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1. 发明授权

US5666642A Extraction of cesium and strontium ions from nuclear waste 失效
标题翻译：从核废料中提取铯和锶离子
公开(公告)号：US5666642A
公开(公告)日：1997-09-09
申请号：US427077
申请日：1995-04-21
申请人： M. Frederick Hawthorne , Gary B. Dunks
发明人： M. Frederick Hawthorne , Gary B. Dunks
IPC分类号： C01D17/00 , C01F11/00 , C08G77/398 , C22B3/26 , C22B60/02 , C22B61/00 , G21C19/46 , G21F9/00 , G21F9/12 , C01F13/00 , C07H15/00
CPC分类号： G21F9/007 , C01D17/00 , C01F11/005 , C08G77/398 , C22B3/0041 , C22B60/026 , C22B61/00 , G21C19/46 , G21F9/125 , Y02P10/234 , Y02W30/883
摘要： Methods and agents for extracting cesium and strontium ions from aqueous solutions, including aqueous fission product waste solutions, are disclosed using substituted metal dicarbollide ions containing one or more chemical groups that increase solubility of the substituted metal dicarbollide ion in non-nitrated, non-chlorinated solvents, or using metal dicarbollide ion-substituted silicones.
摘要翻译：公开了使用含有一个或多个化学基团的取代金属二溴化物离子从水溶液中提取铯和锶离子的方法和试剂，所述化学基团增加了取代的金属二碳化物离子在非硝化的非氯化物中的溶解度溶剂，或使用金属二碳化物离子取代的有机硅。

2. 发明授权

US5698169A Methods and agents for the extraction of cesium and strontium from nuclear waste 失效
标题翻译：从核废料中提取铯和锶的方法和试剂
公开(公告)号：US5698169A
公开(公告)日：1997-12-16
申请号：US459618
申请日：1995-06-02
申请人： M. Frederick Hawthorne , Gary B. Dunks
发明人： M. Frederick Hawthorne , Gary B. Dunks
IPC分类号： C01D17/00 , C01F11/00 , C08G77/398 , C22B3/26 , C22B60/02 , C22B61/00 , G21C19/46 , G21F9/00 , G21F9/12 , C01F1/00
CPC分类号： C01D17/00 , C01F11/005 , C08G77/398 , C22B3/0041 , C22B60/026 , C22B61/00 , G21C19/46 , G21F9/007 , G21F9/125 , Y02P10/234 , Y02W30/883
摘要： Methods and agents for extracting cesium and strontium ions from aqueous solutions, including aqueous fission product waste solutions, are disclosed using substituted metal dicarbollide and/or dicarbaextranide ions containing one or more chemical groups that increase solubility of the substituted metal dicarbollide or dicarbaextranide ions in non-nitrated, non-chlorinated solvents, or using metal dicarbollide or dicarbaextranide ion-substituted silicones.
摘要翻译：公开了使用取代的金属二碳化物和/或二乙二醇+ E，ot + n + EE的离子从水溶液中提取铯和锶离子的方法和试剂，所述方法和试剂含有一种或多种增加其溶解度的化学基团在非硝化的非氯化溶剂中使用取代的金属二碳化物或二碳黑+ E，otl n + EE ide离子，或者使用金属二碳化物或二乙基葡萄糖+ E，otl n + EE理想离子取代的有机硅。

3. 发明授权

US06664426B1 Ether and ester derivatives of the perborate icosahedron 有权
标题翻译：过硼酸二十面体的醚和酯衍生物
公开(公告)号：US06664426B1
公开(公告)日：2003-12-16
申请号：US09592214
申请日：2000-06-12
申请人： M. Frederick Hawthorne , Toralf Peymann , Andreas Maderna
发明人： M. Frederick Hawthorne , Toralf Peymann , Andreas Maderna
IPC分类号： C07F502
CPC分类号： C07F5/027
摘要： New boron icosahedral ethers and esters formed from Cs2[closo-B12(OH)12],; Cs[closo-1-H-1-CB11(OH)11]; and closo-1,12-H2-1,12-C2B10(OH)10 are disclosed. Also set forth are their preparation by reacting the icosahedral boranes [closo-B12H12]2−, [closo-1-CB11H12]− and closo-1,12-(CH2OH)2-1,12-C2B10H10 with an acid anhdride or acid chloride to form the ester or an alkylating agent to form the ether.
摘要翻译：由Cs2 [closo-B12（OH）12]形成的新的二十二面体醚和酯; Cs [closo-1-H-1-CB11（OH）11]; 和closo-1,12-H2-1,12-C2B10（OH）10。还阐述了它们通过使二十面体硼烷[closo-B12H12] 2-，[closo-1-CB11H12] - 和closo-1,12-（CH2OH）2-1,12-C2B10H10与酸或酰氯形成酯或烷基化剂以形成醚。

4. 发明授权

US4062883A Polymer-bound metallocarborane catalyst product and process 失效
标题翻译：聚合物结合金属环硼烷催化剂产品及工艺
公开(公告)号：US4062883A
公开(公告)日：1977-12-13
申请号：US712416
申请日：1976-08-06
申请人： M. Frederick Hawthorne , William Kalb
发明人： M. Frederick Hawthorne , William Kalb
IPC分类号： B01J31/06 , B01J31/16 , B01J31/24 , C07C5/03 , C07C5/22 , C07F5/02 , C07F15/00
CPC分类号： B01J31/069 , B01J31/2404 , C07C5/03 , C07C5/2293 , C07F15/008 , C07F5/027 , B01J2231/52 , B01J2231/645 , B01J31/1658 , C07C2531/06 , C07C2531/24
摘要： A heterogeneous metallocarborane catalyst bound to a polymeric support by a carbon-boron bond. Chloromethylated polystyrene beads provide the support. The catalytic beads are characterized as3,3-(Ph P)-3-H-4 polystyrylmethyl - 3,1,2-Rh C.sub.2 B.sub.9 H.sub.10.
摘要翻译：异质金属硼烷催化剂通过碳 - 硼键与聚合物载体结合。氯甲基化聚苯乙烯珠提供支持。催化珠的特征是3,3-（Ph P）-3-H-4聚苯乙烯基甲基-3,1,2-铑C2B9H10。

5. 发明授权

US08741250B2 Hydroxylation of icosahedral boron compounds 有权
标题翻译：二十面体硼化合物的羟基化
公开(公告)号：US08741250B2
公开(公告)日：2014-06-03
申请号：US13566789
申请日：2012-08-03
申请人： M. Frederick Hawthorne , Oleg Bondarev
发明人： M. Frederick Hawthorne , Oleg Bondarev
IPC分类号： C01B35/10 , C07F5/02
CPC分类号： C01B35/10 , C01B35/14 , C07F5/02
摘要： The present invention relates to a synthetic method for producing a per-hydroxylated icosahedral boron compound via catalytic hydroxylation of icosahedral boron compound using a soft electrophile.
摘要翻译：本发明涉及一种通过使用软亲电子试剂通过二十面体硼化合物的催化羟基化制备全羟基化二十面体硼化合物的合成方法。

6. 发明授权

US6074625A Boron-containing hormone analogs and methods of their use in imaging or killing cells having hormone receptors 失效
标题翻译：含硼激素类似物及其用于成像或杀死具有激素受体的细胞的方法
公开(公告)号：US6074625A
公开(公告)日：2000-06-13
申请号：US808203
申请日：1997-02-28
申请人： M. Frederick Hawthorne , Mark T. Groudine
发明人： M. Frederick Hawthorne , Mark T. Groudine
IPC分类号： G01N33/53 , A61K31/69 , A61K41/00 , A61K47/48 , A61K49/00 , C07F5/02 , G01N33/566 , A61K51/00 , A61M36/14
CPC分类号： A61K41/0095
摘要： Boron containing compounds are targeted to hormonally responsive cells by contacting the cells with a conjugate of a boron containing moiety conjugated to a ligand having binding specificity for an intracellular receptor of the cell. The conjugates are useful for imaging or killing hormonally responsive cells, such as hormonally responsive tumor cells. For target cell killing, the cells are contacted with a .sup.10 B containing moiety conjugated to a ligand having binding specificity for an intracellular hormone receptor of the cells. The .sup.10 B containing moiety becomes associated with the hormone receptor of the cells, which may then be irradiated with neutrons to kill the cells by boron neutron capture. For target cell imaging, the cells are contacted with a .sup.11 B containing moiety conjugated to a ligand having binding specificity for an intracellular hormone receptor of the cells, and the boron that becomes associated with the hormone receptor of the cells may then be imaged using magnetic resonance imaging techniques.
摘要翻译：含硼化合物通过使细胞与与细胞的细胞内受体具有结合特异性的配体缀合的含硼部分的缀合物接触来靶向激素反应性细胞。缀合物可用于成像或杀死激素反应性细胞，例如激素反应性肿瘤细胞。对于靶细胞杀伤，细胞与含有与具有对细胞的细胞内激素受体具有结合特异性的配体缀合的含10B部分接触。含有10B的部分与细胞的激素受体相关联，然后可以用中子照射以通过硼中子捕获来杀死细胞。对于靶细胞成像，将细胞与含有与对细胞的细胞内激素受体具有结合特异性的配体缀合的含有11B的部分接触，然后使用磁共振成像与细胞激素受体相关的硼成像技术。

7. 发明授权

US06323372B1 Synthesis of perhydroxydodecaborate salts and related species 有权
标题翻译：全羟基十二硼酸盐和相关物质的合成
公开(公告)号：US06323372B1
公开(公告)日：2001-11-27
申请号：US09546108
申请日：2000-04-10
申请人： M. Frederick Hawthorne , Toralf Peymann , Axel Hans-Joachim Herzog
发明人： M. Frederick Hawthorne , Toralf Peymann , Axel Hans-Joachim Herzog
IPC分类号： C07F502
CPC分类号： C07F5/027
摘要： New icosahedral borohydrates Cs2[closo-B12(OH)12]; Cs[closo-1-H-1-CB11(OH)11]; and closo-1,12-H2-1,12-C2B10(OH)10 are disclosed. Also set forth are their preparation by refluxing the icosahedral boranes [closo-B12H12]2−, [closo-1-CB11H12]− and closo-1,12-(CH2OH)2-1,12-C2B10H10 with a hydroxylating agent, preferably 30%w hydrogen peroxide.
摘要翻译：新二十面体硼氢化物Cs2 [closo-B12（OH）12]; Cs [closo-1-H-1-CB11（OH）11]; 和closo-1,12-H2-1,12-C2B10（OH）10。还阐述了它们的制备方法是通过将二十面体硼烷[closo-B12H12] 2-，[closo-1-CB11H12]和closo-1,12-（CH2OH）2-1,12-C2B10H10与羟基化剂，优选 30％w过氧化氢。

8. 发明授权

US5648532A Compositions for boron neutron capture therapy and methods thereof 失效
标题翻译：硼中子捕获治疗组合物及其方法
公开(公告)号：US5648532A
公开(公告)日：1997-07-15
申请号：US71702
申请日：1993-06-03
申请人： M. Frederick Hawthorne , Debra Arliene Feakes , Kenneth John Shelly
发明人： M. Frederick Hawthorne , Debra Arliene Feakes , Kenneth John Shelly
IPC分类号： A61K9/127 , A61K33/22 , A61K41/00 , A61K51/00 , A61P35/00 , C07F5/02
CPC分类号： A61K9/127 , A61K41/0095 , C07F5/027
摘要： Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.
摘要翻译：硼中子捕获治疗可以利用XyB20H17L，其中X是碱金属，y为1至4，L为二电子给体，如NH 3和Na 2 B 10 H 9 NCO等。这些硼烷盐可以游离或包封在脂质体中。脂质体可能嵌入其双层碳硼烷中以增加递送的量10B和/或增加脂质体的肿瘤特异性。

9. 发明授权

US5066479A Metallacarborane chelates 失效
标题翻译：金属硼烷螯合物
公开(公告)号：US5066479A
公开(公告)日：1991-11-19
申请号：US200750
申请日：1988-05-31
申请人： M. Frederick Hawthorne
发明人： M. Frederick Hawthorne
IPC分类号： A61K51/10 , C07D231/14
CPC分类号： A61K51/1093 , C07D231/14 , A61K2123/00
摘要： Metallacarborane chelate-antibody compounds which are useful for radioimmunodetection and radiotherapy. The compounds have the formula ##STR1## wherein X is a metal or radioisotope of said metal, Y is a rotation resistant organic chelate bridge moiety, Z is an antibody linkage moiety and AB is an antibody. Metallacarborane chelate and carborane chelate compounds are also disclosed which are useful in preparing the final metallacarborane chelate-antibody compound which is used for radioimmunodetection and radiotherapy.
摘要翻译：可用于放射免疫检测和放射治疗的金属碳纳米胆固醇 - 抗体化合物。所述化合物具有下式：其中X是所述金属的金属或放射性同位素，Y是抗旋转有机螯合桥部分，Z是抗体连接部分，AB是抗体。还公开了金属硼烷螯合物和碳硼烷螯合化合物，其可用于制备用于放射免疫检测和放射治疗的最终金属硼烷螯合物 - 抗体化合物。

10. 发明授权

US4363747A Metallocarborane precursor and catalyst 失效
标题翻译：金属环硼烷前体和催化剂
公开(公告)号：US4363747A
公开(公告)日：1982-12-14
申请号：US273731
申请日：1981-06-15
申请人： M. Frederick Hawthorne , Mark S. Delaney
发明人： M. Frederick Hawthorne , Mark S. Delaney
IPC分类号： B01J31/24 , C07C45/50 , C07F15/00 , B01J31/12
CPC分类号： B01J31/2404 , B01J31/2291 , C07C45/50 , C07F15/0073 , B01J2231/321 , B01J2231/52 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , B01J31/165
摘要： An extraordinarily active carborane catalyst for use in hydrogenation, hydroformulation and isomerization reactions. The new catalyst is a modification of known metallocarborane catalysts having a transition metal symmetrically bonded to the pentagonal face of a dicarborane cage with two triphenylphosphine ligands and one hydrogen ligand occupying the remaining transition metal ligand sites. The new alkene-metallocarborane replaces one of the triphenylphosphine ligands with a lower chelating or bridging alkene which is bound to both the transition metal and the carborane cage.The alkene-metallocarborane catalyst may be used as a homogenous catalyst or may be bound to a suitable polymer support for use as a heterogeneous catalyst. The catalyst has been found to be among the most highly reactive catalysts known to date. It is believed the high reactivity of the new catalyst is due to the in situ irreversible hydrogenation of the alkene side chain to produce an open coordination site on the transition metal atom.
摘要翻译：用于氢化，加氢成型和异构化反应的非常活泼的碳硼烷催化剂。新催化剂是已知的具有二碳硼烷笼的五边形面对称地键合过渡金属的金属多异氰酸酯催化剂的改性，其具有两个三苯基膦配体和一个占据剩余的过渡金属配体位点的氢配体。新的烯烃 - 金属环硼烷用与螯合或桥连烯烃结合的过渡金属和碳硼烷笼两者替代三苯基膦配体之一。烯烃 - 金属环硼烷催化剂可以用作均匀的催化剂，或者可以与合适的聚合物载体结合，用作非均相催化剂。已经发现催化剂是迄今为止已知的最高反应性催化剂。据信，新催化剂的高反应性是由于烯烃侧链的原位不可逆氢化以在过渡金属原子上产生开放的配位点。

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