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1. 发明授权

US07499757B2 Absorbable myocardial lead fixation system 有权
标题翻译：可吸收心肌引导固定系统
公开(公告)号：US07499757B2
公开(公告)日：2009-03-03
申请号：US10971577
申请日：2004-10-22
申请人： M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
发明人： M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
IPC分类号： A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： A myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes a lead body, an anchor mechanism formed of a bioabsorbable or biodegradable polymer for engaging a surface of the patient's heart and a surface feature formed on a portion of the lead body for promoting formation of scar tissue around said portion of the lead body.
摘要翻译：用于将铅的远端固定在患者心脏的心肌内的心肌引线附着系统。该系统包括引线体，由生物可吸收或可生物降解的聚合物形成的锚固机构，用于接合患者心脏的表面，以及形成在引线体的一部分上的表面特征，用于促进在引线体的所述部分周围形成瘢痕组织。

2. 发明授权

US07499759B2 Distal or proximal fixation of over-the-tether myocardial leads 有权
标题翻译：远端或近端固定超过系绳心肌引线
公开(公告)号：US07499759B2
公开(公告)日：2009-03-03
申请号：US10972298
申请日：2004-10-22
申请人： M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
发明人： M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N2001/0578
摘要： The present invention is a myocardial lead attachment system for securing a lead within the myocardium. The attachment system includes an anchor configured to engage the heart, a tether coupled to the anchor and a lead body. The lead body has a proximal end, a distal end, a lumen for accepting the tether and a lock housing in the lumen. A lock structure is on the tether and mates with the lock housing and restrains motion of the lead with respect to the tether in either of a proximal or a distal direction.
摘要翻译：本发明是用于将铅固定在心肌内的心肌引导附着系统。附接系统包括构造成接合心脏的锚，连接到锚固体的系绳和引导体。引线体具有近端，远端，用于接纳系绳的内腔和在内腔中的锁定壳体。锁定结构位于系绳上并且与锁定壳体配合并且在近端或远端方向中抑制引线相对于系绳的运动。

3. 发明授权

US07418298B2 Myocardial lead with fixation mechanism 有权
标题翻译：心肌导联与固定机制
公开(公告)号：US07418298B2
公开(公告)日：2008-08-26
申请号：US10971549
申请日：2004-10-22
申请人： Jason Alan Shiroff , Ronald W. Heil, Jr. , Peter T. Kelley , M. Sean Coe , Randy W. Westlund , Donald F. Palme, II , David B. Yingling
发明人： Jason Alan Shiroff , Ronald W. Heil, Jr. , Peter T. Kelley , M. Sean Coe , Randy W. Westlund , Donald F. Palme, II , David B. Yingling
IPC分类号： A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： The present invention is a myocardial lead attachment system and method for securing a distal end of a lead within the myocardium of a patient's heart. The system includes an anchor, a tether coupled at a distal end to the anchor and a lead body. The lead body has a proximal end, a distal end, and a lumen extending therethrough for receiving the tether. A fixation mechanism is at the distal end of the lead body, and is adapted to collapse to a first configuration during implantation and deploy to a second configuration after implantation.
摘要翻译：本发明是用于将铅的远端固定在患者心脏的心肌内的心肌引导附着系统和方法。该系统包括锚固件，在远端连接到锚固件的系绳和引线主体。引线本体具有近端，远端和延伸穿过其中的内腔，用于接收系绳。固定机构位于引线主体的远端，并且适于在植入期间折叠成第一构型并且在植入之后部署到第二构造。

4. 发明申请

US20080249596A1 MYOCARDIAL LEAD WITH FIXATION MECHANISM 审中-公开
标题翻译：具有固定机构的心理学领域
公开(公告)号：US20080249596A1
公开(公告)日：2008-10-09
申请号：US12139628
申请日：2008-06-16
申请人： Jason Alan Shiroff , Ronald W. Heil , Peter T. Kelley , M. Sean Coe , Randy W. Westlund , Donald F. Palme , David B. Yingling
发明人： Jason Alan Shiroff , Ronald W. Heil , Peter T. Kelley , M. Sean Coe , Randy W. Westlund , Donald F. Palme , David B. Yingling
IPC分类号： A61N1/375
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： The present invention is a myocardial lead attachment system for securing a distal end of a cardiac lead within a myocardium of a patient's heart and anchoring against an epicardium of the patient's heart. The system includes an anchor configured to advance in a first orientation and anchor against an epicardial surface in a second orientation and a tether having a proximal end and a distal end. The anchor is coupled to the distal end of the tether. The system includes a cardiac lead having a lead body, a lumen extending through the lead body, a conductive member, a proximal end, a distal end, and an electrode configured for stimulating the myocardium located at the distal end. The lead body and the lumen are configured such that the lead body can be threaded over the proximal end of the tether and slideably advanced over the tether toward the anchor during implantation. The system includes a fixation mechanism at the distal end of the cardiac lead. The fixation mechanism is adapted to collapse to a first configuration during implantation and deploy to a second configuration after implantation.
摘要翻译：本发明是用于将心脏铅的远端固定在患者心脏的心肌内并锚定在患者心脏的心外膜的心肌引导附着系统。该系统包括锚定构件，其以第一取向前进并且以第二取向锚定抵靠心外膜表面并具有近端和远端的系绳。锚固件联接到系绳的远端。该系统包括具有引线主体的心脏引线，延伸穿过引线本体的内腔，导电部件，近端，远端以及被配置为刺激位于远端的心肌的电极。引线体和内腔被构造成使得引线主体能够在植入期间穿过系绳的近端并且可滑动地在系绳上前进到锚固件。该系统包括在心脏引线的远端处的固定机构。固定机构适于在植入期间折叠成第一构型并且在植入之后部署到第二构造。

5. 发明授权

US06321122B1 Single pass defibrillation/pacing lead with passively attached electrode for pacing and sensing 失效
标题翻译：单次除颤/起搏导联带有被动连接的电极用于起搏和感测
公开(公告)号：US06321122B1
公开(公告)日：2001-11-20
申请号：US09121018
申请日：1998-07-22
申请人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
发明人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
IPC分类号： A61N100
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The second electrode is adapted for positioning and fixation to the wall of the atrium of the heart. A passive fixation element may be used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and passive fixation of the second electrode.
摘要翻译：适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统的单程心内膜引导电极包括具有周向外表面的引线体。引线包括具有第一导电表面的第一远端电极。引线体还具有具有第二导电表面的第二电极。第二电极适于定位并固定在心脏心房的壁上。被动固定元件可以用作第二电极的一部分。引线体还包括有助于第二电极的定位和被动固定的弯曲部分。

6. 发明授权

US08126560B2 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：刺激肺动脉压力感受器的刺激
公开(公告)号：US08126560B2
公开(公告)日：2012-02-28
申请号：US10746852
申请日：2003-12-24
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
IPC分类号： A61N1/18 , A61N1/362
CPC分类号： A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线体，所述远端具有偏压部分，所述偏压部分的外径尺寸设计成邻接肺动脉壁，邻近远端连接的电极和可植入脉冲发电机电耦合到电极。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

7. 发明授权

US06212434B1 Single pass lead system 失效
公开(公告)号：US06212434B1
公开(公告)日：2001-04-03
申请号：US09120824
申请日：1998-07-22
申请人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W. Goebel , Douglas A. Heitkamp , Randall M. Peterfeso
发明人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W. Goebel , Douglas A. Heitkamp , Randall M. Peterfeso
IPC分类号： A61N105
CPC分类号： A61N1/0573 , A61N1/0563
摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

8. 发明授权

US06584362B1 Leads for pacing and/or sensing the heart from within the coronary veins 有权
公开(公告)号：US06584362B1
公开(公告)日：2003-06-24
申请号：US09651340
申请日：2000-08-30
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley , Bruce Tockman , Randy Westlund , Jay A. Warren
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley , Bruce Tockman , Randy Westlund , Jay A. Warren
IPC分类号： A61N105
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead for monitoring or stimulating cardiac activity is provided. The lead is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator. The lead body has one or more electrodes associated therewith. The lead is constructed and arranged so that when it is implanted, the electrodes are housed in the coronary vasculature and urged into intimate contact a vessel wall. A method for implanting the lead into the coronary vasculature is also provided, the method comprising the steps of inserting a stylet into the lead, inserting the lead into the coronary sinus, advancing the lead from the coronary sinus toward the toward the left atrium and into a coronary vein, removing the stylet, and sensing and pacing the heart. Alternatively, the method comprises placing a guide catheter into the coronary sinus, threading a guide wire into the coronary veins, pushing the lead over the guide wire and into the coronary sinus or the coronary vein, and sensing and pacing the heart via the lead in its implanted site in the coronary sinus or the coronary vein.

9. 发明授权

US06505082B1 Single pass lead system 失效
公开(公告)号：US06505082B1
公开(公告)日：2003-01-07
申请号：US09643125
申请日：2000-08-21
申请人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W Goebel , Douglas A Heitkamp , Randall M. Peterfeso
发明人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W Goebel , Douglas A Heitkamp , Randall M. Peterfeso
IPC分类号： A61N105
CPC分类号： A61N1/0573 , A61N1/0563
摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

10. 发明授权

US06345204B1 Single pass lead having retractable, actively attached electrode for pacing and sensing 失效
标题翻译：单通引线具有可伸缩的，主动连接的用于起搏和感测的电极
公开(公告)号：US06345204B1
公开(公告)日：2002-02-05
申请号：US09661531
申请日：2000-09-14
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
IPC分类号： A61N105
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.
摘要翻译：一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。第一和第二电极都适于定位和固定在墙上。活性固定元件用作第二电极的一部分。引线体还包括有助于第二电极的定位和固定的弯曲部分。在另一实施例中，主引线体包括凹部，其中一个端部的心房引线体和主动固定元件可以从凹部位置到固定在心脏壁上的位置。主动固定元件也可以通过转动端子销来移动。

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