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1. 发明申请

US20050112470A1 Alloy for battery grids 审中-公开
标题翻译：电池网合金
公开(公告)号：US20050112470A1
公开(公告)日：2005-05-26
申请号：US10935474
申请日：2004-09-07
申请人： M. Taylor , Albert Toennessen , Juergen Bauer , Paul Korinek , Christian Hansen
发明人： M. Taylor , Albert Toennessen , Juergen Bauer , Paul Korinek , Christian Hansen
IPC分类号： C22C11/06 , H01M4/68
CPC分类号： C22C11/06 , H01M4/685
摘要： An SLI battery for use in vehicle applications includes a container, a positive plate and a negative plate disposed within the container, and a separator disposed within the container and separating the positive plate and the negative plate. The positive plate includes a frame, a lug, and a plurality of wires and is formed by book mold gravity casting. The plate is formed of a lead-based alloy consisting essentially of lead, tin in the range of greater than 0.5 percent to about 1.2 percent, calcium in an amount such that the ratio of tin to calcium of greater than 12:1, and silver in the range of greater than 0 to less than 0.015 percent, where the percentages are based upon the total weight of the alloy.
摘要翻译：用于车辆应用的SLI电池包括容器，正极板和设置在容器内的负极板以及设置在容器内并将正极板和负极板分离的隔板。正极板包括框架，凸耳和多根电线，并通过书模重力铸造形成。该板由基本上由铅，锡在大于0.5％至约1.2％的范围内组成的铅基合金形成，钙的量使得锡与钙的比例大于12:1，和银在大于0至小于0.015％的范围内，其百分比基于合金的总重量。

2. 发明申请

US20050164091A1 Method of producing battery plates 有权
标题翻译：电池板生产方法
公开(公告)号：US20050164091A1
公开(公告)日：2005-07-28
申请号：US11086525
申请日：2005-03-22
申请人： Charles Schaeffer , Jeffrey Troxel , M. Taylor , Wen-Hong Kao , Christian Hansen , Yu-Lin Chen , Dan Cantillon , Bart Sauer
发明人： Charles Schaeffer , Jeffrey Troxel , M. Taylor , Wen-Hong Kao , Christian Hansen , Yu-Lin Chen , Dan Cantillon , Bart Sauer
IPC分类号： H01M4/73 , H01M4/74 , H01M4/84 , H01M4/82 , H01M4/68
CPC分类号： H01M4/73 , H01M4/745 , H01M4/84
摘要： A method of forming battery grids or plates that includes the step of mechanically reshaping or refinishing battery grid wires to improve adhesion between the battery paste and the grid wires. The method is particularly useful in improving the paste adhesion to battery grids formed by a continuous battery grid making process (such as strip expansion, strip stamping, continuous casting) that produces grid wires and nodes with smooth surfaces and a rectangular cross-section. In a preferred version of the method, the grid wires of battery grids produced by a stamping process are deformed such that the grid wires have a cross-section other than the rectangular cross-section produced by the stamping process. The method increases the cycle life of a battery.
摘要翻译：一种形成电池栅格或板的方法，其包括机械整形或修补电池栅格线的步骤，以改善电池糊和栅格线之间的粘附。该方法特别可用于改善通过生产具有光滑表面和矩形横截面的网格线和节点的连续电池网格制作工艺（例如条带扩展，条带冲压，连续铸造）形成的电池栅格的糊粘附性。在该方法的优选方案中，通过冲压工艺产生的电池栅格的栅格线变形，使得栅格线具有除了由冲压工艺产生的矩形横截面之外的横截面。该方法增加了电池的循环寿命。

3. 发明申请

US20190292898A1 MODEL-BASED PARAMETER ESTIMATION FOR DIRECTIONAL DRILLING IN WELLBORE OPERATIONS 审中-公开
公开(公告)号：US20190292898A1
公开(公告)日：2019-09-26
申请号：US15935659
申请日：2018-03-26
申请人： Francesco Quattrone , Christian Hansen , Oliver Hoehn , Joern Koeneke , Bruno Morabito , Rolf Findeisen
发明人： Francesco Quattrone , Christian Hansen , Oliver Hoehn , Joern Koeneke , Bruno Morabito , Rolf Findeisen
IPC分类号： E21B44/04 , G05B13/04 , G05B13/02 , E21B44/06 , E21B45/00 , E21B7/04 , E21B47/04 , E21B49/00
摘要： Examples of techniques for model-based parameter and state estimation for directional drilling in a wellbore operation are provided. In one example implementation according to aspects of the present disclosure, a computer-implemented method includes receiving, by a processing device, measurement data from the wellbore operation. The method further includes performing, by the processing device, an online estimation of at least one of a parameter to generate an estimated parameter and a state to generate an estimated state, the online estimation based at least in part on the measurement data. The method further includes generating, by the processing device, a control input to control an aspect in the wellbore operation based at least in part on the at least one of the estimated parameter and the estimated state. The method further includes executing a control action based on the control input to control the aspect of the wellbore operation.

4. 发明申请

US20130181843A1 INTERFERENCE REDUCTION METHOD FOR DOWNHOLE TELEMETRY SYSTEMS 有权
标题翻译：用于井下远程系统的干扰减少方法
公开(公告)号：US20130181843A1
公开(公告)日：2013-07-18
申请号：US13352714
申请日：2012-01-18
申请人： Sanam Moghaddamnia , Feng Zheng , Imed Ben Brahim , Wojciech Emmerich , Christian Hansen , Jens-Uwe Bruns
发明人： Sanam Moghaddamnia , Feng Zheng , Imed Ben Brahim , Wojciech Emmerich , Christian Hansen , Jens-Uwe Bruns
IPC分类号： G01V3/00
CPC分类号： H04B1/10 , E21B47/18 , G01V11/002
摘要： A method for reducing interference in a received downhole telemetry signal includes: segmenting a received signal; windowing each signal segment; transforming each windowed signal segment into a complex variable domain to generate a plurality of complex variable domain segments with an in-phase component vector I and a quadrature component vector Q; calculating a real amplitude vector A from the I and the Q vectors; filtering interferers in the amplitude vector A for each complex variable domain segment to generate a filtered amplitude vector Ã; recalculating an amplitude of the amplitude vector A using the filtered amplitude vector Ã to generate an output amplitude vector Â; scaling the I and the Q vectors by a factor Â/A to generate an output in-phase component vector I′ and an output quadrature component vector Q′; and transforming I′ and Q′ into the time domain to provide an interference-reduced output signal in the time domain.
摘要翻译：一种用于减少接收的井下遥测信号中的干扰的方法包括：分割接收的信号; 加窗每个信号段; 将每个窗口信号段变换为复数可变域以产生具有同相分量向量I和正交分量向量Q的多个复变量可变域段; 从I和Q向量计算实幅矢量A; 对每个复数可变域段的幅度矢量A中的干扰源进行滤波，以生成滤波幅度矢量。使用滤波的幅度矢量重新计算振幅矢量A的振幅，以产生输出幅度矢量; 将I和Q向量缩放因子/ A以产生输出同相分量矢量I'和输出正交分量矢量Q'; 并将I'和Q'转换成时域，以在时域中提供干扰减小的输出信号。

5. 发明申请

US20090181887A1 USE OF A GLP-1 MOLECULE FOR TREATMENT OF BILIARY DYSKINESIA AND/OR BILIARY PAIN/DISCOMFORT 审中-公开
标题翻译：用于治疗胆汁淤积症和/或胆汁淤积/分泌的GLP-1分子的使用
公开(公告)号：US20090181887A1
公开(公告)日：2009-07-16
申请号：US12066178
申请日：2006-09-06
申请人： Christian Hansen , Henrik Nilsson , Hans T. Schambye , Tina Geritz Nielsen
发明人： Christian Hansen , Henrik Nilsson , Hans T. Schambye , Tina Geritz Nielsen
IPC分类号： A61K38/22 , A61P25/00 , G01N33/566
CPC分类号： A61K38/26 , G01N2333/605 , G01N2500/02 , G01N2800/08 , Y02A50/49
摘要： The present invention relates to molecules, compositions and methods suitable for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree. The peptide hormone glucagon-like peptide-1 (GLP-1) has both anti-secretory effects and smooth muscle relaxatory properties in the gastrointestinal tract. GLP-1 exists in several forms, where the natural occurring GLP-1 molecules are GLP-1 (1-37), GLP-1 (7-37), and the amidated versions GLP-1 (1-36)amide, GLP-1 (7-36)amide. Other molecules capable of binding to and activating the GLP-1 receptor is herein included in the tern GLP-1 molecules. GLP-1 molecules may be naturally occurring or homologues of GLP-1 having one or more amino acid substitutions or modifications. The GLP-1 molecules are used for the manufacture of a medicament for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree.
摘要翻译：本发明涉及适用于治疗或预防来自胆道树的胆汁运动障碍和/或疼痛和/或不适的分子，组合物和方法。肽激素胰高血糖素样肽-1（GLP-1）在胃肠道中具有抗分泌作用和平滑肌松弛性质。 GLP-1以几种形式存在，其中天然存在的GLP-1分子是GLP-1（1-37），GLP-1（7-37）和酰胺化型GLP-1（1-36）酰胺，GLP -1（7-36）酰胺。在GLP-1分子中包括能够结合并激活GLP-1受体的其它分子。 GLP-1分子可以是具有一个或多个氨基酸取代或修饰的GLP-1的天然存在或同源物。 GLP-1分子用于制造用于治疗或预防胆汁运动障碍和/或来自胆道树的疼痛和/或不适的药物。

6. 发明申请

US20070035062A1 Method and facility for the production of a layer-like part 审中-公开
标题翻译：用于生产层状部件的方法和设备
公开(公告)号：US20070035062A1
公开(公告)日：2007-02-15
申请号：US10572939
申请日：2004-09-28
申请人： Christian Hansen , Ursus Kruger , Uwe Pyritz
发明人： Christian Hansen , Ursus Kruger , Uwe Pyritz
IPC分类号： B29C41/34
CPC分类号： C23C14/0005 , C23C14/562 , C25D1/04 , C25D1/20 , H01L39/2454
摘要： Disclosed is a method for producing an HTSC band on a substrate band, for example, a strong bond being created between the substrate band and the band as a result of the production process (e.g. PVD process or galvanic deposition). According to the invention, separation of the highly adhesive band from the substrate band is aided by the fact that the substrate band is made of a shape memory alloy, the shape memory of the band being activated in a separating device by heating and, possibly, cooling. Tension-related stress is generated in the joint on the boundary surface between the bands as a result of the substrate being deformed such that separation of the band from the substrate band is aided or even caused. Also disclosed is a production facility in which the substrate band is made of a shape memory alloy.
摘要翻译：公开了一种在衬底带上制造HTSC带的方法，例如，由于制造工艺（例如，PVD工艺或电镀沉积），在衬底带和带之间产生强键。根据本发明，通过基片带由形状记忆合金制成，通过加热在分离装置中激活带的形状记忆，并且可能地，冷却。由于基板变形而导致带与基板带分离的结果，导致在带之间的边界面上的接头中产生张力相关的应力。还公开了一种生产设备，其中衬底带由形状记忆合金制成。

7. 发明申请

US20060286068A1 G-CSF Conjugates 失效
公开(公告)号：US20060286068A1
公开(公告)日：2006-12-21
申请号：US11463861
申请日：2006-08-10
申请人： Torben Nissen , Kim Andersen , Christian Hansen , Jan Mikkelsen , Hans Schambye
发明人： Torben Nissen , Kim Andersen , Christian Hansen , Jan Mikkelsen , Hans Schambye
IPC分类号： A61K38/19 , C07K14/53
CPC分类号： C07K14/53 , A61K47/60
摘要： Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a low in vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils than non-conjugated recombinant human G-CSF.

8. 发明申请

US20060270829A1 G-CSF CONJUGATES 审中-公开
标题翻译： G-CSF结合
公开(公告)号：US20060270829A1
公开(公告)日：2006-11-30
申请号：US11462335
申请日：2006-08-03
申请人： Torben Nissen , Kim Andersen , Christian Hansen , Jan Mikkelsen , Hans Schambye
发明人： Torben Nissen , Kim Andersen , Christian Hansen , Jan Mikkelsen , Hans Schambye
IPC分类号： A61K31/70 , C07K14/00 , A01N43/04 , C07K16/00 , A61K38/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： C07K14/535 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K47/60 , A61K47/61 , C07K14/53
摘要： The invention relates to polypeptide conjugates comprising a polypeptide exhibiting G-CSF activity and having an amino acid sequence that differs from the amino acid sequence of human G-CSF in at least one specified introduced and/or removed amino acid residue comprising an attachment group for a non-polypeptide moiety, and having at least one non-polypeptide moiety attached to an attachment group of the polypeptide. The attachment group may e.g. be a lysine, cysteine, aspartic acid or glutamic acid residue or a glycosylation site, and the non-polypeptide moiety may e.g. be a polymer such as polyethylene glycol or an oligosaccharide. The conjugate, which has a reduced in vitro bioactivity compared to hG-CSF, has one or more improved properties such as increased biological half-life and increased stimulation of neutrophils.
摘要翻译：本发明涉及多肽缀合物，其包含显示G-CSF活性的多肽，并且具有不同于至少一个指定的引入和/或去除的氨基酸残基中的人G-CSF的氨基酸序列的氨基酸序列，所述氨基酸残基包含用于非多肽部分，并且具有连接到多肽的连接基团的至少一个非多肽部分。附件组可以例如。是赖氨酸，半胱氨酸，天冬氨酸或谷氨酸残基或糖基化位点，并且非多肽部分可以是例如。作为聚合物如聚乙二醇或寡糖。与hG-CSF相比，具有降低的体外生物活性的缀合物具有一种或多种改进的性质，例如增加的生物半衰期和增加的嗜中性粒细胞的刺激。

9. 发明申请

US20060122274A1 Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions 失效
公开(公告)号：US20060122274A1
公开(公告)日：2006-06-08
申请号：US11269289
申请日：2005-11-07
申请人： Christian Hansen , Henrik Nilsson , Stephan Christgau , Jens Andersen
发明人： Christian Hansen , Henrik Nilsson , Stephan Christgau , Jens Andersen
IPC分类号： A61K31/198 , C07F3/02
CPC分类号： A61K33/24 , C07C55/08 , C07C55/10 , C07C57/145 , C07C59/08 , C07C59/19 , C07C59/347
摘要： Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1 g/l to about 100 g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.

10. 发明申请

US20050147587A1 G-CSF conjugates 审中-公开
标题翻译： G-CSF缀合物
公开(公告)号：US20050147587A1
公开(公告)日：2005-07-07
申请号：US11053228
申请日：2005-02-08
申请人： Torben Nissen , Kim Andersen , Christian Hansen , Jan Mikkelsen , Hans Schambye
发明人： Torben Nissen , Kim Andersen , Christian Hansen , Jan Mikkelsen , Hans Schambye
IPC分类号： A61K38/00 , A61K47/42 , C07K20060101 , C07K14/53 , C07K14/535 , A61K38/19
CPC分类号： C07K14/535 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K47/60 , A61K47/61 , C07K14/53
摘要： The invention relates to polypeptide conjugates comprising a polypeptide exhibiting G-CSF activity and having an amino acid sequence that differs from the amino acid sequence of human G-CSF in at least one specified introduced and/or removed amino acid residue comprising an attachment group for a non-polypeptide moiety, and having at least one non-polypeptide moiety attached to an attachment group of the polypeptide. The attachment group may e.g. be a lysine, cysteine, aspartic acid or glutamic acid residue or a glycosylation site, and the non-polypeptide moiety may e.g. be a polymer such as polyethylene glycol or an oligosaccharide. The conjugate, which has a reduced in vitro bioactivity compared to hG-CSF, has one or more improved properties such as increased biological half-life and increased stimulation of neutrophils.
摘要翻译：本发明涉及多肽缀合物，其包含显示G-CSF活性的多肽，并且具有不同于至少一个指定的引入和/或去除的氨基酸残基中的人G-CSF的氨基酸序列的氨基酸序列，所述氨基酸残基包含用于非多肽部分，并且具有连接到多肽的连接基团的至少一个非多肽部分。附件组可以例如。是赖氨酸，半胱氨酸，天冬氨酸或谷氨酸残基或糖基化位点，并且非多肽部分可以是例如。作为聚合物如聚乙二醇或寡糖。与hG-CSF相比，具有降低的体外生物活性的缀合物具有一种或多种改进的性质，例如增加的生物半衰期和增加的嗜中性粒细胞的刺激。

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