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1. 发明授权

US5442043A Peptide conjugate 失效
标题翻译：肽缀合物
公开(公告)号：US5442043A
公开(公告)日：1995-08-15
申请号：US158245
申请日：1993-11-29
申请人： Makoto Fukuta , Satoshi Iinuma , Hiroaki Okada
发明人： Makoto Fukuta , Satoshi Iinuma , Hiroaki Okada
IPC分类号： A61K47/48 , A61K51/08 , A61K35/14 , A61K7/00 , A61K38/00 , A61K38/28 , C07K7/00
CPC分类号： A61K47/48238 , A61K51/083 , A61K51/088
摘要： The present invention provides a conjugate capable of passing the blood-brain barrier comprising a bioactive peptide or protein incapable of passing the blood-brain barrier and a carrier peptide which exhibits substantially no bioactivity and which is capable of passing the blood-brain barrier. The conjugate makes it possible to allow a bioactive peptide or protein incapable of passing the blood-brain barrier to easily pass the blood-brain barrier for uniform transport to the brain without any side effect of the carrier peptide.
摘要翻译：本发明提供了能够通过包含不能通过血脑屏障的生物活性肽或蛋白质的血脑屏障的结合物和基本上不具有生物活性且能够通过血脑屏障的载体肽。该缀合物使得可以允许生物活性肽或蛋白质不能通过血脑屏障以容易地通过血脑屏障，以均匀地输送到脑中，而没有载体肽的任何副作用。

2. 发明授权

US06376461B1 Sustained-release preparation 失效
公开(公告)号：US06376461B1
公开(公告)日：2002-04-23
申请号：US09426716
申请日：1999-10-26
申请人： Yasutaka Igari , Yutaka Yamagata , Satoshi Iinuma , Hiroaki Okada , Kazumichi Yamamoto
发明人： Yasutaka Igari , Yutaka Yamagata , Satoshi Iinuma , Hiroaki Okada , Kazumichi Yamamoto
IPC分类号： A01N3718
CPC分类号： A61K9/5031 , A61K9/0019 , A61K31/00 , A61K38/1816 , A61K38/193 , A61K38/212 , A61K38/27 , A61K38/28
摘要： According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically active substance which is not an endothelin antagonist, and a biodegradable polymer. The sustained-release preparation of the first embodiment is highly efficient in incorporating the water-soluble physiologically active substance and suppresses the initial burst of the water-soluble physiologically active substance. The sustained-release preparation of the present invention is capable of releasing the water-soluble physiologically active substance while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble physiologically active substance in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity. According to a second embodiment, there is provided a sustained-release preparation comprising an anti-endothelin substance and a biodegradable polymer. The sustained-release preparation of the present invention sustainedly releases an anti-endothelin substance, serving well in the treatment of endothelin-associated diseases.

3. 发明授权

US07982880B2 Optical image measurement device 有权
标题翻译：光学图像测量装置
公开(公告)号：US07982880B2
公开(公告)日：2011-07-19
申请号：US12659869
申请日：2010-03-24
申请人： Tsutomu Kikawa , Hiroaki Okada , Takefumi Hayashi , Hisashi Tsukada , Yasufumi Fukuma
发明人： Tsutomu Kikawa , Hiroaki Okada , Takefumi Hayashi , Hisashi Tsukada , Yasufumi Fukuma
IPC分类号： G01B9/02
CPC分类号： G01B9/02067 , A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02064 , G01B9/02089 , G01B9/02091 , G01N21/4795
摘要： A fundus oculi observation device acts as an optical image measurement device capable of measuring an OCT image such as a tomographic image of a fundus oculi, or the like, and is configured so as to calculate the signal level of the formed OCT image, determine whether the signal level exceeds a threshold value, and change the position of a reference mirror so that the signal level is determined to exceed the threshold value.
摘要翻译：眼底观察装置作为能够测量诸如眼底断层图像等OCT图像的光学图像测量装置，并且被配置为计算形成的OCT图像的信号电平，确定是否信号电平超过阈值，并且改变参考镜的位置，使得信号电平被确定为超过阈值。

4. 发明申请

US20100188502A1 Optical image measurement device 有权
标题翻译：光学图像测量装置
公开(公告)号：US20100188502A1
公开(公告)日：2010-07-29
申请号：US12659869
申请日：2010-03-24
申请人： Tsutomu Kikawa , Hiroaki Okada , Takefumi Hayashi , Hisashi Tsukada , Yasufumi fukuma
发明人： Tsutomu Kikawa , Hiroaki Okada , Takefumi Hayashi , Hisashi Tsukada , Yasufumi fukuma
IPC分类号： H04N7/18
CPC分类号： G01B9/02067 , A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02064 , G01B9/02089 , G01B9/02091 , G01N21/4795
摘要： A fundus oculi observation device acts as an optical image measurement device capable of measuring an OCT image such as a tomographic image of a fundus oculi, or the like, and is configured so as to calculate the signal level of the formed OCT image, determine whether the signal level exceeds a threshold value, and change the position of a reference mirror so that the signal level is determined to exceed the threshold value.
摘要翻译：眼底观察装置作为能够测量诸如眼底断层图像等OCT图像的光学图像测量装置，并且被配置为计算形成的OCT图像的信号电平，确定是否信号电平超过阈值，并且改变参考镜的位置，使得信号电平被确定为超过阈值。

5. 发明授权

US07549746B2 Fundus observation device 有权
标题翻译：眼底观察装置
公开(公告)号：US07549746B2
公开(公告)日：2009-06-23
申请号：US11689141
申请日：2007-03-21
申请人： Hisashi Tsukada , Hiroaki Okada , Yutaka Nishio , Yasufumi Fukuma
发明人： Hisashi Tsukada , Hiroaki Okada , Yutaka Nishio , Yasufumi Fukuma
IPC分类号： A61B3/14
CPC分类号： A61B3/102
摘要： A fundus observation device is provided capable of capturing both images of the surface of the fundus oculi and tomographic images of the fundus oculi, and capable of preventing alignment indicators from being reflected in the image of the fundus oculi. Image forming part 220 operates to form surface images based on results of detecting the reflection light by the fundus oculi Ef of the illumination light obtained from a fundus camera unit 1A, and operates to form tomographic images based on results of detecting interference light LC by the OCT unit 150. The fundus camera unit comprises alignment optical systems 110A and 190A, which project an alignment indicator. Detection timing controlling part 210B controls a fundus camera unit 1A and makes it detect the illumination light substantially simultaneously with detection of the interference light. Before the interference light LC and illumination light are substantially simultaneously detected, the alignment controlling part 210 controls the alignment optical system 110A and 190A and terminates the projection of the alignment light indicator. Correction processing part 225 corrects the image position of tomographic images using the surface images obtained substantially simultaneously.
摘要翻译：提供了能够捕获眼底表面的图像和眼底的断层图像的眼底观察装置，并且能够防止对准指示符反映在眼底的图像中。图像形成部件220基于从眼底照相机单元1A获得的照明光的眼底Ef检测反射光的结果来形成表面图像，并且基于通过检测干涉光LC的结果来形成断层图像 OCT单元150.眼底相机单元包括对准光学系统110A和190A，其对准对准指示器。检测定时控制部分210B控制眼底照相机单元1A，并使其在检测到干涉光的同时基本上同时检测照明光。在基本上同时检测干涉光LC和照明光之前，对准控制部210控制对准光学系统110A和190A，并终止对准光指示器的投影。修正处理部225使用基本上同时获得的表面图像来校正断层图像的图像位置。

6. 发明授权

US5750100A Sustained releasable parenteral pharmaceutical preparations and method of producing the same 失效
标题翻译：持续可释放的肠胃外药物制剂及其制备方法
公开(公告)号：US5750100A
公开(公告)日：1998-05-12
申请号：US734636
申请日：1996-10-21
申请人： Yutaka Yamagata , Katsumi Iga , Hiroaki Okada
发明人： Yutaka Yamagata , Katsumi Iga , Hiroaki Okada
IPC分类号： A61K9/14 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/70 , A61K38/00 , A61K38/20 , A61K38/21 , A61K38/28 , A61K47/14 , A61K38/02
CPC分类号： A61K9/2013 , A61K38/2013 , A61K38/212 , A61K38/28 , A61K9/1617 , A61K9/70 , A61K9/0024
摘要： A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid form at room temperature. The molecular weight of the physiologically active peptide or protein is 2,000 dalton or more. The saturated fatty acid includes fatty acids having about 16 to 30 carbon atoms such as palmitic acid, stearic acid, etc. The matrix may be in a pillar or granular form. The parenteral pharmaceutical preparation can be used as an injectable solid administered subcutaneously or intramuscularly (for example, a pellet or tablet for implantation), a suppository or the like, and can release the physiologically active peptide or protein sustainedly for a prolonged period of one week or more.
摘要翻译：肠胃外药物制剂包含含有生理活性肽或蛋白质的基质和饱和脂肪酸的聚甘油二酯，并且所述基质在室温下为固体形式。生理活性肽或蛋白质的分子量为2,000道尔顿或更多。饱和脂肪酸包括具有约16至30个碳原子的脂肪酸，例如棕榈酸，硬脂酸等。基质可以是柱状或颗粒形式。肠胃外药物制剂可以用作皮下或肌肉内给药的可注射固体（例如，用于植入的丸粒或片剂），栓剂等，并且可以持续释放生理活性肽或蛋白质一周的长时间或者更多。

7. 发明授权

US5463195A Key switch 失效
标题翻译：钥匙开关
公开(公告)号：US5463195A
公开(公告)日：1995-10-31
申请号：US172259
申请日：1993-12-23
申请人： Makoto Watanabe , Isao Mochizuki , Yoshitsugu Sato , Takeyuki Takagi , Hiroaki Okada
发明人： Makoto Watanabe , Isao Mochizuki , Yoshitsugu Sato , Takeyuki Takagi , Hiroaki Okada
IPC分类号： H01H13/20 , H01H3/12 , H01H13/14
CPC分类号： H01H3/125 , H01H2239/004
摘要： A key switch of the invention includes a key top having a face on which various characters are displayed and a back face having an engaging portion, a guide support member having two hinge members and a holder plate. The holder plate is provided with support portions which are elastically moved when pushed down by the lower portion of the guide support member to pinch and support the lower portion, and further the engaging portions of the key top can also pinch and support the upper portion of the guide support member by pushing the upper portion. Accordingly, according to the key switch, the fabrication of the guide support member and the holder plate and the fabrication of the guide support member and the key top can be extremely easily performed, and the operating performance of the key top is improved.
摘要翻译：本发明的钥匙开关包括具有显示各种字符的面的键顶和具有接合部的背面，具有两个铰链构件的导向支撑构件和保持板。保持板设置有支撑部分，当被引导支撑构件的下部向下推动时，支撑部分被弹性地移动以夹紧并支撑下部，并且键顶的接合部分还可以夹紧和支撑通过推动上部来引导支撑构件。因此，根据该键开关，能够极其容易地进行导向支撑构件和保持板的制造以及导向支撑构件和键顶的制造，并且提高了键顶的操作性能。

8. 发明授权

US08177362B2 Optical image measurement device 有权
标题翻译：光学图像测量装置
公开(公告)号：US08177362B2
公开(公告)日：2012-05-15
申请号：US12450881
申请日：2008-04-08
申请人： Yutaka Nishio , Hiroaki Okada , Tsutomu Kikawa , Kazuhiko Yumikake
发明人： Yutaka Nishio , Hiroaki Okada , Tsutomu Kikawa , Kazuhiko Yumikake
IPC分类号： A61B3/14
CPC分类号： A61B3/102 , G01N21/4795 , G01N2021/1787
摘要： A device is an OCT device that splits a low-coherence light into a signal light and a reference light, detects an interference light obtained by superimposing the signal light propagated through an eye and the reference light propagated through a reference mirror, and forms an image of an fundus oculi. The device has a scan unit that scans the eye with the signal light. When a cross-section position is designated in an fundus oculi image, the device repetitively scans with the signal light along each cross-section position to repeatedly forms tomographic images at each cross-section position, thereby displaying a tomographic motion image at each cross-section position on a display. An operator can observe the tomographic motion image to designate the range and timing for measurement of a tomographic still image.
摘要翻译：器件是将低相干光分解为信号光和参考光的OCT器件，检测通过叠加通过眼睛传播的信号光和通过参考反射镜传播的参考光而获得的干涉光，并形成图像的眼底。该装置具有用信号灯扫描眼睛的扫描单元。当在眼底图像中指定横截面位置时，该装置利用沿着每个横截面位置的信号光重复扫描以在每个横截面位置处重复形成断层图像，从而在每个横截面位置处显示断层摄影运动图像，显示屏上的截面位置。操作者可以观察层析运动图像来指定断层摄影静止图像的测量的范围和时间。

9. 发明授权

US08098278B2 Optical image measurement device 有权
标题翻译：光学图像测量装置
公开(公告)号：US08098278B2
公开(公告)日：2012-01-17
申请号：US12451621
申请日：2008-05-15
申请人： Kazuhiko Yumikake , Hiroaki Okada , Tsutomu Kikawa
发明人： Kazuhiko Yumikake , Hiroaki Okada , Tsutomu Kikawa
IPC分类号： H04N7/18 , H04N9/47 , A61B3/14
CPC分类号： G01B9/0203 , A61B3/0091 , A61B3/102 , A61B3/152 , G01B9/02044 , G01B9/02077 , G01B9/02083 , G01B9/02091 , G01B2290/65
摘要： A fundus oculi observation device 1 splits a low-coherence light L0 into a signal light LS and a reference light LR, generates an interference light LC from the signal light LS propagated through an eye E and the reference light LR propagated through a reference mirror 174 to detect the interference light LC and, based on the result of the detection, forms a tomographic image of a fundus oculi Ef. The device 1 includes a scan unit 141 configured to scan with the signal light LS, and an LCD and optical system that present a fixation target. The device 1 acquires an image of the fundus oculi Ef in a state that scan a fixation target is presented while scanning with the signal light LS, and based on the image, determines whether fixation is proper or not.
摘要翻译：眼底观察装置1将低相干光L0分解为信号光LS和参考光LR，从通过眼睛E传播的信号光LS和通过参考镜174传播的参考光LR产生干涉光LC 以检测干涉光LC，并且基于检测结果，形成眼底Ef的断层图像。装置1包括被配置为用信号光LS扫描的扫描单元141以及呈现固定目标的LCD和光学系统。设备1在用信号光LS扫描的同时，在扫描固定目标的状态下获取眼底Ef的图像，并且基于该图像确定是否适当的固定。

10. 发明申请

US20080239240A1 OPTICAL IMAGE MEASUREMENT DEVICE 审中-公开
标题翻译：光学图像测量装置
公开(公告)号：US20080239240A1
公开(公告)日：2008-10-02
申请号：US12055693
申请日：2008-03-26
申请人： Hisashi Tsukada , Hiroaki Okada , Yutaka Nishio , Kazuhiko Yumikake
发明人： Hisashi Tsukada , Hiroaki Okada , Yutaka Nishio , Kazuhiko Yumikake
IPC分类号： A61B3/12
CPC分类号： G01B9/02044 , A61B3/102 , G01B9/0203 , G01B9/02077 , G01B9/02091 , G01B2290/65 , G01N21/4795
摘要： An optical image measurement device has: an interference-light generator configured to generate an interference light by splitting a low-coherence light into a signal light and a reference light and superimposing the signal light having passed through an eye and the reference light having passed through a reference object; a detector configured to detect the generated interference light; and a scanner configured to scan a projection position of the signal light on the eye, and the optical image measurement device is configured to form an image of the eye based on a result of detection by the detector. The optical image measurement device comprises a projector configured to project fixation information for fixing the eye onto a fundus oculi of the eye when the scanner scans with the signal light.
摘要翻译：光学图像测量装置具有：干涉光发生器，被配置为通过将低相干光分解为信号光和参考光来产生干涉光，并叠加已经穿过眼睛的信号光和已经穿过的参考光参考对象; 检测器，被配置为检测所产生的干涉光; 以及扫描器，被配置为扫描眼睛上的信号光的投影位置，并且光学图像测量装置被配置为基于检测器的检测结果来形成眼睛的图像。光学图像测量装置包括：投影仪，配置成当扫描仪用信号光扫描时，将固定信息投影到眼睛的眼底上。

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