以一起形成环状结构; Y：氢，各种酯形成基团]}。

5. 发明授权

US6021915A Foldable and simplified water tank 失效
标题翻译：可折叠和简化的水箱
公开(公告)号：US6021915A
公开(公告)日：2000-02-08
申请号：US714980
申请日：1996-09-17
申请人： Kiichiro Shimozono , Norio Oishi , Toshiyuki Takeda
发明人： Kiichiro Shimozono , Norio Oishi , Toshiyuki Takeda
IPC分类号： E03B11/02 , B65D30/02 , E04H4/00 , B65D33/00
CPC分类号： E04H4/0025
摘要： A foldable and simplified water tank characterized by a cylindrical shape and a side wall formed by a sheet made from synthetic resin, and the stiffness of said sheet, measured in accordance with the measuring method prescribed in Japan Industrial Standard L-1096 is from 100 to 1000. The water tank can be made to stand up by itself by only pouring water into it.
摘要翻译：一种折叠简化的水箱，其特征在于圆筒形状和由合成树脂制成的片形成的侧壁，并且根据日本工业标准L-1096中规定的测量方法测量的所述片材的刚度为100至水罐可以自己立起来，只能把水倒入水中。

6. 发明授权

US5159400A Apparatus for testing optical fiber by using detector having virtually broadened dynamic range 失效
标题翻译：用于通过使用具有虚拟宽带动态范围的探测器测试光纤的装置
公开(公告)号：US5159400A
公开(公告)日：1992-10-27
申请号：US766238
申请日：1991-09-24
申请人： Toshiyuki Takeda , Satoshi Matsuura , Akio Ichikawa
发明人： Toshiyuki Takeda , Satoshi Matsuura , Akio Ichikawa
IPC分类号： G01J1/00 , G01J11/00 , G01M11/00
CPC分类号： G01M11/3172
摘要： An optical fiber testing apparatus for testing an optical fiber as to presence and location of a fault such as breakage by inputting a pulsed coherent light beam to the optical fiber and synthesizing a return light beam reflected back from the optical fiber with a reference light beam having a frequency deviated from the pulsed light beam by a predetermined amount, wherein the synthesized waveform is detected through optical heterodyning. The electric signal obtained from the heterodyning detection is detected by an envelope detector, of which dynamic range is effectively virtually broadened by using correcting data prepared previously. The optical fiber test can be accomplished through a single measurement without involving expensiveness of hardware.
摘要翻译：一种光纤测试装置，用于通过向光纤输入脉冲相干光束并合成从光纤反射回来的返回光束，用参考光束来测试光纤是否存在和定位故障，例如断裂，所述参考光束具有频率偏离脉冲光束预定量，其中通过光学外差检测合成波形。由外部检测获得的电信号由包络检测器检测，其中动态范围通过使用之前准备的校正数据被有效地扩大。光纤测试可以通过单个测量来实现，而不涉及硬件的昂贵性。

7. 外观设计

USD462040S1 Caliper body of disk brake for vehicle 失效
标题翻译：用于车辆的盘式制动器的卡钳体
公开(公告)号：USD462040S1
公开(公告)日：2002-08-27
申请号：US29150025
申请日：2001-10-31
申请人： Tetsuyoshi Ueno , Toshiyuki Takeda
设计人： Tetsuyoshi Ueno , Toshiyuki Takeda

8. 发明授权

US6063418A Method and container for insecticidally storing grains 失效
标题翻译：杀虫剂储存方法和容器
公开(公告)号：US6063418A
公开(公告)日：2000-05-16
申请号：US77095
申请日：1998-07-14
申请人： Teizo Sugimoto , Naoshi Itagaki , Hiroshi Kimura , Eiji Wada , Naoki Hayashi , Toshiyuki Takeda , Shiro Yamamoto
发明人： Teizo Sugimoto , Naoshi Itagaki , Hiroshi Kimura , Eiji Wada , Naoki Hayashi , Toshiyuki Takeda , Shiro Yamamoto
IPC分类号： A01F25/00 , A01F25/14 , A23B9/00 , A23B9/18 , A23B9/20 , A23B9/22 , A23K3/02
CPC分类号： A23B9/22 , A23B9/18 , A23B9/20
摘要： A method and a container for long-term storage in a state in which harmful insects do not propagate, in a case in which grains such as unpolished rice or the like are filled and stored. An inner bag (10) made of a flexible material is accommodated in an outer bag (12) which has high-strength. After grains are filled in the inner bag, the inner bag (10) is filled with carbon dioxide gas and is closed. The grains are stored in a state in which harmful insects are exterminated. It is preferable from the standpoint of the insecticidal effect that the inner portion of the inner bag (10) is able to maintain a carbon dioxide gas concentration of 40% or more for 7 days or more. Because the inner bag has the property of a CO.sub.2 permeation amount of less than or equal to 6300 cc/m.sup.2 .multidot.24 hr 1 atm, an oxygen-deficient state can be maintained.
摘要翻译： PCT No.PCT / JP96 / 03704 Sec。 371日期：1998年7月14日 102（e）日期1998年7月14日PCT 1996年12月19日PCT PCT。出版物WO97 / 22258 日期1997年6月26日在填充并储存诸如未磨光米等的颗粒的情况下，在有害昆虫不传播的状态下长期储存的方法和容器。由柔性材料制成的内袋（10）容纳在具有高强度的外袋（12）中。在内袋中填充颗粒后，内袋（10）填充有二氧化碳气体并关闭。谷物被储存在有害昆虫被灭绝的状态。从杀虫效果的观点出发，优选内袋（10）的内部能够将二氧化碳气体浓度保持在40％以上，持续7天以上。因为内袋具有小于或等于6300cc / m2×24小时1atm的CO 2渗透量的性质，因此可以保持缺氧状态。

9. 发明授权

US4756969A Highly electrically conductive filament and a process for preparation thereof 失效
标题翻译：高导电性丝及其制备方法
公开(公告)号：US4756969A
公开(公告)日：1988-07-12
申请号：US64839
申请日：1987-06-19
申请人： Toshiyuki Takeda
发明人： Toshiyuki Takeda
IPC分类号： D01F8/04 , D01D5/34 , D02G3/44 , D02G3/00
CPC分类号： D01D5/34 , D01F1/09 , D02G3/441 , Y10T428/2927 , Y10T428/2929 , Y10T428/2933 , Y10T428/2964 , Y10T428/2967 , Y10T428/2969 , Y10T428/2973 , Y10T428/2978
摘要： A highly electrically conductive composite filament of sheath-core type, comprising core and sheath layers of an electrically non-conductive thermoplastic polymer and a middle layer of electrically conductive thermoplastic polymer containing carbon black between the core and sheath wherein said sheath partially surrounds the outer periphery of said middle layer.
摘要翻译：一种皮芯型高导电复合长丝，包括不导电热塑性聚合物的芯层和护套层，以及在芯和护套之间含有炭黑的导电热塑性聚合物的中间层，其中所述护套部分包围外周的中间层。

10. 发明授权

US4633510A Electronic circuit capable of stably keeping a frequency during presence of a burst 失效
标题翻译：能够在存在突发时稳定地保持频率的电子电路
公开(公告)号：US4633510A
公开(公告)日：1986-12-30
申请号：US687343
申请日：1984-12-28
申请人： Fumiaki Suzuki , Toshiyuki Takeda , Takeo Inoue , Shigeo Nakajima
发明人： Fumiaki Suzuki , Toshiyuki Takeda , Takeo Inoue , Shigeo Nakajima
IPC分类号： H03L7/14 , H04B1/40 , H04B7/15 , H04B7/155 , H04B1/00
CPC分类号： H04B1/40 , H03L7/14
摘要： In a radio communication system, a transmitting section of a substation comprises a controlling circuit (21) for controlling a carrier frequency of a local oscillator (24) in response to a frequency deviation signal. A burst generating circuit (26) generates a burst in response to the input signal, a burst control signal, and a local oscillation signal of the carrier frequency. The transmitting section further comprises a holding circuit (34) responsive to a frequency control signal and the burst control signal. During presence of the burst control signal, the holding circuit holds the frequency control signal received before a beginning of the burst control signal to keep the carrier frequency of the local oscillation signal invariable until an end of the burst control signal. Otherwise, the frequency control signal passes through the holding circuit as it stands. Consequently, the carrier frequency of the local oscillation signal is controlled only during absence of the input signal and is kept invariable during presence of the input signal.
摘要翻译：在无线电通信系统中，变电站的发送部分包括用于响应于频率偏差信号来控制本地振荡器（24）的载波频率的控制电路（21）。突发发生电路（26）响应于输入信号，脉冲串控制信号和载波频率的本地振荡信号产生脉冲串。发送部分还包括响应于频率控制信号和突发控制信号的保持电路（34）。在脉冲串控制信号的存在期间，保持电路保持在突发控制信号开始之前接收到的频率控制信号，以保持本地振荡信号的载波频率不变，直到脉冲串控制信号的结束。否则，频率控制信号就一直通过保持电路。因此，本地振荡信号的载波频率仅在没有输入信号的情况下被控制，并且在存在输入信号的过程中保持不变。

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