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1. 发明申请

US20060184024A1 Tissue thickness measurement device 审中-公开
标题翻译：组织厚度测量装置
公开(公告)号：US20060184024A1
公开(公告)日：2006-08-17
申请号：US11302039
申请日：2005-12-12
申请人： Luiz Da Silva , George Choi , Igor Kochemasov
发明人： Luiz Da Silva , George Choi , Igor Kochemasov
IPC分类号： A61B8/00
CPC分类号： A61B8/0858 , A61B8/4281
摘要： A device is described that can be easily used to accurately measure and monitor tissue thickness using ultrasound. The device comprises a remote control and data processing unit, a handheld ultrasound transducer, a display monitor and means for effectively coupling ultrasound to tissue.
摘要翻译：描述了可以容易地使用超声波来精确地测量和监测组织厚度的装置。该装置包括遥控和数据处理单元，手持超声波换能器，显示监视器和用于有效地将超声波耦合到组织的装置。

2. 发明申请

US20070016061A1 System for measuring and tracking human body fat 审中-公开
标题翻译：用于测量和跟踪人体脂肪的系统
公开(公告)号：US20070016061A1
公开(公告)日：2007-01-18
申请号：US11415560
申请日：2006-05-01
申请人： Luiz Da Silva , George Choi
发明人： Luiz Da Silva , George Choi
IPC分类号： A61B8/14
CPC分类号： A61B8/0858 , A61B5/4869 , A61B5/4872 , A61B8/585
摘要： A system for evaluating health, wellness and fitness, and in particular, to a system that uses an ultrasound transducer to accurately measure fat thickness at a plurality of sites on the human body, records these measurements for long term monitoring, and based on the plurality of measurements calculates the total body composition. The system includes a central control unit to analyze the measurement and display the results in a variety of formats.
摘要翻译：用于评估健康，健康和适应性的系统，特别是使用超声换能器精确测量人体上多个部位的脂肪厚度的系统，记录这些测量用于长期监测，并且基于多个的测量计算总身体组成。该系统包括用于分析测量并以各种格式显示结果的中央控制单元。

3. 发明申请

US20060142750A1 Devices and methods for treatment of skin conditions 有权
标题翻译：用于治疗皮肤病症的装置和方法
公开(公告)号：US20060142750A1
公开(公告)日：2006-06-29
申请号：US11299284
申请日：2005-12-09
申请人： Luiz Da Silva , George Choi
发明人： Luiz Da Silva , George Choi
IPC分类号： A61B18/04
CPC分类号： A61B18/082 , A61B2017/00734 , A61B2017/00761 , A61B2018/00005 , A61B2018/0047 , A61B2018/00714 , A61B2018/00761 , A61B2018/00791
摘要： Devices and methods for the treatment of skin conditions and lesions are disclosed herein. One aspect of the invention is a compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices described herein employ the application of heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 70° C. to about 400° C. by the devices, are achieved in less than about 1 second, and maintained for less than about 1 second. In some embodiments, the skin surface is heated with heat pulses. Thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.
摘要翻译：本文公开了用于治疗皮肤病况和损伤的装置和方法。本发明的一个方面是紧凑的手持装置，其可以被患有皮肤状况的人安全地使用，例如痤疮，疣，冷水泡，瑕疵的皮肤或细皱纹。本文描述的装置使用热量来治疗皮肤病症和损伤。通常，所用装置的峰值温度为约70℃至约400℃，在小于约1秒钟内实现，并保持少于约1秒。在一些实施方案中，用热脉冲加热皮肤表面。热传导将热量从设备传递到皮肤，并引起加速痤疮清除，治疗瑕疵皮肤，瘙痒或细皱纹的生物反应。传热的总热量足够低以防止灼伤。

4. 发明申请

US20060129214A1 Skin treatment device 有权
公开(公告)号：US20060129214A1
公开(公告)日：2006-06-15
申请号：US11216595
申请日：2005-08-30
申请人： Luiz Da Silva , George Choi
发明人： Luiz Da Silva , George Choi
IPC分类号： A61F7/00
CPC分类号： A61B18/082 , A61B2017/00734 , A61B2017/00761
摘要： A compact hand held device is provided that can be safely used by those suffering from acne, blemished skin or fine wrinkles. The hand held device includes an on/off switch and a button that pulses the device when it is placed on the target site. A battery within the device powers a circuit board and drives a short pulse of current through a heating element, which heats up to approximately 300° C. in less than 0.1 sec. Thermal conduction transfers the heat to the skin and causes a biological response that accelerates acne clearing, treats blemished skin or fine wrinkles. The total heat transferred is low enough to prevent burns. Application of acne treatment creams and gels further accelerates treatment

5. 发明申请

US20050113654A1 Body function monitoring mouth guard 审中-公开
标题翻译：身体功能监控口罩
公开(公告)号：US20050113654A1
公开(公告)日：2005-05-26
申请号：US10916787
申请日：2004-08-11
申请人： Paul Weber , Luiz Da Silva , John Wooldridge
发明人： Paul Weber , Luiz Da Silva , John Wooldridge
IPC分类号： A61B5/00 , A61B5/01 , A63B71/08
CPC分类号： A61B5/01 , A61B5/02055 , A61B5/02438 , A61B5/14532 , A61B5/1455 , A61B5/14551 , A61B5/682 , A61B2503/10 , A63B71/085 , A63B2071/088 , A63B2230/50
摘要： A device is described that can be easily used to warn an athlete of potential risk of hyperthermia due to an elevated core body temperature. The mouth guard device continually monitors the users internal or core body temperature and emits an alarm signal when body temperature exceeds a preset value. This invention can protect the physical well being of an athlete as well as improve overall team performance.
摘要翻译：描述了一种可以容易地用于警告运动员由于核心体温升高而引起的高热潜在风险的装置。口罩设备持续监控用户内部或核心体温，并在体温超过预设值时发出报警信号。本发明可以保护运动员的身体健康以及提高团队的整体表现。

6. 发明授权

US06484052B1 Optically generated ultrasound for enhanced drug delivery 失效
标题翻译：光学产生的超声波用于增强药物输送
公开(公告)号：US06484052B1
公开(公告)日：2002-11-19
申请号：US09281371
申请日：1999-03-30
申请人： Steven R. Visuri , Heather L. Campbell , Luiz Da Silva
发明人： Steven R. Visuri , Heather L. Campbell , Luiz Da Silva
IPC分类号： A61N130
CPC分类号： A61M37/0092 , A61B2018/263 , A61M2037/0007
摘要： High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably locally to the targeted site. Local delivery can be accomplished through a needle, cannula, or through a variety of vascular catheters, depending on the location of routes of access. To enhance the systemic or local delivery of the therapeutic compounds, high frequency acoustic waves are generated locally near the target site, and preferably near the site of compound administration. The acoustic waves are produced via laser radiation interaction with an absorbing media and can be produced via thermoelastic expansion, thermodynamic vaporization, material ablation, or plasma formation. Acoustic waves have the effect of temporarily permeabilizing the membranes of local cells, increasing the diffusion of the therapeutic compound into the cells, allowing for decreased total body dosages, decreased side effects, and enabling new therapies.
摘要翻译：类似于超声的高频声波可以增强治疗性化合物递送到细胞中。所递送的化合物可以是化疗药物，抗生素，光动力药物或基因疗法。治疗性化合物系统地或优选局部施用于靶向部位。取决于进入路线的位置，可以通过针头，插管或通过各种血管导管实现局部输送。为了增强治疗化合物的全身或局部递送，在靶位点局部产生高频声波，优选在化合物给药部位附近产生高频声波。声波通过与吸收介质的激光辐射相互作用产生，并且可以通过热弹性膨胀，热力学蒸发，材料消融或等离子体形成来产生。声波具有临时透化局部细胞膜的作用，增加治疗化合物向细胞的扩散，允许减少全身剂量，减少副作用，并使新疗法成为可能。

7. 发明授权

US06466713B2 Optical fiber head for providing lateral viewing 有权
公开(公告)号：US06466713B2
公开(公告)日：2002-10-15
申请号：US09883513
申请日：2001-06-18
申请人： Matthew J. Everett , Billy W. Colston , Dale L. James , Steve Brown , Luiz Da Silva
发明人： Matthew J. Everett , Billy W. Colston , Dale L. James , Steve Brown , Luiz Da Silva
IPC分类号： G02B626
CPC分类号： G02B6/241 , A61B5/0066 , A61B5/0084 , G02B6/262
摘要： The head of an optical fiber comprising the sensing probe of an optical heterodyne sensing device includes a planar surface that intersects the perpendicular to axial centerline of the fiber at a polishing angle &thgr;. The planar surface is coated with a reflective material so that light traveling axially through the fiber is reflected transverse to the fiber's axial centerline, and is emitted laterally through the side of the fiber. Alternatively, the planar surface can be left uncoated. The polishing angle &thgr; must be no greater than 39° or must be at least 51°. The emitted light is reflected from adjacent biological tissue, collected by the head, and then processed to provide real-time images of the tissue. The method for forming the planar surface includes shearing the end of the optical fiber and applying the reflective material before removing the buffer that circumscribes the cladding and the core.

8. 发明授权

US06379325B1 Opto-acoustic transducer for medical applications 失效
标题翻译：用于医疗应用的光学传感器
公开(公告)号：US06379325B1
公开(公告)日：2002-04-30
申请号：US09350494
申请日：1999-07-09
申请人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
发明人： William Benett , Peter Celliers , Luiz Da Silva , Michael Glinsky , Richard London , Duncan Maitland , Dennis Matthews , Peter Krulevich , Abraham Lee
IPC分类号： A61B1720
CPC分类号： A61B18/26 , A61B17/2202 , A61B2017/00106 , A61B2017/22084 , A61B2090/378
摘要： This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.
摘要翻译：本发明是用于在生物介质中产生声振动的光学激活换能器。传感器位于可以位于导管内的光纤的端部。用于操作换能器的能量由通过光纤传输到换能器的激光光学地提供。脉冲激光被吸收在换能器的工作流体中，以产生热压力并随之导致换能器头部的绝热膨胀，使其对环境介质起作用。传感器通过热冷却过程返回到其原始状态。传感器在环境介质中的运动将声能耦合到介质中。通过以高重复率脉冲激光（其可以从CW变化到100kHz），可以在介质中局部地建立超声辐射场。这种生产超声波振动的方法可以在体内用于治疗人类中风相关病症，特别是用于溶解血栓。导管还可以掺入抗血栓溶解药物治疗作为辅助治疗，并且其可以与用于成像和反馈控制的超声波检测设备结合操作。

9. 发明申请

US20100087806A1 Automated Cryogenic Skin Treatment 审中-公开
公开(公告)号：US20100087806A1
公开(公告)日：2010-04-08
申请号：US12575370
申请日：2009-10-07
申请人： Luiz Da Silva , Donald Cohen , Marc Lieberman
发明人： Luiz Da Silva , Donald Cohen , Marc Lieberman
IPC分类号： A61B18/02
CPC分类号： A61B18/0218 , A61B90/361 , A61B2017/00084 , A61B2017/00747
摘要： An apparatus and methods for treating lesions on skin are presented. The apparatus collects information about a lesion and can automatically determine a course of treatment for the lesion. The device can include a controller that positions the nozzle proximate to a surface region of the lesion and automatically dispenses a pulse of the cryogenic fluid from the nozzle. The controller then positions the nozzle proximate to another surface region of the lesion and automatically dispenses a pulse of the cryogenic fluid from the nozzle.

10. 发明申请

US20050261568A1 Multisensor probe for tissue identification 审中-公开
标题翻译：用于组织鉴定的多传感器探针
公开(公告)号：US20050261568A1
公开(公告)日：2005-11-24
申请号：US11139904
申请日：2005-05-26
申请人： Richard Hular , Luiz Da Silva , Charles Chase
发明人： Richard Hular , Luiz Da Silva , Charles Chase
IPC分类号： G01N21/17 , A61B5/00 , A61B5/01 , A61B5/05 , A61B5/145 , A61B5/1459 , A61B10/00 , A61B17/00 , A61B19/00 , G01N21/27
CPC分类号： A61B5/6848 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/061 , A61B5/145 , A61B5/6885 , A61B2017/00796 , A61B2090/062 , A61B2562/0242
摘要： A multisensor probe for continuous real-time tissue identification. The multisensor probe includes a tissue penetrating needle, a plurality of sensors useful in characterizing tissue and a position sensor to measure the depth of the needle into the tissue being diagnosed. The sensors include but are not limited to an optical scattering and absorption spectroscopy sensor, an optical coherence domain reflectometry sensor, an electrical impedance sensor, a temperature sensor, a pO2 sensor, a chemical sensor and other sensors useful in identifying tissue. The sensors may take the form of a plurality of optical fibers extending through said needle. A retractable sheath may be disposed around the distal section of the needle to protect the needle when not in use. The sheath retracts when the probe is inserted into tissue and the position of the sheath relative to the needle may be measured to determine the needle's depth. Systems and methods for tissue identification are also provided.
摘要翻译：用于连续实时组织鉴定的多传感器探头。多传感器探针包括组织穿刺针，用于表征组织的多个传感器和位置传感器，以测量针进入被诊断的组织的深度。这些传感器包括但不限于光学散射和吸收光谱传感器，光学相干畴反射测量传感器，电阻抗传感器，温度传感器，pO 2传感器，化学传感器和其它传感器用于鉴定组织。传感器可以采用延伸穿过所述针的多根光纤的形式。可伸缩护套可以设置在针的远端部分周围，以在不使用时保护针头。当探头插入组织中时，护套缩回，并且可以测量护套相对于针的位置以确定针的深度。还提供了用于组织鉴定的系统和方法。

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